CA2393864A1 - Appareil et methodes de criblage de medicaments - Google Patents

Appareil et methodes de criblage de medicaments Download PDF

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Publication number
CA2393864A1
CA2393864A1 CA002393864A CA2393864A CA2393864A1 CA 2393864 A1 CA2393864 A1 CA 2393864A1 CA 002393864 A CA002393864 A CA 002393864A CA 2393864 A CA2393864 A CA 2393864A CA 2393864 A1 CA2393864 A1 CA 2393864A1
Authority
CA
Canada
Prior art keywords
nucleic acid
sample
drug candidate
high integrity
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002393864A
Other languages
English (en)
Inventor
Anthony P. Shuber
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Exact Sciences Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2393864A1 publication Critical patent/CA2393864A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne des matériels et des méthodes de criblage de médicaments et de candidats médicamenteux en fonction de leur activité par détermination de la présence ou de l'absence d'acide nucléique à haute intégrité dans un échantillon.
CA002393864A 1999-12-07 2000-11-28 Appareil et methodes de criblage de medicaments Abandoned CA2393864A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16945799P 1999-12-07 1999-12-07
US60/169,457 1999-12-07
PCT/US2000/032387 WO2001042503A2 (fr) 1999-12-07 2000-11-28 Appareil et methodes de criblage de medicaments

Publications (1)

Publication Number Publication Date
CA2393864A1 true CA2393864A1 (fr) 2001-06-14

Family

ID=22615780

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002393864A Abandoned CA2393864A1 (fr) 1999-12-07 2000-11-28 Appareil et methodes de criblage de medicaments

Country Status (5)

Country Link
EP (1) EP1238106A2 (fr)
JP (1) JP2003516162A (fr)
AU (1) AU1804401A (fr)
CA (1) CA2393864A1 (fr)
WO (1) WO2001042503A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818404B2 (en) 1997-10-23 2004-11-16 Exact Sciences Corporation Methods for detecting hypermethylated nucleic acid in heterogeneous biological samples
AU4714201A (en) 1999-12-07 2001-06-18 Exact Sciences Corporation Supracolonic aerodigestive neoplasm detection
US6911308B2 (en) 2001-01-05 2005-06-28 Exact Sciences Corporation Methods for detecting, grading or monitoring an H. pylori infection
US7482116B2 (en) 2002-06-07 2009-01-27 Dna Genotek Inc. Compositions and methods for obtaining nucleic acids from sputum
US9109256B2 (en) 2004-10-27 2015-08-18 Esoterix Genetic Laboratories, Llc Method for monitoring disease progression or recurrence
US9777314B2 (en) 2005-04-21 2017-10-03 Esoterix Genetic Laboratories, Llc Analysis of heterogeneous nucleic acid samples
WO2012177656A2 (fr) 2011-06-19 2012-12-27 Abogen, Inc. Dispositifs, solutions et procédés de recueillement d'échantillons
ES2880310T3 (es) 2014-03-07 2021-11-24 Dna Genotek Inc Composición y método para estabilizar ácidos nucleicos en muestras biológicas
US11814686B2 (en) 2017-12-07 2023-11-14 Institut National de la Santéde la Recherche Médicale Method for screening and treating a subject for a cancer
CN113261532A (zh) * 2020-02-17 2021-08-17 中山大学 一种肺癌动物模型的构建方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3413464A (en) * 1965-04-29 1968-11-26 Ibm Method for measuring the nucleic acid in biological cells after enhancement in an acidic solution
US5897999A (en) * 1996-03-22 1999-04-27 The Johns Hopkins University Cancer drug screen based on cell cycle uncoupling
AU3583797A (en) * 1996-06-28 1998-01-21 Regents Of The University Of California, The Enhancement of cancer cell death
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection

Also Published As

Publication number Publication date
WO2001042503A2 (fr) 2001-06-14
WO2001042503A3 (fr) 2001-12-27
JP2003516162A (ja) 2003-05-13
EP1238106A2 (fr) 2002-09-11
AU1804401A (en) 2001-06-18

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Legal Events

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