CA2365540A1 - A novel complex of human kallikrein 2 (hk2) and protease inhibitor-6 (pi-6) in prostate tumor tissue and methods of using the complex - Google Patents
A novel complex of human kallikrein 2 (hk2) and protease inhibitor-6 (pi-6) in prostate tumor tissue and methods of using the complex Download PDFInfo
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- CA2365540A1 CA2365540A1 CA002365540A CA2365540A CA2365540A1 CA 2365540 A1 CA2365540 A1 CA 2365540A1 CA 002365540 A CA002365540 A CA 002365540A CA 2365540 A CA2365540 A CA 2365540A CA 2365540 A1 CA2365540 A1 CA 2365540A1
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- 239000012071 phase Substances 0.000 description 1
- RXNXLAHQOVLMIE-UHFFFAOYSA-N phenyl 10-methylacridin-10-ium-9-carboxylate Chemical compound C12=CC=CC=C2[N+](C)=C2C=CC=CC2=C1C(=O)OC1=CC=CC=C1 RXNXLAHQOVLMIE-UHFFFAOYSA-N 0.000 description 1
- ZWLUXSQADUDCSB-UHFFFAOYSA-N phthalaldehyde Chemical compound O=CC1=CC=CC=C1C=O ZWLUXSQADUDCSB-UHFFFAOYSA-N 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 210000005059 placental tissue Anatomy 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 201000001514 prostate carcinoma Diseases 0.000 description 1
- 238000011471 prostatectomy Methods 0.000 description 1
- 238000001742 protein purification Methods 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 229960003581 pyridoxal Drugs 0.000 description 1
- 235000008164 pyridoxal Nutrition 0.000 description 1
- 239000011674 pyridoxal Substances 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 238000004007 reversed phase HPLC Methods 0.000 description 1
- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 108010017282 serpin B6 Proteins 0.000 description 1
- 210000002027 skeletal muscle Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- 239000000439 tumor marker Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6445—Kallikreins (3.4.21.34; 3.4.21.35)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
- C07K14/8121—Serpins
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/803—Stabe free radicals, e.g. spin immunoassay
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/828—Cancer
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/266,957 US6284873B1 (en) | 1999-03-12 | 1999-03-12 | Complex of human kallikrein 2 (hK2) and protease inhibitor-6 (PI-6) in prostate tumor tissue and methods of using the complex |
| US09/266,957 | 1999-03-12 | ||
| PCT/US2000/001937 WO2000055308A1 (en) | 1999-03-12 | 2000-01-26 | A NOVEL COMPLEX OF HUMAN KALLIKREIN 2 (hK2) AND PROTEASE INHIBITOR-6 (PI-6) IN PROSTATE TUMOR TISSUE AND METHODS OF USING THE COMPLEX |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2365540A1 true CA2365540A1 (en) | 2000-09-21 |
Family
ID=23016693
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002365540A Abandoned CA2365540A1 (en) | 1999-03-12 | 2000-01-26 | A novel complex of human kallikrein 2 (hk2) and protease inhibitor-6 (pi-6) in prostate tumor tissue and methods of using the complex |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US6284873B1 (enExample) |
| EP (1) | EP1159411A1 (enExample) |
| JP (1) | JP2002538818A (enExample) |
| AU (1) | AU778038B2 (enExample) |
| CA (1) | CA2365540A1 (enExample) |
| WO (1) | WO2000055308A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1798838B (zh) | 2003-04-04 | 2012-01-04 | 洛桑大学 | 一种蛋白酶的抑制剂蛋白及其用途 |
| US20040242461A1 (en) * | 2003-04-08 | 2004-12-02 | Schneider Michael D. | Modulators of telomere stability |
| ATE403448T1 (de) * | 2003-04-28 | 2008-08-15 | Johnson & Johnson Medical Ltd | Schmerz-empfindliche therapeutische wundverbände |
| GB2408207A (en) | 2003-11-24 | 2005-05-25 | Johnson & Johnson Medical Ltd | Wound dressing for the controlled release of therapeutic agents comprising also an inhibitor of a protease enzyme & a linker group cleavable by such an enzyme |
| AU2006292212A1 (en) * | 2005-09-19 | 2007-03-29 | The Johns Hopkins University | Biomarker for prostate cancer |
| US9347946B2 (en) * | 2010-09-23 | 2016-05-24 | Biocept, Inc. | Methods and reagents for signal amplification |
| JP7355140B2 (ja) * | 2022-02-28 | 2023-10-03 | 住友ベークライト株式会社 | セリンプロテアーゼの検出用または測定用試薬 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4731326A (en) * | 1984-06-04 | 1988-03-15 | Ortho Diagnostic Systems Inc. | Disease diagnosis by detection of shed normal tissue antigens |
| US5730968A (en) * | 1994-03-31 | 1998-03-24 | Sterling Winthrop Inc. | Segmented chelating polymers as imaging and therapeutic agents |
-
1999
- 1999-03-12 US US09/266,957 patent/US6284873B1/en not_active Expired - Fee Related
-
2000
- 2000-01-26 JP JP2000605726A patent/JP2002538818A/ja active Pending
- 2000-01-26 CA CA002365540A patent/CA2365540A1/en not_active Abandoned
- 2000-01-26 WO PCT/US2000/001937 patent/WO2000055308A1/en not_active Ceased
- 2000-01-26 AU AU27376/00A patent/AU778038B2/en not_active Ceased
- 2000-01-26 EP EP00905737A patent/EP1159411A1/en not_active Withdrawn
- 2000-09-22 US US09/667,288 patent/US6472143B1/en not_active Expired - Lifetime
-
2001
- 2001-06-15 US US09/882,648 patent/US20010031860A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2737600A (en) | 2000-10-04 |
| US6284873B1 (en) | 2001-09-04 |
| AU778038B2 (en) | 2004-11-11 |
| JP2002538818A (ja) | 2002-11-19 |
| EP1159411A1 (en) | 2001-12-05 |
| US6472143B1 (en) | 2002-10-29 |
| WO2000055308A1 (en) | 2000-09-21 |
| US20010031860A1 (en) | 2001-10-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |