CA2348657C - Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante - Google Patents

Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante Download PDF

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Publication number
CA2348657C
CA2348657C CA2348657A CA2348657A CA2348657C CA 2348657 C CA2348657 C CA 2348657C CA 2348657 A CA2348657 A CA 2348657A CA 2348657 A CA2348657 A CA 2348657A CA 2348657 C CA2348657 C CA 2348657C
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Canada
Prior art keywords
sequence
seq
dna
exon
amplification
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CA2348657A
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English (en)
French (fr)
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CA2348657A1 (fr
Inventor
Jean Weissenbach
Jamile Hazan
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Centre National de la Recherche Scientifique CNRS
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Centre National de la Recherche Scientifique CNRS
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Priority to CA2848454A priority Critical patent/CA2848454C/fr
Publication of CA2348657A1 publication Critical patent/CA2348657A1/fr
Application granted granted Critical
Publication of CA2348657C publication Critical patent/CA2348657C/fr
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Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/05Animals comprising random inserted nucleic acids (transgenic)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA2348657A 1999-09-03 2000-09-04 Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante Expired - Lifetime CA2348657C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2848454A CA2848454C (fr) 1999-09-03 2000-09-04 Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante.

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR9911097A FR2798138B1 (fr) 1999-09-03 1999-09-03 Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante
FR99/11097 1999-09-03
PCT/FR2000/002433 WO2001018198A1 (fr) 1999-09-03 2000-09-04 Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2848454A Division CA2848454C (fr) 1999-09-03 2000-09-04 Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante.

Publications (2)

Publication Number Publication Date
CA2348657A1 CA2348657A1 (fr) 2001-03-15
CA2348657C true CA2348657C (fr) 2014-07-08

Family

ID=9549552

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2348657A Expired - Lifetime CA2348657C (fr) 1999-09-03 2000-09-04 Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante
CA2848454A Expired - Lifetime CA2848454C (fr) 1999-09-03 2000-09-04 Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante.

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2848454A Expired - Lifetime CA2848454C (fr) 1999-09-03 2000-09-04 Clonage, expression et caracterisation du gene spg4 responsable de la forme la plus frequente de paraplegie spastique autosomique dominante.

Country Status (5)

Country Link
US (2) US6924126B1 (enExample)
JP (2) JP2003508074A (enExample)
CA (2) CA2348657C (enExample)
FR (1) FR2798138B1 (enExample)
WO (1) WO2001018198A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2647224C (en) * 2006-03-30 2015-12-29 Duke University Identification of a novel gene underlying familial spastic paraplegia
EP1897891A1 (en) 2006-09-11 2008-03-12 Institut National De La Sante Et De La Recherche Medicale (Inserm) Diagnosis of hereditary spastic paraplegias (HSP) by detection of a mutation in the KIAA1840 gene or protein
WO2009127211A1 (en) * 2008-04-14 2009-10-22 Aarhus Universitet Methods and kits for determining spinal dysmyelination
JP6208104B2 (ja) * 2014-09-16 2017-10-04 株式会社日立製作所 生体認証システム、生体認証処理装置、生体認証方法、生体情報取得端末および情報端末
KR101889072B1 (ko) 2017-09-15 2018-08-16 한국생명공학연구원 디지털 PCR을 이용한 유전성 강직성 대마비(Hereditary spastic paraplegia, HSP) 관련 유전자 SPG4의 거대결손 검증법
CN117820470B (zh) * 2024-03-04 2024-05-31 暨南大学 人源性重组抗Spastin抗体及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6197551B1 (en) * 1998-01-27 2001-03-06 Millennium Pharmaceuticals, Inc. Spoil-1 protein and nucleic acid molecules and uses therefor
WO1998046743A1 (en) * 1997-04-15 1998-10-22 The Wellcome Trust Limited As Trustee To The Wellcome Trust Novel ldl-receptor
WO1999042622A1 (en) * 1998-02-23 1999-08-26 Dana-Farber Cancer Institute, Inc. Method for identifying mismatch repair glycosylase reactive sites, compound and uses thereof_____________________________________

Also Published As

Publication number Publication date
JP5965594B2 (ja) 2016-08-10
CA2848454A1 (fr) 2001-03-15
CA2348657A1 (fr) 2001-03-15
CA2848454C (fr) 2018-04-17
WO2001018198A1 (fr) 2001-03-15
US20050266479A1 (en) 2005-12-01
FR2798138B1 (fr) 2004-05-21
JP2003508074A (ja) 2003-03-04
US6924126B1 (en) 2005-08-02
JP2011254824A (ja) 2011-12-22
FR2798138A1 (fr) 2001-03-09

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