CA2377931A1 - Novel mammalian calcium channels and related probes, cell lines and methods - Google Patents

Novel mammalian calcium channels and related probes, cell lines and methods Download PDF

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Publication number
CA2377931A1
CA2377931A1 CA002377931A CA2377931A CA2377931A1 CA 2377931 A1 CA2377931 A1 CA 2377931A1 CA 002377931 A CA002377931 A CA 002377931A CA 2377931 A CA2377931 A CA 2377931A CA 2377931 A1 CA2377931 A1 CA 2377931A1
Authority
CA
Canada
Prior art keywords
leu
ser
gly
val
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002377931A
Other languages
English (en)
French (fr)
Inventor
Terrance P. Snutch
David L. Baillie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taro Pharmaceuticals Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/346,794 external-priority patent/US7297504B1/en
Application filed by Individual filed Critical Individual
Publication of CA2377931A1 publication Critical patent/CA2377931A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurosurgery (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA002377931A 1999-07-02 2000-07-04 Novel mammalian calcium channels and related probes, cell lines and methods Abandoned CA2377931A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/346,794 1999-07-02
US09/346,794 US7297504B1 (en) 1997-02-28 1999-07-02 Methods for identifying agonists and antagonists of human T-type calcium channels
PCT/CA2000/000794 WO2001002561A2 (en) 1999-07-02 2000-07-04 Mammalian calcium channels and related probes, cell lines and methods

Publications (1)

Publication Number Publication Date
CA2377931A1 true CA2377931A1 (en) 2001-01-11

Family

ID=23361077

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002377931A Abandoned CA2377931A1 (en) 1999-07-02 2000-07-04 Novel mammalian calcium channels and related probes, cell lines and methods

Country Status (6)

Country Link
US (3) US7157243B1 (enExample)
EP (2) EP1190053A2 (enExample)
JP (1) JP2003504020A (enExample)
AU (1) AU5957100A (enExample)
CA (1) CA2377931A1 (enExample)
WO (1) WO2001002561A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020009772A1 (en) * 1997-02-28 2002-01-24 Terry P. Snutch Novel human calcium channels and related probes, cell lines and mehtods
US6358706B1 (en) * 1999-10-26 2002-03-19 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human alpha1G-C T-Type calcium channel
EP1465609A2 (en) * 2001-11-07 2004-10-13 Medical Research Council Modulation of dopaminergic neurons
WO2004035000A2 (en) * 2002-10-17 2004-04-29 Merck & Co., Inc. Enhancement of sleep with t-type calcium channel antagonists
WO2004060917A2 (en) 2003-01-07 2004-07-22 Neuromed Technologies, Inc. Fluorescence based t-type channel assay
US7157461B2 (en) 2003-07-23 2007-01-02 Bristol-Myers Squibb Co. Substituted dihydropyrimidine inhibitors of calcium channel function
US7166603B2 (en) 2003-07-23 2007-01-23 Bristol-Myers Squibb Co. Dihydropyrimidone inhibitors of calcium channel function
US7195893B2 (en) 2003-08-14 2007-03-27 Neuromed Pharmaceuticals Ltd. Nucleic acids encoding α2δ calcium channel subunits and methods for making and using them
US7504431B2 (en) 2004-04-16 2009-03-17 Bristol-Myers Squibb Company Sulfonyl amide inhibitors of calcium channel function
ES2842289T3 (es) 2008-02-29 2021-07-13 Vm Therapeutics Llc Compuestos para tratar el síndrome del dolor y otros trastornos
US12365898B2 (en) 2021-06-29 2025-07-22 The Medical College Of Wisconsin, Inc. Calcium channel 3.2 inhibitory peptides and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5386025A (en) * 1990-02-20 1995-01-31 The Salk Institute Biotechnology/Industrial Associates Calcium channel compositions and methods
US5429921A (en) * 1988-04-04 1995-07-04 The Salk Institute Biotechnology/Industrial Assoc. Inc. Assays for agonists and antagonists of recombinant human calcium channels
US5401629A (en) * 1990-08-07 1995-03-28 The Salk Institute Biotechnology/Industrial Associates, Inc. Assay methods and compositions useful for measuring the transduction of an intracellular signal
DE4110785A1 (de) 1991-04-04 1992-10-08 Bayer Ag Gewebe-spezifische humane neuronale calcium-kanal-subtypen und deren verwendung
US5688938A (en) * 1991-08-23 1997-11-18 The Brigham & Women's Hospital, Inc. Calcium receptor-active molecules
US5837479A (en) * 1992-09-22 1998-11-17 Young; Donald A. Screening assays for inhibitors of mammalian prostaglandin H synthase-2
EP0778890B1 (en) 1993-07-30 2000-09-27 Elan Pharmaceuticals, Inc. Dna encoding a human calcium channel alpha-1e subunit
US5712158A (en) 1995-06-06 1998-01-27 Warner-Lambert Company Cell line for the rapid expression of functional calcium channels
US5804436A (en) * 1996-08-02 1998-09-08 Axiom Biotechnologies, Inc. Apparatus and method for real-time measurement of cellular response
US7297504B1 (en) * 1997-02-28 2007-11-20 Neuromed Pharmaceuticals Ltd. Methods for identifying agonists and antagonists of human T-type calcium channels
US20020009772A1 (en) * 1997-02-28 2002-01-24 Terry P. Snutch Novel human calcium channels and related probes, cell lines and mehtods
US6528630B1 (en) 1997-12-03 2003-03-04 Merck & Co., Inc. Calcium channel compositions and methods
EP1042468B1 (en) * 1997-12-03 2006-10-18 Merck & Co., Inc. Low-voltage activated calcium channel compositions and methods
EP1036170A1 (en) * 1997-12-05 2000-09-20 Loyola University Of Chicago T-type voltage-gated calcium channels and method of using same
US20030125269A1 (en) 1998-08-26 2003-07-03 Ming Li T-type calcium channel
US6309858B1 (en) 1998-09-29 2001-10-30 Syntex (U.S.A.) Llc T-type calcium channel variants; compositions thereof; and uses
WO2000070044A2 (en) 1999-05-13 2000-11-23 The Johns Hopkins University Human brain t calcium channel alpha-subunit splice variants
US6783933B1 (en) 1999-09-15 2004-08-31 The Johns Hopkins University School Of Medicine CACNA1G polynucleotide, polypeptide and methods of use therefor
US6358706B1 (en) * 1999-10-26 2002-03-19 Ortho-Mcneil Pharmaceutical, Inc. DNA encoding human alpha1G-C T-Type calcium channel

Also Published As

Publication number Publication date
US20070207523A1 (en) 2007-09-06
EP1780278A3 (en) 2007-06-27
WO2001002561A3 (en) 2001-06-28
AU5957100A (en) 2001-01-22
WO2001002561A2 (en) 2001-01-11
JP2003504020A (ja) 2003-02-04
US7157243B1 (en) 2007-01-02
EP1190053A2 (en) 2002-03-27
US7517672B2 (en) 2009-04-14
US7501263B2 (en) 2009-03-10
US20070178553A1 (en) 2007-08-02
EP1780278A2 (en) 2007-05-02

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20130408