EP1222933A1 - Génération et/ou réduction de nouveau tissu pulmonaire dans un poumon atteint, par modulation de la voie Wnt - Google Patents

Génération et/ou réduction de nouveau tissu pulmonaire dans un poumon atteint, par modulation de la voie Wnt Download PDF

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Publication number
EP1222933A1
EP1222933A1 EP01200123A EP01200123A EP1222933A1 EP 1222933 A1 EP1222933 A1 EP 1222933A1 EP 01200123 A EP01200123 A EP 01200123A EP 01200123 A EP01200123 A EP 01200123A EP 1222933 A1 EP1222933 A1 EP 1222933A1
Authority
EP
European Patent Office
Prior art keywords
wnt
cell
pathway
compound according
anyone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP01200123A
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German (de)
English (en)
Inventor
designation of the inventor has not yet been filed The
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Leids Universitair Medisch Centrum LUMC
Original Assignee
Leids Universitair Medisch Centrum LUMC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leids Universitair Medisch Centrum LUMC filed Critical Leids Universitair Medisch Centrum LUMC
Priority to EP01200123A priority Critical patent/EP1222933A1/fr
Priority to CA002434431A priority patent/CA2434431A1/fr
Priority to PCT/NL2002/000025 priority patent/WO2002055109A2/fr
Priority to US10/250,954 priority patent/US20040223952A1/en
Priority to EP02710537A priority patent/EP1351711A2/fr
Publication of EP1222933A1 publication Critical patent/EP1222933A1/fr
Withdrawn legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EP01200123A 2001-01-15 2001-01-15 Génération et/ou réduction de nouveau tissu pulmonaire dans un poumon atteint, par modulation de la voie Wnt Withdrawn EP1222933A1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP01200123A EP1222933A1 (fr) 2001-01-15 2001-01-15 Génération et/ou réduction de nouveau tissu pulmonaire dans un poumon atteint, par modulation de la voie Wnt
CA002434431A CA2434431A1 (fr) 2001-01-15 2002-01-15 Formation et/ou la reduction de nouveaux tissus pulmonaires dans un poumon affecte
PCT/NL2002/000025 WO2002055109A2 (fr) 2001-01-15 2002-01-15 Formation et/ou la reduction de nouveaux tissus pulmonaires dans un poumon affecte
US10/250,954 US20040223952A1 (en) 2001-01-15 2002-01-15 Generation and/or reduction of new lung tissue in an affected lung
EP02710537A EP1351711A2 (fr) 2001-01-15 2002-01-15 Formation et/ou la reduction de nouveaux tissus pulmonaires dans un poumon affecte

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01200123A EP1222933A1 (fr) 2001-01-15 2001-01-15 Génération et/ou réduction de nouveau tissu pulmonaire dans un poumon atteint, par modulation de la voie Wnt

Publications (1)

Publication Number Publication Date
EP1222933A1 true EP1222933A1 (fr) 2002-07-17

Family

ID=8179748

Family Applications (2)

Application Number Title Priority Date Filing Date
EP01200123A Withdrawn EP1222933A1 (fr) 2001-01-15 2001-01-15 Génération et/ou réduction de nouveau tissu pulmonaire dans un poumon atteint, par modulation de la voie Wnt
EP02710537A Withdrawn EP1351711A2 (fr) 2001-01-15 2002-01-15 Formation et/ou la reduction de nouveaux tissus pulmonaires dans un poumon affecte

Family Applications After (1)

Application Number Title Priority Date Filing Date
EP02710537A Withdrawn EP1351711A2 (fr) 2001-01-15 2002-01-15 Formation et/ou la reduction de nouveaux tissus pulmonaires dans un poumon affecte

Country Status (4)

Country Link
US (1) US20040223952A1 (fr)
EP (2) EP1222933A1 (fr)
CA (1) CA2434431A1 (fr)
WO (1) WO2002055109A2 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007090872A2 (fr) * 2006-02-09 2007-08-16 Novartis Ag Agents de liaison de la proteine-4 apparentee a frizzled (sfrp-4)
EP2366432A1 (fr) 2010-03-16 2011-09-21 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibiteurs de kinase 3 de synthèse de glycogène à utiliser dans les procédés thérapeutiques et procédé de criblage associé

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1548100A1 (fr) * 2003-11-11 2005-06-29 DeltaCell B.V. Inhibition de la differéntiation des cellules souches, prolifération améliorée et induction sélective de l'apoptose par les facteurs de WNT
CN1981054A (zh) * 2004-05-14 2007-06-13 加利福尼亚大学董事会 用抗wnt2单克隆抗体和sirna治疗癌症的方法
US8198244B2 (en) 2006-12-07 2012-06-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Regulation of skin characteristics by DICKKOPF1 (DKK1)
EP2450707B1 (fr) * 2010-11-04 2016-04-27 University of Pécs Modèle de tissu de poumon
EP3524274A3 (fr) 2009-07-15 2020-01-01 Zhenglun Zhu Gérer le traitement de troubles prolifératifs cellulaires en utilisant l'expression de hom-1
KR101268478B1 (ko) 2010-03-08 2013-06-04 한국원자력연구원 Dkk3 발현 또는 활성 억제제를 함유하는 암 예방 및 치료용 조성물
US10975357B2 (en) 2017-06-27 2021-04-13 Trustees Of Boston University Methods and compositions related to differentiated lung cells

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998013493A2 (fr) * 1996-09-24 1998-04-02 Lxr Biotechnology, Inc. Famille de genes codant les peptides lies a l'apoptose, peptides ainsi codes et leurs procedes d'utilisation
WO1998054325A1 (fr) * 1997-05-29 1998-12-03 The Government Of The United States Of America,Re Presented By The Secretary, Department Of Health And Human Services Frp humaine et fragments de cette derniere et leurs utilisations
WO1999022000A1 (fr) * 1997-10-27 1999-05-06 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Proteine inhibitrice de la voie de signalisation wnt
WO2000038709A1 (fr) * 1998-12-31 2000-07-06 Chiron Corporation Traitement de troubles d'hyperproliferation a l'aide de caseine kinase i
WO2000052047A2 (fr) * 1999-03-05 2000-09-08 Millennium Pharmaceuticals, Inc. Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations
WO2001019855A2 (fr) * 1999-09-13 2001-03-22 American Home Products Corporation Compositions pharmaceutiques et modalite d'utilisation de proteine sfrp
WO2001044279A2 (fr) * 1999-12-17 2001-06-21 Chiron Corporation Proteines de mammifere associees dishevelled

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6004528A (en) * 1997-09-18 1999-12-21 Bergstein; Ivan Methods of cancer diagnosis and therapy targeted against the cancer stemline
US6066500A (en) * 1999-06-25 2000-05-23 Isis Pharmaceuticals Inc. Antisense modulation of Beta catenin expression

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998013493A2 (fr) * 1996-09-24 1998-04-02 Lxr Biotechnology, Inc. Famille de genes codant les peptides lies a l'apoptose, peptides ainsi codes et leurs procedes d'utilisation
WO1998054325A1 (fr) * 1997-05-29 1998-12-03 The Government Of The United States Of America,Re Presented By The Secretary, Department Of Health And Human Services Frp humaine et fragments de cette derniere et leurs utilisations
WO1999022000A1 (fr) * 1997-10-27 1999-05-06 Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts Proteine inhibitrice de la voie de signalisation wnt
WO2000038709A1 (fr) * 1998-12-31 2000-07-06 Chiron Corporation Traitement de troubles d'hyperproliferation a l'aide de caseine kinase i
WO2000052047A2 (fr) * 1999-03-05 2000-09-08 Millennium Pharmaceuticals, Inc. Proteine humaine et molecules d'acide nucleique associees a dickkopf et leurs utilisations
WO2001019855A2 (fr) * 1999-09-13 2001-03-22 American Home Products Corporation Compositions pharmaceutiques et modalite d'utilisation de proteine sfrp
WO2001044279A2 (fr) * 1999-12-17 2001-06-21 Chiron Corporation Proteines de mammifere associees dishevelled

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
BARKER N., CLEVERS H.: "Catenins, Wnt signaling and cancer", BIOESSAYS, vol. 22, November 2000 (2000-11-01), pages 961 - 965, XP002174508 *
BIENZ M., CLEVERS H.: "Linking colorectal cancer to Wnt signaling", CELL, vol. 103, 13 October 2000 (2000-10-13), pages 311 - 320, XP002174510 *
CALVO, R. ET AL.: "Altered HOX and WNT7A expression in human lung cancer", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 23, 7 November 2000 (2000-11-07), pages 12776 - 12781, XP002174507 *
DENNIS S. ET AL: "A secreted Frizzled related protein, FrzA, selectively associates with Wnt-1 protein and regulates Wnt-1 signaling.", J. CELL. SCI., vol. 112, 1999, pages 3815 - 3820, XP002174506 *
DUMONTELLE J ET AL: "Inhibition of expression of the endogenous mammary oncogene Wnt-1 by antisense oligodeoxynucleotides", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 36, March 1995 (1995-03-01), pages 515, XP002147584, ISSN: 0197-016X *
GILBERT KA AND RANNELS DE: "From Limbs to Lungs: a Newt Perspective on Compensatory Lung Growth", NEWS PHYSIOL. SCI., vol. 14, December 1999 (1999-12-01), pages 260 - 267, XP001013538 *
GLINKA ET AL: "Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 391, no. 6665, 22 January 1998 (1998-01-22), pages 357 - 362, XP002096088, ISSN: 0028-0836 *
MORIN PJ: "beta-catenin signaling and cancer", BIOESSAYS, vol. 21, December 1999 (1999-12-01), pages 1021 - 1030, XP002174509 *
POLANEC J ET AL: "EFFECT OF WNT-1 ANTISENSE RNA ON THE OUTGROWTH OF A MAMMARY ADENOCARCINOMA CELL LINE EXPRESSING THAT ONCOGENE", JCP. CLINICAL MOLECULAR PATHOLOGY, LONDON, GB, vol. 49, no. 3, June 1996 (1996-06-01), pages 166 - 169, XP000929749, ISSN: 1355-2910 *
WODARZ A. AND NUSSE R.: "Mechanisms of Wnt signaling in development", ANN. REV. CELL DEVEL. BIOL., vol. 14, 1998, pages 59 - 88, XP001012698 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007090872A2 (fr) * 2006-02-09 2007-08-16 Novartis Ag Agents de liaison de la proteine-4 apparentee a frizzled (sfrp-4)
WO2007090872A3 (fr) * 2006-02-09 2007-11-29 Novartis Ag Agents de liaison de la proteine-4 apparentee a frizzled (sfrp-4)
EP2366432A1 (fr) 2010-03-16 2011-09-21 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibiteurs de kinase 3 de synthèse de glycogène à utiliser dans les procédés thérapeutiques et procédé de criblage associé
WO2011113586A1 (fr) 2010-03-16 2011-09-22 Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Inhibiteurs de la glycogène synthase kinase 3 destinés à être utilisés dans des méthodes thérapeutiques, et procédé de criblage associé

Also Published As

Publication number Publication date
EP1351711A2 (fr) 2003-10-15
US20040223952A1 (en) 2004-11-11
WO2002055109A3 (fr) 2002-10-03
CA2434431A1 (fr) 2002-07-18
WO2002055109A2 (fr) 2002-07-18

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