CA2380760A1 - Nouvelles molecules analogues a l'interferon beta - Google Patents

Nouvelles molecules analogues a l'interferon beta Download PDF

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Publication number
CA2380760A1
CA2380760A1 CA002380760A CA2380760A CA2380760A1 CA 2380760 A1 CA2380760 A1 CA 2380760A1 CA 002380760 A CA002380760 A CA 002380760A CA 2380760 A CA2380760 A CA 2380760A CA 2380760 A1 CA2380760 A1 CA 2380760A1
Authority
CA
Canada
Prior art keywords
polypeptide
interferon
amino acid
beta
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002380760A
Other languages
English (en)
Inventor
Anders Hjelholt Pedersen
Hans Thalsgaard Schambye
Kim Vilbour Andersen
Claus Bornaes
Poul Baad Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Maxygen ApS
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2380760A1 publication Critical patent/CA2380760A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/555—Interferons [IFN]
    • C07K14/565—IFN-beta
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A61K38/215—IFN-beta
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Biomedical Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un conjugué qui présente une activité d'interféron .beta. et contient au moins une première fraction non polypeptidique liée de manière covalente à un polypeptide d'interféron .beta., dont la séquence d'acides aminés diffère de celle de l'interféron .beta. humain de type sauvage par au moins un résidu d'acide aminé introduit et au moins un résidu d'acide aminé enlevé, y compris un groupe se fixant à ladite première fraction non polypeptidique. La première fraction non polypeptidique est par exemple une molécule polymère ou une fraction sucre. Le conjugué est particulièrement utile en thérapie.
CA002380760A 1999-08-27 2000-08-25 Nouvelles molecules analogues a l'interferon beta Abandoned CA2380760A1 (fr)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
DKPA199901197 1999-08-27
DKPA199901197 1999-08-27
US16078299P 1999-10-21 1999-10-21
US60/160,782 1999-10-21
DKPA199901691 1999-11-26
DKPA199901691 1999-11-26
DKPA200000194 2000-02-07
DKPA200000194 2000-02-07
DKPA200000363 2000-03-07
DKPA200000363 2000-03-07
DKPA200000642 2000-04-14
DKPA200000642 2000-04-14
PCT/DK2000/000471 WO2001015736A2 (fr) 1999-08-27 2000-08-25 Nouvelles molecules analogues a l'interferon beta

Publications (1)

Publication Number Publication Date
CA2380760A1 true CA2380760A1 (fr) 2001-03-08

Family

ID=27545189

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002380760A Abandoned CA2380760A1 (fr) 1999-08-27 2000-08-25 Nouvelles molecules analogues a l'interferon beta

Country Status (14)

Country Link
EP (1) EP1328295A2 (fr)
JP (1) JP2003527090A (fr)
KR (1) KR20020034181A (fr)
CN (1) CN1501815A (fr)
AU (1) AU6687000A (fr)
BR (1) BR0013638A (fr)
CA (1) CA2380760A1 (fr)
CZ (1) CZ2002521A3 (fr)
HU (1) HUP0302674A2 (fr)
IL (1) IL147581A0 (fr)
MX (1) MXPA02001969A (fr)
NO (1) NO20020929L (fr)
SK (1) SK2942002A3 (fr)
WO (1) WO2001015736A2 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9915548A (pt) 1998-10-16 2001-08-14 Biogen Inc Proteìnas de fusão de interferon-beta e usos
DK1121156T3 (da) * 1998-10-16 2006-06-06 Biogen Idec Inc Polymerkonjugater af interferon-beta-1a samt deres anvendelse
US7144574B2 (en) 1999-08-27 2006-12-05 Maxygen Aps Interferon β variants and conjugates
US7431921B2 (en) 2000-04-14 2008-10-07 Maxygen Aps Interferon beta-like molecules
AU2002212107A1 (en) * 2000-11-02 2002-05-15 Maxygen Aps New multimeric interferon beta polypeptides
IL156059A0 (en) * 2001-02-27 2003-12-23 Maxygen Aps NEW INTERFERON beta-LIKE MOLECULES
AU2002254174A1 (en) * 2001-03-13 2002-09-24 Vical Incorporated Interferon-beta polynucleotide therapy for autoimmune and inflammatory diseases
KR100511749B1 (ko) * 2001-11-06 2005-09-02 선바이오(주) 변형된 인터페론-베타, 및 이의 화학적으로 변형된 배합체
EP3669887A1 (fr) 2002-01-18 2020-06-24 Biogen MA Inc. Composés polymères de polyalkylène et leurs utilisations
WO2004020468A2 (fr) * 2002-08-28 2004-03-11 Maxygen Aps Molecules d'interferon de type $g(b) pour le traitement du cancer
AU2003303635B2 (en) 2002-12-26 2009-07-23 Mountain View Pharmaceuticals, Inc. Polymer conjugates of interferon-beta with enhanced biological potency
CN101880326B (zh) * 2003-08-25 2018-02-16 东丽株式会社 干扰素‑β复合物
EP1674113A1 (fr) * 2004-12-22 2006-06-28 F. Hoffmann-La Roche Ag Conjugués de l'IGF-1 et du poly(éthylène glycol)
WO2008020968A2 (fr) * 2006-08-08 2008-02-21 Novartis Ag Interféron bêta recombinant présentant une activité biologique améliorée
US7625555B2 (en) 2007-06-18 2009-12-01 Novagen Holding Corporation Recombinant human interferon-like proteins
CL2008002399A1 (es) * 2007-08-16 2009-01-02 Pharmaessentia Corp Conjugado sustancialmente puro que posee una porcion polimerica, una porcion proteica (interferon alfa 2b) y un ligante alifatico de 1 a 10 atomos de carbono, util en el tratamiento de las hepatitis b o c.
CN104043112B (zh) * 2014-07-01 2016-03-30 哈药集团生物工程有限公司 一种含有重组人干扰素α-2b(假单胞菌)的软膏药物组合物
CA2964390A1 (fr) 2014-11-06 2016-05-12 Pharmaessentia Corporation Regime posologique pour l'interferon pegyle
WO2017194783A1 (fr) * 2016-05-13 2017-11-16 Orionis Biosciences Nv Interféron bêta mutant ciblé, et utilisations associées

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987000056A1 (fr) * 1985-06-26 1987-01-15 Cetus Corporation Solubilisation de proteines pour des compositions pharmaceutiques utilisant une conjugaison de polymeres
US4917888A (en) * 1985-06-26 1990-04-17 Cetus Corporation Solubilization of immunotoxins for pharmaceutical compositions using polymer conjugation
US5206344A (en) * 1985-06-26 1993-04-27 Cetus Oncology Corporation Interleukin-2 muteins and polymer conjugation thereof
US4904584A (en) * 1987-12-23 1990-02-27 Genetics Institute, Inc. Site-specific homogeneous modification of polypeptides
US5218092A (en) * 1988-09-29 1993-06-08 Kyowa Hakko Kogyo Co., Ltd. Modified granulocyte-colony stimulating factor polypeptide with added carbohydrate chains
IL113280A (en) * 1994-04-12 2004-12-15 Res Dev Foundation A preparation for the treatment of self-immunization diseases with the help of interferon of one type
US5738846A (en) * 1994-11-10 1998-04-14 Enzon, Inc. Interferon polymer conjugates and process for preparing the same
EP1017794A1 (fr) * 1997-02-06 2000-07-12 Novo Nordisk A/S Conjugats polypeptide-polymere a groupes de fixation ajoutes et/ou retires
CN1269805A (zh) * 1997-07-14 2000-10-11 博尔德生物技术公司 生长激素和相关蛋白的衍生物
DK1121156T3 (da) * 1998-10-16 2006-06-06 Biogen Idec Inc Polymerkonjugater af interferon-beta-1a samt deres anvendelse

Also Published As

Publication number Publication date
AU6687000A (en) 2001-03-26
SK2942002A3 (en) 2002-08-06
HUP0302674A2 (hu) 2003-11-28
BR0013638A (pt) 2002-05-14
NO20020929D0 (no) 2002-02-26
EP1328295A2 (fr) 2003-07-23
WO2001015736A2 (fr) 2001-03-08
KR20020034181A (ko) 2002-05-08
NO20020929L (no) 2002-04-25
WO2001015736A3 (fr) 2003-05-22
IL147581A0 (en) 2002-08-14
MXPA02001969A (es) 2003-07-21
JP2003527090A (ja) 2003-09-16
CN1501815A (zh) 2004-06-02
CZ2002521A3 (cs) 2002-05-15

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued