CA2382812A1 - Structures cristallines de domaines de proteines tyrosine kinases de recepteur et de leurs ligands - Google Patents

Structures cristallines de domaines de proteines tyrosine kinases de recepteur et de leurs ligands Download PDF

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Publication number
CA2382812A1
CA2382812A1 CA002382812A CA2382812A CA2382812A1 CA 2382812 A1 CA2382812 A1 CA 2382812A1 CA 002382812 A CA002382812 A CA 002382812A CA 2382812 A CA2382812 A CA 2382812A CA 2382812 A1 CA2382812 A1 CA 2382812A1
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CA
Canada
Prior art keywords
tyrosine kinase
protein tyrosine
receptor protein
ligand
crystal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002382812A
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English (en)
Inventor
Joseph Schlessinger
Stevan B. Hubbard
Moosa Mohammadi
Alexander Plotnikov
Zhongtao Zhang
Xiang-Peng Kong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York University NYU
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2382812A1 publication Critical patent/CA2382812A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

La présente invention concerne la détermination et l'utilisation de structures tridimensionnelles de protéines tyrosine kinases de récepteur (RPTK) et/ou de leurs ligands. Un groupe particulier de ces structures comprend des structures tridimensionnelles du domaine extracellulaire des RPTK. Les structures tridimensionnelles des RPTK peuvent faciliter la conception et l'identification de modulateurs de la fonction RPTK. D'autres structures de ce type peuvent comprendre des ligands RPTK, tels qu'un facteur de cellules souches ou un fragment de ce dernier. Les modulateurs de la fonction RPTK peuvent être utilisés pour traiter des maladies induites par une activité inappropriée de RPTK.
CA002382812A 1999-08-30 2000-08-30 Structures cristallines de domaines de proteines tyrosine kinases de recepteur et de leurs ligands Abandoned CA2382812A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15181099P 1999-08-30 1999-08-30
US60/151,810 1999-08-30
PCT/US2000/023744 WO2001016181A2 (fr) 1999-08-30 2000-08-30 Structures cristallines de domaines de proteines tyrosine kinases de recepteur et de leurs ligands

Publications (1)

Publication Number Publication Date
CA2382812A1 true CA2382812A1 (fr) 2001-03-08

Family

ID=22540331

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002382812A Abandoned CA2382812A1 (fr) 1999-08-30 2000-08-30 Structures cristallines de domaines de proteines tyrosine kinases de recepteur et de leurs ligands

Country Status (5)

Country Link
EP (1) EP1212365A2 (fr)
JP (1) JP2003513016A (fr)
AU (1) AU7087000A (fr)
CA (1) CA2382812A1 (fr)
WO (1) WO2001016181A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098914A2 (fr) * 2001-06-07 2002-12-12 F. Hoffmann-La Roche Ag Mutants de proteines de liaison du facteur de croissance insulinomimetique (igf) et methodes de production d'antagonistes
JP2007520997A (ja) * 2003-01-21 2007-08-02 スミスクライン ビーチャム コーポレーション ＥｒｂＢ４共結晶
US7303893B1 (en) 2003-08-28 2007-12-04 Takeda San Diego, Inc. Crystallization of c-KIT tyrosine kinase leading to autoinhibited crystal structure
JP5360738B2 (ja) * 2008-03-03 2013-12-04 国立大学法人 奈良先端科学技術大学院大学 細胞増殖促進活性を有するペプチド
CN104177492B (zh) * 2014-07-21 2017-02-22 暨南大学 FGFR2c胞外段类似物及其编码基因与应用
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
EP3583120B1 (fr) 2017-02-17 2022-10-05 Denali Therapeutics Inc. Polypeptides de liaison au récepteur de transferrine modifiés
EP3612234B1 (fr) 2017-04-20 2024-03-13 ADC Therapeutics SA Polythérapie avec un conjugué anticorps anti-axl-médicament
JP7280241B2 (ja) * 2017-08-10 2023-05-23 デナリ セラピューティクス インコーポレイテッド 操作されたトランスフェリン受容体結合ポリペプチド
CN115746111A (zh) * 2021-09-02 2023-03-07 中国科学院天津工业生物技术研究所 一种转录调控因子LysG的突变体及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998007835A2 (fr) * 1996-08-21 1998-02-26 Sugen, Inc. Structures cristallines d'une proteine tyrosine kinase

Also Published As

Publication number Publication date
EP1212365A2 (fr) 2002-06-12
AU7087000A (en) 2001-03-26
JP2003513016A (ja) 2003-04-08
WO2001016181A3 (fr) 2002-01-24
WO2001016181A2 (fr) 2001-03-08

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued
FZDE Discontinued

Effective date: 20090831