CA2353596A1 - Methode d'immobilisation d'oligonucleotides - Google Patents

Methode d'immobilisation d'oligonucleotides Download PDF

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Publication number
CA2353596A1
CA2353596A1 CA002353596A CA2353596A CA2353596A1 CA 2353596 A1 CA2353596 A1 CA 2353596A1 CA 002353596 A CA002353596 A CA 002353596A CA 2353596 A CA2353596 A CA 2353596A CA 2353596 A1 CA2353596 A1 CA 2353596A1
Authority
CA
Canada
Prior art keywords
nucleic acid
subunit
polymer
moiety
particle
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002353596A
Other languages
English (en)
Inventor
Joseph D. Kittle, Jr.
Christopher P. Adams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Picoscript Ltd LLP
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2353596A1 publication Critical patent/CA2353596A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

Landscapes

  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

L'invention concerne de nouvelles compositions permettant d'introduire dans une cellule une molécule d'acide nucléique capable de moduler le génotype et le phénotype. Le gène peut être introduit dans un hôte mammalien au moyen d'un vecteur d'expression sous forme d'ADN nu ou conjugué à des supports, en particulier des supports cationiques. La conjugaison s'effectue au moyen d'une fraction contenant de l'éthylène reliée à la molécule d'acide nucléique. Les techniques et compositions selon l'invention s'utilisent pour soigner ou traiter n'importe laquelle d'une série de troubles génétiques.
CA002353596A 1998-12-04 1999-12-03 Methode d'immobilisation d'oligonucleotides Abandoned CA2353596A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11089198P 1998-12-04 1998-12-04
US60/110,891 1998-12-04
PCT/US1999/028666 WO2000034343A1 (fr) 1998-12-04 1999-12-03 Methode d'immobilisation d'oligonucleotides

Publications (1)

Publication Number Publication Date
CA2353596A1 true CA2353596A1 (fr) 2000-06-15

Family

ID=22335488

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002353596A Abandoned CA2353596A1 (fr) 1998-12-04 1999-12-03 Methode d'immobilisation d'oligonucleotides

Country Status (4)

Country Link
EP (1) EP1155056A4 (fr)
AU (1) AU1750400A (fr)
CA (1) CA2353596A1 (fr)
WO (1) WO2000034343A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201913688TA (en) 2016-03-03 2020-03-30 Univ Massachusetts Closed-ended linear duplex dna for non-viral gene transfer
CN110709696B (zh) * 2017-06-22 2022-01-04 昭和电工株式会社 寡核苷酸的混合物的分离分析方法
CN115667530A (zh) 2020-03-24 2023-01-31 世代生物公司 非病毒dna载体和其用于表达因子ix治疗剂的用途
CA3172591A1 (fr) 2020-03-24 2021-09-30 Douglas Anthony KERR Vecteurs d'adn non viraux et leurs utilisations pour exprimer des agents therapeutiques de la maladie de gaucher
EP4329885A1 (fr) 2021-04-27 2024-03-06 Generation Bio Co. Vecteurs d'adn non viraux exprimant des anticorps thérapeutiques et leurs utilisations
WO2023177655A1 (fr) 2022-03-14 2023-09-21 Generation Bio Co. Compositions vaccinales prime-boost hétérologues et méthodes d'utilisation
WO2024040222A1 (fr) 2022-08-19 2024-02-22 Generation Bio Co. Adn à extrémités fermées clivable (adnce) et ses procédés d'utilisation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749647A (en) * 1984-06-22 1988-06-07 Genetic Systems Corporation Polymerization-induced separation assay using recognition pairs
US5034428A (en) * 1986-06-19 1991-07-23 Board Of Regents Of The University Of Washington Immobilized biomolecules and method of making same
EP0537299A1 (fr) * 1990-03-29 1993-04-21 Gilead Sciences, Inc. Conjugues a base de disulfure d'oligonucleotide et d'un agent de transport
US5658731A (en) * 1990-04-09 1997-08-19 Europaisches Laboratorium Fur Molekularbiologie 2'-O-alkylnucleotides as well as polymers which contain such nucleotides
FR2679255B1 (fr) * 1991-07-17 1993-10-22 Bio Merieux Procede d'immobilisation d'un fragment nucleique par fixation passive sur un support solide, support solide ainsi obtenu et son utilisation.
JPH06121698A (ja) * 1992-10-12 1994-05-06 Canon Inc Ｄｎａプローブ用モノマー、ｄｎａプローブ、及びその製造方法
US5630978A (en) * 1995-06-07 1997-05-20 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Preparation of biologically active molecules by molecular imprinting
US6001991A (en) * 1996-10-04 1999-12-14 Isis Pharmaceuticals Inc. Antisense oligonucleotide modulation of MDR P-glycoprotein gene expression
US5932711A (en) * 1997-03-05 1999-08-03 Mosaic Technologies, Inc. Nucleic acid-containing polymerizable complex

Also Published As

Publication number Publication date
EP1155056A1 (fr) 2001-11-21
AU1750400A (en) 2000-06-26
EP1155056A4 (fr) 2004-05-12
WO2000034343A1 (fr) 2000-06-15

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Legal Events

Date Code Title Description
FZDE Discontinued