AU2002350660A1 - Non-neurotoxic plasminogen activating factors for treating stroke - Google Patents
Non-neurotoxic plasminogen activating factors for treating strokeInfo
- Publication number
- AU2002350660A1 AU2002350660A1 AU2002350660A AU2002350660A AU2002350660A1 AU 2002350660 A1 AU2002350660 A1 AU 2002350660A1 AU 2002350660 A AU2002350660 A AU 2002350660A AU 2002350660 A AU2002350660 A AU 2002350660A AU 2002350660 A1 AU2002350660 A1 AU 2002350660A1
- Authority
- AU
- Australia
- Prior art keywords
- treating stroke
- activating factors
- plasminogen activating
- neurotoxic plasminogen
- neurotoxic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000013566 Plasminogen Human genes 0.000 title 1
- 108010051456 Plasminogen Proteins 0.000 title 1
- 230000003213 activating Effects 0.000 title 1
- 231100000501 nonneurotoxic Toxicity 0.000 title 1
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2008201735A AU2008201735A1 (en) | 2001-11-02 | 2008-04-16 | Non-neurotoxic plasminogen activating factors for treating stroke |
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10153601A DE10153601A1 (en) | 2001-11-02 | 2001-11-02 | DSPA for the treatment of stroke |
DE10153601.1 | 2001-11-02 | ||
EP01130006A EP1308166B1 (en) | 2001-11-02 | 2001-12-17 | Non-neurotoxic plasminogen activating factors for treating stroke |
EP01130006.8 | 2001-12-17 | ||
PCT/EP2002/012204 WO2003037363A2 (en) | 2001-11-02 | 2002-10-31 | Non-neurotoxic plasminogen activating factors for treating stroke |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2008201735A Division AU2008201735A1 (en) | 2001-11-02 | 2008-04-16 | Non-neurotoxic plasminogen activating factors for treating stroke |
Publications (3)
Publication Number | Publication Date |
---|---|
AU2002350660A1 true AU2002350660A1 (en) | 2003-07-10 |
AU2002350660B2 AU2002350660B2 (en) | 2008-04-10 |
AU2002350660C1 AU2002350660C1 (en) | 2008-10-09 |
Family
ID=7704253
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AU2002350660A Ceased AU2002350660C1 (en) | 2001-11-02 | 2002-10-31 | Non-neurotoxic plasminogen activating factors for treating stroke |
Country Status (27)
Country | Link |
---|---|
US (7) | US20050048027A1 (en) |
EP (4) | EP1308166B1 (en) |
JP (2) | JP5004407B2 (en) |
KR (3) | KR100816221B1 (en) |
CN (2) | CN101156948A (en) |
AT (3) | ATE440614T1 (en) |
AU (1) | AU2002350660C1 (en) |
BR (1) | BR0213856A (en) |
CA (1) | CA2465792C (en) |
CY (3) | CY1108446T1 (en) |
DE (3) | DE10153601A1 (en) |
DK (3) | DK1308166T3 (en) |
EA (3) | EA010858B1 (en) |
ES (3) | ES2332576T3 (en) |
HK (1) | HK1057328A1 (en) |
HR (1) | HRP20040383B1 (en) |
HU (1) | HU230163B1 (en) |
IL (1) | IL205695A0 (en) |
MX (1) | MXPA04004155A (en) |
NO (1) | NO329789B1 (en) |
NZ (2) | NZ532903A (en) |
PL (1) | PL208343B1 (en) |
PT (3) | PT1308166E (en) |
SG (1) | SG148034A1 (en) |
SI (2) | SI1997510T1 (en) |
WO (1) | WO2003037363A2 (en) |
ZA (1) | ZA200403285B (en) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10153601A1 (en) | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA for the treatment of stroke |
PL1622639T3 (en) * | 2003-05-02 | 2013-06-28 | Lundbeck H As | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
WO2004096267A1 (en) * | 2003-05-02 | 2004-11-11 | Paion Gmbh | Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke |
US20060135425A1 (en) * | 2003-05-02 | 2006-06-22 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
US20080057050A1 (en) * | 2003-05-02 | 2008-03-06 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
CA2524342A1 (en) * | 2003-05-05 | 2004-11-18 | Paion Deutschland Gmbh | Glutamate receptor antagonists as neuroprotectives |
DE10342518A1 (en) * | 2003-09-12 | 2005-05-12 | Paion Gmbh | Plasminogen activators with reduced lysine binding capacity |
JP2006241109A (en) * | 2005-03-04 | 2006-09-14 | Paion Deutschland Gmbh | FUSION PROTEIN CONTAINING ANTIBODY AGAINST HUMAN P SELECTIN AND DSPAalpha1 |
AR068914A1 (en) * | 2007-10-18 | 2009-12-16 | Paion Deutschland Gmbh | USE OF A PLASMINOGEN ACTIVATOR FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF APOPLEJIA |
WO2011107299A2 (en) | 2010-04-16 | 2011-09-09 | Paion Deutschland Gmbh | Method for the manufacture of recombinant dspa alpha1 |
MX337248B (en) * | 2011-01-05 | 2016-02-19 | Thrombogenics Nv | Plasminogen and plasmin variants. |
US9644196B2 (en) | 2011-08-12 | 2017-05-09 | Thrombogenics Nv | Plasminogen and plasmin variants |
US11613744B2 (en) | 2018-12-28 | 2023-03-28 | Vertex Pharmaceuticals Incorporated | Modified urokinase-type plasminogen activator polypeptides and methods of use |
PE20211664A1 (en) * | 2018-12-28 | 2021-08-26 | Catalyst Biosciences Inc | MODIFIED PLASMINOGEN ACTIVATOR POLYPEPTIDES, UROKINASE TYPE, AND METHODS OF USE |
Family Cites Families (56)
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IL68561A (en) | 1982-05-05 | 1991-01-31 | Genentech Inc | Preparation of polypeptide with human tissue plasminogen activator function,processes for making it,and dna and transformed cell intermediates thereof |
US4766075A (en) | 1982-07-14 | 1988-08-23 | Genentech, Inc. | Human tissue plasminogen activator |
US5244806A (en) * | 1985-08-26 | 1993-09-14 | Eli Lilly And Company | DNA encoding novel tissue plasminogen activator derivatives having kringles 1 and 2 deleted, vectors and host cells |
DE3643158A1 (en) | 1986-04-21 | 1987-11-19 | Boehringer Mannheim Gmbh | TISSUE PLASMINOGEN ACTIVATOR (TPA) DERIVATIVE AND ITS PRODUCTION |
JPH087179B2 (en) * | 1986-09-27 | 1996-01-29 | 日本碍子株式会社 | Gas sensor |
WO1988005081A2 (en) * | 1986-12-30 | 1988-07-14 | Cetus Corporation | Novel plasminogen activator |
IL87276A (en) * | 1987-08-03 | 1995-07-31 | Fujisawa Pharmaceutical Co | Analog of tissue plasminogen activator comprising only the kringle 2 and protease domain dna encoding the same processes for the preparation thereof and pharmaceutical compositions containing the same |
EP0386240B1 (en) * | 1987-10-29 | 1995-07-19 | Yamanouchi Pharmaceutical Co. Ltd. | Novel polypeptide compounds |
US5094953A (en) * | 1988-03-21 | 1992-03-10 | Genentech, Inc. | Human tissue plasminogen activator variants |
IE69054B1 (en) * | 1988-07-20 | 1996-08-07 | Schering Ag | Vampire bat salivary plasminogen activators |
DE3825253A1 (en) | 1988-07-25 | 1990-02-01 | Boehringer Mannheim Gmbh | T-PA DERIVATIVE AND ITS PRODUCTION |
US5714145A (en) * | 1988-09-02 | 1998-02-03 | Genentech, Inc. | Tissue plasminogen activator having zymogenic or fibrin specific properties |
JPH0273774A (en) * | 1988-09-09 | 1990-03-13 | Nec Corp | Facsimile equipment |
GB8901422D0 (en) * | 1989-01-23 | 1989-03-15 | Fujisawa Pharmaceutical Co | New tissue plasminogen activator |
US5676947A (en) * | 1989-02-07 | 1997-10-14 | Boehringer Manneheim Gmbh | Method for treating thromboembolic conditions using thrombolytically active proteins |
DE3903581A1 (en) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | FABRIC PLASMINOGEN ACTIVATOR DERIVATIVE |
DE3917949A1 (en) * | 1989-05-30 | 1991-01-24 | Schering Ag | New fibrin specific thrombolytic agent v-PA |
US6008019A (en) | 1989-02-13 | 1999-12-28 | Schering Aktiengesellschaft | Plasminogen activator from saliva of the vampire bat |
WO1990009438A1 (en) * | 1989-02-13 | 1990-08-23 | Schering Aktiengesellschaft Berlin Und Bergkamen | Novel thrombolytic |
DE3904580A1 (en) | 1989-02-13 | 1990-08-16 | Schering Ag | Thrombolytic agent |
US5891664A (en) * | 1989-04-07 | 1999-04-06 | Cancerforskningsfondet Af 1989 | Vectors and methods for recombinant production of uPA-binding fragments of the human urokinase-type plasminogen receptor (uPAR) |
CA2051676A1 (en) * | 1989-04-07 | 1990-10-08 | Keld Dano | Urokinase-type plasminogen activator receptor |
JPH0352119A (en) * | 1989-07-19 | 1991-03-06 | Matsushita Electric Ind Co Ltd | Optical recording and reproducing device |
NL8902454A (en) | 1989-10-03 | 1991-05-01 | Stichting Centraal Lab | MUTANTS OF THE HUMANE PLASMINOGENIC ACTIVATOR INHIBITOR 1 (PAI-1), THEIR PREPARATION AND USE, AND RECOMBINANT POLYNUCLEOTIDES INCLUDING GENETIC INFORMATION CODING FOR THESE MUTANTS. |
US5326700A (en) * | 1990-11-06 | 1994-07-05 | Eli Lilly And Company | DNA sequences encoding t-PA derivatives with cleavable sites |
DE4123845A1 (en) * | 1991-07-18 | 1993-01-21 | Boehringer Mannheim Gmbh | Compsn. for treating thromboembolic disease with plasminogen activator |
DE59204945D1 (en) * | 1991-04-16 | 1996-02-15 | Boehringer Mannheim Gmbh | PHARMACEUTICAL PACKAGING UNIT CONTAINING PLASMINOGEN ACTIVATORS FOR MULTIPLE BOLUS ADMINISTRATION |
US5595736A (en) * | 1991-04-22 | 1997-01-21 | Eli Lilly And Company | Compounds and methods for treatment of thromboembolic disorders |
NL9101520A (en) * | 1991-09-09 | 1993-04-01 | Stork Fibron Bv | METHOD FOR MANUFACTURING AN EDIBLE PRODUCT |
ATE145669T1 (en) | 1991-12-16 | 1996-12-15 | Genentech Inc | T-PA SUBSTITUTION VARIANTS WITH IMPROVED FIBRIN SPECIFICITY |
EP0677107B1 (en) * | 1992-12-04 | 1997-08-06 | Schering Aktiengesellschaft | Clotting inhibitor made from protostomia saliva |
US5510330A (en) * | 1994-03-25 | 1996-04-23 | Boehringer Mannheim Gmbh | Combinations of thrombolytically active proteins and non-heparin anticoagulants, and uses thereof. |
GB9412131D0 (en) * | 1994-06-17 | 1994-08-10 | British Bio Technology | Thrombolytic composition |
DE4423574A1 (en) | 1994-07-05 | 1996-01-11 | Boehringer Mannheim Gmbh | Non-glycosylated plasminogen activator derivatives and their use when there is an increased risk of bleeding |
US5827832A (en) * | 1995-03-06 | 1998-10-27 | Interneuron Pharmaceuticals, Inc. | Method of protecting brain tissue from cerebral infarction subsequent to ischemia |
US5786187A (en) * | 1995-09-21 | 1998-07-28 | The Research Foundation Of State University Of New York | Method for reducing neuronal degeneration associated with seizure |
US5945432A (en) * | 1995-12-22 | 1999-08-31 | The University Of Vermont And State Agricultural College | Thrombolytic agents and thienopyridine derivatives in acute stroke |
US20020081294A1 (en) * | 1996-01-23 | 2002-06-27 | Genentech, Inc. | Co-administration of a thrombolytic and an anti-CD18 antibody in stroke |
US5731186A (en) * | 1996-02-05 | 1998-03-24 | Schering Aktiengesellschaft | Method for the production of rDSPA α1 |
US6235947B1 (en) * | 1997-04-14 | 2001-05-22 | Takeda Chemical Industries, Ltd. | D-mannitol and its preparation |
US5830349A (en) * | 1996-07-22 | 1998-11-03 | Dana Corporation | Flow inverter for filters |
US6235278B1 (en) | 1996-10-01 | 2001-05-22 | University Of Georgia Research Foundation, Inc. | Biological insect control agents expressing insect-specific toxin genes, methods and compositions |
US6008109A (en) * | 1997-12-19 | 1999-12-28 | Advanced Micro Devices, Inc. | Trench isolation structure having a low K dielectric encapsulated by oxide |
KR20010069066A (en) * | 2000-01-12 | 2001-07-23 | 이종원 | Culturing Method Which Allows Growth of Animal Cells Under Hypoxic Condition |
DE10008646A1 (en) | 2000-02-24 | 2001-09-13 | Kempten Elektroschmelz Gmbh | Molded body used as a cooking plate comprises an adhesion- and scratch-resistant surface coating made of glass and/or glass-ceramic formed on hot-pressed, gas pressure-sintered , reaction-bound or hot isostatically pressed silicon nitride |
GB0025473D0 (en) * | 2000-10-17 | 2000-11-29 | Pfizer Ltd | Pharmaceutical combinations |
US20020089179A1 (en) * | 2000-12-30 | 2002-07-11 | Levon Guyumjan | Hose coupling apparatus and method |
DE10153601A1 (en) | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA for the treatment of stroke |
PL1622639T3 (en) | 2003-05-02 | 2013-06-28 | Lundbeck H As | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
US20060135425A1 (en) | 2003-05-02 | 2006-06-22 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
US20080057050A1 (en) | 2003-05-02 | 2008-03-06 | Paion Deutschland Gmbh | Intravenous injection of plasminogen non-neurotoxic activators for treating cerebral stroke |
WO2004096267A1 (en) | 2003-05-02 | 2004-11-11 | Paion Gmbh | Intravenous injection of non-neurotoxic plasminogen activators for the treatment of stroke |
CA2524342A1 (en) | 2003-05-05 | 2004-11-18 | Paion Deutschland Gmbh | Glutamate receptor antagonists as neuroprotectives |
US20050085478A1 (en) | 2003-08-22 | 2005-04-21 | Pharmacia Corporation | Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage |
DE10342518A1 (en) | 2003-09-12 | 2005-05-12 | Paion Gmbh | Plasminogen activators with reduced lysine binding capacity |
AR068914A1 (en) | 2007-10-18 | 2009-12-16 | Paion Deutschland Gmbh | USE OF A PLASMINOGEN ACTIVATOR FOR THE PREPARATION OF A MEDICINAL PRODUCT FOR THE TREATMENT OF APOPLEJIA |
-
2001
- 2001-11-02 DE DE10153601A patent/DE10153601A1/en not_active Ceased
- 2001-12-17 DK DK01130006T patent/DK1308166T3/en active
- 2001-12-17 AT AT01130006T patent/ATE440614T1/en active
- 2001-12-17 DE DE50115077T patent/DE50115077D1/en not_active Expired - Lifetime
- 2001-12-17 EP EP01130006A patent/EP1308166B1/en not_active Expired - Lifetime
- 2001-12-17 PT PT01130006T patent/PT1308166E/en unknown
- 2001-12-17 ES ES01130006T patent/ES2332576T3/en not_active Expired - Lifetime
-
2002
- 2002-10-31 NZ NZ532903A patent/NZ532903A/en not_active IP Right Cessation
- 2002-10-31 CA CA2465792A patent/CA2465792C/en not_active Expired - Fee Related
- 2002-10-31 PL PL369872A patent/PL208343B1/en unknown
- 2002-10-31 SI SI200230980T patent/SI1997510T1/en unknown
- 2002-10-31 WO PCT/EP2002/012204 patent/WO2003037363A2/en active Application Filing
- 2002-10-31 KR KR1020047006691A patent/KR100816221B1/en not_active IP Right Cessation
- 2002-10-31 SI SI200230745T patent/SI1441757T1/en unknown
- 2002-10-31 US US10/494,004 patent/US20050048027A1/en not_active Abandoned
- 2002-10-31 DK DK08012976.0T patent/DK1997510T3/en active
- 2002-10-31 DE DE50212548T patent/DE50212548D1/en not_active Expired - Lifetime
- 2002-10-31 CN CNA2007101051509A patent/CN101156948A/en active Pending
- 2002-10-31 CN CNB028234782A patent/CN100446810C/en not_active Expired - Fee Related
- 2002-10-31 NZ NZ545414A patent/NZ545414A/en not_active IP Right Cessation
- 2002-10-31 KR KR1020097025518A patent/KR20090128583A/en not_active Application Discontinuation
- 2002-10-31 AU AU2002350660A patent/AU2002350660C1/en not_active Ceased
- 2002-10-31 JP JP2003539706A patent/JP5004407B2/en not_active Expired - Fee Related
- 2002-10-31 EP EP10011603A patent/EP2368567A1/en not_active Withdrawn
- 2002-10-31 AT AT08012976T patent/ATE547115T1/en active
- 2002-10-31 EP EP02785348A patent/EP1441757B1/en not_active Expired - Lifetime
- 2002-10-31 SG SG200604427-5A patent/SG148034A1/en unknown
- 2002-10-31 BR BR0213856-5A patent/BR0213856A/en not_active Application Discontinuation
- 2002-10-31 AT AT02785348T patent/ATE401910T1/en active
- 2002-10-31 EA EA200400624A patent/EA010858B1/en not_active IP Right Cessation
- 2002-10-31 PT PT08012976T patent/PT1997510E/en unknown
- 2002-10-31 EA EA201000386A patent/EA201000386A1/en unknown
- 2002-10-31 EA EA200801714A patent/EA013707B1/en not_active IP Right Cessation
- 2002-10-31 PT PT02785348T patent/PT1441757E/en unknown
- 2002-10-31 EP EP08012976A patent/EP1997510B1/en not_active Expired - Lifetime
- 2002-10-31 MX MXPA04004155A patent/MXPA04004155A/en active IP Right Grant
- 2002-10-31 KR KR1020077017712A patent/KR20070087248A/en active Application Filing
- 2002-10-31 DK DK02785348T patent/DK1441757T3/en active
- 2002-10-31 HU HU0402165A patent/HU230163B1/en not_active IP Right Cessation
- 2002-10-31 ES ES08012976T patent/ES2382224T3/en not_active Expired - Lifetime
- 2002-10-31 ES ES02785348T patent/ES2311070T3/en not_active Expired - Lifetime
-
2003
- 2003-11-07 HK HK03108108.9A patent/HK1057328A1/en not_active IP Right Cessation
-
2004
- 2004-04-30 HR HRP20040383AA patent/HRP20040383B1/en not_active IP Right Cessation
- 2004-04-30 ZA ZA200403285A patent/ZA200403285B/en unknown
- 2004-06-01 NO NO20042262A patent/NO329789B1/en not_active IP Right Cessation
-
2005
- 2005-12-20 US US11/311,475 patent/US20060142195A1/en not_active Abandoned
-
2008
- 2008-06-27 US US12/163,828 patent/US8071091B2/en not_active Expired - Fee Related
- 2008-08-22 US US12/196,785 patent/US8119597B2/en not_active Expired - Fee Related
- 2008-10-23 CY CY20081101193T patent/CY1108446T1/en unknown
-
2009
- 2009-01-05 JP JP2009000322A patent/JP2009137983A/en not_active Withdrawn
- 2009-11-19 CY CY20091101206T patent/CY1109648T1/en unknown
-
2010
- 2010-05-11 IL IL205695A patent/IL205695A0/en unknown
-
2012
- 2012-02-10 US US13/370,706 patent/US20130039902A1/en not_active Abandoned
- 2012-04-30 CY CY20121100407T patent/CY1112957T1/en unknown
-
2014
- 2014-01-09 US US14/151,390 patent/US20140199287A1/en not_active Abandoned
-
2016
- 2016-03-24 US US15/079,550 patent/US20170051268A1/en not_active Abandoned
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