CA2381976A1 - Compositions pharmaceutiques contenant des derives de thiazolidinedione et procede de preparation - Google Patents

Compositions pharmaceutiques contenant des derives de thiazolidinedione et procede de preparation Download PDF

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Publication number
CA2381976A1
CA2381976A1 CA002381976A CA2381976A CA2381976A1 CA 2381976 A1 CA2381976 A1 CA 2381976A1 CA 002381976 A CA002381976 A CA 002381976A CA 2381976 A CA2381976 A CA 2381976A CA 2381976 A1 CA2381976 A1 CA 2381976A1
Authority
CA
Canada
Prior art keywords
formula
pharmaceutically acceptable
compound
acceptable salt
tautomeric form
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002381976A
Other languages
English (en)
Inventor
Michael Urquhart
Robin Edwin Buckingham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9919465.6A external-priority patent/GB9919465D0/en
Priority claimed from GBGB9919842.6A external-priority patent/GB9919842D0/en
Priority claimed from GBGB9920149.3A external-priority patent/GB9920149D0/en
Application filed by Individual filed Critical Individual
Publication of CA2381976A1 publication Critical patent/CA2381976A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne une composition pharmaceutique comprenant une quantité efficace non toxique d'un composé représenté par la formule (I), ou d'une forme tautomère de celui-ci, et/ou d'un sel acceptable d'un point de vue pharmaceutique de celui-ci, et/ou d'un solvate acceptable d'un point de vue pharmaceutique de celui-ci, formule dans laquelle A?1¿ représente OH ou -OSO¿2?OH, R?1¿ représente un atome d'hydrogène ou un groupe alkyle C¿1-6?, et R?2¿ et R?3¿ représentent chacun l'hydrogène ou R?2¿ et R?3¿ représentent tous deux une liaison. L'invention concerne également un support acceptable d'un point de vue pharmaceutique. L'invention concerne enfin de nouveaux composés utilisés dans une telle composition, et l'utilisation de ces composés et de cette composition en médecine.
CA002381976A 1999-08-17 2000-08-14 Compositions pharmaceutiques contenant des derives de thiazolidinedione et procede de preparation Abandoned CA2381976A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9919465.6 1999-08-17
GBGB9919465.6A GB9919465D0 (en) 1999-08-17 1999-08-17 Novel compounds
GB9919842.6 1999-08-20
GBGB9919842.6A GB9919842D0 (en) 1999-08-20 1999-08-20 Novel compounds
GBGB9920149.3A GB9920149D0 (en) 1999-08-25 1999-08-25 Novel compounds
GB9920149.3 1999-08-25
PCT/EP2000/007926 WO2001012628A1 (fr) 1999-08-17 2000-08-14 Compositions pharmaceutiques contenant des derives de thiazolidinedione et procede de preparation

Publications (1)

Publication Number Publication Date
CA2381976A1 true CA2381976A1 (fr) 2001-02-22

Family

ID=27269792

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002381976A Abandoned CA2381976A1 (fr) 1999-08-17 2000-08-14 Compositions pharmaceutiques contenant des derives de thiazolidinedione et procede de preparation

Country Status (15)

Country Link
EP (1) EP1202991A1 (fr)
JP (1) JP2003507379A (fr)
KR (1) KR20020022812A (fr)
CN (1) CN1379776A (fr)
AU (1) AU7408900A (fr)
BR (1) BR0013375A (fr)
CA (1) CA2381976A1 (fr)
CZ (1) CZ2002531A3 (fr)
HU (1) HUP0202438A2 (fr)
IL (1) IL148164A0 (fr)
MX (1) MXPA02001716A (fr)
NO (1) NO20020777L (fr)
PL (1) PL353886A1 (fr)
TR (1) TR200200438T2 (fr)
WO (1) WO2001012628A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001090356A1 (fr) * 2000-05-25 2001-11-29 Yamanouchi Pharmaceutical Co., Ltd. Promoteur de pgc-1 humain
WO2003029251A1 (fr) * 2001-09-28 2003-04-10 Biocon Limited Procede de synthese de derives thiazolidinedione
GB0129871D0 (en) * 2001-12-13 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
GB0130509D0 (en) * 2001-12-20 2002-02-06 Smithkline Beecham Plc Novel pharmaceutical
KR100450700B1 (ko) * 2002-03-22 2004-10-01 주식회사종근당 티아졸리딘디온 유도체 화합물 및 이를 함유하는 약제학적조성물
KR20050068860A (ko) 2003-12-30 2005-07-05 엘지.필립스 엘시디 주식회사 듀얼 플레이트 유기전계 발광소자용 상부기판 및 그의제조방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE186724T1 (de) * 1987-09-04 1999-12-15 Beecham Group Plc Substituierte thiazolidindionderivate
GB8919417D0 (en) * 1989-08-25 1989-10-11 Beecham Group Plc Novel compounds
GB9218830D0 (en) * 1992-09-05 1992-10-21 Smithkline Beecham Plc Novel compounds
SG47100A1 (en) * 1994-02-10 1998-03-20 Smithkline Beecham Plc Use of insulin sensitisers for treating renal diseases

Also Published As

Publication number Publication date
KR20020022812A (ko) 2002-03-27
BR0013375A (pt) 2002-07-23
WO2001012628A1 (fr) 2001-02-22
AU7408900A (en) 2001-03-13
IL148164A0 (en) 2002-09-12
NO20020777D0 (no) 2002-02-15
MXPA02001716A (es) 2002-08-06
JP2003507379A (ja) 2003-02-25
EP1202991A1 (fr) 2002-05-08
TR200200438T2 (tr) 2002-05-21
CN1379776A (zh) 2002-11-13
HUP0202438A2 (hu) 2002-12-28
CZ2002531A3 (cs) 2002-07-17
PL353886A1 (en) 2003-12-01
NO20020777L (no) 2002-02-15

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Legal Events

Date Code Title Description
FZDE Discontinued