CA2366062A1 - Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations - Google Patents
Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations Download PDFInfo
- Publication number
- CA2366062A1 CA2366062A1 CA002366062A CA2366062A CA2366062A1 CA 2366062 A1 CA2366062 A1 CA 2366062A1 CA 002366062 A CA002366062 A CA 002366062A CA 2366062 A CA2366062 A CA 2366062A CA 2366062 A1 CA2366062 A1 CA 2366062A1
- Authority
- CA
- Canada
- Prior art keywords
- seq
- dkk
- atcc
- accession number
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4718—Cytokine-induced proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
L'invention concerne de nouveaux polypeptides, de nouvelles protéines et de nouvelles molécules d'acide nucléique Dkk et associées à Dkk. En plus de protéines Dkk et associées à Dkk isolées et complètes, l'invention concerne également des protéines de fusion isolées, des peptides antigéniques et des anticorps. L'invention concerne en outre des molécules d'acide nucléique Dkk et associées à Dkk, des vecteurs d'expression recombinants contenant une molécule d'acide nucléique de la présente invention, des cellules hôtes dans lesquelles on a introduit lesdits vecteurs d'expression et des animaux transgéniques non humains dans lesquels un gène Dkk ou associé à Dkk a été introduit ou dissocié. L'invention concerne par ailleurs des méthodes diagnostiques, thérapeutiques et de criblage qui utilisent les compositions de la présente invention.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26302299A | 1999-03-05 | 1999-03-05 | |
US09/263,022 | 1999-03-05 | ||
PCT/US2000/005452 WO2000052047A2 (fr) | 1999-03-05 | 2000-03-03 | Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2366062A1 true CA2366062A1 (fr) | 2000-09-08 |
CA2366062C CA2366062C (fr) | 2014-06-17 |
Family
ID=23000057
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2366062A Expired - Lifetime CA2366062C (fr) | 1999-03-05 | 2000-03-03 | Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP1161445A2 (fr) |
AU (1) | AU3510200A (fr) |
CA (1) | CA2366062C (fr) |
WO (1) | WO2000052047A2 (fr) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001063295A2 (fr) * | 2000-02-24 | 2001-08-30 | Oxford Glycosciences (Uk) Ltd. | Proteine dpi-6, cible therapeutique putative et biomarqueur pour les troubles neuropsychiatriques et neurologiques |
EP1222933A1 (fr) * | 2001-01-15 | 2002-07-17 | Academisch Ziekenhuis Leiden h.o.d.n., Leids Universitair Medisch Centrum | Génération et/ou réduction de nouveau tissu pulmonaire dans un poumon atteint, par modulation de la voie Wnt |
HUP0303194A2 (hu) * | 2001-02-16 | 2003-12-29 | Genentech, Inc. | DKK-1 és antagonistái alkalmazásai |
EP1573024A4 (fr) | 2001-04-10 | 2007-08-29 | Agensys Inc | Acides nucleiques et proteines correspondantes utiles pour la detection et le traitement de divers cancers |
US20040038860A1 (en) | 2002-05-17 | 2004-02-26 | Allen Kristina M. | Reagents and methods for modulating dkk-mediated interactions |
CA2446582A1 (fr) * | 2001-05-17 | 2002-11-21 | Genome Therapeutics Corporation | Reactifs et procedes destines a moduler des interactions induites par dkk |
ES2304210B1 (es) * | 2002-10-15 | 2009-09-28 | Genentech, Inc | Utilizacion de dkk-5, procedimiento y equipo de diagnostico de trastornos resistentes a la insulina e hibridoma y anticuerpo contra dkk-5. |
US8124087B2 (en) | 2002-12-05 | 2012-02-28 | Board Of Trustees Of The University Of Arkansas | Methods of controlling bone loss by inhibiting DKK1 |
US7811750B2 (en) * | 2002-12-05 | 2010-10-12 | Board Of Trustees Of The University Of Arkansas | Molecular determinants of myeloma bone disease and use thereof |
WO2004053063A2 (fr) * | 2002-12-05 | 2004-06-24 | The Board Of Trustees Of The University Of Arkansas System | Determinants moleculaires de maladie osseuse de type myelome et utilisations de ceux-ci |
US8637506B2 (en) * | 2003-09-22 | 2014-01-28 | Enzo Biochem, Inc. | Compositions and methods for bone formation and remodeling |
WO2005049797A2 (fr) * | 2003-11-17 | 2005-06-02 | Merck & Co., Inc. | Proteine dickkopf-4 de macaque de buffon, nucleotides codant pour ladite proteine, et utilisations de cette proteine |
WO2005049640A2 (fr) | 2003-11-17 | 2005-06-02 | Merck & Co., Inc. | Proteine dickkopf-1 de singe rhesus, nucleotides codant ladite proteine, et procedes d'utilisation |
US8343922B2 (en) * | 2004-05-19 | 2013-01-01 | Enzo Biochem, Inc. | Compositions and methods for the stimulation or enhancement of bone formation and the self-renewal of cells |
WO2006010534A1 (fr) * | 2004-07-28 | 2006-02-02 | F.Hoffmann-La Roche Ag | Dickkopf 3 en tant que cible / marqueur de la defaillance des cellules beta |
EP2336177A1 (fr) | 2004-08-04 | 2011-06-22 | Amgen, Inc | anticorps anti-DKK-1 |
EP1896495A2 (fr) | 2005-03-30 | 2008-03-12 | Novartis Vaccines and Diagnostics, Inc. | Modulateurs de produit d'epissage de dkkl-1 pour diagnostic et therapie du cancer |
WO2007104181A1 (fr) * | 2006-03-13 | 2007-09-20 | Shanghai Cancer Institute | Utilisations de la protéine dkk-1 dans le diagnostic de cancers |
EP2589658B1 (fr) | 2010-07-01 | 2018-11-21 | National University Corporation Okayama University | Polypeptide de région partielle de la protéine reic/dkk-3 |
KR20130021315A (ko) * | 2011-08-22 | 2013-03-05 | 인하대학교 산학협력단 | Dkk2 단백질 또는 그 유전자를 포함하는 발기부전 예방 또는 치료용 조성물 및 그의 용도 |
EP3990474A1 (fr) * | 2019-06-25 | 2022-05-04 | Friedrich Miescher Institute for Biomedical Research | Promoteur pour l'expression spécifique de gènes dans des cellules exprimant une protéine acide fibrillaire gliale |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2001507227A (ja) * | 1996-12-20 | 2001-06-05 | ヒューマン ジノーム サイエンシーズ,インコーポレイテッド | 小脳および胚に特異的なタンパク質 |
DK0975755T3 (da) * | 1997-04-16 | 2007-06-11 | Millennium Pharm Inc | CRSP-protein (cysteinrige udskilte proteiner), nukleinsyremolekyler der koder herfor samt anvendelser deraf |
DE19747418C1 (de) * | 1997-10-27 | 1999-07-15 | Deutsches Krebsforsch | Inhibitor-Protein des wnt-Signalwegs |
DE19844293C2 (de) * | 1998-09-18 | 2002-03-14 | B & S Elektronische Geraete Gm | Beleuchtungseinrichtung |
-
2000
- 2000-03-03 AU AU35102/00A patent/AU3510200A/en not_active Abandoned
- 2000-03-03 WO PCT/US2000/005452 patent/WO2000052047A2/fr not_active Application Discontinuation
- 2000-03-03 CA CA2366062A patent/CA2366062C/fr not_active Expired - Lifetime
- 2000-03-03 EP EP00913706A patent/EP1161445A2/fr not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
CA2366062C (fr) | 2014-06-17 |
WO2000052047A2 (fr) | 2000-09-08 |
AU3510200A (en) | 2000-09-21 |
WO2000052047A3 (fr) | 2001-02-01 |
WO2000052047A9 (fr) | 2002-03-14 |
EP1161445A2 (fr) | 2001-12-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20200303 |