CA2385609A1 - Creation de regions de liaison a sequence et longueur variables, pour molecules a domaine double ou multiple - Google Patents

Creation de regions de liaison a sequence et longueur variables, pour molecules a domaine double ou multiple Download PDF

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Publication number
CA2385609A1
CA2385609A1 CA002385609A CA2385609A CA2385609A1 CA 2385609 A1 CA2385609 A1 CA 2385609A1 CA 002385609 A CA002385609 A CA 002385609A CA 2385609 A CA2385609 A CA 2385609A CA 2385609 A1 CA2385609 A1 CA 2385609A1
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CA
Canada
Prior art keywords
domain
library
repeated
polypeptide
domains
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002385609A
Other languages
English (en)
Inventor
Stephen J. Reinl
John A. Lindbo
Thomas Turpen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kentucky Bioprocessing LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2385609A1 publication Critical patent/CA2385609A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1093—General methods of preparing gene libraries, not provided for in other subgroups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Immunology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne des procédés et des compositions pour la création d'une molécule d'ADN, d'ARN ou de protéine, comprenant deux ou plusieurs domaines polypeptidiques ou nucléotidiques reliés par une région de liaison. Lesdites méthodes sont utilisées pour la génération de banques de segments de liaison aléatoires d'acides nucléiques codant pour des polypeptides à domaine double ou multiple. Lesdites régions de liaison se caractérisent par une longueur et une séquence variables.
CA002385609A 1999-09-24 2000-09-22 Creation de regions de liaison a sequence et longueur variables, pour molecules a domaine double ou multiple Abandoned CA2385609A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15597899P 1999-09-24 1999-09-24
US60/155,978 1999-09-24
PCT/US2000/025965 WO2001023543A1 (fr) 1999-09-24 2000-09-22 Creation de regions de liaison a sequence et longueur variables, pour molecules a domaine double ou multiple

Publications (1)

Publication Number Publication Date
CA2385609A1 true CA2385609A1 (fr) 2001-04-05

Family

ID=22557557

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002385609A Abandoned CA2385609A1 (fr) 1999-09-24 2000-09-22 Creation de regions de liaison a sequence et longueur variables, pour molecules a domaine double ou multiple

Country Status (8)

Country Link
EP (1) EP1218501A1 (fr)
JP (1) JP2003510073A (fr)
KR (1) KR20020059413A (fr)
AU (1) AU782856B2 (fr)
CA (1) CA2385609A1 (fr)
RU (1) RU2002110820A (fr)
WO (1) WO2001023543A1 (fr)
ZA (1) ZA200202066B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2426194T3 (es) * 2005-08-02 2013-10-21 Planet Biotechnology, Inc. Proteínas quiméricas del receptor de toxina mejoradas y proteínas quiméricas del receptor de toxina para el tratamiento y la prevención de anthrax
TWI738987B (zh) * 2017-03-16 2021-09-11 免疫功坊股份有限公司 接合單元及包含接合單元之分子構建體

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5977438A (en) * 1988-02-26 1999-11-02 Biosource Technologies, Inc. Production of peptides in plants as viral coat protein fusions
US5747334A (en) * 1990-02-15 1998-05-05 The University Of North Carolina At Chapel Hill Random peptide library
AU5670194A (en) * 1992-11-20 1994-06-22 Enzon, Inc. Linker for linked fusion polypeptides
US6187564B1 (en) * 1997-07-10 2001-02-13 Beth Israel Deaconess Medical Center DNA encoding erythropoietin multimers having modified 5′ and 3′ sequences and its use to prepare EPO therapeutics

Also Published As

Publication number Publication date
KR20020059413A (ko) 2002-07-12
RU2002110820A (ru) 2004-01-27
WO2001023543A1 (fr) 2001-04-05
ZA200202066B (en) 2003-05-28
AU782856B2 (en) 2005-09-01
JP2003510073A (ja) 2003-03-18
EP1218501A1 (fr) 2002-07-03
AU7601700A (en) 2001-04-30

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