CA2359687A1 - Derives de cholestane insatures et leur utilisation pour preparer des medicaments destines a reguler la meiose - Google Patents

Derives de cholestane insatures et leur utilisation pour preparer des medicaments destines a reguler la meiose Download PDF

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Publication number
CA2359687A1
CA2359687A1 CA002359687A CA2359687A CA2359687A1 CA 2359687 A1 CA2359687 A1 CA 2359687A1 CA 002359687 A CA002359687 A CA 002359687A CA 2359687 A CA2359687 A CA 2359687A CA 2359687 A1 CA2359687 A1 CA 2359687A1
Authority
CA
Canada
Prior art keywords
cholesta
dimethyl
alpha
dien
designates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002359687A
Other languages
English (en)
Inventor
Thorsten Blume
Peter Esperling
Joachim Kuhnke
Christa Hegele-Hartung
Monika Lessl
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2359687A1 publication Critical patent/CA2359687A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0094—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing nitrile radicals, including thiocyanide radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Reproductive Health (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention concerne des dérivés de cholestane insaturés pharmaceutiquement actifs, des compositions pharmaceutiques qui les contiennent comme principes actifs, et l'utilisation de ces nouveaux composés pour préparer des médicaments. On a en particulier découvert que les dérivés de cholestane insaturés de cette invention peuvent être utilisés pour réguler la méiose.
CA002359687A 1999-02-10 2000-02-09 Derives de cholestane insatures et leur utilisation pour preparer des medicaments destines a reguler la meiose Abandoned CA2359687A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP99250040.5 1999-02-10
EP99250040 1999-02-10
PCT/EP2000/001074 WO2000047604A1 (fr) 1999-02-10 2000-02-09 Derives de cholestane insatures et leur utilisation pour preparer des medicaments destines a reguler la meiose

Publications (1)

Publication Number Publication Date
CA2359687A1 true CA2359687A1 (fr) 2000-08-17

Family

ID=8241140

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002359687A Abandoned CA2359687A1 (fr) 1999-02-10 2000-02-09 Derives de cholestane insatures et leur utilisation pour preparer des medicaments destines a reguler la meiose

Country Status (15)

Country Link
EP (1) EP1150993A1 (fr)
JP (1) JP2002536456A (fr)
KR (1) KR20010101820A (fr)
CN (1) CN1368977A (fr)
AU (1) AU3279700A (fr)
BR (1) BR0008065A (fr)
CA (1) CA2359687A1 (fr)
CZ (1) CZ20012866A3 (fr)
HU (1) HUP0200280A2 (fr)
IL (1) IL143735A0 (fr)
NO (1) NO20013901L (fr)
PL (1) PL350557A1 (fr)
SK (1) SK11382001A3 (fr)
WO (1) WO2000047604A1 (fr)
ZA (1) ZA200107387B (fr)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716777A (en) * 1994-06-23 1998-02-10 Novo Nordisk A/S Regulation of meiosis using sterols
WO1996027658A1 (fr) * 1995-03-06 1996-09-12 Novo Nordisk A/S Stimulation de la meiose
CN1191543A (zh) * 1995-06-23 1998-08-26 诺沃挪第克公司 减数分裂调控化合物
ATE238339T1 (de) * 1996-12-20 2003-05-15 Novo Nordisk As Verbindungen zur regulierung der meiose

Also Published As

Publication number Publication date
SK11382001A3 (sk) 2002-01-07
EP1150993A1 (fr) 2001-11-07
NO20013901D0 (no) 2001-08-10
ZA200107387B (en) 2002-12-06
NO20013901L (no) 2001-08-10
PL350557A1 (en) 2002-12-16
IL143735A0 (en) 2002-04-21
WO2000047604A1 (fr) 2000-08-17
JP2002536456A (ja) 2002-10-29
HUP0200280A2 (hu) 2002-07-29
AU3279700A (en) 2000-08-29
BR0008065A (pt) 2001-11-06
CZ20012866A3 (cs) 2002-01-16
KR20010101820A (ko) 2001-11-14
CN1368977A (zh) 2002-09-11

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Legal Events

Date Code Title Description
FZDE Discontinued