DK1150667T3 - Langkædet cyclohexenonalkohol til behandling af amytrofisk lateralsklerose - Google Patents
Langkædet cyclohexenonalkohol til behandling af amytrofisk lateralskleroseInfo
- Publication number
- DK1150667T3 DK1150667T3 DK00902903T DK00902903T DK1150667T3 DK 1150667 T3 DK1150667 T3 DK 1150667T3 DK 00902903 T DK00902903 T DK 00902903T DK 00902903 T DK00902903 T DK 00902903T DK 1150667 T3 DK1150667 T3 DK 1150667T3
- Authority
- DK
- Denmark
- Prior art keywords
- sup
- lateral sclerosis
- active ingredient
- cyclohexenone
- long
- Prior art date
Links
- FWFSEYBSWVRWGL-UHFFFAOYSA-N cyclohex-2-enone Chemical compound O=C1CCCC=C1 FWFSEYBSWVRWGL-UHFFFAOYSA-N 0.000 title abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 1
- 201000010901 lateral sclerosis Diseases 0.000 title 1
- 208000005264 motor neuron disease Diseases 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 230000004770 neurodegeneration Effects 0.000 abstract 2
- 208000015122 neurodegenerative disease Diseases 0.000 abstract 2
- 230000003449 preventive effect Effects 0.000 abstract 2
- 101150017120 sod gene Proteins 0.000 abstract 2
- 229940126585 therapeutic drug Drugs 0.000 abstract 2
- -1 alcohol compound Chemical class 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/06—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms
- C07C403/08—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by singly-bound oxygen atoms by hydroxy groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
- C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
- C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
- C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
- C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
- C07C49/713—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3331299 | 1999-02-10 | ||
| JP18054699A JP4469441B2 (ja) | 1999-02-10 | 1999-06-25 | 神経変性疾患の予防又は治療薬 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1150667T3 true DK1150667T3 (da) | 2004-08-30 |
Family
ID=26371993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00902903T DK1150667T3 (da) | 1999-02-10 | 2000-02-10 | Langkædet cyclohexenonalkohol til behandling af amytrofisk lateralsklerose |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7166642B1 (enExample) |
| EP (1) | EP1150667B1 (enExample) |
| JP (1) | JP4469441B2 (enExample) |
| AT (1) | ATE270884T1 (enExample) |
| CA (1) | CA2360246C (enExample) |
| DE (1) | DE60012143T2 (enExample) |
| DK (1) | DK1150667T3 (enExample) |
| ES (1) | ES2223456T3 (enExample) |
| PT (1) | PT1150667E (enExample) |
| WO (1) | WO2000047199A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4861560B2 (ja) * | 2001-02-19 | 2012-01-25 | 株式会社明治 | 糖尿病合併症治療剤 |
| WO2002094252A1 (en) * | 2001-05-24 | 2002-11-28 | Meiji Dairies Corporation | Preventive or remedy for diseases caused by cerebrovascular disturbances |
| MXPA04005512A (es) * | 2001-12-13 | 2004-12-06 | Firmenich & Cie | Compuestos para liberacion controlada de moleculas activas. |
| CA2519178C (en) | 2003-03-28 | 2010-01-12 | Meiji Dairies Corporation | Process for producing cyclohexenone long-chain alcohols |
| FR2860233B1 (fr) * | 2003-09-26 | 2007-10-19 | Univ Pasteur | Composes promoteurs de la differenciation des precurseurs d'oligodendrocytes et modulateurs de l'activation microgliale, compositions et utilisations. |
| CA2583699C (en) * | 2004-10-13 | 2012-11-20 | Meiji Dairies Corporation | Stat3 phosphorylation inhibitor and notch1 expression inhibitor |
| CN101065119B (zh) * | 2004-11-25 | 2010-08-25 | 明治乳业株式会社 | 肾功能不全的改良剂 |
| CN101180041B (zh) * | 2005-01-18 | 2011-04-13 | 明治乳业株式会社 | 感觉障碍治疗剂 |
| US20080312336A1 (en) * | 2005-05-26 | 2008-12-18 | Keisuke Satoh | Preventive and/or Therapeutic Agent for Diabetic Vascular Disorder and Respiratory Disorder |
| KR102088078B1 (ko) * | 2012-11-21 | 2020-03-12 | 골든 바이오테크놀러지 코포레이션 | 신경퇴행성 질환을 치료하기 위한 방법 및 조성물 |
| BR112018014841B1 (pt) * | 2016-01-22 | 2022-03-03 | Taiho Pharmaceutical Co., Ltd. | Álcoois de cadeia longa cicloexenona, seus usos e métodos para a produção dos mesmos com alta pureza |
| CN110187044B (zh) * | 2019-01-17 | 2021-04-27 | 山东省农业科学院家禽研究所 | 一种银翘解毒口服液的质量检测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0448697B1 (fr) * | 1989-10-13 | 1996-04-10 | Neurofit | Analogues de la vitamine a, leurs applications, notamment en tant que molecules cytotrophiques et cytoprotectrices, et compositions pharmaceutiques les contenant |
| ATE105282T1 (de) | 1992-11-18 | 1994-05-15 | Medafor | Langkettige fettalkohole mit neurotropischer und gedaechtnissfoerdernder wirkung. |
| US5843641A (en) * | 1993-02-26 | 1998-12-01 | Massachusetts Institute Of Technology | Methods for the daignosis, of familial amyotrophic lateral sclerosis |
| US5786391A (en) | 1995-01-11 | 1998-07-28 | Cornell Research Foundation, Inc. | Regulating gene expression using retinoids with Ch2 OH or related groups at the side chain terminal position |
| US5731354A (en) * | 1996-05-06 | 1998-03-24 | Clarion Pharmaceuticals Inc. | Treatment for the inhibition of neuro-degenerative disease states |
| DE69811905T2 (de) | 1997-08-13 | 2003-11-06 | Meiji Milk Products Co. Ltd., Tokio/Tokyo | Cyclohexenon langketten alkohol und diese enthaltendes arzneimittel |
-
1999
- 1999-06-25 JP JP18054699A patent/JP4469441B2/ja not_active Expired - Fee Related
-
2000
- 2000-02-10 ES ES00902903T patent/ES2223456T3/es not_active Expired - Lifetime
- 2000-02-10 DK DK00902903T patent/DK1150667T3/da active
- 2000-02-10 PT PT00902903T patent/PT1150667E/pt unknown
- 2000-02-10 US US09/890,969 patent/US7166642B1/en not_active Expired - Fee Related
- 2000-02-10 WO PCT/JP2000/000742 patent/WO2000047199A1/en not_active Ceased
- 2000-02-10 AT AT00902903T patent/ATE270884T1/de not_active IP Right Cessation
- 2000-02-10 CA CA002360246A patent/CA2360246C/en not_active Expired - Fee Related
- 2000-02-10 EP EP00902903A patent/EP1150667B1/en not_active Expired - Lifetime
- 2000-02-10 DE DE60012143T patent/DE60012143T2/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2000297034A (ja) | 2000-10-24 |
| ES2223456T3 (es) | 2005-03-01 |
| EP1150667B1 (en) | 2004-07-14 |
| CA2360246C (en) | 2008-04-15 |
| CA2360246A1 (en) | 2000-08-17 |
| US7166642B1 (en) | 2007-01-23 |
| ATE270884T1 (de) | 2004-07-15 |
| PT1150667E (pt) | 2004-09-30 |
| WO2000047199A1 (en) | 2000-08-17 |
| DE60012143T2 (de) | 2004-11-25 |
| JP4469441B2 (ja) | 2010-05-26 |
| DE60012143D1 (de) | 2004-08-19 |
| EP1150667A1 (en) | 2001-11-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TNSN05104A1 (fr) | Derives de thiazole pour le traitement de troubles neurodegeneratifs | |
| DE69811905D1 (de) | Cyclohexenon langketten alkohol und diese enthaltendes arzneimittel | |
| DK1150667T3 (da) | Langkædet cyclohexenonalkohol til behandling af amytrofisk lateralsklerose | |
| EP0849256A4 (en) | AMIDE COMPOUNDS AND THEIR USE | |
| MY141661A (en) | 17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | |
| DE60329316D1 (de) | Phenylcarboxamide als beta-sekretase-hemmer zur behandlung von alzheimer | |
| HUP0203300A2 (hu) | Immunoszuppresszáns 2,4-diamino-pirimidin vegyületek, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
| HUP0400732A2 (hu) | Gyógyászatilag hatékony uridin-észterek | |
| MA25809A1 (fr) | Derives d'arylmethylamine pour usage comme inhibiteurs de tryptase | |
| MA26956A1 (fr) | Pyrimidine-2,4,6,triones inhibitrices de metalloproteinases. | |
| TW200609227A (en) | Inhibitors of 11-beta-hydroxy steroid dehydrogenase type 1 | |
| GEP20053675B (en) | Pyridazinone Aldose Reductase Inhibitors | |
| WO2002089782A3 (en) | Dioxanes and uses thereof | |
| ATE316962T1 (de) | Pyrimidin-derivate als selective inhibitoren von cox-2 | |
| NO20025510D0 (no) | Tienodibenzoazulenforbindelser som tumor nekrose faktor inhibitorer | |
| MXPA04003611A (es) | Piperidina- y piperazinacetaminas como inhibidores de la 17 beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes. | |
| BR9911010A (pt) | Inibidores de sucinamida de enzima de conversão da interleucina-1beta | |
| DE60216239T8 (de) | Verwendung von Cyclohexenon-Derivaten zur Herstellung eines Arzneimittels zur Behandlung von Dysurie | |
| DE60139409D1 (de) | Pharmazeutische zusammensetzungen die ein dibenzocyclooctanlignanderivat enthalten zur vorbeugung und behandlung neurodegenerativer erkrankungen | |
| EP1201240A3 (en) | Heterocyclic derivatives useful as pharmaceutical agents | |
| HUP0001773A2 (hu) | Szubsztituált tetrahidropiridinszármazékok, eljárás előállításukra, továbbá a vegyületeket tartalmazó gyógyászati készítmények | |
| ATE185803T1 (de) | N-hydroxy-harnstoff-derivate als entzündunghemmende mittel | |
| DE60238666D1 (de) | Cyclohexenon derivate zur behandlung der diabetischen neuropathie | |
| KR950032194A (ko) | 신규푸린유도체 및 그 약학적으로 허용되는 염 | |
| EP0605728A4 (en) | Chromone derivative and aldose reductase inhibitor containing the same as active ingredient. |