CA2386539A1 - Method for production of l-cysteine or l-cysteine derivatives by fermentation - Google Patents
Method for production of l-cysteine or l-cysteine derivatives by fermentation Download PDFInfo
- Publication number
- CA2386539A1 CA2386539A1 CA002386539A CA2386539A CA2386539A1 CA 2386539 A1 CA2386539 A1 CA 2386539A1 CA 002386539 A CA002386539 A CA 002386539A CA 2386539 A CA2386539 A CA 2386539A CA 2386539 A1 CA2386539 A1 CA 2386539A1
- Authority
- CA
- Canada
- Prior art keywords
- cysteine
- micro
- production
- fermentation
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/12—Methionine; Cysteine; Cystine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
The invention relates to a method for production of l-cysteine or l-cysteine derivatives by means of a fermentation with micro-organisms and micro-organisms suitable for said method. The micro-organism strain adapted to fermentative production of l-cysteine or l-cysteine derivatives comprises a deregulated cysteine metabolism which is not dependent upon an altered cysB
activity. Said micro-organism strain is furthermore characterized by an elevated cysB activity, whereby the cysB activity comprises a regulation pattern typical for a wild type cysB.
activity. Said micro-organism strain is furthermore characterized by an elevated cysB activity, whereby the cysB activity comprises a regulation pattern typical for a wild type cysB.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19949579A DE19949579C1 (en) | 1999-10-14 | 1999-10-14 | Microorganism with deregulated cysteine metabolism, useful for high-level production of cysteine and its derivatives, has increased activity of the CysB transcription regulator |
DE19949579.3 | 1999-10-14 | ||
PCT/EP2000/009720 WO2001027307A1 (en) | 1999-10-14 | 2000-10-05 | Method for production of l-cysteine or l-cysteine derivatives by fermentation |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2386539A1 true CA2386539A1 (en) | 2001-04-19 |
CA2386539C CA2386539C (en) | 2007-04-17 |
Family
ID=7925659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002386539A Expired - Fee Related CA2386539C (en) | 1999-10-14 | 2000-10-05 | Method for production of l-cysteine or l-cysteine derivatives by fermentation |
Country Status (11)
Country | Link |
---|---|
EP (1) | EP1220940B2 (en) |
JP (1) | JP2003511086A (en) |
KR (1) | KR100505336B1 (en) |
CN (1) | CN1262646C (en) |
AT (1) | ATE231918T1 (en) |
CA (1) | CA2386539C (en) |
DE (2) | DE19949579C1 (en) |
DK (1) | DK1220940T3 (en) |
SK (1) | SK4972002A3 (en) |
TW (1) | TWI249575B (en) |
WO (1) | WO2001027307A1 (en) |
Cited By (10)
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---|---|---|---|---|
US8008048B2 (en) | 2008-03-06 | 2011-08-30 | Ajinomoto Co., Inc. | L-cysteine-producing bacterium and a method for producing L-cysteine |
DE102011075656A1 (en) | 2011-05-11 | 2012-03-29 | Wacker Chemie Ag | Producing L-cystine useful as food additive, preferably in baking industry, as ingredient in cosmetics and as starting material for producing active pharmaceutical ingredient, comprises fermenting microorganism strain in fermentation medium |
US8293506B2 (en) | 2009-02-25 | 2012-10-23 | Ajinomoto Co., Inc. | L-cysteine-producing bacterium and a method for producing L-cysteine |
WO2013000864A1 (en) | 2011-06-30 | 2013-01-03 | Wacker Chemie Ag | Method for production of natural l-cysteine by fermentation |
US8383372B2 (en) | 2008-03-06 | 2013-02-26 | Ajinomoto Co., Inc. | L-cysteine producing bacterium and a method for producing L-cysteine |
WO2013171098A2 (en) | 2012-05-18 | 2013-11-21 | Wacker Chemie Ag | Method for the fermentative production of l-cystein and derivates of said amino acid |
DE102012216527A1 (en) | 2012-09-17 | 2014-03-20 | Wacker Chemie Ag | Process for the fermentative production of L-cysteine and derivatives of this amino acid |
US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
US9611461B2 (en) | 2013-03-19 | 2017-04-04 | National University Corporation NARA Institute of Science and Technology | Enterobacteriaceae bacteria exhibiting increased L-cysteine producing ability |
WO2021197632A1 (en) | 2020-04-03 | 2021-10-07 | Wacker Chemie Ag | Biocatalyst as a core component of an enzyme-catalyzed redox system for the biocatalytic reduction of cystine |
Families Citing this family (68)
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DE10046934A1 (en) * | 2000-09-21 | 2002-04-18 | Consortium Elektrochem Ind | Process for the fermentative production of non-proteinogenic L-amino acids |
ATE406455T1 (en) * | 2001-07-11 | 2008-09-15 | Evonik Degussa Gmbh | METHOD FOR PRODUCING L-THREONINE USING STRAINS OF THE ENTEROBACTERIACEAE FAMILY |
US7348037B2 (en) | 2002-08-16 | 2008-03-25 | Evonik Degussa Gmbh | Sulfur-containing animal-feed additives |
DE10237479A1 (en) * | 2002-08-16 | 2004-02-26 | Degussa Ag | Animal feed additive containing sulfur |
JP2006517796A (en) | 2003-02-18 | 2006-08-03 | メタボリック エクスプローラー | Method for producing an evolved microorganism capable of generating or modifying a metabolic pathway |
WO2004113373A1 (en) * | 2003-06-21 | 2004-12-29 | University Of Sheffield | Overexpression of the cyddc transporter |
DE10331291A1 (en) | 2003-07-10 | 2005-02-17 | Consortium für elektrochemische Industrie GmbH | Variants of 3-phosphoglycerate dehydrogenase with reduced inhibition by L-serine and genes coding for it |
RU2275425C2 (en) * | 2003-11-03 | 2006-04-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) | Bacterium belonging to genus escherichia as producer of l-cysteine and method for preparing l-cysteine |
JP2009118740A (en) | 2006-03-03 | 2009-06-04 | Ajinomoto Co Inc | Method for producing l-amino acid |
WO2007119574A2 (en) | 2006-03-23 | 2007-10-25 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna |
JP2009165355A (en) | 2006-04-28 | 2009-07-30 | Ajinomoto Co Inc | L-amino acid-producing microorganism and method for producing l-amino acid |
WO2007136133A1 (en) | 2006-05-23 | 2007-11-29 | Ajinomoto Co., Inc. | A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family |
JP5297804B2 (en) | 2006-07-25 | 2013-09-25 | 協和発酵バイオ株式会社 | Amino acid production method |
RU2006143864A (en) | 2006-12-12 | 2008-06-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF GENES cynT, cynS, cynX, OR cynR, OR THEIR COMBINATION IS DECREASED |
JP2010041920A (en) | 2006-12-19 | 2010-02-25 | Ajinomoto Co Inc | Method for producing l-amino acid |
WO2008090770A1 (en) | 2007-01-22 | 2008-07-31 | Ajinomoto Co., Inc. | Microorganism capable of producing l-amino acid, and method for production of l-amino acid |
DE102007007333A1 (en) | 2007-02-14 | 2008-08-21 | Wacker Chemie Ag | Process for the purification of L-cysteine |
JP2010110216A (en) | 2007-02-20 | 2010-05-20 | Ajinomoto Co Inc | Method for producing l-amino acid or nucleic acid |
JP2010110217A (en) | 2007-02-22 | 2010-05-20 | Ajinomoto Co Inc | L-amino acid-producing microorganism and method for producing l-amino acid |
JP5319521B2 (en) | 2007-04-06 | 2013-10-16 | 協和発酵バイオ株式会社 | Dipeptide production method |
JP2011067095A (en) | 2008-01-10 | 2011-04-07 | Ajinomoto Co Inc | Method for producing target substance by fermentation process |
EP2248906A4 (en) | 2008-01-23 | 2012-07-11 | Ajinomoto Kk | Method of producing l-amino acid |
RU2008105793A (en) | 2008-02-19 | 2009-08-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) | METHOD FOR DESIGNING OPERONS CONTAINING TRANSLATION-CONJUGATED GENES, BACTERIA CONTAINING SUCH OPERON, METHOD FOR PRODUCING USEFUL METABOLITIS AND METHOD FOR EXPRESS MONITORING |
EP2246420B1 (en) | 2008-02-21 | 2014-12-31 | Ajinomoto Co., Inc. | L-cysteine-producing bacterium, and method for production of l-cysteine |
EP2298880A4 (en) | 2008-03-18 | 2012-02-08 | Kyowa Hakko Kirin Co Ltd | Industrially useful microorganism |
EP2330184B1 (en) | 2008-09-01 | 2020-11-25 | Shinshu University | Process for producing a useful substance in coryneform bacteria |
BRPI0918299B1 (en) | 2008-09-08 | 2018-08-14 | Ajinomoto Co., Inc. | METHOD FOR PRODUCING L-AMINO ACID |
EP2382320B1 (en) | 2009-01-23 | 2018-04-18 | Ajinomoto Co., Inc. | Process for producing l-amino acids employing bacteria of the enterobacteriacea family in a culture medium with controlled glycerol concentration |
JP5662167B2 (en) | 2009-02-09 | 2015-01-28 | 協和発酵バイオ株式会社 | Method for producing L-amino acid |
US9023622B2 (en) | 2009-02-10 | 2015-05-05 | Kyowa Hakko Bio Co., Ltd. | Method for producing L-amino acid using a microorganism with decreased aspartate aminotransferase activity |
JPWO2010095642A1 (en) | 2009-02-18 | 2012-08-23 | 国立大学法人信州大学 | Method for producing useful substances |
JP5359409B2 (en) | 2009-03-12 | 2013-12-04 | 味の素株式会社 | L-cysteine producing bacterium and method for producing L-cysteine |
JPWO2011013707A1 (en) | 2009-07-29 | 2013-01-10 | 味の素株式会社 | Method for producing L-amino acid |
RU2009136544A (en) | 2009-10-05 | 2011-04-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) | METHOD FOR PRODUCING L-CISTEINE USING THE ENTEROBACTERIACEAE FAMILY BACTERIA |
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JP2013074795A (en) | 2010-02-08 | 2013-04-25 | Ajinomoto Co Inc | MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID |
RU2471868C2 (en) | 2010-02-18 | 2013-01-10 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) | Mutant adenylate cyclase, dna coding it, bacteria of enterobacteriaceae family containing said dan and method for preparing l-amino acids |
RU2482188C2 (en) | 2010-07-21 | 2013-05-20 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) | METHOD FOR PREPARING L-ARGININE WITH USE OF BACTERIA OF GENUS Escherichia WHEREIN astCADBE OPERON IS INACTIVATED |
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EP2617808B1 (en) | 2010-09-14 | 2016-06-15 | Ajinomoto Co., Inc. | Sulfur-containing amino acid-producing bacterium and method for producing sulfur-containing amino acids |
JP2014036576A (en) | 2010-12-10 | 2014-02-27 | Ajinomoto Co Inc | Method for producing l-amino acids |
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US9567616B2 (en) | 2011-02-09 | 2017-02-14 | Kyowa Hakko Bio Co., Ltd. | Process for producing target substance by fermentation |
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JP2014131487A (en) | 2011-04-18 | 2014-07-17 | Ajinomoto Co Inc | Method for producing l-cysteine |
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US20150118720A1 (en) | 2012-04-13 | 2015-04-30 | Kyowa Hakko Bio Co., Ltd. | Process for producing amino acid |
EP2700715B1 (en) | 2012-08-20 | 2018-07-25 | Evonik Degussa GmbH | Method for manufacturing L-amino acids using improved strains of the enterobacteriaceae family by means of fermentation |
RU2013118637A (en) | 2013-04-23 | 2014-10-27 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE yjjK GENE IS ADJUSTABLE |
DE102013209274A1 (en) | 2013-05-17 | 2014-11-20 | Wacker Chemie Ag | Microorganism and method for fermentative overproduction of gamma-glutamylcysteine and derivatives of this dipeptide |
JP2016165225A (en) | 2013-07-09 | 2016-09-15 | 味の素株式会社 | Method for producing useful substance |
RU2013140115A (en) | 2013-08-30 | 2015-03-10 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") | METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED |
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JP6459962B2 (en) | 2013-10-21 | 2019-01-30 | 味の素株式会社 | Method for producing L-amino acid |
RU2014105547A (en) | 2014-02-14 | 2015-08-20 | Адзиномото Ко., Инк. | METHOD FOR PRODUCING L-AMINO ACIDS USING THE ENTEROBACTERIACEAE FAMILY HAVING A SUPER EXPRESSED GENE yajL |
RU2015120052A (en) | 2015-05-28 | 2016-12-20 | Аджиномото Ко., Инк. | A method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family in which gshA gene expression is weakened |
CN109121422B (en) | 2016-02-25 | 2021-12-21 | 味之素株式会社 | Method for producing L-amino acids using bacteria of the Enterobacteriaceae family overexpressing genes coding for iron exporters |
JP7066977B2 (en) | 2017-04-03 | 2022-05-16 | 味の素株式会社 | Manufacturing method of L-amino acid |
WO2020071538A1 (en) | 2018-10-05 | 2020-04-09 | Ajinomoto Co., Inc. | Method for producing target substance by bacterial fermentation |
KR102112286B1 (en) * | 2018-12-05 | 2020-05-19 | 서울대학교산학협력단 | Gene related to acid resistance and methanotrophs comprising the same |
WO2020171227A1 (en) | 2019-02-22 | 2020-08-27 | Ajinomoto Co., Inc. | METHOD FOR PRODUCING L-AMINO ACIDS USING A BACTERIUM BELONGING TO THE FAMILY Enterobacteriaceae HAVING OVEREXPRESSED ydiJ GENE |
BR112021017870A2 (en) | 2019-04-05 | 2021-12-07 | Ajinomoto Kk | Method for producing an l-amino acid |
JP2022550084A (en) | 2019-09-25 | 2022-11-30 | 味の素株式会社 | Method for producing L-amino acid by bacterial fermentation |
EP4172310A1 (en) | 2020-06-26 | 2023-05-03 | Wacker Chemie AG | Improved cysteine-producing strains |
WO2023165684A1 (en) | 2022-03-01 | 2023-09-07 | Wacker Chemie Ag | Improved cysteine-producing strains |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19539952A1 (en) * | 1995-10-26 | 1997-04-30 | Consortium Elektrochem Ind | Process for the preparation of O-acetylserine, L-cysteine and L-cysteine-related products |
DE19726083A1 (en) * | 1997-06-19 | 1998-12-24 | Consortium Elektrochem Ind | Microorganisms and processes for the fermentative production of L-cysteine, L-cystine, N-acetyl-serine or thiazolidine derivatives |
-
1999
- 1999-10-14 DE DE19949579A patent/DE19949579C1/en not_active Expired - Fee Related
-
2000
- 2000-10-05 JP JP2001530510A patent/JP2003511086A/en active Pending
- 2000-10-05 CN CNB008142726A patent/CN1262646C/en not_active Expired - Fee Related
- 2000-10-05 SK SK497-2002A patent/SK4972002A3/en unknown
- 2000-10-05 KR KR10-2002-7004742A patent/KR100505336B1/en not_active IP Right Cessation
- 2000-10-05 DK DK00969413T patent/DK1220940T3/en active
- 2000-10-05 AT AT00969413T patent/ATE231918T1/en active
- 2000-10-05 CA CA002386539A patent/CA2386539C/en not_active Expired - Fee Related
- 2000-10-05 WO PCT/EP2000/009720 patent/WO2001027307A1/en active IP Right Grant
- 2000-10-05 DE DE50001193T patent/DE50001193D1/en not_active Expired - Lifetime
- 2000-10-05 EP EP00969413A patent/EP1220940B2/en not_active Expired - Lifetime
- 2000-10-16 TW TW089121607A patent/TWI249575B/en not_active IP Right Cessation
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8008048B2 (en) | 2008-03-06 | 2011-08-30 | Ajinomoto Co., Inc. | L-cysteine-producing bacterium and a method for producing L-cysteine |
US8383372B2 (en) | 2008-03-06 | 2013-02-26 | Ajinomoto Co., Inc. | L-cysteine producing bacterium and a method for producing L-cysteine |
US8293506B2 (en) | 2009-02-25 | 2012-10-23 | Ajinomoto Co., Inc. | L-cysteine-producing bacterium and a method for producing L-cysteine |
US9234223B2 (en) | 2011-04-01 | 2016-01-12 | Ajinomoto Co., Inc. | Method for producing L-cysteine |
US9074230B2 (en) | 2011-05-11 | 2015-07-07 | Wacker Chemie Ag | Method for producing L-cystine by fermentation under controlled oxygen saturation |
DE102011075656A1 (en) | 2011-05-11 | 2012-03-29 | Wacker Chemie Ag | Producing L-cystine useful as food additive, preferably in baking industry, as ingredient in cosmetics and as starting material for producing active pharmaceutical ingredient, comprises fermenting microorganism strain in fermentation medium |
WO2012152664A1 (en) | 2011-05-11 | 2012-11-15 | Wacker Chemie Ag | Method for producing l-cystine by fermentation under controlled oxygen saturation |
WO2013000864A1 (en) | 2011-06-30 | 2013-01-03 | Wacker Chemie Ag | Method for production of natural l-cysteine by fermentation |
US8802399B2 (en) | 2011-06-30 | 2014-08-12 | Wacker Chemie Ag | Method for production of natural L-cysteine by fermentation |
DE102012208359A1 (en) | 2012-05-18 | 2013-11-21 | Wacker Chemie Ag | Process for the fermentative production of L-cysteine and derivatives of this amino acid |
WO2013171098A2 (en) | 2012-05-18 | 2013-11-21 | Wacker Chemie Ag | Method for the fermentative production of l-cystein and derivates of said amino acid |
DE102012216527A1 (en) | 2012-09-17 | 2014-03-20 | Wacker Chemie Ag | Process for the fermentative production of L-cysteine and derivatives of this amino acid |
WO2014040955A1 (en) | 2012-09-17 | 2014-03-20 | Wacker Chemie Ag | Method for the fermentative production of l-cysteine and derivatives of said amino acid |
US9347078B2 (en) | 2012-09-17 | 2016-05-24 | Wacker Chemie Ag | Method for the fermentative production of L-cysteine and derivatives of said amino acid |
US9611461B2 (en) | 2013-03-19 | 2017-04-04 | National University Corporation NARA Institute of Science and Technology | Enterobacteriaceae bacteria exhibiting increased L-cysteine producing ability |
WO2021197632A1 (en) | 2020-04-03 | 2021-10-07 | Wacker Chemie Ag | Biocatalyst as a core component of an enzyme-catalyzed redox system for the biocatalytic reduction of cystine |
Also Published As
Publication number | Publication date |
---|---|
DE50001193D1 (en) | 2003-03-06 |
EP1220940B2 (en) | 2010-07-28 |
SK4972002A3 (en) | 2002-09-10 |
DE19949579C1 (en) | 2000-11-16 |
EP1220940A1 (en) | 2002-07-10 |
CA2386539C (en) | 2007-04-17 |
WO2001027307A1 (en) | 2001-04-19 |
ATE231918T1 (en) | 2003-02-15 |
DK1220940T3 (en) | 2003-06-23 |
TWI249575B (en) | 2006-02-21 |
JP2003511086A (en) | 2003-03-25 |
KR20020059620A (en) | 2002-07-13 |
CN1379823A (en) | 2002-11-13 |
EP1220940B1 (en) | 2003-01-29 |
CN1262646C (en) | 2006-07-05 |
KR100505336B1 (en) | 2005-07-29 |
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