CA2381539A1 - Molecules de detection du glucose presentant des proprietes fluorescentes choisies - Google Patents

Molecules de detection du glucose presentant des proprietes fluorescentes choisies Download PDF

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Publication number
CA2381539A1
CA2381539A1 CA002381539A CA2381539A CA2381539A1 CA 2381539 A1 CA2381539 A1 CA 2381539A1 CA 002381539 A CA002381539 A CA 002381539A CA 2381539 A CA2381539 A CA 2381539A CA 2381539 A1 CA2381539 A1 CA 2381539A1
Authority
CA
Canada
Prior art keywords
recited
group
glucose
fluorescent compound
sensor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002381539A
Other languages
English (en)
Inventor
Christopher B. Darrow
Joe Anh Tran
Douglas R. Cary
Joe H. Satcher, Jr.
Stephen M. Lane
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Medtronic Minimed Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2381539A1 publication Critical patent/CA2381539A1/fr
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Diabetes (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Pyrane Compounds (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne une molécule fluorescente de détection d'une substance à analyser, utilisant le transfert d'électrons intramoléculaire. Cette molécule est conçue pour présenter des propriétés fluorescentes choisies en présence de substances à analyser telles que les saccharides. Ces propriétés fluorescentes choisies comprennent la longueur d'onde d'excitation, la longueur d'onde d'émission, la durée de vie de la fluorescence, le rendement quantique, la photostabilité, la solubilité, et la sensibilité à la température ou au pH. Le composé comprend un aryle ou un acide boronique substitué en phényl qui agit comme un composant reconnaissant le substrat; un composant d'activation de la fluorescence et un fluorophore. Le fluorophore et le composant d'activation sont choisis de sorte que la valeur de l'énergie libre destinée au transfert d'électrons soit inférieure à environ 3,0 kcal mol?-1¿. L'invention concerne également des composés fluorescents excités à des longueurs d'onde supérieures à 400 nm et émettant à des longueurs d'onde supérieures à 450 nm, ce qui est avantageux pour les transmissions optiques percutanées. Le fluorophore est généralement choisi parmi des complexes de transition métal-ligand et des composés de thiazine, oxazine, oxazone, ou oxazine-un ainsi que des composés d'anthracène. Le composé fluorescent peut être immobilisé dans une matrice polymère biocompatible perméable au glucose pouvant être implantée sous la peau.
CA002381539A 1999-09-15 2000-09-15 Molecules de detection du glucose presentant des proprietes fluorescentes choisies Abandoned CA2381539A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15410399P 1999-09-15 1999-09-15
US60/154,103 1999-09-15
PCT/US2000/025295 WO2001020334A1 (fr) 1999-09-15 2000-09-15 Molecules de detection du glucose presentant des proprietes fluorescentes choisies

Publications (1)

Publication Number Publication Date
CA2381539A1 true CA2381539A1 (fr) 2001-03-22

Family

ID=22550013

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002381539A Abandoned CA2381539A1 (fr) 1999-09-15 2000-09-15 Molecules de detection du glucose presentant des proprietes fluorescentes choisies

Country Status (5)

Country Link
EP (1) EP1214596A1 (fr)
JP (1) JP2003509442A (fr)
AU (1) AU7582200A (fr)
CA (1) CA2381539A1 (fr)
WO (1) WO2001020334A1 (fr)

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Also Published As

Publication number Publication date
AU7582200A (en) 2001-04-17
JP2003509442A (ja) 2003-03-11
EP1214596A1 (fr) 2002-06-19
WO2001020334A1 (fr) 2001-03-22

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FZDE Discontinued