CA2401120A1 - Lactames en tant qu'inhibiteurs de production de proteines a-beta - Google Patents

Lactames en tant qu'inhibiteurs de production de proteines a-beta Download PDF

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Publication number
CA2401120A1
CA2401120A1 CA002401120A CA2401120A CA2401120A1 CA 2401120 A1 CA2401120 A1 CA 2401120A1 CA 002401120 A CA002401120 A CA 002401120A CA 2401120 A CA2401120 A CA 2401120A CA 2401120 A1 CA2401120 A1 CA 2401120A1
Authority
CA
Canada
Prior art keywords
phenyl
substituted
alkyl
ethyl
occurrence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002401120A
Other languages
English (en)
Inventor
Lorin Andrew Thompson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Pharma Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2401120A1 publication Critical patent/CA2401120A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouveaux lactames représentés par la formule générale (I), leurs compositions pharmaceutiques et leurs procédés d'utilisation. Ces nouveaux composés inhibent le traitement de la protéine précurseur amyloïde et, d'une manière plus spécifique, inhibent la production de peptides A.beta., prévenant ainsi la formation de dépôts neurologiques de la protéine amyloïde. Plus particulièrement, l'invention concerne le traitement de troubles neurologiques liés à la production de la protéine .beta.-amyloïde, notamment la maladie d'Alzheimer et le syndrome de Down.
CA002401120A 2000-03-28 2001-03-27 Lactames en tant qu'inhibiteurs de production de proteines a-beta Abandoned CA2401120A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19251700P 2000-03-28 2000-03-28
US60/192,517 2000-03-28
PCT/US2001/009703 WO2001072324A1 (fr) 2000-03-28 2001-03-27 Lactames en tant qu'inhibiteurs de production de proteines a-beta

Publications (1)

Publication Number Publication Date
CA2401120A1 true CA2401120A1 (fr) 2001-10-04

Family

ID=22709993

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002401120A Abandoned CA2401120A1 (fr) 2000-03-28 2001-03-27 Lactames en tant qu'inhibiteurs de production de proteines a-beta

Country Status (5)

Country Link
EP (1) EP1267906A1 (fr)
JP (1) JP2003528150A (fr)
AU (1) AU2001249477A1 (fr)
CA (1) CA2401120A1 (fr)
WO (1) WO2001072324A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8235258B2 (en) 2005-04-19 2012-08-07 Kamterter Ii, L.L.C. Systems for the control and use of fluids and particles

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2001261728A1 (en) 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
TW200502221A (en) 2002-10-03 2005-01-16 Astrazeneca Ab Novel lactams and uses thereof
EP1636196A1 (fr) * 2003-03-14 2006-03-22 AstraZeneca AB Nouveaux lactames et leurs utilisations
ZA200603165B (en) * 2003-11-03 2007-07-25 Probiodrug Ag Combinations useful for the treatment of neuronal disorders
WO2006065218A1 (fr) * 2004-12-14 2006-06-22 Astrazeneca Ab Nouvelles sondes moleculaires

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA002100B1 (ru) * 1996-12-23 2001-12-24 Элан Фармасьютикалз, Инк. ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ
EP1089980A1 (fr) * 1998-06-22 2001-04-11 Elan Pharmaceuticals, Inc. Composes d'inhibition de la liberation du peptide beta-amyloide et/ou de sa synthese
HRP990246A2 (en) * 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8235258B2 (en) 2005-04-19 2012-08-07 Kamterter Ii, L.L.C. Systems for the control and use of fluids and particles

Also Published As

Publication number Publication date
AU2001249477A1 (en) 2001-10-08
EP1267906A1 (fr) 2003-01-02
WO2001072324A1 (fr) 2001-10-04
JP2003528150A (ja) 2003-09-24

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Legal Events

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FZDE Dead