CA2398929C - Neuroprotective, antithrombotic and anti-flammatory uses of activated protein c (apc) - Google Patents
Neuroprotective, antithrombotic and anti-flammatory uses of activated protein c (apc) Download PDFInfo
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- CA2398929C CA2398929C CA2398929A CA2398929A CA2398929C CA 2398929 C CA2398929 C CA 2398929C CA 2398929 A CA2398929 A CA 2398929A CA 2398929 A CA2398929 A CA 2398929A CA 2398929 C CA2398929 C CA 2398929C
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
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- A61K38/4866—Protein C (3.4.21.69)
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
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- C12Y—ENZYMES
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18022700P | 2000-02-04 | 2000-02-04 | |
| US60/180,227 | 2000-02-04 | ||
| PCT/US2001/003758 WO2001056532A2 (en) | 2000-02-04 | 2001-02-05 | Neuroprotective, antithrombotic and anti-inflammatory uses of activated protein c (apc) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2398929A1 CA2398929A1 (en) | 2001-08-09 |
| CA2398929C true CA2398929C (en) | 2011-05-31 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2398929A Expired - Fee Related CA2398929C (en) | 2000-02-04 | 2001-02-05 | Neuroprotective, antithrombotic and anti-flammatory uses of activated protein c (apc) |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7074402B2 (enExample) |
| EP (1) | EP1255556B1 (enExample) |
| JP (1) | JP2004508280A (enExample) |
| AT (1) | ATE504310T1 (enExample) |
| AU (1) | AU2001238034A1 (enExample) |
| CA (1) | CA2398929C (enExample) |
| DE (1) | DE60144366D1 (enExample) |
| WO (1) | WO2001056532A2 (enExample) |
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| US20040096443A1 (en) * | 2002-03-08 | 2004-05-20 | Traynelis Stephen Francis | Treatment of neurodegenerative diseases and conditions using par1 antagonists |
| ATE550073T1 (de) | 2001-06-13 | 2012-04-15 | Univ Sydney | Protein c für die wundheilung |
| US20030073636A1 (en) * | 2001-09-19 | 2003-04-17 | Oklahoma Medical Research Foundation | Method of treating diabetes |
| CA2499458C (en) * | 2002-09-30 | 2013-11-12 | Socratech L.L.C. | Protein s protects the nervous system from injury |
| CA2508276C (en) * | 2002-12-05 | 2018-03-27 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| WO2004056309A2 (en) * | 2002-12-05 | 2004-07-08 | Socratech L.L.C. | Neuroprotective activity of activated protein c is independent of its anticoagulant activity |
| US20070142272A1 (en) * | 2003-01-24 | 2007-06-21 | Zlokovic Berislav V | Neuroprotective activity of activated protein c independent of its anticoagulant activity |
| US9192657B2 (en) * | 2003-07-08 | 2015-11-24 | The Scripps Research Institute | Activated protein C variants with normal cytoprotective activity but reduced anticoagulant activity |
| CA2574598A1 (en) * | 2004-07-23 | 2006-02-09 | The University Of Rochester | Activated protein c inhibits undesirable effects of plasminogen activator in the brain |
| US20080293631A1 (en) * | 2005-01-07 | 2008-11-27 | Christopher John Jackson | Treatment for Autoimmune and Inflammatory Conditions |
| US7785857B2 (en) * | 2006-08-31 | 2010-08-31 | Saint Louis University | Protein C variant |
| AU2008280782B2 (en) | 2007-07-20 | 2014-01-23 | Diamedica Inc. | Tissue kallikrein for the treatment of diseases associated with amyloid protein |
| WO2009099642A2 (en) * | 2008-02-05 | 2009-08-13 | The Board Of Trustees Of The Leland Stanford Junior University | Proteomic analysis of active multiple sclerosis lesions |
| CN102458454A (zh) * | 2009-04-22 | 2012-05-16 | 森诺姆尼有限公司 | 用于治疗亨廷顿病的组织激肽释放酶 |
| US20150150954A1 (en) | 2012-07-04 | 2015-06-04 | The University Of Sydney | Treatment of inflammatory skin disorders |
| CN104122396A (zh) * | 2013-04-23 | 2014-10-29 | 中国科学院上海生命科学研究院 | 维生素k依赖性蛋白s作为糖尿病标志物的应用 |
| DK3137102T3 (da) | 2014-04-16 | 2021-10-11 | Zz Biotech Llc | Apc til anvendelse til behandling af unormal kutan ardannelse |
| ES2890623T3 (es) | 2014-04-16 | 2022-01-20 | Zz Biotech Llc | Uso del análogo de APC para curar heridas |
| CN105806818B (zh) * | 2016-04-01 | 2019-11-22 | 南京医科大学 | 检测血小板nmda受体活性的方法及其应用 |
| WO2017212476A1 (en) | 2016-06-05 | 2017-12-14 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Novel molecules for the treatment of inflammation |
| KR20190122706A (ko) | 2017-03-09 | 2019-10-30 | 다이어메디카 인코포레이티드 | 조직 칼리크레인 1의 투약 형태 |
| CA3176941A1 (en) * | 2020-03-24 | 2021-09-30 | Talengen International Limited | Method and medicine for treating huntington's disease |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5084274A (en) * | 1987-11-17 | 1992-01-28 | Scripps Clinic And Research Foundation | Inhibition of arterial thrombotic occlusion or thromboembolism |
| US5009889A (en) * | 1987-12-31 | 1991-04-23 | Oklahoma Medical Research Foundation | Treatment of dysfunctional vascular endothelium using activated protein C |
| AT402153B (de) * | 1989-06-26 | 1997-02-25 | Immuno Ag | Protein-s-hältige pharmazeutische präparation |
| US5254532A (en) * | 1989-06-26 | 1993-10-19 | Immuno Aktiengesellschaft Fur Chemisch-Medizinische Produkte | Preparation for treating and preventing thromboses and thromboembolic complications, use of such a preparation and a method of producing the same |
| IL131615A0 (en) * | 1997-03-24 | 2001-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
| CN1265598A (zh) * | 1997-06-05 | 2000-09-06 | 伊莱利利公司 | 治疗血栓形成性疾病的方法 |
| HUP0001237A3 (en) * | 1997-10-20 | 2002-01-28 | Lilly Co Eli | Methods for treating vascular disorders |
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- 2001-02-05 DE DE60144366T patent/DE60144366D1/de not_active Expired - Lifetime
- 2001-02-05 WO PCT/US2001/003758 patent/WO2001056532A2/en not_active Ceased
- 2001-02-05 CA CA2398929A patent/CA2398929C/en not_active Expired - Fee Related
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- 2001-02-05 EP EP01910427A patent/EP1255556B1/en not_active Expired - Lifetime
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| EP1255556A4 (en) | 2003-07-02 |
| WO2001056532A2 (en) | 2001-08-09 |
| JP2004508280A (ja) | 2004-03-18 |
| DE60144366D1 (de) | 2011-05-19 |
| WO2001056532A3 (en) | 2001-12-06 |
| CA2398929A1 (en) | 2001-08-09 |
| ATE504310T1 (de) | 2011-04-15 |
| US20020028199A1 (en) | 2002-03-07 |
| US7074402B2 (en) | 2006-07-11 |
| EP1255556A2 (en) | 2002-11-13 |
| EP1255556B1 (en) | 2011-04-06 |
| AU2001238034A1 (en) | 2001-08-14 |
| WO2001056532A9 (en) | 2003-01-09 |
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