ZA200206853B - 5-hydroxy indazole derivatives for treating glaucoma. - Google Patents
5-hydroxy indazole derivatives for treating glaucoma. Download PDFInfo
- Publication number
- ZA200206853B ZA200206853B ZA200206853A ZA200206853A ZA200206853B ZA 200206853 B ZA200206853 B ZA 200206853B ZA 200206853 A ZA200206853 A ZA 200206853A ZA 200206853 A ZA200206853 A ZA 200206853A ZA 200206853 B ZA200206853 B ZA 200206853B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydrogen
- alkyl
- indazol
- halogen
- aminopropyl
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title description 13
- ZHDXWEPRYNHNDC-UHFFFAOYSA-N 1h-indazol-5-ol Chemical class OC1=CC=C2NN=CC2=C1 ZHDXWEPRYNHNDC-UHFFFAOYSA-N 0.000 title description 2
- 239000001257 hydrogen Substances 0.000 claims description 74
- 229910052739 hydrogen Inorganic materials 0.000 claims description 74
- 150000001875 compounds Chemical class 0.000 claims description 59
- 125000000217 alkyl group Chemical group 0.000 claims description 57
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 41
- 229910052736 halogen Inorganic materials 0.000 claims description 31
- 150000002367 halogens Chemical class 0.000 claims description 30
- 150000002431 hydrogen Chemical class 0.000 claims description 25
- 229910052799 carbon Inorganic materials 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 18
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 14
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 11
- 125000000623 heterocyclic group Chemical group 0.000 claims description 10
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 8
- LIRGIBHYEVBULM-UHFFFAOYSA-N [3-(2-aminopropyl)-2h-indazol-5-yl] 2-methylpropanoate Chemical compound C1=C(OC(=O)C(C)C)C=C2C(CC(N)C)=NNC2=C1 LIRGIBHYEVBULM-UHFFFAOYSA-N 0.000 claims description 5
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- 230000004406 elevated intraocular pressure Effects 0.000 claims description 3
- NQJNCNUFJIFXEG-UHFFFAOYSA-N 1-(5-methoxy-2h-indazol-3-yl)propan-2-amine Chemical compound COC1=CC=C2NN=C(CC(C)N)C2=C1 NQJNCNUFJIFXEG-UHFFFAOYSA-N 0.000 claims description 2
- ZNYROIPGZTXHCH-UHFFFAOYSA-N 3-(2-aminopropyl)-6-fluoro-2h-indazol-5-ol Chemical compound FC1=C(O)C=C2C(CC(N)C)=NNC2=C1 ZNYROIPGZTXHCH-UHFFFAOYSA-N 0.000 claims description 2
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- 206010030043 Ocular hypertension Diseases 0.000 description 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19028300P | 2000-03-17 | 2000-03-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200206853B true ZA200206853B (en) | 2004-11-02 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200206853A ZA200206853B (en) | 2000-03-17 | 2002-08-27 | 5-hydroxy indazole derivatives for treating glaucoma. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1268439A1 (ko) |
| JP (1) | JP2003535821A (ko) |
| KR (1) | KR20030095183A (ko) |
| CN (1) | CN1450995A (ko) |
| AR (1) | AR026708A1 (ko) |
| AU (2) | AU1918001A (ko) |
| BR (1) | BR0017163A (ko) |
| CA (1) | CA2401959A1 (ko) |
| MX (1) | MXPA02008825A (ko) |
| PL (1) | PL365422A1 (ko) |
| WO (1) | WO2001070701A1 (ko) |
| ZA (1) | ZA200206853B (ko) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6960579B1 (en) | 1998-05-19 | 2005-11-01 | Alcon Manufacturing, Ltd. | Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders |
| DE60209486T2 (de) | 2001-06-01 | 2006-08-03 | Alcon Inc. | Pyranoindazole und ihre verwendung in der glaukombehandlung |
| TW593302B (en) | 2001-12-20 | 2004-06-21 | Alcon Inc | Novel benzodifuranimidazoline and benzofuranimidazoline derivatives and their use for the treatment of glaucoma |
| US7196082B2 (en) * | 2002-11-08 | 2007-03-27 | Merck & Co. Inc. | Ophthalmic compositions for treating ocular hypertension |
| CN100384827C (zh) * | 2002-11-08 | 2008-04-30 | 默克公司 | 用于治疗高眼压症的眼用组合物 |
| JP2006510742A (ja) * | 2002-11-08 | 2006-03-30 | メルク エンド カムパニー インコーポレーテッド | 高眼圧治療用眼科組成物 |
| CA2506204A1 (en) | 2002-12-13 | 2004-07-01 | Alcon, Inc. | Novel benzopyran analogs and their use for the treatment of glaucoma |
| JP2004262812A (ja) * | 2003-02-28 | 2004-09-24 | Rohto Pharmaceut Co Ltd | 眼圧低下剤 |
| JP2007504236A (ja) * | 2003-09-04 | 2007-03-01 | メルク エンド カムパニー インコーポレーテッド | 高眼圧症を治療するための眼用組成物 |
| US7129257B1 (en) | 2003-12-15 | 2006-10-31 | Alcon, Inc. | Pyrazolo[3,4- e]benzoxazoles for the treatment of glaucoma |
| US7338972B1 (en) | 2003-12-15 | 2008-03-04 | Alcon, Inc. | Substituted 1-alkylamino-1H-indazoles for the treatment of glaucoma |
| WO2005058911A2 (en) | 2003-12-15 | 2005-06-30 | Alcon, Inc. | Substituted [1,4]oxazino[2,3-g]indazoles for the treatment of glaucoma |
| ATE460415T1 (de) | 2004-11-29 | 2010-03-15 | Warner Lambert Co | Therapeutische pyrazoloä3,4-büpyridine und - indazole |
| WO2006062839A1 (en) | 2004-12-08 | 2006-06-15 | Alcon, Inc. | Use of dioxindoindazoles and dioxoloindazoles for treating glaucoma |
| KR100972921B1 (ko) * | 2009-12-02 | 2010-07-28 | 제이케이이앤씨 주식회사 | 회전 격판식 선회류 세정 및 탈취장치 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2680366B1 (fr) * | 1991-08-13 | 1995-01-20 | Adir | Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO1999059499A2 (en) * | 1998-05-19 | 1999-11-25 | Alcon Laboratories, Inc. | Serotonergic 5ht7 receptor compounds for treating ocular and cns disorders |
| GB9819020D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Ltd | Chemical compounds III |
| US6664286B1 (en) * | 1998-09-18 | 2003-12-16 | Alcon Manufacturing, Ltd. | Serotonergic 5ht2 agonists for treating glaucoma |
-
2000
- 2000-11-14 BR BR0017163-8A patent/BR0017163A/pt not_active IP Right Cessation
- 2000-11-14 MX MXPA02008825A patent/MXPA02008825A/es unknown
- 2000-11-14 WO PCT/US2000/031143 patent/WO2001070701A1/en not_active Application Discontinuation
- 2000-11-14 PL PL00365422A patent/PL365422A1/xx not_active Application Discontinuation
- 2000-11-14 CA CA002401959A patent/CA2401959A1/en not_active Abandoned
- 2000-11-14 CN CN00819348A patent/CN1450995A/zh active Pending
- 2000-11-14 AU AU1918001A patent/AU1918001A/xx active Pending
- 2000-11-14 EP EP00982109A patent/EP1268439A1/en not_active Withdrawn
- 2000-11-14 AU AU2001219180A patent/AU2001219180B2/en not_active Ceased
- 2000-11-14 KR KR1020027011862A patent/KR20030095183A/ko not_active Application Discontinuation
- 2000-11-14 JP JP2001568911A patent/JP2003535821A/ja active Pending
- 2000-12-01 AR ARP000106395A patent/AR026708A1/es unknown
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2002
- 2002-08-27 ZA ZA200206853A patent/ZA200206853B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1268439A1 (en) | 2003-01-02 |
| JP2003535821A (ja) | 2003-12-02 |
| AU1918001A (en) | 2001-10-03 |
| WO2001070701A1 (en) | 2001-09-27 |
| MXPA02008825A (es) | 2004-10-15 |
| KR20030095183A (ko) | 2003-12-18 |
| BR0017163A (pt) | 2003-01-14 |
| CA2401959A1 (en) | 2001-09-27 |
| AU2001219180B2 (en) | 2005-04-07 |
| AR026708A1 (es) | 2003-02-26 |
| CN1450995A (zh) | 2003-10-22 |
| PL365422A1 (en) | 2005-01-10 |
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