WO1994013650A1 - Derives heterocycliques et leur utilisation comme produits pharmaceutiques - Google Patents

Derives heterocycliques et leur utilisation comme produits pharmaceutiques Download PDF

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Publication number
WO1994013650A1
WO1994013650A1 PCT/EP1993/003269 EP9303269W WO9413650A1 WO 1994013650 A1 WO1994013650 A1 WO 1994013650A1 EP 9303269 W EP9303269 W EP 9303269W WO 9413650 A1 WO9413650 A1 WO 9413650A1
Authority
WO
WIPO (PCT)
Prior art keywords
formula
pharmaceutically acceptable
compound
group
alkyl
Prior art date
Application number
PCT/EP1993/003269
Other languages
English (en)
Inventor
David Haigh
Harshad Kantilal Rami
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Priority to JP6513713A priority Critical patent/JPH08504199A/ja
Publication of WO1994013650A1 publication Critical patent/WO1994013650A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un composé de la formule (I) ou une forme tautomère et/ou ses sels acceptables sur le plan pharmaceutique, et/ou un solvate pharmaceutiquement acceptable dudit composé. Dans cette formule, A1 représente un groupe aromatique hétérocyclique substitué ou non substitué; A2 représente un noyau benzène ayant trois substituants facultatifs; R1 et R2 représentent d'une manière indépendante hydrogène, ou R1 et R2 forment ensemble une liaison; R3 et R4 représentent chacun d'une manière indépendante un groupe nitrile ou un groupe de la formule -COR5, dans laquelle R5 représente un hydroxy, un alcoxy, un alkyle, un aryle ou un groupe de la formule -NR6R7 dans laquelle R6 et R7 représentent d'une manière indépendante l'hydrogène ou un alkyle, ou R6 et R7 forment ensemble un noyau hétérocyclique avec l'atome d'azote auquel ils sont liés; X représente NR, R représentant un atome d'hydrogène, un groupe alkyle, un groupe acyle, un groupe aralkyle avec une fraction aryle substituée ou non, ou encore un groupe aryle substitué ou non; et n est un nombre entier de 2 à 6. L'invention concerne également un procédé de préparation d'un tel composé, une composition pharmaceutique contenant un tel composé et l'utilisation d'un tel composé et d'une telle composition en médecine.
PCT/EP1993/003269 1992-12-04 1993-11-22 Derives heterocycliques et leur utilisation comme produits pharmaceutiques WO1994013650A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP6513713A JPH08504199A (ja) 1992-12-04 1993-11-22 複素環誘導体および医薬におけるそれらの使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9225386.3 1992-12-04
GB929225386A GB9225386D0 (en) 1992-12-04 1992-12-04 Novel compounds

Publications (1)

Publication Number Publication Date
WO1994013650A1 true WO1994013650A1 (fr) 1994-06-23

Family

ID=10726132

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1993/003269 WO1994013650A1 (fr) 1992-12-04 1993-11-22 Derives heterocycliques et leur utilisation comme produits pharmaceutiques

Country Status (3)

Country Link
JP (1) JPH08504199A (fr)
GB (1) GB9225386D0 (fr)
WO (1) WO1994013650A1 (fr)

Cited By (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999016758A1 (fr) * 1997-10-27 1999-04-08 Dr. Reddy's Research Foundation Nouvelles compositions heterocycliques et leur utilisation en medecine; procedes de leur fabrication et compositions pharmaceutiques les contenant
WO1999019313A1 (fr) * 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Nouveaux composes tricycliques et leur utilisation en medecine, procede de preparation de ces derniers et compositions pharmaceutiques les contenant
EP0930299A1 (fr) * 1996-08-19 1999-07-21 Japan Tobacco Inc. Derives d'acide propionique et applications de ces derives
US6054453A (en) * 1997-10-27 2000-04-25 Redd's Research Foundation Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
WO2000066572A1 (fr) * 1999-04-28 2000-11-09 Dr. Reddy's Research Foundation Heterocycles bicycliques substitues, procede pour leur preparation et leur utilisation comme agents contre l'obesite et comme agents hypocholesterolemiques
US6194446B1 (en) 1996-07-01 2001-02-27 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds
US6265401B1 (en) 1997-10-27 2001-07-24 Reddy-Cheminor, Inc. Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
US6294580B1 (en) 1996-02-28 2001-09-25 Glaxo Wellcome Inc. Substituted 4-hydroxy-phenylalcanoic acid derivatives with agonist activity to PPAR-gamma
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
US6417212B1 (en) 1999-08-27 2002-07-09 Eli Lilly & Company Modulators of peroxisome proliferator activated receptors
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
US6444816B1 (en) 1997-10-27 2002-09-03 Dr. Reddy's Research Foundation Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
WO2002100812A1 (fr) * 2001-04-20 2002-12-19 Eisai Co., Ltd. Dérivé de l'acide carboxylique et son sel
US6509374B2 (en) 2000-04-17 2003-01-21 Novo Nordisk A/S Compounds, their preparation and use
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
WO2003053974A1 (fr) * 2001-12-21 2003-07-03 Dr. Reddy's Laboratories Ltd. Nouveaux composes et leur utilisation en medecine, procede de preparation de ceux-ci et compositions pharmaceutiques les contenant
US6642389B2 (en) 2001-05-15 2003-11-04 Hoffmann-La Roche Inc. Oxazole derivatives
US6747049B2 (en) 2002-07-03 2004-06-08 Hoffmann-La Roche Inc. Oxazole derivatives
US6809095B2 (en) 1997-10-27 2004-10-26 Dr. Reddy's Laboratories Ltd. Bicyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
US6809110B2 (en) 2002-08-30 2004-10-26 Hoffmann-La Roche Inc. Thiazole derivatives
US6869967B2 (en) 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
US6890947B2 (en) 2002-09-12 2005-05-10 Hoffmann-La Roche Inc. Indolyl derivatives
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
US7041837B2 (en) 2001-07-26 2006-05-09 Cadilla Healthcare Limited Heterocyclic compounds having hypolipidemic, hypocholesteremic activities process for their preparation and pharmaceutical compositions containing them and their use in medicine
US7067530B2 (en) 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
US7098228B2 (en) 2002-11-25 2006-08-29 Hoffmann-La Roche Inc. Indolyl derivatives
US7192970B2 (en) * 2002-11-26 2007-03-20 Chipscreen Biosciences, Ltd. Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
BG65370B1 (bg) * 2000-01-19 2008-04-30 Cadila Healthcare Ltd. Съединения с хиполипидемично и хипохолестеремичнодействие, метод за производството им и фармацевтични композиции, които ги съдържат
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
WO2012104869A1 (fr) 2011-01-31 2012-08-09 Cadila Healthcare Limited Traitement de la lipodystrophie
WO2015001573A1 (fr) 2013-07-05 2015-01-08 Cadila Healthcare Limited Compositions synergiques
US9814697B2 (en) 2013-04-22 2017-11-14 Cadila Healthcare Limited Composition for nonalcoholic fatty liver disease (NAFLD)
US10098868B2 (en) 2013-07-25 2018-10-16 Cadila Healthcare Limited Formula comprising a hypolipidemic agent
US10112898B2 (en) 2013-09-06 2018-10-30 Cadila Healthcare Limited Process for the preparation of saroglitazar pharmaceutical salts
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
US10435363B2 (en) 2013-05-30 2019-10-08 Cadila Healthcare Limited Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
US11433050B2 (en) 2016-12-09 2022-09-06 Cadila Healthcare Ltd. Treatment for primary biliary cholangitis

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019702A1 (fr) * 1990-06-14 1991-12-26 Pfizer Inc. Derives d'acide 3-aryl-2-hydroxypropionique et leurs analogues utilises comme agents hypoglycemiques
WO1992002520A1 (fr) * 1990-08-06 1992-02-20 Beecham Group P.L.C. Derives d'oxazolidine dione

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991019702A1 (fr) * 1990-06-14 1991-12-26 Pfizer Inc. Derives d'acide 3-aryl-2-hydroxypropionique et leurs analogues utilises comme agents hypoglycemiques
WO1992002520A1 (fr) * 1990-08-06 1992-02-20 Beecham Group P.L.C. Derives d'oxazolidine dione

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
TAKASHI SOHDA ET AL: "Studies on antidiabetic agents.II. Synthesis of 5-[4-(1-methylcyclohexylmethoxy)-benzyl]thiazolidine-2,4-dione(ADD-3878) and its derivatives", CHEMICAL AND PHARMACEUTICAL BULLETIN., vol. 30, no. 10, October 1982 (1982-10-01), TOKYO JP, pages 3580 - 3600 *

Cited By (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6294580B1 (en) 1996-02-28 2001-09-25 Glaxo Wellcome Inc. Substituted 4-hydroxy-phenylalcanoic acid derivatives with agonist activity to PPAR-gamma
US6194446B1 (en) 1996-07-01 2001-02-27 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds
US6541497B1 (en) 1996-07-01 2003-04-01 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds
US6353027B1 (en) 1996-07-01 2002-03-05 Eli Lilly And Company Hypoglycemic and hypolipidemic compounds
EP0930299A1 (fr) * 1996-08-19 1999-07-21 Japan Tobacco Inc. Derives d'acide propionique et applications de ces derives
EP0930299A4 (fr) * 1996-08-19 1999-07-21
US6204277B1 (en) 1996-08-19 2001-03-20 Japan Tobacco Inc. Propionic acid derivatives and applications thereof
US6440961B1 (en) 1997-10-27 2002-08-27 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
WO1999019313A1 (fr) * 1997-10-27 1999-04-22 Dr. Reddy's Research Foundation Nouveaux composes tricycliques et leur utilisation en medecine, procede de preparation de ces derniers et compositions pharmaceutiques les contenant
US6265401B1 (en) 1997-10-27 2001-07-24 Reddy-Cheminor, Inc. Bicyclic compounds and their use in medicine, process for their preparation and pharmaceutical compositions containing them
US6130214A (en) * 1997-10-27 2000-10-10 Dr. Reddy's Research Foundation Benzothiazin and benzoxazin derivatives; their preparation and uses
US6331627B1 (en) 1997-10-27 2001-12-18 Reddy's Laboratories Ltd. Intermediates of benzoxazinone derivatives and preparation thereof
GB2364304A (en) * 1997-10-27 2002-01-23 Reddy Research Foundation Novel tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
US6054453A (en) * 1997-10-27 2000-04-25 Redd's Research Foundation Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
US6369067B1 (en) 1997-10-27 2002-04-09 Dr. Reddy's Research Foundation Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
WO1999016758A1 (fr) * 1997-10-27 1999-04-08 Dr. Reddy's Research Foundation Nouvelles compositions heterocycliques et leur utilisation en medecine; procedes de leur fabrication et compositions pharmaceutiques les contenant
US6846824B2 (en) 1997-10-27 2005-01-25 Dr. Reddy's Laboratories Ltd. Bicyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
US6444816B1 (en) 1997-10-27 2002-09-03 Dr. Reddy's Research Foundation Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
US6809095B2 (en) 1997-10-27 2004-10-26 Dr. Reddy's Laboratories Ltd. Bicyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
US6939988B1 (en) 1997-10-27 2005-09-06 Dr. Reddy's Laboratories Limited Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
US6664411B2 (en) 1997-10-27 2003-12-16 Dr. Reddy's Laboratories Limited Heterocyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
US6548666B1 (en) 1997-10-27 2003-04-15 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
GB2364304B (en) * 1997-10-27 2003-04-23 Reddy Research Foundation Novel tricyclic compounds and their use in medicine process for their preparation and pharmaceutical compositions containing them
US7119198B2 (en) 1997-10-27 2006-10-10 Dr. Reddy's Research Foundation Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
US7053217B2 (en) 1997-10-27 2006-05-30 Dr. Reddy's Laboratories Limited Monocyclic compounds and their use in medicine: process for their preparation and pharmaceutical compositions containing them
US6608194B1 (en) 1997-10-27 2003-08-19 Dr. Reddy's Laboratories Limited Tricyclic compounds and their use in medicine; process for their preparation and pharmaceutical compositions containing them
US6972294B1 (en) 1999-04-20 2005-12-06 Novo Nordisk, A/S Compounds, their preparation and use
WO2000066572A1 (fr) * 1999-04-28 2000-11-09 Dr. Reddy's Research Foundation Heterocycles bicycliques substitues, procede pour leur preparation et leur utilisation comme agents contre l'obesite et comme agents hypocholesterolemiques
US7348426B1 (en) 1999-04-28 2008-03-25 Dr. Reddy's Laboraties Limited Substituted bicyclic heterocycles, process for their preparation and their use as antiobesity and hypocholesterolemic agents
US6610696B2 (en) 1999-08-27 2003-08-26 Eli Lilly And Company Modulators of peroxisome proliferator activated receptors
US6417212B1 (en) 1999-08-27 2002-07-09 Eli Lilly & Company Modulators of peroxisome proliferator activated receptors
US6825222B2 (en) 1999-08-27 2004-11-30 Eli Lilly And Company Modulators of peroxisome proliferator activated receptors
BG65370B1 (bg) * 2000-01-19 2008-04-30 Cadila Healthcare Ltd. Съединения с хиполипидемично и хипохолестеремичнодействие, метод за производството им и фармацевтични композиции, които ги съдържат
US6867218B2 (en) 2000-01-28 2005-03-15 Novo Nordisk A/S Compounds, their preparation and use
US6555577B1 (en) 2000-01-28 2003-04-29 Novo Nordisk A/S Compounds, their preparation and use
US6509374B2 (en) 2000-04-17 2003-01-21 Novo Nordisk A/S Compounds, their preparation and use
US7544835B2 (en) 2001-04-20 2009-06-09 Eisai R&D Management Co., Ltd. Carboxylic acid derivative and salt thereof
WO2002100812A1 (fr) * 2001-04-20 2002-12-19 Eisai Co., Ltd. Dérivé de l'acide carboxylique et son sel
US6642389B2 (en) 2001-05-15 2003-11-04 Hoffmann-La Roche Inc. Oxazole derivatives
US8110598B2 (en) 2001-07-26 2012-02-07 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
US8558009B2 (en) 2001-07-26 2013-10-15 Cadila Healthcare Limited Pyrroles having hypolipidemic hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them and their use in medicine
US7041837B2 (en) 2001-07-26 2006-05-09 Cadilla Healthcare Limited Heterocyclic compounds having hypolipidemic, hypocholesteremic activities process for their preparation and pharmaceutical compositions containing them and their use in medicine
US7323491B2 (en) 2001-07-26 2008-01-29 Cadila Healthcare Limited Heterocyclic compounds, their preparation, pharmaceutical compositions containing them and their use in medicine
US7067530B2 (en) 2001-07-30 2006-06-27 Novo Nordisk A/S Compounds, their preparation and use
US6869967B2 (en) 2001-07-30 2005-03-22 Novo Nordisk A/S Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives
US7371777B2 (en) 2001-08-17 2008-05-13 Eisai Co., Ltd. Cyclic compound and PPAR agonist
US7220877B2 (en) 2001-10-17 2007-05-22 Novo Nordisk A/S Compounds, their preparation and use
WO2003053974A1 (fr) * 2001-12-21 2003-07-03 Dr. Reddy's Laboratories Ltd. Nouveaux composes et leur utilisation en medecine, procede de preparation de ceux-ci et compositions pharmaceutiques les contenant
US6747049B2 (en) 2002-07-03 2004-06-08 Hoffmann-La Roche Inc. Oxazole derivatives
US6809110B2 (en) 2002-08-30 2004-10-26 Hoffmann-La Roche Inc. Thiazole derivatives
US6890947B2 (en) 2002-09-12 2005-05-10 Hoffmann-La Roche Inc. Indolyl derivatives
US7098228B2 (en) 2002-11-25 2006-08-29 Hoffmann-La Roche Inc. Indolyl derivatives
US7192970B2 (en) * 2002-11-26 2007-03-20 Chipscreen Biosciences, Ltd. Noncyclic 1,3-dicarbonyl compounds as dual PPAR agonists with potent antihyperglycemic and antihyperlipidemic activity
US7816385B2 (en) 2002-12-20 2010-10-19 High Point Pharmaceuticals, Llc Dimeric dicarboxylic acid derivatives, their preparation and use
US9783495B2 (en) 2011-01-31 2017-10-10 Cadila Healthcare Limited Treatment for lipodystrophy
EP3009136A1 (fr) 2011-01-31 2016-04-20 Cadila Healthcare Limited Traitement de la lipodystrophie
US10017470B2 (en) 2011-01-31 2018-07-10 Cadila Healthcare Limited Treatment for lipodystrophy
WO2012104869A1 (fr) 2011-01-31 2012-08-09 Cadila Healthcare Limited Traitement de la lipodystrophie
US9814697B2 (en) 2013-04-22 2017-11-14 Cadila Healthcare Limited Composition for nonalcoholic fatty liver disease (NAFLD)
US10435363B2 (en) 2013-05-30 2019-10-08 Cadila Healthcare Limited Process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
US9957230B2 (en) 2013-07-05 2018-05-01 Cadila Healthcare Limited Synergistic compositions
WO2015001573A1 (fr) 2013-07-05 2015-01-08 Cadila Healthcare Limited Compositions synergiques
US9656954B2 (en) 2013-07-05 2017-05-23 Cadila Healthcare Limited Synergistic compositions
US10315993B2 (en) 2013-07-05 2019-06-11 Cadila Healthcare Limited Synergistic compositions
EP3120845A1 (fr) 2013-07-05 2017-01-25 Cadila Healthcare Limited Compositions synergiques
US10098868B2 (en) 2013-07-25 2018-10-16 Cadila Healthcare Limited Formula comprising a hypolipidemic agent
US10112898B2 (en) 2013-09-06 2018-10-30 Cadila Healthcare Limited Process for the preparation of saroglitazar pharmaceutical salts
US10385017B2 (en) 2015-10-14 2019-08-20 Cadila Healthcare Limited Pyrrole compound, compositions and process for preparation thereof
US11433050B2 (en) 2016-12-09 2022-09-06 Cadila Healthcare Ltd. Treatment for primary biliary cholangitis
US11872209B2 (en) 2016-12-09 2024-01-16 Zydus Lifesciences Limited Treatment for primary biliary cholangitis

Also Published As

Publication number Publication date
GB9225386D0 (en) 1993-01-27
JPH08504199A (ja) 1996-05-07

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