CA2401959A1 - 5-hydroxy indazole derivatives for treating glaucoma - Google Patents

5-hydroxy indazole derivatives for treating glaucoma Download PDF

Info

Publication number
CA2401959A1
CA2401959A1 CA002401959A CA2401959A CA2401959A1 CA 2401959 A1 CA2401959 A1 CA 2401959A1 CA 002401959 A CA002401959 A CA 002401959A CA 2401959 A CA2401959 A CA 2401959A CA 2401959 A1 CA2401959 A1 CA 2401959A1
Authority
CA
Canada
Prior art keywords
hydrogen
4alkyl
indazol
aminopropyl
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002401959A
Other languages
English (en)
French (fr)
Inventor
Jesse A. May
Zixia Feng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alcon Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2401959A1 publication Critical patent/CA2401959A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002401959A 2000-03-17 2000-11-14 5-hydroxy indazole derivatives for treating glaucoma Abandoned CA2401959A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19028300P 2000-03-17 2000-03-17
US60/190,283 2000-03-17
PCT/US2000/031143 WO2001070701A1 (en) 2000-03-17 2000-11-14 5-hydroxy indazole derivatives for treating glaucoma

Publications (1)

Publication Number Publication Date
CA2401959A1 true CA2401959A1 (en) 2001-09-27

Family

ID=22700701

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002401959A Abandoned CA2401959A1 (en) 2000-03-17 2000-11-14 5-hydroxy indazole derivatives for treating glaucoma

Country Status (12)

Country Link
EP (1) EP1268439A1 (ko)
JP (1) JP2003535821A (ko)
KR (1) KR20030095183A (ko)
CN (1) CN1450995A (ko)
AR (1) AR026708A1 (ko)
AU (2) AU2001219180B2 (ko)
BR (1) BR0017163A (ko)
CA (1) CA2401959A1 (ko)
MX (1) MXPA02008825A (ko)
PL (1) PL365422A1 (ko)
WO (1) WO2001070701A1 (ko)
ZA (1) ZA200206853B (ko)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
DK1392292T3 (da) 2001-06-01 2006-05-29 Alcon Inc Pyranoindazoler og deres anvendelse til behandling af glaukom
TW593302B (en) 2001-12-20 2004-06-21 Alcon Inc Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma
WO2004043354A2 (en) 2002-11-08 2004-05-27 Merck & Co., Inc. Ophthalmic compositions for treating ocular hypertension
CN100384827C (zh) * 2002-11-08 2008-04-30 默克公司 用于治疗高眼压症的眼用组合物
US7196082B2 (en) * 2002-11-08 2007-03-27 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
JP2006511556A (ja) 2002-12-13 2006-04-06 アルコン，インコーポレイテッド 新規のベンゾピラン類似体及び緑内障の治療のためのそれらの使用
JP2004262812A (ja) * 2003-02-28 2004-09-24 Rohto Pharmaceut Co Ltd 眼圧低下剤
US7494983B2 (en) * 2003-09-04 2009-02-24 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
US7338972B1 (en) 2003-12-15 2008-03-04 Alcon, Inc. Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma
WO2005058911A2 (en) 2003-12-15 2005-06-30 Alcon, Inc. Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma
US7129257B1 (en) 2003-12-15 2006-10-31 Alcon, Inc. Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma
DK1828182T3 (da) 2004-11-29 2010-05-10 Warner Lambert Co Terapeutiske pyrazol[3,4-B]pyridiner og indazoler
US7425572B2 (en) 2004-12-08 2008-09-16 Alcon, Inc. Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma
KR100972921B1 (ko) * 2009-12-02 2010-07-28 제이케이이앤씨 주식회사 회전 격판식 선회류 세정 및 탈취장치

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
CN1301161A (zh) * 1998-05-19 2001-06-27 艾尔科实验室公司 用于治疗眼睛和中枢神经系统障碍的血清素激活的5ht7受体化合物
GB9819020D0 (en) * 1998-09-01 1998-10-28 Cerebrus Ltd Chemical compounds III
EP1112106B1 (en) * 1998-09-18 2005-11-23 Alcon Manufacturing Ltd. Serotonergic 5ht2 agonists for treating glaucoma

Also Published As

Publication number Publication date
ZA200206853B (en) 2004-11-02
AU1918001A (en) 2001-10-03
MXPA02008825A (es) 2004-10-15
CN1450995A (zh) 2003-10-22
EP1268439A1 (en) 2003-01-02
AU2001219180B2 (en) 2005-04-07
PL365422A1 (en) 2005-01-10
AR026708A1 (es) 2003-02-26
WO2001070701A1 (en) 2001-09-27
KR20030095183A (ko) 2003-12-18
JP2003535821A (ja) 2003-12-02
BR0017163A (pt) 2003-01-14

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead