DK1220940T3 - Process for fermentative preparation of L-cysteine or L-cysteine derivatives - Google Patents

Process for fermentative preparation of L-cysteine or L-cysteine derivatives

Info

Publication number
DK1220940T3
DK1220940T3 DK00969413T DK00969413T DK1220940T3 DK 1220940 T3 DK1220940 T3 DK 1220940T3 DK 00969413 T DK00969413 T DK 00969413T DK 00969413 T DK00969413 T DK 00969413T DK 1220940 T3 DK1220940 T3 DK 1220940T3
Authority
DK
Denmark
Prior art keywords
cysteine
micro
derivatives
cysb
fermentative preparation
Prior art date
Application number
DK00969413T
Other languages
Danish (da)
Inventor
Thomas Maier
Christoph Winterhalter
Original Assignee
Consortium Elektrochem Ind
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7925659&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1220940(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Consortium Elektrochem Ind filed Critical Consortium Elektrochem Ind
Application granted granted Critical
Publication of DK1220940T3 publication Critical patent/DK1220940T3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C12P13/12—Methionine; Cysteine; Cystine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

The invention relates to a method for production of l-cysteine or l-cysteine derivatives by means of a fermentation with micro-organisms and micro-organisms suitable for said method. The micro-organism strain adapted to fermentative production of l-cysteine or l-cysteine derivatives comprises a deregulated cysteine metabolism which is not dependent upon an altered cysB activity. Said micro-organism strain is furthermore characterized by an elevated cysB activity, whereby the cysB activity comprises a regulation pattern typical for a wild type cysB.
DK00969413T 1999-10-14 2000-10-05 Process for fermentative preparation of L-cysteine or L-cysteine derivatives DK1220940T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19949579A DE19949579C1 (en) 1999-10-14 1999-10-14 Microorganism with deregulated cysteine metabolism, useful for high-level production of cysteine and its derivatives, has increased activity of the CysB transcription regulator
PCT/EP2000/009720 WO2001027307A1 (en) 1999-10-14 2000-10-05 Method for production of l-cysteine or l-cysteine derivatives by fermentation

Publications (1)

Publication Number Publication Date
DK1220940T3 true DK1220940T3 (en) 2003-06-23

Family

ID=7925659

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00969413T DK1220940T3 (en) 1999-10-14 2000-10-05 Process for fermentative preparation of L-cysteine or L-cysteine derivatives

Country Status (11)

Country Link
EP (1) EP1220940B2 (en)
JP (1) JP2003511086A (en)
KR (1) KR100505336B1 (en)
CN (1) CN1262646C (en)
AT (1) ATE231918T1 (en)
CA (1) CA2386539C (en)
DE (2) DE19949579C1 (en)
DK (1) DK1220940T3 (en)
SK (1) SK4972002A3 (en)
TW (1) TWI249575B (en)
WO (1) WO2001027307A1 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10046934A1 (en) * 2000-09-21 2002-04-18 Consortium Elektrochem Ind Process for the fermentative production of non-proteinogenic L-amino acids
ES2269712T3 (en) * 2001-07-11 2007-04-01 Degussa Gmbh PROCESS FOR THE PREPARATION OF L-AMINO ACIDS THAT USES ENVIRONMENTAL FAMILY STRAPS.
DE10237479A1 (en) * 2002-08-16 2004-02-26 Degussa Ag Animal feed additive containing sulfur
US7348037B2 (en) 2002-08-16 2008-03-25 Evonik Degussa Gmbh Sulfur-containing animal-feed additives
MXPA05008857A (en) 2003-02-18 2006-03-09 Metabolic Explorer Sa Method for the production of evolved microorganisms which permit the generation or modification of metabolic pathways.
WO2004113373A1 (en) * 2003-06-21 2004-12-29 University Of Sheffield Overexpression of the cyddc transporter
DE10331291A1 (en) 2003-07-10 2005-02-17 Consortium für elektrochemische Industrie GmbH Variants of 3-phosphoglycerate dehydrogenase with reduced inhibition by L-serine and genes coding for it
RU2275425C2 (en) * 2003-11-03 2006-04-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) Bacterium belonging to genus escherichia as producer of l-cysteine and method for preparing l-cysteine
JP2009118740A (en) 2006-03-03 2009-06-04 Ajinomoto Co Inc Method for producing l-amino acid
WO2007119574A2 (en) 2006-03-23 2007-10-25 Ajinomoto Co., Inc. A method for producing an l-amino acid using bacterium of the enterobacteriaceae family with attenuated expression of a gene coding for small rna
JP2009165355A (en) 2006-04-28 2009-07-30 Ajinomoto Co Inc L-amino acid-producing microorganism and method for producing l-amino acid
WO2007136133A1 (en) 2006-05-23 2007-11-29 Ajinomoto Co., Inc. A method for producing an l-amino acid using a bacterium of the enterobacteriaceae family
EP2050816A4 (en) 2006-07-25 2009-11-18 Kyowa Hakko Bio Co Ltd Method for production of amino acid
RU2006143864A (en) 2006-12-12 2008-06-20 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE EXPRESSION OF GENES cynT, cynS, cynX, OR cynR, OR THEIR COMBINATION IS DECREASED
JP2010041920A (en) 2006-12-19 2010-02-25 Ajinomoto Co Inc Method for producing l-amino acid
CN101627110B (en) 2007-01-22 2014-08-13 味之素株式会社 Microorganism capable of producing l-amino acid, and method for production of l-amino acid
DE102007007333A1 (en) 2007-02-14 2008-08-21 Wacker Chemie Ag Process for the purification of L-cysteine
JP2010110216A (en) 2007-02-20 2010-05-20 Ajinomoto Co Inc Method for producing l-amino acid or nucleic acid
JP2010110217A (en) 2007-02-22 2010-05-20 Ajinomoto Co Inc L-amino acid-producing microorganism and method for producing l-amino acid
CN101715484B (en) 2007-04-06 2014-02-19 协和发酵生化株式会社 Method for producing dipeptide
JP2011067095A (en) 2008-01-10 2011-04-07 Ajinomoto Co Inc Method for producing target substance by fermentation process
EP2248906A4 (en) 2008-01-23 2012-07-11 Ajinomoto Kk Method of producing l-amino acid
RU2008105793A (en) 2008-02-19 2009-08-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR DESIGNING OPERONS CONTAINING TRANSLATION-CONJUGATED GENES, BACTERIA CONTAINING SUCH OPERON, METHOD FOR PRODUCING USEFUL METABOLITIS AND METHOD FOR EXPRESS MONITORING
JP5476545B2 (en) 2008-02-21 2014-04-23 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
JP5332237B2 (en) 2008-03-06 2013-11-06 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
DE602009000714D1 (en) 2008-03-06 2011-03-24 Ajinomoto Kk L-cysteine-producing bacterium and process for producing L-cysteine
WO2009116566A1 (en) 2008-03-18 2009-09-24 協和発酵キリン株式会社 Industrially useful microorganism
JP5833311B2 (en) 2008-09-01 2015-12-16 国立大学法人信州大学 Production method of useful substances
EP2336347B1 (en) 2008-09-08 2017-03-15 Ajinomoto Co., Inc. An l-amino acid-producing microorganism and a method for producing an l-amino acid
BRPI1007069A2 (en) 2009-01-23 2015-08-25 Ajinomoto Kk Method for producing an 1-amino acid.
JP5662167B2 (en) 2009-02-09 2015-01-28 協和発酵バイオ株式会社 Method for producing L-amino acid
WO2010092959A1 (en) 2009-02-10 2010-08-19 協和発酵バイオ株式会社 Method for producing amino acid
US20120034669A1 (en) 2009-02-18 2012-02-09 Kyowa Hakko Bio Co., Ltd. Process for producing useful substance
JP5463528B2 (en) 2009-02-25 2014-04-09 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
JP5359409B2 (en) 2009-03-12 2013-12-04 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
JPWO2011013707A1 (en) 2009-07-29 2013-01-10 味の素株式会社 Method for producing L-amino acid
RU2009136544A (en) 2009-10-05 2011-04-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) METHOD FOR PRODUCING L-CISTEINE USING THE ENTEROBACTERIACEAE FAMILY BACTERIA
JP5817529B2 (en) 2009-11-30 2015-11-18 味の素株式会社 L-cysteine producing bacterium and method for producing L-cysteine
JP2013074795A (en) 2010-02-08 2013-04-25 Ajinomoto Co Inc MUTANT rpsA GENE AND METHOD FOR PRODUCING L-AMINO ACID
RU2471868C2 (en) 2010-02-18 2013-01-10 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) Mutant adenylate cyclase, dna coding it, bacteria of enterobacteriaceae family containing said dan and method for preparing l-amino acids
RU2501858C2 (en) 2010-07-21 2013-12-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR OBTAINING L-AMINOACID USING BACTERIUM OF Enterobacteriaceae FAMILY
RU2482188C2 (en) 2010-07-21 2013-05-20 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) METHOD FOR PREPARING L-ARGININE WITH USE OF BACTERIA OF GENUS Escherichia WHEREIN astCADBE OPERON IS INACTIVATED
BR112013006031A2 (en) 2010-09-14 2016-06-07 Ajinomoto Kk bacteria, and method for producing a sulfur-containing amino acid, a related substance, or a mixture thereof.
JP2014036576A (en) 2010-12-10 2014-02-27 Ajinomoto Co Inc Method for producing l-amino acids
EP2479279A1 (en) 2011-01-20 2012-07-25 Evonik Degussa GmbH Method for producing sulphuric amino acids by means of fermentation
EP2674499B1 (en) 2011-02-09 2020-04-01 Kyowa Hakko Bio Co., Ltd. Method for producing target substance by fermentation process
JP2014087259A (en) 2011-02-22 2014-05-15 Ajinomoto Co Inc L-cysteine-producing bacterium, and production method of l-cysteine
WO2012137689A1 (en) * 2011-04-01 2012-10-11 味の素株式会社 Method for producing l-cysteine
US9234223B2 (en) 2011-04-01 2016-01-12 Ajinomoto Co., Inc. Method for producing L-cysteine
JP2014131487A (en) 2011-04-18 2014-07-17 Ajinomoto Co Inc Method for producing l-cysteine
DE102011075656A1 (en) 2011-05-11 2012-03-29 Wacker Chemie Ag Producing L-cystine useful as food additive, preferably in baking industry, as ingredient in cosmetics and as starting material for producing active pharmaceutical ingredient, comprises fermenting microorganism strain in fermentation medium
DE102011078481A1 (en) 2011-06-30 2013-01-03 Wacker Chemie Ag Process for the fermentative production of natural L-cysteine
RU2011134436A (en) 2011-08-18 2013-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACID USING THE ENTEROBACTERIACEAE FAMILY POSSESSING AN INCREASED EXPRESSION OF GENES OF THE CASCADE OF THE FORMATION OF FLAGELLS AND CELL MOBILITY
EP2628792A1 (en) 2012-02-17 2013-08-21 Evonik Industries AG Cell with reduced ppGppase activity
BR112014025215A2 (en) 2012-04-13 2017-07-11 Kyowa Hakko Bio Co Ltd process to produce amino acid
DE102012208359A1 (en) 2012-05-18 2013-11-21 Wacker Chemie Ag Process for the fermentative production of L-cysteine and derivatives of this amino acid
EP2700715B1 (en) 2012-08-20 2018-07-25 Evonik Degussa GmbH Method for manufacturing L-amino acids using improved strains of the enterobacteriaceae family by means of fermentation
DE102012216527A1 (en) 2012-09-17 2014-03-20 Wacker Chemie Ag Process for the fermentative production of L-cysteine and derivatives of this amino acid
EP2977442B1 (en) * 2013-03-19 2018-02-28 National University Corporation Nara Institute of Science and Technology Enterobacteriaceae bacteria exhibiting increased l-cysteine producing ability
RU2013118637A (en) 2013-04-23 2014-10-27 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE ENTEROBACTERIACEAE FAMILY IN WHICH THE yjjK GENE IS ADJUSTABLE
DE102013209274A1 (en) 2013-05-17 2014-11-20 Wacker Chemie Ag Microorganism and method for fermentative overproduction of gamma-glutamylcysteine and derivatives of this dipeptide
JP2016165225A (en) 2013-07-09 2016-09-15 味の素株式会社 Method for producing useful substance
RU2013140115A (en) 2013-08-30 2015-03-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF THE znuACB GENERAL CLUSTER IS DISORDERED
JP5958653B2 (en) 2013-10-02 2016-08-02 味の素株式会社 Ammonia control device and ammonia control method
RU2013144250A (en) 2013-10-02 2015-04-10 Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" (ЗАО "АГРИ") METHOD FOR PRODUCING L-AMINO ACIDS USING THE BACTERIA OF THE Enterobacteriaceae FAMILY IN WHICH THE EXPRESSION OF A GENE CODING A PHOSPHATE TRANSPORTER IS DECREASED
JP6459962B2 (en) 2013-10-21 2019-01-30 味の素株式会社 Method for producing L-amino acid
RU2014105547A (en) 2014-02-14 2015-08-20 Адзиномото Ко., Инк. METHOD FOR PRODUCING L-AMINO ACIDS USING THE ENTEROBACTERIACEAE FAMILY HAVING A SUPER EXPRESSED GENE yajL
RU2015120052A (en) 2015-05-28 2016-12-20 Аджиномото Ко., Инк. A method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family in which gshA gene expression is weakened
BR112018017227A2 (en) 2016-02-25 2019-02-05 Ajinomoto Kk method to produce an l-amino acid
JP7066977B2 (en) 2017-04-03 2022-05-16 味の素株式会社 Manufacturing method of L-amino acid
WO2020071538A1 (en) 2018-10-05 2020-04-09 Ajinomoto Co., Inc. Method for producing target substance by bacterial fermentation
KR102112286B1 (en) * 2018-12-05 2020-05-19 서울대학교산학협력단 Gene related to acid resistance and methanotrophs comprising the same
BR112021014194A2 (en) 2019-02-22 2021-12-28 Ajinomoto Kk Method for producing an l-amino acid
BR112021017870A2 (en) 2019-04-05 2021-12-07 Ajinomoto Kk Method for producing an l-amino acid
JP2022550084A (en) 2019-09-25 2022-11-30 味の素株式会社 Method for producing L-amino acid by bacterial fermentation
CN115244183A (en) 2020-04-03 2022-10-25 瓦克化学股份公司 Biocatalysts as core components of enzymatic redox systems for the biocatalytic reduction of cystine
JP2023532871A (en) 2020-06-26 2023-08-01 ワッカー ケミー アクチエンゲゼルシャフト improved cysteine-producing strain
CN118742558A (en) 2022-03-01 2024-10-01 瓦克化学股份公司 Improved cysteine producing strains

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19539952A1 (en) * 1995-10-26 1997-04-30 Consortium Elektrochem Ind Process for the preparation of O-acetylserine, L-cysteine and L-cysteine-related products
DE19726083A1 (en) * 1997-06-19 1998-12-24 Consortium Elektrochem Ind Microorganisms and processes for the fermentative production of L-cysteine, L-cystine, N-acetyl-serine or thiazolidine derivatives

Also Published As

Publication number Publication date
CN1379823A (en) 2002-11-13
EP1220940B2 (en) 2010-07-28
SK4972002A3 (en) 2002-09-10
KR100505336B1 (en) 2005-07-29
DE19949579C1 (en) 2000-11-16
EP1220940A1 (en) 2002-07-10
CA2386539C (en) 2007-04-17
EP1220940B1 (en) 2003-01-29
WO2001027307A1 (en) 2001-04-19
CA2386539A1 (en) 2001-04-19
DE50001193D1 (en) 2003-03-06
ATE231918T1 (en) 2003-02-15
KR20020059620A (en) 2002-07-13
CN1262646C (en) 2006-07-05
JP2003511086A (en) 2003-03-25
TWI249575B (en) 2006-02-21

Similar Documents

Publication Publication Date Title
DK1220940T3 (en) Process for fermentative preparation of L-cysteine or L-cysteine derivatives
PH12014500480A1 (en) Equal-containing fermentation product of soybean embryonic axis, and method for production thereof
BR0207287A (en) Glycosamine and method of manufacturing glycosamine from microbial biomass
DK1040182T3 (en) Process for the preparation of biomass by photosynthesis
WO2007055984A3 (en) Enzyme and methodology for the treatment of a biomass
EP1571223A3 (en) L-cysteine-producing microorganism and a method for producing L-cysteine
DK1633779T3 (en) Oxidoreductase from Pichia capsulata
DK1208205T3 (en) Methods for producing L-amino acids by increasing cellular NADPH
AU2001260542A1 (en) Extracts from spermatophyte plants with immunomodulating activity
DE602004008183D1 (en) Process for the preparation of L-cysteine using a bacterium belonging to the genus Escherichia
DK0625571T3 (en) Microorganisms, their use, and the method of preparing L-alpha amino acids
TWI255855B (en) Process for preparing O-acetyl-l-serine by fermentation
DK0794256T3 (en) Method for Culturing Microorganisms with Methanol Metabolic Process
DK1191106T3 (en) Process for Fermentative Preparation of Non-Proteinogenic L-Amino Acids
NZ508404A (en) Alcoholic fermentation using a mineral-enriched yeast as a nutrient source
DE60023187D1 (en) PREPARATION AND PURIFICATION OF MYCOPHENOLIC ACID
MX2010001045A (en) Method for producing spores and metabolites from fungal microorganisms and uses thereof.
ES2088512T3 (en) BIOTECHNOLOGICAL PROCEDURE FOR THE PREPARATION OF S - (+) - 2,2-DIMETILCICLOPROPANCARBOXAMIDA AND R - (-) - 2,2-DIMETILCICLOPROPANCARBOXILICO.
BRPI0512761A (en) Method for L-Lysine Fermetation Using a Soybean Acid Hydrolyzate and Method for Producing L-Lysine from a Cultivated Product
PT1210446E (en) MODIFIED UBIQUITIN REGULATION SYSTEM
SE0000055D0 (en) Novel process
FR2692908B1 (en) Process for the co-fermentation of glucose and xylose into ethanol by mixed culture of microorganisms.
JPS5771396A (en) Preparation of coenzyme q10
ATE491036T1 (en) PRODUCTION OF OPTICALLY ACTIVE ALCOHOLS USING WHOLE CELL CATALYSTS
DE69930071D1 (en) Fermentation process for the production of erythritol by means of a mutant of Candida sp. with high salt tolerance