BR0203371A - Preparação de dialquilpiridilboranos - Google Patents
Preparação de dialquilpiridilboranosInfo
- Publication number
- BR0203371A BR0203371A BR0203371-2A BR0203371A BR0203371A BR 0203371 A BR0203371 A BR 0203371A BR 0203371 A BR0203371 A BR 0203371A BR 0203371 A BR0203371 A BR 0203371A
- Authority
- BR
- Brazil
- Prior art keywords
- grignard
- dialkylpyridylboranes
- preparation
- reagent
- alkoxydialkylborane
- Prior art date
Links
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 2
- 239000007818 Grignard reagent Substances 0.000 abstract 1
- 150000004795 grignard reagents Chemical class 0.000 abstract 1
- 150000005748 halopyridines Chemical class 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
"PREPARAçãO DE DIALQUILPIRIDILBORANOS". presente invenção refere-se a um método de prepação de dialquilpiridilboranos pela reação do reagente piridina de Grignard com um alcoxidialquilborano ou uma trialquilborano. A reação pode ser conduzida a uma temperatura desde cerca de 0<198>C até cerca de 40<198>C. O reagente piridina de Grignard é de preferência preparado in situ pela reação de um reagente Grignard (RMgX) com uma halopiridina em um solvente apropriado, tal como tetrahidrofurano, seguida pela adição de um alcoxidialquilborano ou um trialquilborano para formar um dialquilpiridilborano.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31518301P | 2001-08-27 | 2001-08-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0203371A true BR0203371A (pt) | 2003-05-27 |
Family
ID=23223262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0203371-2A BR0203371A (pt) | 2001-08-27 | 2002-08-23 | Preparação de dialquilpiridilboranos |
Country Status (18)
Country | Link |
---|---|
US (1) | US6570017B2 (pt) |
EP (1) | EP1288217B1 (pt) |
JP (1) | JP2003096084A (pt) |
KR (1) | KR20030019112A (pt) |
CN (1) | CN1401649A (pt) |
AT (1) | ATE321766T1 (pt) |
BR (1) | BR0203371A (pt) |
CA (1) | CA2399834C (pt) |
CZ (1) | CZ20022642A3 (pt) |
DE (1) | DE60210224T2 (pt) |
ES (1) | ES2256416T3 (pt) |
HU (1) | HUP0202868A3 (pt) |
IL (1) | IL151379A0 (pt) |
MX (1) | MXPA02008364A (pt) |
PL (1) | PL355706A1 (pt) |
RU (1) | RU2002122947A (pt) |
YU (1) | YU59502A (pt) |
ZA (1) | ZA200206778B (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011149822A1 (en) * | 2010-05-26 | 2011-12-01 | Boehringer Ingelheim International Gmbh | 2-oxo-1,2-dihydropyridin-4-ylboronic acid derivatives |
CN103483366B (zh) * | 2013-09-05 | 2017-02-08 | 润泽制药(苏州)有限公司 | 甲氧基二乙基硼烷的制备方法 |
KR20180101342A (ko) * | 2015-11-17 | 2018-09-12 | 다우 아그로사이언시즈 엘엘씨 | 4-((6-(2-(2,4-디플루오로페닐)-1,1-디플루오로-2-히드록시-3-(1h-1,2,4-트리아졸-1-일)프로필)피리딘-3-일)옥시)벤조니트릴 및 제조방법 |
CN117402184B (zh) * | 2023-12-15 | 2024-04-26 | 山东国邦药业有限公司 | 一种二乙基甲氧基硼烷的制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2961831D1 (en) * | 1978-11-07 | 1982-02-25 | Ici Plc | Alkylborane complexes with aromatic amines, solutions thereof for use as hydroborating and reducing agents, and processes for their manufacture |
GB8304613D0 (en) * | 1983-02-18 | 1983-03-23 | Ici Plc | Chemical process |
DE4320432A1 (de) * | 1993-06-21 | 1994-12-22 | Bayer Ag | Substituierte Mono- und Bipyridylmethylderivate |
US5486534A (en) * | 1994-07-21 | 1996-01-23 | G. D. Searle & Co. | 3,4-substituted pyrazoles for the treatment of inflammation |
PL344004A1 (en) * | 1998-05-05 | 2001-09-10 | Hoffmann La Roche | Pyrazole derivatives as p-38 map kinase inhibitors |
-
2002
- 2002-07-31 CZ CZ20022642A patent/CZ20022642A3/cs unknown
- 2002-08-09 YU YU59502A patent/YU59502A/sh unknown
- 2002-08-15 DE DE60210224T patent/DE60210224T2/de not_active Expired - Fee Related
- 2002-08-15 AT AT02255717T patent/ATE321766T1/de not_active IP Right Cessation
- 2002-08-15 EP EP02255717A patent/EP1288217B1/en not_active Expired - Lifetime
- 2002-08-15 ES ES02255717T patent/ES2256416T3/es not_active Expired - Lifetime
- 2002-08-21 IL IL15137902A patent/IL151379A0/xx unknown
- 2002-08-23 CN CN02142212A patent/CN1401649A/zh active Pending
- 2002-08-23 JP JP2002243438A patent/JP2003096084A/ja active Pending
- 2002-08-23 US US10/226,429 patent/US6570017B2/en not_active Expired - Fee Related
- 2002-08-23 ZA ZA200206778A patent/ZA200206778B/xx unknown
- 2002-08-23 CA CA002399834A patent/CA2399834C/en not_active Expired - Fee Related
- 2002-08-23 BR BR0203371-2A patent/BR0203371A/pt not_active IP Right Cessation
- 2002-08-26 KR KR1020020050579A patent/KR20030019112A/ko not_active Application Discontinuation
- 2002-08-26 RU RU2002122947/04A patent/RU2002122947A/ru unknown
- 2002-08-26 PL PL02355706A patent/PL355706A1/xx unknown
- 2002-08-26 HU HU0202868A patent/HUP0202868A3/hu unknown
- 2002-08-26 MX MXPA02008364A patent/MXPA02008364A/es active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
CN1401649A (zh) | 2003-03-12 |
CA2399834C (en) | 2006-08-22 |
US20030083312A1 (en) | 2003-05-01 |
DE60210224D1 (de) | 2006-05-18 |
YU59502A (sh) | 2004-12-31 |
CZ20022642A3 (cs) | 2003-09-17 |
IL151379A0 (en) | 2003-04-10 |
ZA200206778B (en) | 2004-02-23 |
JP2003096084A (ja) | 2003-04-03 |
EP1288217B1 (en) | 2006-03-29 |
RU2002122947A (ru) | 2004-03-10 |
US6570017B2 (en) | 2003-05-27 |
EP1288217A3 (en) | 2003-09-17 |
ATE321766T1 (de) | 2006-04-15 |
HU0202868D0 (pt) | 2002-10-28 |
DE60210224T2 (de) | 2007-01-11 |
KR20030019112A (ko) | 2003-03-06 |
MXPA02008364A (es) | 2003-03-04 |
ES2256416T3 (es) | 2006-07-16 |
HUP0202868A3 (en) | 2004-04-28 |
CA2399834A1 (en) | 2003-02-27 |
HUP0202868A2 (hu) | 2003-06-28 |
EP1288217A2 (en) | 2003-03-05 |
PL355706A1 (en) | 2003-03-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2010003887A (es) | Metodo para produicir 2?-desoxi-5-azacitidina (decitabina). | |
BRPI0713190A2 (pt) | método para a preparação de um composto | |
MX2008010481A (es) | Compuestos que tienen afinado para el receptor f-ht6. | |
EP1191612A3 (en) | Luminescence device, display apparatus and metal coordination compound | |
BRPI0408492A (pt) | processo para preparar ditioésteres | |
BRPI0516911A (pt) | método para a preparação de um composto e composto de anilina | |
BRPI0519557A2 (pt) | composto fluoroquÍmico, composiÇço de revestimento, artigo, e, mÉtodo para fabricar um composto fluoroquÍmico | |
MX2010001576A (es) | Compuestos 3´sustituidos que tienen afinidad con el receptor 5-hidroxitriptamina 6 (5-ht6). | |
ATE427174T1 (de) | Syntheseverfahren fur metallnanopartikel | |
WO2008147812A3 (en) | 4' substituted compounds having 5-ht6 receptor affinity | |
IL188716A0 (en) | Method for preparing 4??-amino-4'-dimethyl-4- | |
DE112007001452A5 (de) | Verfahren zur Herstellung von wasserstoffreichen Cyclosiloxanen | |
BR0203371A (pt) | Preparação de dialquilpiridilboranos | |
Smith et al. | Addition of alkyllithiums to 3 H-quinazoline-4-thione and various substituted quinazoline derivatives; application in synthesis | |
BR0315671A (pt) | Processo para a preparação de um composto | |
ATE517075T1 (de) | Verfahren zur herstellung von halogensubstituiertem benzoldimethanol | |
Lemos et al. | Reactions of azovinylphosphonates with nucleophilic alkenes and heterocycles: Synthesis of tetrahydropyridazine-3-phosphonate and 2-substituted-1-hydrazonoethylphosphonate derivatives | |
Ye et al. | Catalyst-free system for reductive addition of terminal alkynes via 2, 2′-dithiosalicylic acid in water | |
KR940009197A (ko) | 벤젠보린산 유도체, 그 제조방법 및 합성중간체로서의 그 사용 | |
Everson Da Silva et al. | Investigation of Chemoselective Reaction of 2-Amino-8-hydroxyquinoline with Arylsulfonylchloride Derivatives | |
Tarassoli et al. | Synthesis and Characterization of New Silicon and Titanium Derivatives of Bis (anilino) phosphine Oxide | |
TW200800932A (en) | Method for preparation of epoxy compound | |
WO2008062471A3 (en) | A mild method for the production of di-n-propylacetic acid (valproic acid) | |
RU2003101868A (ru) | Способ получения метилхлорсиланов | |
BR0104316A (pt) | Procedimento, livre de emissões, para a obtenção de cobre e outros metais |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE 6A., E 7A., ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2055 DE 25/05/2010. |