CA2393766A1 - Matrice de biopuces, haute densite, adressable par colonnes et rangees - Google Patents

Matrice de biopuces, haute densite, adressable par colonnes et rangees Download PDF

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Publication number
CA2393766A1
CA2393766A1 CA002393766A CA2393766A CA2393766A1 CA 2393766 A1 CA2393766 A1 CA 2393766A1 CA 002393766 A CA002393766 A CA 002393766A CA 2393766 A CA2393766 A CA 2393766A CA 2393766 A1 CA2393766 A1 CA 2393766A1
Authority
CA
Canada
Prior art keywords
conductive
electrode
probes
target molecule
impedance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002393766A
Other languages
English (en)
Inventor
George N. Maracas
Peiming Zhang
Song Shi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Motorola Solutions Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2393766A1 publication Critical patent/CA2393766A1/fr
Abandoned legal-status Critical Current

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0046—Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3276—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a hybridisation with immobilised receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00279—Features relating to reactor vessels
    • B01J2219/00306—Reactor vessels in a multiple arrangement
    • B01J2219/00313—Reactor vessels in a multiple arrangement the reactor vessels being formed by arrays of wells in blocks
    • B01J2219/00315—Microtiter plates
    • B01J2219/00317—Microwell devices, i.e. having large numbers of wells
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00511—Walls of reactor vessels
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00653—Making arrays on substantially continuous surfaces the compounds being bound to electrodes embedded in or on the solid supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00677—Ex-situ synthesis followed by deposition on the substrate
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00698—Measurement and control of process parameters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/0068—Means for controlling the apparatus of the process
    • B01J2219/00702—Processes involving means for analysing and characterising the products
    • B01J2219/00704—Processes involving means for analysing and characterising the products integrated with the reactor apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nanotechnology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Materials Engineering (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Composite Materials (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)

Abstract

L'invention concerne un procédé et un dispositif comprenant une plate-forme destinée à une matrice de biopuces, haute densité, adressable par colonnes et rangées. On peut utiliser ce dispositif en tant que matrice de biopuces haute densité, dans la détection électronique ou électrochimique d'interactions moléculaires entre des molécules sondes liées à des régions déterminées de la matrice, et des molécules cibles exposées à la matrice.
CA002393766A 1999-12-15 2000-12-14 Matrice de biopuces, haute densite, adressable par colonnes et rangees Abandoned CA2393766A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US46450099A 1999-12-15 1999-12-15
US09/464,500 1999-12-15
PCT/US2000/034222 WO2001043870A2 (fr) 1999-12-15 2000-12-14 Matrice de biopuces, haute densite, adressable par colonnes et rangees

Publications (1)

Publication Number Publication Date
CA2393766A1 true CA2393766A1 (fr) 2001-06-21

Family

ID=23844193

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002393766A Abandoned CA2393766A1 (fr) 1999-12-15 2000-12-14 Matrice de biopuces, haute densite, adressable par colonnes et rangees

Country Status (5)

Country Link
EP (1) EP1251955A2 (fr)
JP (1) JP2003517149A (fr)
AU (1) AU2108901A (fr)
CA (1) CA2393766A1 (fr)
WO (1) WO2001043870A2 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2492674A1 (fr) 2011-02-28 2012-08-29 Lexogen GmbH Réseaux de biocapteurs formé par jonctions d'électrodes fonctionnalisées

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US6824669B1 (en) * 2000-02-17 2004-11-30 Motorola, Inc. Protein and peptide sensors using electrical detection methods
US6824974B2 (en) 2001-06-11 2004-11-30 Genorx, Inc. Electronic detection of biological molecules using thin layers
CA2450109A1 (fr) * 2001-06-11 2003-05-22 Genorx, Inc. Detection electronique de molecules biologiques au moyen de fines couches
GB2377026A (en) * 2001-06-29 2002-12-31 Imp College Innovations Ltd Electrically addressable electrochemical cell array
DE10145700A1 (de) * 2001-09-17 2003-04-10 Infineon Technologies Ag Biochip-Anordnung, Sensor-Anordnung und Verfahren zum Betreiben einer Biochip-Anordnung
US7074519B2 (en) * 2001-10-26 2006-07-11 The Regents Of The University Of California Molehole embedded 3-D crossbar architecture used in electrochemical molecular memory device
DE10211358B4 (de) * 2002-03-14 2006-10-26 Siemens Ag Vertikal-Impedanz-Sensor-Anordnung und Verfahren zum Herstellen einer Vertikal-Impedanz-Sensor-Anordnung
FR2839783B1 (fr) * 2002-05-17 2004-08-06 Apibio Nouvelle disposition des sites de liaison d'une biopuce
FR2840072B1 (fr) * 2002-05-24 2004-08-06 Apibio Biopuce presentant une organisation amelioree
DE10228125A1 (de) * 2002-06-24 2004-01-22 Infineon Technologies Ag Biosensor-Array und Verfahren zum Betreiben eines Biosensor-Arrays
DE10228124A1 (de) * 2002-06-24 2004-01-29 Infineon Technologies Ag Biosensor-Array und Verfahren zum Betreiben eines Biosensor-Arrays
DE50305588D1 (de) * 2002-06-24 2006-12-14 Siemens Ag Biosensor-array und verfahren zum betreiben eines biosensor-arrays
US6962822B2 (en) 2002-08-07 2005-11-08 International Business Machines Corporation Discrete nano-textured structures in biomolecular arrays, and method of use
WO2004027422A1 (fr) * 2002-09-17 2004-04-01 Olympus Corporation Procede d'agencement de constituants par reaction de liquide sur une surface de substrat pour la detection d'une substance cible par la reaction de constituants multiples sur substrat, appareil de mise en oeuvre et elements utilises dans le procede
DE10257604A1 (de) * 2002-12-09 2004-07-22 Axaron Bioscience Ag Kapazitiver Nachweis von gebundenen Molekülen
US7138121B2 (en) 2003-01-23 2006-11-21 Spangler Brenda D Biosensors utilizing dendrimer-immobilized ligands and there use thereof
GB2398751A (en) 2003-02-28 2004-09-01 Univ Surrey A dielectrophoretic separation device
JP2004298783A (ja) * 2003-03-31 2004-10-28 Kitakyushu Foundation For The Advancement Of Industry Science & Technology 化学物質分離膜及びその製造方法、並びに化学物質の検出方法及び化学物質検出装置
US7399400B2 (en) 2003-09-30 2008-07-15 Nano-Proprietary, Inc. Nanobiosensor and carbon nanotube thin film transistors
EP1682880A1 (fr) 2003-10-08 2006-07-26 Philips Intellectual Property & Standards GmbH Capteur d'ondes acoustiques en volume
US20080070803A1 (en) * 2003-10-15 2008-03-20 Egeland Ryan D Electrochemical Treatment Of Substrates
KR101165860B1 (ko) 2003-10-16 2012-07-13 하이 캉 라이프 코포레이션 리미티드 생물학적 샘플에서 핵산을 검출하는 장치 및 방법
US7390622B2 (en) 2003-10-16 2008-06-24 Hai Kang Life Corporation Limited Apparatus and methods for detecting nucleic acid in biological samples
US20050244811A1 (en) * 2003-12-15 2005-11-03 Nano-Proprietary, Inc. Matrix array nanobiosensor
DE102004031672A1 (de) 2004-06-30 2006-01-19 Infineon Technologies Ag Planar-Sensor-Anordnung, Sensor-Array und Verfahren zum Herstellen einer Planar-Sensor-Anordnung
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JP5176235B2 (ja) * 2008-07-03 2013-04-03 国立大学法人東北大学 電気化学測定装置
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DE102013207779A1 (de) * 2012-10-23 2014-05-15 Heraeus Precious Metals Gmbh & Co. Kg Multischichtaufbau mit alternierenden leitenden und nicht leitenden Schichten
US9523642B2 (en) * 2012-11-09 2016-12-20 Taiwan Semiconductor Manufacturing Company, Ltd. Integrated electro-microfluidic probe card, system and method for using the same
US10286376B2 (en) 2012-11-14 2019-05-14 Vibrant Holdings, Llc Substrates, systems, and methods for array synthesis and biomolecular analysis
EP4030167A1 (fr) * 2013-02-15 2022-07-20 Vibrant Holdings, LLC Procédés et compositions de détection de l'électrochimioluminescence amplifiée
CN103627788A (zh) * 2013-08-21 2014-03-12 中山大学达安基因股份有限公司 一种电化学基因传感器生物芯片的制备方法
US9498142B2 (en) 2014-07-03 2016-11-22 Heraeus Deutschland GmbH & Co. KG Multi-layered structure and method
WO2016102178A1 (fr) 2014-12-23 2016-06-30 Heraeus Sensor Technology Gmbh Capteur de détection de particules polarisables et/ou électriquement conductrices et procédé de réglage d'un tel capteur
WO2016121952A1 (fr) * 2015-01-29 2016-08-04 アラム株式会社 Capteur de liquide
JP6116080B1 (ja) * 2016-04-26 2017-04-19 日本航空電子工業株式会社 電気化学測定方法、電気化学測定装置及びトランスデューサ
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KR102423723B1 (ko) * 2020-08-27 2022-07-21 성균관대학교산학협력단 플라즈모닉 우물 기반 핵산 검출장치 및 롤투롤 공정을 이용한 이의 제조방법

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GB9810568D0 (en) * 1998-05-18 1998-07-15 Imco 1097 Limited Electrode system

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2492674A1 (fr) 2011-02-28 2012-08-29 Lexogen GmbH Réseaux de biocapteurs formé par jonctions d'électrodes fonctionnalisées
WO2012116386A1 (fr) 2011-02-28 2012-09-07 Lexogen Gmbh Réseau de biocapteurs formé par des jonctions d'électrodes fonctionnalisées

Also Published As

Publication number Publication date
JP2003517149A (ja) 2003-05-20
WO2001043870A3 (fr) 2002-02-21
WO2001043870A2 (fr) 2001-06-21
EP1251955A2 (fr) 2002-10-30
AU2108901A (en) 2001-06-25

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FZDE Discontinued