CA2399834C - Preparation of dialkylpyridylboranes - Google Patents

Preparation of dialkylpyridylboranes Download PDF

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Publication number
CA2399834C
CA2399834C CA002399834A CA2399834A CA2399834C CA 2399834 C CA2399834 C CA 2399834C CA 002399834 A CA002399834 A CA 002399834A CA 2399834 A CA2399834 A CA 2399834A CA 2399834 C CA2399834 C CA 2399834C
Authority
CA
Canada
Prior art keywords
reagent
c10alkyl
alkoxydialkylborane
grignard
pyridine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002399834A
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English (en)
French (fr)
Other versions
CA2399834A1 (en
Inventor
David Harold Brown Ripin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CA2399834A1 publication Critical patent/CA2399834A1/en
Application granted granted Critical
Publication of CA2399834C publication Critical patent/CA2399834C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002399834A 2001-08-27 2002-08-23 Preparation of dialkylpyridylboranes Expired - Fee Related CA2399834C (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31518301P 2001-08-27 2001-08-27
US60/315,183 2001-08-27

Publications (2)

Publication Number Publication Date
CA2399834A1 CA2399834A1 (en) 2003-02-27
CA2399834C true CA2399834C (en) 2006-08-22

Family

ID=23223262

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002399834A Expired - Fee Related CA2399834C (en) 2001-08-27 2002-08-23 Preparation of dialkylpyridylboranes

Country Status (18)

Country Link
US (1) US6570017B2 (https=)
EP (1) EP1288217B1 (https=)
JP (1) JP2003096084A (https=)
KR (1) KR20030019112A (https=)
CN (1) CN1401649A (https=)
AT (1) ATE321766T1 (https=)
BR (1) BR0203371A (https=)
CA (1) CA2399834C (https=)
CZ (1) CZ20022642A3 (https=)
DE (1) DE60210224T2 (https=)
ES (1) ES2256416T3 (https=)
HU (1) HUP0202868A3 (https=)
IL (1) IL151379A0 (https=)
MX (1) MXPA02008364A (https=)
PL (1) PL355706A1 (https=)
RU (1) RU2002122947A (https=)
YU (1) YU59502A (https=)
ZA (1) ZA200206778B (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8648192B2 (en) * 2010-05-26 2014-02-11 Boehringer Ingelheim International Gmbh 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives
CN103483366B (zh) * 2013-09-05 2017-02-08 润泽制药(苏州)有限公司 甲氧基二乙基硼烷的制备方法
US20180370946A1 (en) * 2015-11-17 2018-12-27 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
CN117402184B (zh) * 2023-12-15 2024-04-26 山东国邦药业有限公司 一种二乙基甲氧基硼烷的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0010947B1 (en) * 1978-11-07 1982-01-13 Imperial Chemical Industries Plc Alkylborane complexes with aromatic amines, solutions thereof for use as hydroborating and reducing agents, and processes for their manufacture
GB8304613D0 (en) * 1983-02-18 1983-03-23 Ici Plc Chemical process
DE4320432A1 (de) * 1993-06-21 1994-12-22 Bayer Ag Substituierte Mono- und Bipyridylmethylderivate
US5486534A (en) * 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
CA2329065A1 (en) * 1998-05-05 1999-11-11 Francisco Xavier Talamas Pyrazole derivatives as p-38 map kinase inhibitors

Also Published As

Publication number Publication date
DE60210224D1 (de) 2006-05-18
US20030083312A1 (en) 2003-05-01
PL355706A1 (en) 2003-03-10
CZ20022642A3 (cs) 2003-09-17
CA2399834A1 (en) 2003-02-27
JP2003096084A (ja) 2003-04-03
KR20030019112A (ko) 2003-03-06
ZA200206778B (en) 2004-02-23
BR0203371A (pt) 2003-05-27
DE60210224T2 (de) 2007-01-11
CN1401649A (zh) 2003-03-12
ES2256416T3 (es) 2006-07-16
YU59502A (sh) 2004-12-31
EP1288217A2 (en) 2003-03-05
US6570017B2 (en) 2003-05-27
HUP0202868A2 (hu) 2003-06-28
EP1288217A3 (en) 2003-09-17
HU0202868D0 (https=) 2002-10-28
EP1288217B1 (en) 2006-03-29
IL151379A0 (en) 2003-04-10
RU2002122947A (ru) 2004-03-10
MXPA02008364A (es) 2003-03-04
HUP0202868A3 (en) 2004-04-28
ATE321766T1 (de) 2006-04-15

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