CA2375673C - Sequences d'adn derivees du genome du papillomavirus hpv39, leur application au diagnostic in vitro et a la production de composition immunogene - Google Patents
Sequences d'adn derivees du genome du papillomavirus hpv39, leur application au diagnostic in vitro et a la production de composition immunogene Download PDFInfo
- Publication number
- CA2375673C CA2375673C CA002375673A CA2375673A CA2375673C CA 2375673 C CA2375673 C CA 2375673C CA 002375673 A CA002375673 A CA 002375673A CA 2375673 A CA2375673 A CA 2375673A CA 2375673 C CA2375673 C CA 2375673C
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- Canada
- Prior art keywords
- hpv39
- nucleotide
- dna
- sequence
- chosen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/084—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9016044A FR2670797A1 (fr) | 1990-12-20 | 1990-12-20 | Sequences d'adn determinees derivees du genome du papillomavirus hpv39, application de ces sequences au diagnostic in vitro d'infection par ce papillomavirus, et a la production de composition immunogene. |
| FRFR90/16044 | 1990-12-20 | ||
| CA002098819A CA2098819C (fr) | 1990-12-20 | 1991-12-20 | Sequences d'adn derivees du genome du papillomavirus hpv39, leur application au diagnostic in vitro et a la production de composition immunogene |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002098819A Division CA2098819C (fr) | 1990-12-20 | 1991-12-20 | Sequences d'adn derivees du genome du papillomavirus hpv39, leur application au diagnostic in vitro et a la production de composition immunogene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2375673A1 CA2375673A1 (fr) | 1992-07-09 |
| CA2375673C true CA2375673C (fr) | 2005-05-17 |
Family
ID=9403488
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002375673A Expired - Lifetime CA2375673C (fr) | 1990-12-20 | 1991-12-20 | Sequences d'adn derivees du genome du papillomavirus hpv39, leur application au diagnostic in vitro et a la production de composition immunogene |
| CA002098819A Expired - Lifetime CA2098819C (fr) | 1990-12-20 | 1991-12-20 | Sequences d'adn derivees du genome du papillomavirus hpv39, leur application au diagnostic in vitro et a la production de composition immunogene |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002098819A Expired - Lifetime CA2098819C (fr) | 1990-12-20 | 1991-12-20 | Sequences d'adn derivees du genome du papillomavirus hpv39, leur application au diagnostic in vitro et a la production de composition immunogene |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US5656423A (enExample) |
| EP (1) | EP0563255B1 (enExample) |
| JP (1) | JP3859696B2 (enExample) |
| AT (1) | ATE112316T1 (enExample) |
| CA (2) | CA2375673C (enExample) |
| DE (1) | DE69104380T2 (enExample) |
| DK (1) | DK0563255T3 (enExample) |
| ES (1) | ES2062887T3 (enExample) |
| FR (1) | FR2670797A1 (enExample) |
| WO (1) | WO1992011369A1 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5639871A (en) * | 1988-09-09 | 1997-06-17 | Roche Molecular Systems, Inc. | Detection of human papillomavirus by the polymerase chain reaction |
| GB9621091D0 (en) | 1996-10-09 | 1996-11-27 | Fondation Pour Le Perfectionem | Attenuated microorganisms strains and their uses |
| MXPA01004287A (es) * | 1998-10-26 | 2002-06-04 | Ventana Med Syst Inc | Deteccion del virus del papiloma humano en frotis de papanicolau (pap). |
| US7569344B2 (en) * | 1998-10-26 | 2009-08-04 | Ventana Medical Systems, Inc. | Detection of human papilloma virus in papanicolaou (Pap) smears |
| EP1169480A4 (en) * | 1999-04-14 | 2005-02-02 | Musc Found For Res Dev | TOXIC AGENTS AND RIBOZYMES SPECIFIC TO TISSUE AND SPECIFIC PATHOGENS |
| US20060275784A1 (en) * | 1999-10-26 | 2006-12-07 | Ventana Medical Systems, Inc. | Detection of Human Papilloma Virus in Papanicolaou (Pap) Smears |
| US20040229298A1 (en) * | 2000-11-11 | 2004-11-18 | Lu Peter S. | Methods and compositions for treating cervical cancer |
| US7312041B2 (en) * | 2001-02-16 | 2007-12-25 | Arbor Vita Corporation | Methods of diagnosing cervical cancer |
| WO2003008649A1 (en) * | 2001-07-20 | 2003-01-30 | Board Of Regents, The University Of Texas System | Methods and compositions relating to hpv-associated pre-cancerous and cancerous growths, including cin |
| CA2491034A1 (en) * | 2002-06-26 | 2004-01-08 | The Penn State Research Foundation | Methods and materials for treating human papillomavirus infections |
| EP1537415B1 (en) | 2002-09-09 | 2008-12-17 | Arbor Vita Corporation | Methods of diagnosing cervical cancer |
| BRPI0414801A (pt) | 2003-09-25 | 2006-11-14 | Third Wave Tech Inc | detecção de hpv |
| WO2005063286A1 (en) | 2003-12-23 | 2005-07-14 | Arbor Vita Corporation | Antibodies for oncogenic strains of hpv and methods of their use |
| ATE476528T1 (de) | 2004-12-08 | 2010-08-15 | Gen Probe Inc | Nukleinsäuredetektion aus verschiedenen typen des humanen papillomavirus |
| MX2007006845A (es) * | 2004-12-10 | 2007-10-23 | Genera Biosystems Pty Ltd | Deteccion del virus del papiloma humano (vph) utilizando un clasificador de celulas activadas fluorescentes (facs), sondas de acido nucleico y microgranulos. |
| US7732166B2 (en) * | 2005-11-15 | 2010-06-08 | Oncohealth Corporation | Detection method for human pappilomavirus (HPV) and its application in cervical cancer |
| US7972776B2 (en) * | 2005-11-15 | 2011-07-05 | Oncohealth Corporation | Protein chips for HPV detection |
| US8080643B2 (en) * | 2006-09-05 | 2011-12-20 | Third Wave Technologies, Inc. | HPV primers |
| US8968995B2 (en) * | 2008-11-12 | 2015-03-03 | Oncohealth Corp. | Detection, screening, and diagnosis of HPV-associated cancers |
| US8865162B2 (en) | 2008-06-13 | 2014-10-21 | Oncohealth Corp. | Monoclonal antibodies against HPV proteins |
| CN101730847B (zh) * | 2007-04-05 | 2015-03-18 | 分类生物系统有限公司 | 组合物及检测方法 |
| GB0820822D0 (en) * | 2008-11-13 | 2008-12-24 | Inst Catala D Oncologia | Novel product and processes |
| JP2012526286A (ja) | 2009-05-07 | 2012-10-25 | オンコヘルス コーポレーション | ヒトパピローマウイルス（ｈｐｖ）およびｈｐｖ関連癌の初期段階および後期段階の検出、スクリーニング、および診断のための高度または≧ｃｉｎ２の同定 |
| WO2011084598A1 (en) | 2010-01-08 | 2011-07-14 | Oncohealth Corporation | High throughput cell-based hpv immunoassays for diagnosis and screening of hpv-associated cancers |
| WO2011149897A1 (en) * | 2010-05-25 | 2011-12-01 | Qiagen Gaithersburg, Inc. | Fast results hybrid capture assay and associated strategically-truncated probes |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2593828B2 (fr) * | 1986-01-31 | 1990-05-04 | Pasteur Institut | Sonde a papillomavirus et procede de diagnostic in-vitro d'infections a papillomavirus |
| FR2629458B2 (fr) * | 1987-07-31 | 1991-08-09 | Ire Celltarg Sa | Nouvelles sondes d'acides nucleiques specifiques de differents types de virus de papillome humain |
| US5447839A (en) * | 1988-09-09 | 1995-09-05 | Hoffmann-La Roche Inc. | Detection of human papillomavirus by the polymerase chain reaction |
| US5182377A (en) * | 1988-09-09 | 1993-01-26 | Hoffmann-La Roche Inc. | Probes for detection of human papillomavirus |
| FR2641081A1 (enExample) * | 1988-12-23 | 1990-06-29 | Medgenix Group |
-
1990
- 1990-12-20 FR FR9016044A patent/FR2670797A1/fr active Granted
-
1991
- 1991-12-20 CA CA002375673A patent/CA2375673C/fr not_active Expired - Lifetime
- 1991-12-20 WO PCT/FR1991/001053 patent/WO1992011369A1/fr not_active Ceased
- 1991-12-20 DK DK92903034.4T patent/DK0563255T3/da active
- 1991-12-20 JP JP50307192A patent/JP3859696B2/ja not_active Expired - Lifetime
- 1991-12-20 EP EP92903034A patent/EP0563255B1/fr not_active Expired - Lifetime
- 1991-12-20 CA CA002098819A patent/CA2098819C/fr not_active Expired - Lifetime
- 1991-12-20 US US08/074,879 patent/US5656423A/en not_active Expired - Lifetime
- 1991-12-20 DE DE69104380T patent/DE69104380T2/de not_active Expired - Lifetime
- 1991-12-20 ES ES92903034T patent/ES2062887T3/es not_active Expired - Lifetime
- 1991-12-20 AT AT92903034T patent/ATE112316T1/de not_active IP Right Cessation
-
1995
- 1995-06-06 US US08/468,057 patent/US5665535A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ES2062887T3 (es) | 1994-12-16 |
| JP3859696B2 (ja) | 2006-12-20 |
| WO1992011369A1 (fr) | 1992-07-09 |
| DE69104380T2 (de) | 1995-02-09 |
| EP0563255B1 (fr) | 1994-09-28 |
| CA2098819C (fr) | 2002-06-18 |
| FR2670797B1 (enExample) | 1994-08-19 |
| CA2375673A1 (fr) | 1992-07-09 |
| FR2670797A1 (fr) | 1992-06-26 |
| ATE112316T1 (de) | 1994-10-15 |
| EP0563255A1 (fr) | 1993-10-06 |
| CA2098819A1 (fr) | 1992-06-21 |
| US5656423A (en) | 1997-08-12 |
| DK0563255T3 (da) | 1994-10-24 |
| DE69104380D1 (de) | 1994-11-03 |
| JPH06504672A (ja) | 1994-06-02 |
| US5665535A (en) | 1997-09-09 |
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