CA2373704A1 - Prevention of post surgical adhesions using a fibrin monomer sealant - Google Patents
Prevention of post surgical adhesions using a fibrin monomer sealant Download PDFInfo
- Publication number
- CA2373704A1 CA2373704A1 CA002373704A CA2373704A CA2373704A1 CA 2373704 A1 CA2373704 A1 CA 2373704A1 CA 002373704 A CA002373704 A CA 002373704A CA 2373704 A CA2373704 A CA 2373704A CA 2373704 A1 CA2373704 A1 CA 2373704A1
- Authority
- CA
- Canada
- Prior art keywords
- fibrin
- composition
- polymer
- monomer
- wound site
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- WEXRUCMBJFQVBZ-UHFFFAOYSA-N pentobarbital Chemical compound CCCC(C)C1(CC)C(=O)NC(=O)NC1=O WEXRUCMBJFQVBZ-UHFFFAOYSA-N 0.000 description 1
- 239000012466 permeate Substances 0.000 description 1
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- 238000013310 pig model Methods 0.000 description 1
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- 239000005017 polysaccharide Substances 0.000 description 1
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- 239000011780 sodium chloride Substances 0.000 description 1
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- 239000011343 solid material Substances 0.000 description 1
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- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/046—Fibrin; Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/106—Fibrin; Fibrinogen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13690199P | 1999-06-01 | 1999-06-01 | |
| US60/136,901 | 1999-06-01 | ||
| PCT/US2000/015213 WO2000072852A1 (en) | 1999-06-01 | 2000-06-01 | Prevention of post surgical adhesions using a fibrin monomer sealant |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2373704A1 true CA2373704A1 (en) | 2000-12-07 |
Family
ID=22474921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002373704A Abandoned CA2373704A1 (en) | 1999-06-01 | 2000-06-01 | Prevention of post surgical adhesions using a fibrin monomer sealant |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6613325B1 (enExample) |
| EP (1) | EP1187623A1 (enExample) |
| JP (1) | JP2003500170A (enExample) |
| AU (1) | AU771557B2 (enExample) |
| CA (1) | CA2373704A1 (enExample) |
| NO (1) | NO20015759L (enExample) |
| NZ (1) | NZ515585A (enExample) |
| WO (1) | WO2000072852A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4648697A (en) | 1996-09-23 | 1998-04-14 | Chandrashekar Pathak | Methods and devices for preparing protein concentrates |
| AU2002213195A1 (en) * | 2000-10-13 | 2002-04-22 | Baxter Healthcare S.A. | Reduction or prevention of post-surgical adhesion formation with fibrinogen |
| AU2002213194A1 (en) * | 2000-10-13 | 2002-04-22 | Baxter Healthcare S.A. | Fibrinogen plus a non-plasmin-acting fibrinolysis inhibitor for the reduction or prevention of adhesion formation |
| NL1020426C2 (nl) * | 2002-04-18 | 2003-10-21 | Tno | Modificatie van de eigenschappen van een fibrinematrix met betrekking tot groei en ingroei van cellen. |
| US7758654B2 (en) | 2004-05-20 | 2010-07-20 | Kensey Nash Corporation | Anti-adhesion device |
| EP1748803A2 (en) * | 2004-05-27 | 2007-02-07 | Humanitas Mirasole S.p.A. | Use of fibrin for separating body organs |
| EP1846505B1 (en) | 2005-02-09 | 2015-11-11 | Covidien LP | Synthetic sealants |
| US8414907B2 (en) | 2005-04-28 | 2013-04-09 | Warsaw Orthopedic, Inc. | Coatings on medical implants to guide soft tissue healing |
| US9119901B2 (en) | 2005-04-28 | 2015-09-01 | Warsaw Orthopedic, Inc. | Surface treatments for promoting selective tissue attachment to medical impants |
| WO2010040131A2 (en) * | 2008-10-03 | 2010-04-08 | Replication Medical, Inc. | Vessel protection device |
| US20130202656A1 (en) | 2012-02-03 | 2013-08-08 | Dynasil Biomedical Corporation | Systems and kits for the fabrication of tissue patches |
| WO2013172721A1 (en) | 2012-05-18 | 2013-11-21 | Wise Lyn Marie | Combination treatments and compositions for wound healing |
| CN107530476A (zh) | 2015-03-12 | 2018-01-02 | 般财团法人化学及血清疗法研究所 | 使用脱细胞化组织的抗粘连材料和代用生物膜 |
| US9540548B1 (en) | 2015-08-07 | 2017-01-10 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
| US9833538B2 (en) | 2015-08-07 | 2017-12-05 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
| CA2994959A1 (en) | 2015-08-07 | 2017-02-16 | Xcede Technologies, Inc. | Adhesive compositions and related methods |
| EP3400029B1 (en) * | 2016-01-07 | 2022-03-02 | Eio Biomedical Ltd | Compositions for reducing tissue adhesions |
| WO2020121289A1 (en) | 2018-12-12 | 2020-06-18 | Omrix Biopharmaceuticals Ltd. | Low concentrated protein compositions for preventing tissue adhesion |
| IL263679A (en) | 2018-12-12 | 2019-03-31 | Omrix Biopharmaceuticals Ltd | Kits, methods, and compositions for preventing tissue adhesion |
| CA3144487C (en) | 2019-08-01 | 2024-01-02 | Km Biologics Co., Ltd. | Tissue fibrosis inhibitor in which biocompatible polymer is used |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6054122A (en) | 1990-11-27 | 2000-04-25 | The American National Red Cross | Supplemented and unsupplemented tissue sealants, methods of their production and use |
| CN1091315A (zh) * | 1992-10-08 | 1994-08-31 | E·R·斯奎布父子公司 | 血纤维蛋白封闭剂组合物及其使用方法 |
| CA2114290C (en) * | 1993-01-27 | 2006-01-10 | Nagabushanam Totakura | Post-surgical anti-adhesion device |
| US5702715A (en) | 1995-10-27 | 1997-12-30 | Drying Technology | Reinforced biological sealants |
| US6056970A (en) * | 1998-05-07 | 2000-05-02 | Genzyme Corporation | Compositions comprising hemostatic compounds and bioabsorbable polymers |
-
2000
- 2000-06-01 JP JP2000620964A patent/JP2003500170A/ja active Pending
- 2000-06-01 CA CA002373704A patent/CA2373704A1/en not_active Abandoned
- 2000-06-01 EP EP00939511A patent/EP1187623A1/en not_active Withdrawn
- 2000-06-01 US US09/585,030 patent/US6613325B1/en not_active Expired - Fee Related
- 2000-06-01 WO PCT/US2000/015213 patent/WO2000072852A1/en not_active Ceased
- 2000-06-01 NZ NZ515585A patent/NZ515585A/en unknown
- 2000-06-01 AU AU54588/00A patent/AU771557B2/en not_active Ceased
-
2001
- 2001-11-26 NO NO20015759A patent/NO20015759L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NZ515585A (en) | 2004-06-25 |
| AU771557B2 (en) | 2004-03-25 |
| US6613325B1 (en) | 2003-09-02 |
| WO2000072852A1 (en) | 2000-12-07 |
| EP1187623A1 (en) | 2002-03-20 |
| NO20015759D0 (no) | 2001-11-26 |
| JP2003500170A (ja) | 2003-01-07 |
| NO20015759L (no) | 2002-01-29 |
| AU5458800A (en) | 2000-12-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20090601 |