CA2398908C - Adenosine a2a receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver - Google Patents
Adenosine a2a receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver Download PDFInfo
- Publication number
- CA2398908C CA2398908C CA002398908A CA2398908A CA2398908C CA 2398908 C CA2398908 C CA 2398908C CA 002398908 A CA002398908 A CA 002398908A CA 2398908 A CA2398908 A CA 2398908A CA 2398908 C CA2398908 C CA 2398908C
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- Prior art keywords
- adenosine
- receptor
- cirrhosis
- fatty liver
- receptor antagonist
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18154600P | 2000-02-10 | 2000-02-10 | |
| US60/181,546 | 2000-02-10 | ||
| PCT/US2001/004341 WO2001058241A2 (en) | 2000-02-10 | 2001-02-12 | Adenosine a2a receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2398908A1 CA2398908A1 (en) | 2001-08-16 |
| CA2398908C true CA2398908C (en) | 2009-12-15 |
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|---|---|---|---|
| CA002398908A Expired - Fee Related CA2398908C (en) | 2000-02-10 | 2001-02-12 | Adenosine a2a receptor antagonists for treating and preventing hepatic fibrosis, cirrhosis and fatty liver |
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| Country | Link |
|---|---|
| US (1) | US6555545B2 (https=) |
| EP (1) | EP1272897B1 (https=) |
| JP (1) | JP2004502640A (https=) |
| AT (1) | ATE394104T1 (https=) |
| AU (2) | AU3812401A (https=) |
| CA (1) | CA2398908C (https=) |
| DE (1) | DE60133887D1 (https=) |
| DK (1) | DK1272897T3 (https=) |
| ES (1) | ES2307593T3 (https=) |
| PT (1) | PT1272897E (https=) |
| WO (1) | WO2001058241A2 (https=) |
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| US6196459B1 (en) * | 1998-05-11 | 2001-03-06 | Ubiq Incorporated | Smart card personalization in a multistation environment |
| WO2003080649A2 (en) * | 2002-03-20 | 2003-10-02 | Regents Of The University Of Minnesota | Induction of hepatocyte proliferation in vitro by inhibition of cell cycle inhibitors |
| ITRM20070088A1 (it) * | 2007-02-19 | 2008-08-20 | Francesco Fringuelli | Composti derivati della colchicina, procedimento per la loro preparazione e usi in campo medico. |
| CA2695989A1 (en) * | 2007-08-10 | 2009-02-19 | Glaxosmithkline Llc | Certain nitrogen containing bicyclic chemical entities for treating viral infections |
| EP2217233B1 (en) * | 2007-10-26 | 2018-08-08 | New York University School of Medicine | Methods and compositions for treating hepatic diseases |
| ES2541141T3 (es) * | 2008-01-31 | 2015-07-16 | Astellas Pharma Inc. | Composición farmacéutica para el tratamiento de las enfermedades del hígado graso |
| US8536306B2 (en) | 2008-10-01 | 2013-09-17 | The Scripps Research Institute | Human A2A adenosine receptor crystals and uses thereof |
| US20100204265A1 (en) * | 2009-02-09 | 2010-08-12 | Genelabs Technologies, Inc. | Certain Nitrogen Containing Bicyclic Chemical Entities for Treating Viral Infections |
| AU2010222289B2 (en) | 2009-03-13 | 2013-07-11 | Advinus Therapeutics Private Limited | Substituted fused pyrimidine compounds |
| EP2408775B1 (en) * | 2009-03-20 | 2015-06-17 | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. | Oxidated derivatives of triazolylpurines useful as ligands of the adenosine a2a receptor and their use as medicaments |
| EP2499142B1 (en) | 2009-11-09 | 2016-09-21 | Advinus Therapeutics Limited | Substituted fused pyrimidine compounds, its preparation and uses thereof |
| ES2579949T3 (es) | 2010-02-05 | 2016-08-17 | Heptares Therapeutics Limited | Derivados de 1,2,4-triazin-4-amina |
| WO2012066330A1 (en) | 2010-11-17 | 2012-05-24 | Heptares Therapeutics Limited | Compounds useful as a2a receptor inhibitors |
| WO2019002606A1 (en) | 2017-06-30 | 2019-01-03 | Selvita S.A. | ADENOSINE A2A RECEPTOR 5,6-BICYCLO-IMIDAZO [1,2-A] PYRAZINE MODULATORS |
| JP7391022B2 (ja) | 2017-12-19 | 2023-12-04 | インペティス・バイオサイエンシーズ・リミテッド | がんの処置のための医薬組成物 |
| IL275817B2 (en) | 2018-01-04 | 2024-04-01 | Impetis Biosciences Ltd | Tricyclic compounds, compositions and medicinal applications thereof |
| WO2020128036A1 (en) | 2018-12-21 | 2020-06-25 | Ryvu Therapeutics S.A. | Modulators of the adenosine a2a receptor |
| WO2025018901A1 (en) | 2023-07-17 | 2025-01-23 | Ryvu Therapeutics S.A. | Modulators of the adenosine a2a and a2b receptor |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US4705658A (en) | 1986-04-07 | 1987-11-10 | Capsule Technology International, Ltd. | Method for drying gelatin in the manufacture of hard shell gelatin capsules |
| US5063233A (en) | 1986-11-14 | 1991-11-05 | Ciba-Geigy Corporation | N9 -cyclopentyl-substituted adenine derivatives useful as adenosine receptor agonists |
| US4968697A (en) | 1987-02-04 | 1990-11-06 | Ciba-Geigy Corporation | 2-substituted adenosine 5'-carboxamides as antihypertensive agents |
| US5036381A (en) | 1990-06-15 | 1991-07-30 | Motorola, Inc. | Multiple electronic devices within a single carrier structure |
| GB2264948B (en) | 1992-03-13 | 1996-10-16 | Merck & Co Inc | Human adenosine receptors |
| US5426101A (en) | 1992-09-30 | 1995-06-20 | Merrell Dow Pharmaceuticals Inc. | 2-substituted adenosines with A-2 receptor affinity |
| WO1994023723A1 (en) | 1993-04-15 | 1994-10-27 | New York University | Adenosine receptor agonists for the promotion of wound healing |
| US5877180A (en) * | 1994-07-11 | 1999-03-02 | University Of Virginia Patent Foundation | Method for treating inflammatory diseases with A2a adenosine receptor agonists |
| US5859019A (en) | 1997-03-07 | 1999-01-12 | Trustees Of The University Of Pennsylvania | Methods for protecting against cardiac ischemia by administering adenosine A2a receptor antagonists |
| US6211165B1 (en) * | 1997-05-09 | 2001-04-03 | The Trustees Of The University Of Pennsylvania | Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists |
| AU7449598A (en) * | 1997-05-23 | 1998-12-11 | Nippon Shinyaku Co. Ltd. | Medicinal composition for prevention or treatment of hepatopathy |
| US5916910A (en) | 1997-06-04 | 1999-06-29 | Medinox, Inc. | Conjugates of dithiocarbamates with pharmacologically active agents and uses therefore |
| US6303619B1 (en) * | 1998-03-12 | 2001-10-16 | University Of Virginia | Meta-substituted acidic 8-phenylxanthine antagonists of A3 human adenosine receptors |
| US6232297B1 (en) * | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
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2001
- 2001-02-12 US US09/780,365 patent/US6555545B2/en not_active Expired - Lifetime
- 2001-02-12 AU AU3812401A patent/AU3812401A/xx active Pending
- 2001-02-12 AT AT01910529T patent/ATE394104T1/de not_active IP Right Cessation
- 2001-02-12 DE DE60133887T patent/DE60133887D1/de not_active Expired - Lifetime
- 2001-02-12 DK DK01910529T patent/DK1272897T3/da active
- 2001-02-12 CA CA002398908A patent/CA2398908C/en not_active Expired - Fee Related
- 2001-02-12 PT PT01910529T patent/PT1272897E/pt unknown
- 2001-02-12 EP EP01910529A patent/EP1272897B1/en not_active Expired - Lifetime
- 2001-02-12 JP JP2001557366A patent/JP2004502640A/ja active Pending
- 2001-02-12 ES ES01910529T patent/ES2307593T3/es not_active Expired - Lifetime
- 2001-02-12 WO PCT/US2001/004341 patent/WO2001058241A2/en not_active Ceased
- 2001-02-12 AU AU2001238124A patent/AU2001238124B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| DE60133887D1 (de) | 2008-06-19 |
| ATE394104T1 (de) | 2008-05-15 |
| WO2001058241A2 (en) | 2001-08-16 |
| CA2398908A1 (en) | 2001-08-16 |
| WO2001058241A9 (en) | 2002-10-17 |
| EP1272897A2 (en) | 2003-01-08 |
| ES2307593T3 (es) | 2008-12-01 |
| AU3812401A (en) | 2001-08-20 |
| US20020002145A1 (en) | 2002-01-03 |
| PT1272897E (pt) | 2008-08-18 |
| US6555545B2 (en) | 2003-04-29 |
| AU2001238124B2 (en) | 2006-05-25 |
| DK1272897T3 (da) | 2008-09-15 |
| EP1272897B1 (en) | 2008-05-07 |
| JP2004502640A (ja) | 2004-01-29 |
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