CA2380760A1 - New interferon beta-like molecules - Google Patents

New interferon beta-like molecules Download PDF

Info

Publication number
CA2380760A1
CA2380760A1 CA002380760A CA2380760A CA2380760A1 CA 2380760 A1 CA2380760 A1 CA 2380760A1 CA 002380760 A CA002380760 A CA 002380760A CA 2380760 A CA2380760 A CA 2380760A CA 2380760 A1 CA2380760 A1 CA 2380760A1
Authority
CA
Canada
Prior art keywords
polypeptide
interferon
amino acid
beta
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002380760A
Other languages
English (en)
French (fr)
Inventor
Anders Hjelholt Pedersen
Hans Thalsgaard Schambye
Kim Vilbour Andersen
Claus Bornaes
Poul Baad Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxygen ApS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2380760A1 publication Critical patent/CA2380760A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
CA002380760A 1999-08-27 2000-08-25 New interferon beta-like molecules Abandoned CA2380760A1 (en)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
DKPA199901197 1999-08-27
DKPA199901197 1999-08-27
US16078299P 1999-10-21 1999-10-21
US60/160,782 1999-10-21
DKPA199901691 1999-11-26
DKPA199901691 1999-11-26
DKPA200000194 2000-02-07
DKPA200000194 2000-02-07
DKPA200000363 2000-03-07
DKPA200000363 2000-03-07
DKPA200000642 2000-04-14
DKPA200000642 2000-04-14
PCT/DK2000/000471 WO2001015736A2 (en) 1999-08-27 2000-08-25 Interferon-beta conjugates

Publications (1)

Publication Number Publication Date
CA2380760A1 true CA2380760A1 (en) 2001-03-08

Family

ID=27545189

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002380760A Abandoned CA2380760A1 (en) 1999-08-27 2000-08-25 New interferon beta-like molecules

Country Status (14)

Country Link
EP (1) EP1328295A2 (zh)
JP (1) JP2003527090A (zh)
KR (1) KR20020034181A (zh)
CN (1) CN1501815A (zh)
AU (1) AU6687000A (zh)
BR (1) BR0013638A (zh)
CA (1) CA2380760A1 (zh)
CZ (1) CZ2002521A3 (zh)
HU (1) HUP0302674A2 (zh)
IL (1) IL147581A0 (zh)
MX (1) MXPA02001969A (zh)
NO (1) NO20020929L (zh)
SK (1) SK2942002A3 (zh)
WO (1) WO2001015736A2 (zh)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1329082C (zh) 1998-10-16 2007-08-01 拜奥根Idec马萨诸塞公司 干扰素－β－1a的聚合物缀合物及其使用
TR200101087T2 (tr) 1998-10-16 2001-09-21 Biogen, Inc. İnterferon beta-füzyon proteinleri ve kullanımları
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
AU2002212107A1 (en) * 2000-11-02 2002-05-15 Maxygen Aps New multimeric interferon beta polypeptides
YU48703A (sh) * 2001-02-27 2006-05-25 Maxygen Aps Novi interferonu beta-slični molekuli
AU2002254174A1 (en) * 2001-03-13 2002-09-24 Vical Incorporated Interferon-beta polynucleotide therapy for autoimmune and inflammatory diseases
KR100511749B1 (ko) * 2001-11-06 2005-09-02 선바이오(주) 변형된 인터페론-베타, 및 이의 화학적으로 변형된 배합체
KR100964411B1 (ko) 2002-01-18 2010-06-15 바이오겐 아이덱 엠에이 인코포레이티드 생물학적 활성 화합물과 컨쥬게이팅되는 잔기를 갖는 폴리알킬렌 글리콜
WO2004020468A2 (en) * 2002-08-28 2004-03-11 Maxygen Aps Interferon beta-like molecules for treatment of cancer
US9125880B2 (en) * 2002-12-26 2015-09-08 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency
PL1666496T3 (pl) * 2003-08-25 2014-08-29 Toray Industries Kompozyt interferonu beta
EP1674113A1 (en) * 2004-12-22 2006-06-28 F. Hoffmann-La Roche Ag Conjugates of insulin-like growth factor-1 (IGF-1) and poly(ethylene glycol)
KR20090047452A (ko) * 2006-08-08 2009-05-12 노바티스 백신즈 앤드 다이아그노스틱스, 인크. 생물학적 활성이 증강된 재조합 인터페론-베타
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
CL2008002399A1 (es) * 2007-08-16 2009-01-02 Pharmaessentia Corp Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
CN104043112B (zh) * 2014-07-01 2016-03-30 哈药集团生物工程有限公司 一种含有重组人干扰素α-2b(假单胞菌)的软膏药物组合物
EP4282485A3 (en) 2014-11-06 2024-01-17 PharmaEssentia Corporation Dosage regimen for pegylated interferon
EP3454887B1 (en) * 2016-05-13 2021-01-20 Orionis Biosciences BV Targeted mutant interferon-beta and uses thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
WO1987000056A1 (en) * 1985-06-26 1987-01-15 Cetus Corporation Solubilization of proteins for pharmaceutical compositions using polymer conjugation
US4917888A (en) * 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
IL113280A (en) * 1994-04-12 2004-12-15 Res Dev Foundation A preparation for the treatment of self-immunization diseases with the help of interferon of one type
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
JP2001511162A (ja) * 1997-02-06 2001-08-07 ノボ ノルディスク アクティーゼルスカブ 付加され、そして／又は除去された付着基を有するポリペプチド−ポリマー結合体
DE69838552T2 (de) * 1997-07-14 2008-05-21 Bolder Biotechnology, Inc., Louisville Derivate des wachstumshormons und verwandte proteine
CN1329082C (zh) * 1998-10-16 2007-08-01 拜奥根Idec马萨诸塞公司 干扰素－β－1a的聚合物缀合物及其使用

Also Published As

Publication number Publication date
WO2001015736A3 (en) 2003-05-22
EP1328295A2 (en) 2003-07-23
JP2003527090A (ja) 2003-09-16
KR20020034181A (ko) 2002-05-08
AU6687000A (en) 2001-03-26
NO20020929L (no) 2002-04-25
WO2001015736A2 (en) 2001-03-08
NO20020929D0 (no) 2002-02-26
IL147581A0 (en) 2002-08-14
HUP0302674A2 (hu) 2003-11-28
MXPA02001969A (es) 2003-07-21
CZ2002521A3 (cs) 2002-05-15
CN1501815A (zh) 2004-06-02
BR0013638A (pt) 2002-05-14
SK2942002A3 (en) 2002-08-06

Similar Documents

Publication Publication Date Title
US6531122B1 (en) Interferon-β variants and conjugates
EP1366075B1 (en) New interferon beta-like molecules
US7144574B2 (en) Interferon β variants and conjugates
US7504237B2 (en) Polynucleotides encoding interferon gamma polypeptides
US20090030183A1 (en) Interferon Beta-Like Molecules
CA2380760A1 (en) New interferon beta-like molecules
US7390638B2 (en) S99T C-11 Truncated polynucleotides encoding interferon gamma polypeptide variants
US7230081B1 (en) Interferon gamma conjugates
US20020169290A1 (en) New multimeric interferon beta polypeptides
US7524931B2 (en) Full-length interferon gamma polypeptide variants
WO2002036628A2 (en) New multimeric interferon beta polypeptides
ZA200200337B (en) New interferon beta-like molecules.
AU2002235727A1 (en) New interferon beta-like molecules
ZA200303964B (en) New interferon beta-like molecules.
AU782635B2 (en) Interferon gamma conjugates

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued