CA2380653A1 - Mofetilmycophenolate associe a peg-ifn-alpha - Google Patents
Mofetilmycophenolate associe a peg-ifn-alpha Download PDFInfo
- Publication number
- CA2380653A1 CA2380653A1 CA002380653A CA2380653A CA2380653A1 CA 2380653 A1 CA2380653 A1 CA 2380653A1 CA 002380653 A CA002380653 A CA 002380653A CA 2380653 A CA2380653 A CA 2380653A CA 2380653 A1 CA2380653 A1 CA 2380653A1
- Authority
- CA
- Canada
- Prior art keywords
- ifn
- alpha
- peg
- effective amount
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 title description 10
- 229960004866 mycophenolate mofetil Drugs 0.000 title description 4
- HPNSFSBZBAHARI-RUDMXATFSA-N mycophenolic acid Chemical compound OC1=C(C\C=C(/C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-RUDMXATFSA-N 0.000 claims abstract description 42
- HPNSFSBZBAHARI-UHFFFAOYSA-N micophenolic acid Natural products OC1=C(CC=C(C)CCC(O)=O)C(OC)=C(C)C2=C1C(=O)OC2 HPNSFSBZBAHARI-UHFFFAOYSA-N 0.000 claims abstract description 40
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne l'utilisation d'une quantité thérapeutiquement efficace de IFN-? associée à une quantité thérapeutiquement efficace d'un sel pharmaceutiquement acceptable ou promédicament d'acide mycophénolique, en vue de fabriquer des médicaments permettant de traiter des patients atteints d'affections hépatiques. Les composants sont administrés pendant une période de temps au moins assez longue pour réduire la quantité de HCV-RNA présente dans le sang périphérique desdits patients à moins de 100 copies/ml au bout de 24 semaines après la fin du traitement.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP99115950.0 | 1999-08-13 | ||
| EP99115950 | 1999-08-13 | ||
| US18790700P | 2000-03-08 | 2000-03-08 | |
| US60/187,907 | 2000-03-08 | ||
| PCT/EP2000/007666 WO2001012214A2 (fr) | 1999-08-13 | 2000-08-08 | Mofetilmycophenolate associe a peg-ifn-alpha |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2380653A1 true CA2380653A1 (fr) | 2001-02-22 |
Family
ID=29762814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002380653A Abandoned CA2380653A1 (fr) | 1999-08-13 | 2000-08-08 | Mofetilmycophenolate associe a peg-ifn-alpha |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1220683A2 (fr) |
| JP (1) | JP2003507339A (fr) |
| CN (1) | CN1368887A (fr) |
| AU (1) | AU7408200A (fr) |
| BR (1) | BR0013252A (fr) |
| CA (1) | CA2380653A1 (fr) |
| HU (1) | HUP0202525A3 (fr) |
| MX (1) | MXPA02001296A (fr) |
| PE (1) | PE20010490A1 (fr) |
| PL (1) | PL357367A1 (fr) |
| RU (1) | RU2002105485A (fr) |
| TR (1) | TR200200401T2 (fr) |
| WO (1) | WO2001012214A2 (fr) |
| ZA (1) | ZA200200280B (fr) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0307553D0 (en) * | 2003-04-01 | 2003-05-07 | Novartis Ag | Organic compounds |
| US20070049593A1 (en) | 2004-02-24 | 2007-03-01 | Japan Tobacco Inc. | Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor |
| PT1719773E (pt) | 2004-02-24 | 2009-06-03 | Japan Tobacco Inc | Compostos heterotetracíclicos fundidos e a sua utilização como inibidores da polimerase do hcv |
| DE602005022895D1 (de) * | 2004-08-12 | 2010-09-23 | Schering Corp | Stabile pegylierte interferon-formulierung |
| US7659263B2 (en) | 2004-11-12 | 2010-02-09 | Japan Tobacco Inc. | Thienopyrrole compound and use thereof as HCV polymerase inhibitor |
| US8017612B2 (en) | 2006-04-18 | 2011-09-13 | Japan Tobacco Inc. | Piperazine compound and use thereof as a HCV polymerase inhibitor |
| WO2010110503A1 (fr) * | 2009-03-27 | 2010-09-30 | 주식회사 중외제약 | Protéine fusionnée d'interféron-α (ifn-α) comprenant l'ifn-α et un peptide de transduction cytoplasmique (ctp) |
| GB2515941A (en) | 2011-10-21 | 2015-01-07 | Abbvie Inc | Methods for treating HCV comprising at least two direct acting antiviral agent, ribavirin but not interferon |
| EA201490836A1 (ru) | 2011-10-21 | 2014-11-28 | Эббви Инк. | Комбинационное лечение (например, с abt-072 или abt-333) с помощью daa для применения при лечении hcv |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| PL3215193T3 (pl) * | 2014-11-06 | 2024-03-18 | Pharmaessentia Corporation | Reżim podawania pegylowanego interferonu |
| CN109689063A (zh) | 2016-04-28 | 2019-04-26 | 埃默里大学 | 含有炔烃的核苷酸和核苷治疗组合物及其相关用途 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5908621A (en) * | 1995-11-02 | 1999-06-01 | Schering Corporation | Polyethylene glycol modified interferon therapy |
| MY125300A (en) * | 1999-02-26 | 2006-07-31 | Inst Of Molecular And Cell Biology | Synergistic combination for treatment of viral-mediated diseases |
-
2000
- 2000-08-08 BR BR0013252-7A patent/BR0013252A/pt not_active IP Right Cessation
- 2000-08-08 CA CA002380653A patent/CA2380653A1/fr not_active Abandoned
- 2000-08-08 PE PE2000000804A patent/PE20010490A1/es not_active Application Discontinuation
- 2000-08-08 WO PCT/EP2000/007666 patent/WO2001012214A2/fr not_active Application Discontinuation
- 2000-08-08 HU HU0202525A patent/HUP0202525A3/hu unknown
- 2000-08-08 JP JP2001516559A patent/JP2003507339A/ja active Pending
- 2000-08-08 AU AU74082/00A patent/AU7408200A/en not_active Abandoned
- 2000-08-08 TR TR2002/00401T patent/TR200200401T2/xx unknown
- 2000-08-08 PL PL00357367A patent/PL357367A1/xx not_active Application Discontinuation
- 2000-08-08 MX MXPA02001296A patent/MXPA02001296A/es unknown
- 2000-08-08 EP EP00962297A patent/EP1220683A2/fr not_active Withdrawn
- 2000-08-08 CN CN00811397A patent/CN1368887A/zh active Pending
- 2000-08-08 RU RU2002105485/15A patent/RU2002105485A/ru not_active Application Discontinuation
-
2002
- 2002-01-11 ZA ZA200200280A patent/ZA200200280B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001012214A3 (fr) | 2001-10-04 |
| ZA200200280B (en) | 2003-04-11 |
| MXPA02001296A (es) | 2002-07-22 |
| HUP0202525A2 (hu) | 2002-11-28 |
| TR200200401T2 (tr) | 2002-06-21 |
| AU7408200A (en) | 2001-03-13 |
| WO2001012214A2 (fr) | 2001-02-22 |
| JP2003507339A (ja) | 2003-02-25 |
| HUP0202525A3 (en) | 2003-11-28 |
| RU2002105485A (ru) | 2004-01-27 |
| PL357367A1 (en) | 2004-07-26 |
| BR0013252A (pt) | 2002-04-16 |
| CN1368887A (zh) | 2002-09-11 |
| EP1220683A2 (fr) | 2002-07-10 |
| PE20010490A1 (es) | 2001-04-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |