WO2001083801A3 - A method for isolating salinomycin from fermentation broth - Google Patents

A method for isolating salinomycin from fermentation broth Download PDF

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Publication number
WO2001083801A3
WO2001083801A3 PCT/SK2001/000015 SK0100015W WO0183801A3 WO 2001083801 A3 WO2001083801 A3 WO 2001083801A3 SK 0100015 W SK0100015 W SK 0100015W WO 0183801 A3 WO0183801 A3 WO 0183801A3
Authority
WO
WIPO (PCT)
Prior art keywords
salinomycin
fermentation broth
isolating
granulated
filtration
Prior art date
Application number
PCT/SK2001/000015
Other languages
French (fr)
Other versions
WO2001083801A2 (en
Inventor
Maria Jakubcova
Dusan Lucina
Milos Bosansky
Gabriela Borosova
Pavol Ivanic
Original Assignee
Biotika As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotika As filed Critical Biotika As
Priority to CA002407708A priority Critical patent/CA2407708A1/en
Priority to DE10196144T priority patent/DE10196144T1/en
Priority to SI200120024A priority patent/SI21043A/en
Priority to AU2001255144A priority patent/AU2001255144A1/en
Priority to BR0110589-2A priority patent/BR0110589A/en
Publication of WO2001083801A2 publication Critical patent/WO2001083801A2/en
Publication of WO2001083801A3 publication Critical patent/WO2001083801A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Processing Of Solid Wastes (AREA)
  • Soil Conditioners And Soil-Stabilizing Materials (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present solution refers to a method of isolating salinomycin for the purpose of obtaining a granulated product. The purpose aforementioned is reached by a method for isolating salinomycin from the fermentation broth according to the invention, the nature of which consists in that the fermentation broth of salinomycin is adjusted to an acidic pH range. A suitable inert filtration aid such as diatomaceous earth, zeolites, wood flour or a mixture thereof is added in an amount of 5 to 20 wt % referred to the weight of the fermentation broth. The biomass is separated by filtration, granulated and dried in a fluid bed drier. The dry granules are ground and sieved to a required particle size.
PCT/SK2001/000015 2000-05-04 2001-05-03 A method for isolating salinomycin from fermentation broth WO2001083801A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA002407708A CA2407708A1 (en) 2000-05-04 2001-05-03 A method for isolating salinomycin from fermentation broth
DE10196144T DE10196144T1 (en) 2000-05-04 2001-05-03 Process for the isolation of salinomycin from a fermentation broth
SI200120024A SI21043A (en) 2000-05-04 2001-05-03 A method for isolating salinomycin from fermentation broth
AU2001255144A AU2001255144A1 (en) 2000-05-04 2001-05-03 A method for isolating salinomycin from fermentation broth
BR0110589-2A BR0110589A (en) 2000-05-04 2001-05-03 Salinomycin isolation process from fermentation broth

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SK664-2000A SK283167B6 (en) 2000-05-04 2000-05-04 Method for isolation of salinomycin from the fermented soil
SKPV0664-2000 2000-05-04

Publications (2)

Publication Number Publication Date
WO2001083801A2 WO2001083801A2 (en) 2001-11-08
WO2001083801A3 true WO2001083801A3 (en) 2002-06-13

Family

ID=20435891

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SK2001/000015 WO2001083801A2 (en) 2000-05-04 2001-05-03 A method for isolating salinomycin from fermentation broth

Country Status (8)

Country Link
AU (1) AU2001255144A1 (en)
BR (1) BR0110589A (en)
CA (1) CA2407708A1 (en)
CZ (1) CZ20023429A3 (en)
DE (1) DE10196144T1 (en)
SI (1) SI21043A (en)
SK (1) SK283167B6 (en)
WO (1) WO2001083801A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108478536A (en) * 2018-03-30 2018-09-04 内蒙古拜克生物有限公司 A kind of salinomycin prilling process

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2655275A1 (en) * 2006-06-13 2007-12-21 Phibro Animal Health Corporation Use of fast-release pristinamycin-type and polyether ionophore type antimicrobial agents in the production of ethanol

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2353998A1 (en) * 1972-10-27 1975-05-07 Kaken Chemical Co Antibiotic salinomycin - produced by cultivating Streptomyces albus and extracting the medium and mycelium
US4009262A (en) * 1975-04-21 1977-02-22 Eli Lilly And Company Antibiotic a-28086 recovery process
EP0000037A1 (en) * 1977-06-01 1978-12-20 Kaken Chemical Company, Ltd. Method of producing salinomycin type antibiotics and new salinomycin type antibiotics
US4395491A (en) * 1980-02-15 1983-07-26 Hoechst Aktiengesellschaft Method for isolating solid matter from a salinomycin culture broth
JPS61247398A (en) * 1986-01-21 1986-11-04 Kaken Pharmaceut Co Ltd Production of salinomycin
US5529911A (en) * 1990-12-21 1996-06-25 Hoechst Aktiengesellschaft Preparation of granules containing salinomycin

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2353998A1 (en) * 1972-10-27 1975-05-07 Kaken Chemical Co Antibiotic salinomycin - produced by cultivating Streptomyces albus and extracting the medium and mycelium
US4009262A (en) * 1975-04-21 1977-02-22 Eli Lilly And Company Antibiotic a-28086 recovery process
EP0000037A1 (en) * 1977-06-01 1978-12-20 Kaken Chemical Company, Ltd. Method of producing salinomycin type antibiotics and new salinomycin type antibiotics
US4395491A (en) * 1980-02-15 1983-07-26 Hoechst Aktiengesellschaft Method for isolating solid matter from a salinomycin culture broth
JPS61247398A (en) * 1986-01-21 1986-11-04 Kaken Pharmaceut Co Ltd Production of salinomycin
US5529911A (en) * 1990-12-21 1996-06-25 Hoechst Aktiengesellschaft Preparation of granules containing salinomycin

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 198650, Derwent World Patents Index; Class B04, AN 1986-329951, XP002180786 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108478536A (en) * 2018-03-30 2018-09-04 内蒙古拜克生物有限公司 A kind of salinomycin prilling process

Also Published As

Publication number Publication date
WO2001083801A2 (en) 2001-11-08
CA2407708A1 (en) 2001-11-08
DE10196144T1 (en) 2003-04-17
BR0110589A (en) 2003-04-01
SI21043A (en) 2003-04-30
SK6642000A3 (en) 2002-01-07
SK283167B6 (en) 2003-03-04
AU2001255144A1 (en) 2001-11-12
CZ20023429A3 (en) 2003-04-16

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