CA2360246C - Use of a cyclohexenone long-chain alcohol for treating neurodegenerative diseases - Google Patents

Use of a cyclohexenone long-chain alcohol for treating neurodegenerative diseases Download PDF

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Publication number
CA2360246C
CA2360246C CA002360246A CA2360246A CA2360246C CA 2360246 C CA2360246 C CA 2360246C CA 002360246 A CA002360246 A CA 002360246A CA 2360246 A CA2360246 A CA 2360246A CA 2360246 C CA2360246 C CA 2360246C
Authority
CA
Canada
Prior art keywords
compound
group
solution
hexane
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002360246A
Other languages
English (en)
French (fr)
Other versions
CA2360246A1 (en
Inventor
Bang Luu
Gaby Schmitt
Florence Keyling
Celine Girlanda-Junges
Philippe Chabert
Jean-Philippe Loeffler
Bernadette Lutz-Bucher
Jose-Luis Gonzalez De Aguilar
Masashi Yamada
Yukie Suma
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Universite de Strasbourg
Meiji Co Ltd
Original Assignee
Meiji Dairies Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Dairies Corp filed Critical Meiji Dairies Corp
Publication of CA2360246A1 publication Critical patent/CA2360246A1/en
Application granted granted Critical
Publication of CA2360246C publication Critical patent/CA2360246C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
    • C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
    • C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002360246A 1999-02-10 2000-02-10 Use of a cyclohexenone long-chain alcohol for treating neurodegenerative diseases Expired - Fee Related CA2360246C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP3331299 1999-02-10
JP11/33312 1999-02-10
JP11/180546 1999-06-25
JP18054699A JP4469441B2 (ja) 1999-02-10 1999-06-25 神経変性疾患の予防又は治療薬
PCT/JP2000/000742 WO2000047199A1 (en) 1999-02-10 2000-02-10 Use of a cyclohexenone long-chain alcohol for treating neurodegenerative diseases

Publications (2)

Publication Number Publication Date
CA2360246A1 CA2360246A1 (en) 2000-08-17
CA2360246C true CA2360246C (en) 2008-04-15

Family

ID=26371993

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002360246A Expired - Fee Related CA2360246C (en) 1999-02-10 2000-02-10 Use of a cyclohexenone long-chain alcohol for treating neurodegenerative diseases

Country Status (10)

Country Link
US (1) US7166642B1 (enExample)
EP (1) EP1150667B1 (enExample)
JP (1) JP4469441B2 (enExample)
AT (1) ATE270884T1 (enExample)
CA (1) CA2360246C (enExample)
DE (1) DE60012143T2 (enExample)
DK (1) DK1150667T3 (enExample)
ES (1) ES2223456T3 (enExample)
PT (1) PT1150667E (enExample)
WO (1) WO2000047199A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4861560B2 (ja) * 2001-02-19 2012-01-25 株式会社明治 糖尿病合併症治療剤
WO2002094252A1 (en) * 2001-05-24 2002-11-28 Meiji Dairies Corporation Preventive or remedy for diseases caused by cerebrovascular disturbances
MXPA04005512A (es) * 2001-12-13 2004-12-06 Firmenich & Cie Compuestos para liberacion controlada de moleculas activas.
CA2519178C (en) 2003-03-28 2010-01-12 Meiji Dairies Corporation Process for producing cyclohexenone long-chain alcohols
FR2860233B1 (fr) * 2003-09-26 2007-10-19 Univ Pasteur Composes promoteurs de la differenciation des precurseurs d'oligodendrocytes et modulateurs de l'activation microgliale, compositions et utilisations.
CA2583699C (en) * 2004-10-13 2012-11-20 Meiji Dairies Corporation Stat3 phosphorylation inhibitor and notch1 expression inhibitor
CN101065119B (zh) * 2004-11-25 2010-08-25 明治乳业株式会社 肾功能不全的改良剂
CN101180041B (zh) * 2005-01-18 2011-04-13 明治乳业株式会社 感觉障碍治疗剂
US20080312336A1 (en) * 2005-05-26 2008-12-18 Keisuke Satoh Preventive and/or Therapeutic Agent for Diabetic Vascular Disorder and Respiratory Disorder
KR102088078B1 (ko) * 2012-11-21 2020-03-12 골든 바이오테크놀러지 코포레이션 신경퇴행성 질환을 치료하기 위한 방법 및 조성물
BR112018014841B1 (pt) * 2016-01-22 2022-03-03 Taiho Pharmaceutical Co., Ltd. Álcoois de cadeia longa cicloexenona, seus usos e métodos para a produção dos mesmos com alta pureza
CN110187044B (zh) * 2019-01-17 2021-04-27 山东省农业科学院家禽研究所 一种银翘解毒口服液的质量检测方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0448697B1 (fr) * 1989-10-13 1996-04-10 Neurofit Analogues de la vitamine a, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant
ATE105282T1 (de) 1992-11-18 1994-05-15 Medafor Langkettige fettalkohole mit neurotropischer und gedaechtnissfoerdernder wirkung.
US5843641A (en) * 1993-02-26 1998-12-01 Massachusetts Institute Of Technology Methods for the daignosis, of familial amyotrophic lateral sclerosis
US5786391A (en) 1995-01-11 1998-07-28 Cornell Research Foundation, Inc. Regulating gene expression using retinoids with Ch2 OH or related groups at the side chain terminal position
US5731354A (en) * 1996-05-06 1998-03-24 Clarion Pharmaceuticals Inc. Treatment for the inhibition of neuro-degenerative disease states
DE69811905T2 (de) 1997-08-13 2003-11-06 Meiji Milk Products Co. Ltd., Tokio/Tokyo Cyclohexenon langketten alkohol und diese enthaltendes arzneimittel

Also Published As

Publication number Publication date
JP2000297034A (ja) 2000-10-24
ES2223456T3 (es) 2005-03-01
EP1150667B1 (en) 2004-07-14
CA2360246A1 (en) 2000-08-17
US7166642B1 (en) 2007-01-23
DK1150667T3 (da) 2004-08-30
ATE270884T1 (de) 2004-07-15
PT1150667E (pt) 2004-09-30
WO2000047199A1 (en) 2000-08-17
DE60012143T2 (de) 2004-11-25
JP4469441B2 (ja) 2010-05-26
DE60012143D1 (de) 2004-08-19
EP1150667A1 (en) 2001-11-07

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Effective date: 20160210