TWI358456B - Method of determining susceptibility of high myopi - Google Patents

Description

1358456 - Patent Specification No. 97135019 Amendment Date: August 3, 100. Description of the Invention: [Technical Field of the Invention] The present invention relates to a method for detecting myopia, and more particularly to a method for detecting a BICD1 gene. Single nucleotide polymorphism (SNP) is a method for detecting myopia and/or myopia-related complications. Furthermore, the present invention is more related to a method of screening for treating or inhibiting myopia. [Prior Art] Myopia means that in the case of relaxation, parallel rays parallel to the visual axis converge in front of the retina through the refraction of the eyeball refractive system, which is a refractive error. When a person with myopia looks at a distant object, it cannot be clearly imaged on the retina, so that the image is focused on the vitreous armor of the eyeball, not the retina. Myopia is widely present in the world, and the treatment of myopia is related to ethnicity, gender, and age (Invest Ophthalmol Vis Sci 1997; 38: 334-40; Optom Vis Sci 2001; 78: 234-9; J Formos Med Assoc 2001; :684-91). In the United States, 25% of people between the ages of 12 and 54 suffer from myopia (Arch Ophthalmol 1983; 101: 405-7), and the rate of whites suffering from myopia (28.1%) is higher than that of African-Americans (19.4%) (Invest Ophthalmol) Vis Sci 1997; 38: 334-40). In all myopic populations, the proportion of high myopia (diopter 幺-5.0 D) is 27% to 33%, and the prevalence is 1.7% to 2% (Arch Ophthalmol 1983; 101: 405-7). In the world, Taiwan is a high-risk area that belongs to myopia. If diopter-6.0 D is used as high myopia, Taiwan has a higher proportion of high myopia than Asian countries, and 18% of male students and 24% of female students in Taiwan suffer from myopia (J Formos Med Assoc 2001; 100:684- 91), this ratio is even higher than 1358456. The patent specification of illusion No. 135019 is amended. The date of revision: the proportion of young people in Singapore on August 3, 100 (l3"%) (〇ptom Vis sci 2001;78:234-9 In the national surveys of 1995 and 2000, the prevalence of myopia in the Bay continued to increase. High myopia may cause blindness, such as 'related to retinal detachment, yellow spot degeneration, and glaucoma. 5.6% of all blind children in the United States are related to myopia. Although myopia can be treated or corrected by glasses, contact lenses, Orthokeratology, and Laser Refractive Surgery (LASIK), none of the above methods can inhibit retinal detachment, yellow-lumen degeneration, and glaucoma caused by myopia. produce. In addition, excessive use of contact lenses (Curr Opin Ophthalmol 1998; 9: 66-71), Orthokeratology (J Refract Surg 2003; 19: S247-9) and other surgical procedures may also increase the risk of complications in the eye. In the United States, it is necessary to spend 250 million to treat myopia each year (Arch Ophthalmol 1994; 112: 1526-30). Many environmental factors have been shown to be associated with myopia, and twin studies have shown a significant relationship between myopia and heredity, with family heritability estimated to be between 58% and 90% (Invest Ophthalmol Vis Sci 2001; 42:1232-6; Genet Epidemiol 1988) ;5:171-81; Hum Hered • 1991; 41:151-6; Br J Ophthalmol 2001; 85:1470-6). Experiments have confirmed that family history is an important cause of high myopia (Invest Ophthalmol Vis Sci 2004; 45: 3446-52; Optom Vis Sci 1996; 73: 279-82; JAMA 1994; 271:1323-7; Invest Ophthalmol Vis Sci 2002; : 3633-40; Optom Vis Sci 1999; 76: 387-92; Invest Ophthalmol Vis Sci 2004; 45: 2873-8). However, only a few studies have found genes associated with myopia, but no evidence of large data has been obtained. Therefore, medically, a biomarker is needed as a reference for the detection and treatment of the 1358456 revision date, August 3, pp. 97135019, and the mitigation of myopia and its complications. SUMMARY OF THE INVENTION The present invention provides a method of determining whether an individual is responsive to myopia, including: obtaining a biological sample from the individual, and a CD1 gene in the biological nucleus (at least the sequence identification number D). Single ^ 2 § §: - )) 'where the single-core * acid polymorphism of the dangerous genotype exists, then clothing shows that the individual is sensitive to myopia. A further method of screening for a substance that inhibits or treats a complication includes the step of causing a test substance and a table to be contacted with each other and selecting a substance, as compared with The ability of the mcD1 gene to express. The invention further provides an evaluation-individual pair-the myopia treatment medicine book: 'including the measurement-BICD】gene mononuclear acid polymorphism, basin = material core (four) (four) when a recording type, table (four) individual pair兮Myopia & Ampoule has a good response (positive reaction). The present invention further provides a kit for detecting myopia sensitivity, = a plurality of reagents, a buffer, and an enzyme for the single nucleotide polymorphism of a plurality of BICD1 genes. In order to make the above and other objects and features of the present invention easy to understand, the preferred embodiments are described below, and are described below in conjunction with the accompanying drawings: U^ [Embodiment] In the case of implementation, the present invention provides - A method of determining the individual's easy-to-grey myopic myopia, including obtaining from at least one of the SNp of the BiCD gene in the biological sample (dngje I358:456 Patent Specification No. 97135019 Revision Amendment Date: 100 years 8 The 3rd nucleotide polymorphism.) genotype '-the presence of this SNE_gene-type is not obvious that the individual has nearsightedness. This SNP genotype was selected from the following subgroups: SNPs rs7966276, rsl 151029, rs2650122 and rsl0771923. The variation of this genotype can be a BICD1 gene sequence

A change in column V, for example, may be a single nucleotide change that may alter the peptide encoding the BICD1 gene, resulting in different translations or causing transcriptional function of the gene to be affected. In the present invention, whether the genotype is susceptible to myopia and/or myopia complications can be used, such as primer extension (for example, PinPoint analysis, MassextendTM, SPC-SBE, or GOOD analysis), hybridization (for example, , TaqMan analysis, bead arry, or SNP wafers, ligation (eg, compositional green fluorescent label tt, (CFET tags)), and enzyme cleavage (RFLP, Invader® analysis), PCR-SSCP (single strand conformation polymorphism), MRD (mismatch repair dection), BeadArrayTM, or SNPlexTM. First, a biological sample containing nucleotides (DNA) is collected or collected from one body. The individual of the present invention may be a mammal, preferably a human or an individual suffering from myopia and/or myopia-related complications. • Individuals of the invention include, but are not limited to, adults, young children or infants. The biological sample of the present invention may be collected or isolated from any source having chromosomal DNA, and the so-called sources include blood, amniotic fluid, cerebrospinal fluid, or tissue fluid of the skin, muscle, oral mucosa, placenta, gastrointestinal tract or other organs. Next, analyze whether there is a BICD1 genotype in the DNA sample that is likely to cause myopia. In one embodiment of the invention, the BICD1 genotype can be identified by TaqMan technology. Briefly, PCR primers and TaqMan MGB probes were designed using Primer Express version 2.0, reacted in a GeneAmp 9700 thermal reaction cell and a 96-liter L disk, and the revision date was revised using the specification of Ί 358456 No. 97135019: August 3 ABI Prism 7500 Sequence Detection System and ABI Prism 7500 SDS software version 1. (Measure and analyze fluorescence intensity. In another embodiment, genotyping can be used to identify SNP genes For the related procedure, refer to Mutat Res 2005; 573:70-82, which can be used for genetic typing analysis using Illumina BeadArray technology (Sentrix® Array Matrix) [Shen, 2005 #135]. Simply put, specific oligonucleosides Acid (allelic specific oligonucleotide) is bound to DNA, amplified by PCR and arrayed by Cy-3 and Cy-5 primers for array hybridization and genotyping analysis. In another embodiment, commercialization can be used. Gene chip to identify the genotype of SNP in the BICD1 gene. For example, the Affymetrix GeneChip® Human Mapping 500K array kit consists of two arrays, each of which can be analyzed. Approximately 250,000 SNPs are hybridized by conventional methods and analyzed by the BRLMM clustering algorithm. In addition, if the gene mutation (diversity) causes the production or disappearance of the restriction enzyme cleavage site, the restriction enzyme can also be used. Cutting (digestion) to determine each genotype of the BICD1 gene. First, PCR is used to amplify the bicD 1 gene in a biological sample, followed by an RFLP analysis. The cleaved DNA fragment can show the presence or absence of a specific BICD1 genotype. Further, the relationship between the presence or absence of each genotype and myopia is known. In another embodiment, each SNP genotype of the BICD1 gene can be identified by sequence analysis (sequencing). First, PCR or other appropriate methods are used. Amplify the BICD1 gene or nucleotide, and then analyze the sequence of BICD1 nucleotide acid, BICD1 nucleotide fragment, BICD1 gene DNA, BICD1 gene DNA fragment by a conventional procedure and compare the above nucleotides/ The difference between the nucleotide fragment or the genomic DNA/DNA fragment and the known BICD1 gene sequence. If there is the above-mentioned 1358*456 Patent No. 97135019, the revision date is amended:]〇〇 August 3rd ---------Gene-type-existence--represents this corpus callosum to myopia _ and / or or myopia phase-off-concurrency-symptom--susceptibility. The skilled person may use different methods to identify or detect the SNP of the BICD1 gene, and the skilled artisan can easily understand and

V Perform the above method or other methods. The "myopia susceptibility" as used in the present invention means that the individual is susceptible to or not susceptible to myopia when a certain genotype of the SNP of the present invention is present. The "low myopia susceptibility" as used in the present invention means that the individual is not susceptible to myopia when a certain genotype of the SNP of the present invention is present. The "high myopia susceptibility" as used in the present invention means that the individual is prone to myopia when a certain genotype of the SNP of the present invention is present. In one embodiment of the present invention, when SNP rsl0771923 has a dual gene G genotype, or SNP rsll51029 has a dual gene T genotype, it indicates that the individual is more prone to myopia, and the risk of myopia is higher than other genotypes. At least 1.2 times. In another embodiment of the invention, when SNP rs7966276 has the genotype of the dual gene A, it indicates that the individual is less prone to myopia, and the risk of developing myopia is at least 0.6 times lower than other genotypes. It should be noted that this individual also increases or decreases the risk of myopia due to other factors, such as illness or the environment. In another embodiment of the present invention, the present invention provides a substance (candidate drug) for screening for treatment of myopia and/or myopia-related complications, comprising contacting a substance to be tested with a cell exhibiting the BICD1 gene, and The substance that regulates the BICD1 gene can be screened compared to the control group (cells not exposed to the drug candidate). The genotype of the BICD1 gene (eg, SNP rs7966276, rsl 151029, rs2650122, and rs 10771923) can be used as a search or 1358456 a---------------------- - The State of the State No. 9 has revised the date of this amendment: the biomarker for the treatment of myopia and/or myopia-related complications was identified on the 3rd of the new year. This method is by screening for a substance that alters the expression of the BICD1 gene. For example, a cell is exposed to a test substance or a mixed test substance composition (sequentially or simultaneously), and the expression of the BICD1 gene of the cell is analyzed, and BiCD of the cells not treated with the terrestrial soil and the cells treated with the test substance are compared. 1 gene expression. This test substance can be a known or unknown compound. Tear " substances include, but are not limited to, guanidine compounds, small molecule drugs, glycans, nucleotides, proteins or peptides. For example, the test substance can be - small molecule interfering RNA. 'in

In one embodiment of the present invention, the test substance can inhibit or slow down myopia and/or by visually treating complications by SNP 771923, SNP rsll51029 or SNP rs7966276. In another embodiment of the present invention, the present invention further provides a method for treating, slowing down myopia and/or myopia-related complications, comprising administering to the individual an effective amount of a myopia therapeutic agent (the myopia treatment drug is obtained by the above method. The expression "11" by (4) BICD1 gene expression or activity can inhibit dimorphism and induce myopia and / or myopia-related complications. Gene expression to achieve treatment or inhibition of the two pairs of inventions - the implementation of the state, the invention provides Comment on the agricultural cause:: The method 'includes analysis of the SNP of the (10) gene. If the individual has a certain SNP genotype, the table can be used to treat myopia with good response. In the type method, the above BiCDi Gene gene labeling (base '··, °" Estimating a body for myopia and/or myopia-related complications 10 1358456 Revision date: August 3 曰 又 又 。 § § § § § § § § § When the S genotype is susceptible to myopia, 对1, rsl〇771923, the dual gene σ, or SNp = , indicates that the individual may have a myopia treatment; its - the "good response," And without this special The individual of (10) is more likely to have a broader response to the myopia treatment drug than the individual, and the individual is also more prone to myopia and/or myopia. In another embodiment of the invention, the invention is more A kit is provided for analyzing a biological sample obtained by an individual, and detecting the individual to the myopic gate i and the set includes - or a plurality of reagents for detecting one or a plurality of SNP genotypes in the BICD1 gene. The "t-set" includes - or a plurality of SNP tests: one or a plurality of SNPs in a plurality of types - (eg, 'biological reagents, containers, packaging styles". SNP detection of the present invention Kits include, but are not limited to, probes and primer combinations (eg, two aqMxian probes/primer combinations) 'nucleic acid arrays/microarrays, and include 'several k-pins, primers, or other detection reagents Magnetic bead. The kit of the present invention may optionally include various electronic devices, such as an array (DNA wafer) and a microfluidic control system ("lab_Gn_a_ehip, 'system". The group of the present invention may include no electronic device' and includes one Or #several s Lu

(d) detection kits - generally include - or a plurality of detection reagents, and he must have components (such as 'buffers, enzymes, such as 〇να polymerase or hgases, chain extension nucleus (4), for example, dNTp, and sDNA termination nucleus Bitter acid 'positive control sequence, negative control sequence

The J SNP-certified kit may include - or a plurality of skirts to analyze the target Γ 358456, No. 97135019, the revised specification - the content of the nucleotides 'Compare the target nucleotide with "Month 2

3^吏太(四)明书 to explain how to use this set: To (4) SNP In one embodiment, the set of the present invention includes: Qing '(10) m group is a bribe array, or = column (compartmentanzed kits), such as 4 + ^ ^ "妯mchip" system. ) such as #派控控制系统 / "probe of the probe" such as the dual gene specificity; in the above array (wafer), and each used dual gene position. The polynuclear is directed to, .... In a specific area, each chemical program (the thousands to hundreds of sleeves can include, for example, a plurality of sputums). The independent nucleoside probes are arranged on the miniaturized raft. Early delivery of multiple probes can be combined into the solid support array of the buffer group: including 'for example - or a plurality of reagents, - slow gene detection can be detected - or multiple BiCD 1 SNP two less - substance used The difference and detection of p A are few but not limited to, the nucleotide sequence of the nucleotide, which can be complementary to a certain position of the (4) m genotype, a limit: the standard enzyme) to identify - specific sequence, - the calibration of the primer or the use of % In the present invention-embodiment, the present invention, this region two: Erbo 029, rS2650122, and / or _771923, when the facial sputum has a south degree myopia susceptibility SNp base _ body is a high-risk group of myopia .引...:根Γ= I35S456 泰z No. 97135019 Patent Specification Amendment Revision Date: August 3, 100 -- rs796-6276 ' rsll-51029 '-rs265〇l22 rs 1-0771923-03⁄4 Sequence on both sides design. In addition, after analyzing the differences in the dual genes, the differences in the dual genes can be analyzed by mass spectrometry, fluorescence or luminescence.

V [Examples] 1. Gene Screening In this example, myopia studies were performed on 4000 subjects, respectively. The subjects can be broadly divided into four categories: (1) young males, (2) college students, (3) φ hospital staff, and (4) ophthalmic clinical patients. If the subject's diopter < -6.0 D' and the other eye's diopter $ _4.0 D is classified as high myopia, and if the subject has a poor visual acuity, the diopter is 2 -1.5 D, then The class was tested as a control group. All subjects were between the ages of 17 and 45 and were all Chinese. In the first step of the implementation, the Affymetrix GeneChip® Human Mapping 500K chipset was used, each consisting of 2 wafers, each of which could analyze approximately 250,000 SNPs (about 262,000 for Nsp wafers and 238,000 for Sty wafers). In order to maintain the DNA sample at the appropriate quality, the OD 260/280 value of all DNA samples was controlled between 1.7 and 2.0, and the OD260/230 value was greater than 1. 〇, taking about ι·5 pg (30 μΐ) Genomic DNA of 50 ng/μΐ) was genotyped and the BRLMM algorithm was used to obtain the results of the genotyping analysis. At the same time, in order to reduce the error, all analyses must meet the following conditions: a per sampie cau rate of at least 90% for each SNP, at least 90° per sample. The SNP interpretation rate (per §νρ call rate) is at least 1% higher for each SNP minor dual gene, and satisfies the Huff equilibrium > o.ool). Based on the above results, the SNPrs380619 is further divided into 13 1358453⁄4--------------------^ Patent No. 97130019 amended this revision period: August 3, 100 Analysis. Then use the PLINK program (Jm J //G(9)ei 2007;81:559-75) to calculate the genotype and dual gene frequencies, and perform the χ 2 test to analyze the relationship between the dual gene, SNP genotype and high myopia. In order to analyze genotype relationships in various genetic models, the obtained genotyping analysis data was placed into dominant, recessive, and additive modes, and a trend test was performed. Gene effects including various variables (gender and age) were introduced into the regression analysis, and linear regression models were used to analyze the relationship between each SNP and diopter. Since the diopter greater than -3D is common in Taiwanese, the subjects were divided into normal/moderate myopia (g-3D) and high myopia ($-6D), and logistic regression (Logistic Regression) ) Analyze phenotypes. Hap-clustering was used to analyze the haplotype. The preliminary analysis of this example showed the 10 most relevant SNPs, and the p value was at least 0.0002. The 10 SNPs are located on chromosomes 2, 4, 6, 12, 16, 17 and 21, respectively, and are located at non-adjacent locations. 2. Second step of gene screening In the second step of the present embodiment, one of the most relevant SNPs screened by the wafer is first used, and the 200 kb region at the front and rear ends of each SNP is regarded as a candidate region. In these 10 regions, we selected 384 SNPs and 1536 patients tested genotypes. The refractive power of this 1536 subjects was < -6 D or > - 1.5D, respectively. Genotype identification is using Illumina

The operating platform of BeadArray technology (Sentrix® Array Matrix) (Mutat Res 2005; 573:70-82), this platform will be revised with the dual-party 1358456 Ref. 97135019 patent specification. Amendment date: August 3, 2010 - Gene-specific oligonucleotides - binding and amplified by PCR-program. The hybridization procedure and gene localization analysis of the crystal-chip were performed using primers calibrated with Cy-3 and Cy-5, respectively. Each SNP was repeated 30 times to calculate the highest gene frequency k 〇 Ί ' Overall, the success rate of gene identification in this second step was 97.1%. We found that the most relevant SNP (rs7966276) is located on the BICD1 gene of chromosome 12pll, with a p-value of l.l3xl (T04, and other SNPs in the BICD1 gene are also highly correlated (SNP rsll51029, p= 4.78x10) 4; SNP rs2650122, p= 3.65xl〇·2; • SNP rsl0771923, p= 2.70xl0-2) 3. The third step of gene screening in the third step, using TaqMan technology (Applied Biosystems [ABI], Foster City, USA) to analyze the highly correlated SNPs obtained in the second step. Briefly, PCR primers and TaqMan MGB probes were designed with Primer Express version 2.0 in 96-well plates and GeneAmp 9700 thermal cyclers. The reaction was completed and the fluorescence intensity was measured and analyzed using the ABI Prism 7500 Sequence Detection System and the ABI Prism 7500 SDS software version 1.0 software. In this third step, all subjects, regardless of their diopter DNA, SNP _ genotyping was performed. In the third step, the BICD1 gene was mainly focused, and the SNPs of sl0771923, SNP rsll51029, and SNP rs7966276 of more than 3,000 subjects were analyzed in different genetic models. Due to the effect, the gene frequencies of each SNP are shown in Table 1. Referring to Table 2, when the secondary dual gene G of rsl0771923 has an additive effect (p = 0.00088, 〇R = 1.22) or 1358456------ ----------------------------- - A patent specification No. 97135019 Amendment date: 100 years August 3 rs 1 15 The dominant deleterious of 1029 can obtain the most relevant results in two phenotypes (g-3D as a control group and S -6 D as a myopia), while SNP rs7966276 The correlation with myopia was lower than that of the other two SNPs. When the myopia was analyzed as a continuous variable, the three SNPs showed significant results, as shown in Table 3. Figure 1 shows the frequency of the SNP rsll51029 dual gene T The relationship between the diopter and the diopter, the horizontal axis represents the diopter. Table 1, the dual gene frequency and BICD1 gene typing analysis rsl0771923 rsll51029 rs7966276 diopter sample number MAF sample number MAF sample number MAF ^ -3D 1305 0.375 0630 0.211 1215 0.040 -3D to -6D 941 0.400 1148 0.228 953 0.027 ^ -6D 1027 0.423 1139 0.247 794 0.0 25 total 3273 0.397 3917 0.226 2962 0.032

MAF (minor allele frequency)·•minor dual gene frequency table 2. Logistic regression analysis of binary features (normal/moderate myopia vs. high myopia) genotype 〇R(p value) N (%) N (%) N (%) total additive additivity recessive rsl0771923 AA AG GG ^-3 D 509 614 182 1305 1.22 1.30 1.30 S-6D (39.0) 338 (47.1) 510 (14.0) 179 1027 (0.00088) (0.0024) (0.021) (32.9) (49.7) (17.4) rsl 151029 AA AT D T-3-3 D 1027 519 84 1630 1.22 1.30 1.21 ^-6 D (63.0) 646 (31.8) 423 (5.15) 70 1139 (0.0017) ( 0.00088) (0.263) (56.7) (37.1) (6.14) rs 79662 76 TT AT AA ^-3 D 1122 90 n 1215 0.61 0.62 ^-6 D (92.3) 755 (7.40) 39 (0.24) 〇 (〇) 794 (0.0114) (0.0161) (95.0) (4.91)

16 1358456 Patent Specification No. 97135019 Amendment Date: August 3, 3, Table 3 - Analysis of Flexion and Luminosity by Linear Regression Model - Genotype Additive Recessive P値βχ 100 Ρ値Β χ 100 Ρ値Β χ 100 Ρ値rsl0771923 0.0128 48.4 0.0032 29.2 0.0115 35.4 0.0230 rsl 151029 0.020 46.9 0.0060 28.8 0.0060 29.6 0.181 rs7966276 0.022 -125.1 0.0060 -62.7 0.0077 -173.8 0.260 Although the invention has been disclosed above in the preferred embodiment, it is not The scope of the present invention is defined by the scope of the appended claims, which is defined by the scope of the appended claims. quasi. 17 1338456 Rev. 97135019 Patent Specification [Description of Schematic] Figure 1 shows the relationship between rsl 151029 dual gene degrees. [Description of main component symbols] 〇Revised date:] The frequency of T on August 3 of the following year and each refraction i * »> 1358456 Ref. 97] 350] Patent specification No. 9 Amendment date: 〇〇Year August 3, Sequence Listing. <110> Kaohsiung Medical University <120> Method for determining the risk of an individual suffering from high myopia v <340> 097135019 <141> 2008-09-12 <160> 1 < 210〉 1 <211> 270,957

≪ 212> DNA < 213 > Homo sapiens < 400> 1 atttccttct ccctttcccc gccagcttcg catccatctc ccccaccccg taaccccctc 60 ctgcctccat ccaccggggc tatggccgca gaagaggtat tgcagacggt ggaccattat 120 aagactgaga tagagaggct aaccaaggag ctcacggaga ccacccacga gaagatccag 180 gctgccgagt acgggctggt ggtgctggag gagaagctga ccctcaaaca gcagtatgat 240 gaactggagg ctgagtacga cagcctcaaa caggagctgg agcagctcaa agaggtgagt 300 tgcctgtcac ctctcccttt cctggccctc actcccccca cccgcaaggc ccactcatca 360 tgatcaagaa gtcataaagg aggtgattga aaggactgtt ttttcttcta gggccctttg 420 ttggtaagag aagattgaaa gagtccattg tttcctcccc caagagaaaa attgcctaag 480 aaatgaatat ataagctgga atttgggagg caatggctgt ttggcctgcg ggggagggag 540 attagtaaga gtcatcaagt ctcagcactc taagacgaca ttcaagtggg ttggaatgta 600 taaatcaaac ttctcaaaac cgctgttatc tcaaacccag gtttcagcga caatttcgta 660 gtccacaaaa gtgatgaggt ttgtgcctga ggacccacaa tttcaggatt tagactgtgt 720 Ggcacctcag ctttcctctg gatgtaacca ctccttggtg agagagggaa ctcctcacca 780 atcccatttg acaaaggcta ggcaatcttc attct gcttg gctttagtca ttcttgtcat 840 tgggctgcag aagaaaaaca actttgctgg gtgatcccac tgccttgatt tcacctcgga 900 gcgaggctgg gccatgtcca astcttatga ggtcaccctg actagaaaaa attgaactca 960 cctacaaata gtctgaaaga gtggtgtata tcaaatacgr gggtagtgtt gcaittcaaa 1020 tgaggctctt ctggttgaaa tgatatattt ataaaaccag aatatcaaaa atgggtgatg 1080 tataatgtct ctttagtttt ttggtatttg gcctctttta aagcctgtcg gatgtatggg 1140 agaaaacaat gaacgtgctt tgatttccta tcagtcactc ttaagaacat acatattgtt 1200 taagtaactc ggtctttttt atctgattct tgaggcacta tgggtagcaa ataaccactt 1260 acaaatttaa atgtaaiata cactcctttt ctgtgtgtca agtccttatt tttaggtgca 1320 tattgacatt taaatgttaa ttattgtttg gcatataata tcaaaaatct attaittatt 1380 itatgctgtt acagttaaaa gatgtgattt atgacatact gaatcaactt gccttccaat 1440 ttagtgtgta atatggtaag catttatact tttagatatg tcttattttt atttggatgc 1500 ctgtctacca aaaaataaat gtactaccta tgattaaaaa tcccaactag gaatctaatt 1560 135845¾ ^ a - 'No. 97135019 Patent specification revised Revision date: 100 years August 3曰tngtgtgtc aggctgraaa rtictggtt c ctanttact iaccatgtac ctgtctggtc 1620 itaacaacag ctggacttgi tiataitnc caacuagat t2ggctgaca tgntaaatg 1680 cagrgargct aaacctrgtg aagtgaggaa gcaggatgat gactgtcarr ctcagagatg Π40 tttigatatt gtctatacct atcaacactg ctttsccaag atagggaagr gcaaaccaga 1800 aagtggtaag ccatcacctt cttgataaag gagarggact iaatttaatg aaargtacct 1860 cttactgact itgcigcttg autaaacaa tccnctagg gatatttctg tcangcact 1920 taccttgcai agcaaaccti aargcaattg tgrnigccr ttgcracacc atgagcittg 1980 catcccaagt ctttaacaca aaagctagca cacagtgggc atgaaatati ttatgaaaga 2040 atcagtttgt actagaagaa ggcacact11 tatcaagggt tcactagtca atattgarta 2100 gtgttagata aatactaaga aaattaggat gtataggaag tgacagatgt taataaaact 2160 acctgtat ta gmcaccag cagtaatgag aaaaatgtga aaaaaacgtt ttgtaggaai 2220 aatgtaactg tggtttctta atacagaata atgcaaatac caactaaaat rttttctata 2280 aatattttaa latatatttt gttctatata gcaggaggtt aataaaaatt taccagcatt 2340 atrtuacta aacgaitctt gttcatatat ttattttcag ttgcatttag cataagtgaa 2400 attcgagatt cctaaaaaac iggtttatac Agttaiataa aaa tgtartt taggtaataa 2460 aattattata gttgattatt tgatagtgag gcctartatr tnattcrrt aaacatagaa 2520 tatactttag ttggaaatat aacttaaatg agttaaattg atttcaagta acatttcttg 2580 tatgaaaagt aaatccaaaa taattgtgca aactgaggtg ttccaacacc tcagutrga 2640 aaaatatttt gtgagtgttt tgatttttca aaagaaagtt ttgctcatca ggtatgtata 2700 giaaatgatg ttgcattata tctataaagc caagcataaa ataaatcttt gcttatttct 2760 aggatttttg aacaaatatg atttatttaa aaataattga accagtttar gggaatgtca 2820 acagaaaact actgtattaa gtccaaattg gacattagta atttgcagta tagcaacatg 2880 gctcagtcrt tgcagatcat tttgttttcc agagtcagta cccaccaatg rtgctacctt 2940 ccttcccagg ctaggtactg ctgtgacaat aatgcaagtc ggcagtgrtg cctaaagaig 3000 tgcaaaatca agaagatgaa attcatiaaa tttttttcct agttatttct tccctcaact 3060 caattgtttt ttgacctggc ctgatgttgt ttagtgctct gcatggacta ctgtaattca 3120 gctcacagaa gaacacactt gaaagaatag tactaaggat ttgaaaaaag gatgacttct 3180 gacaicatca aagtgttctc cttttcatga ttctttgggc agctggacag agcagtargt 3240 ccactagaat acttgagtct ggtrttgtga tttcacaagt aacacngct c ttcagtgac 3300 ctgagtgagg gtcacccatg cccagtcatg ttcagggcct ggctgattat argtttggga 3360 tgtacgiaaa tcagcactgt gcgcctgtca cccaggccag aatagtgttt gaagaagagt 3420 catagctcca aaataacctg aaaactaaaa atatacatat ataaaaatac cttggatcta 3480 aacttaagag ttttttttac accgcatgtr ctcactcata gatgggaatt gaacaatgag 3540 aacacatgga cacaggaagg ggaacatcac actctgggga ctgttgtggg gtggggggas 3600 gggggatgga tagcattagg agatatacct aatgctaaat gacgagttaa tgggtgcagc 3660 acaccagcat ggcacatgta tacatatgta actaatctgc acgttgtgca catgtaccct 3720 aaaacttaaa gtataataat aaaaaaaaag agtttrrttt taactiaaaa atggtrgaaa 3780 tttaaaatgt tgtaaagttg aaaaagagcc ccttagaaag gaatgattea gcattact £ a 3840 iggcatttta aaaaggaaat gtarctgtga gacagctita gaaaagtttt gcagcttgga 3900 taccgtaaac latgcactaa tgagcrtcaa cccarrtict tgenanu grcaacccig 3960 acaccaagga tagnaccag ctgctgaaga agcactftcr ggacattggg cagcttttic 4020 111tggagee aactctanc tttncaggg ttatagttaa atcattcaac acaaaaatat 4080 2 amended date: 1 August 3, the following year

97 1358456] Patent specification No. 35019 Revised gtacttacac agttttagag cttgtcacat tggtgacctg atgaa ^ tgcca cttaaaiiac ctagattcai ctttaagcag aangttuc ccttcagaig cttagaaaga ttgrtagttt ctutatatc tttaagnct aaatcacaaa aicatatggc aagaaaaacc ccagatiret tttccaatct atgaataaac ataaagagac agttaaiact taartgatet atct〇aacta tgatttttaa cttctctcat tgtttttart ttittatttt attttatttt auttgagat ggagtetege actttcaccc agcctggagt gcggtggtgt gatctcggci cactgcaagc tccacciccc gggticacgc cattctccig cctcagcctc cggagtagci gasaciacac gcattcacca ccacacctgg ctaatttttc gtaittttag tagagatggg ctttcacctt gttagccagg atggtctcga tgtttttaaa gaaaaaarat ttacatttat latcaaatta atettaaaat ctaaaataca ttaagatatg cttttggaaa clgtttacaa acaacctcaa caaataaaca teategetti caaicacatt tcttttrtie tggacccagt tgctctaact tgcactatcc cttttttttt ttrttttttt tttgagatgg agtttcactc ttgttgccca ggctggagtg caatggtgtg atctcggctc accgcaaatt ctgccrcttg ggttcaagtg attcttctgc ttcagcctcc egagtageta ggattacagg catgcgccac cacacctggc cagttttgta tttttagtag Agatetage git tcttcatgtt ggtgaggttg gtcttgaact cccgacctca ggtgatccgc ctgcctcagc ctcccaaagt gctgggatta caggcgtgag cccccacgcc cagccccttc tttttatttg aaatcaagat ttegtetetg gegaagttat ttctcagata taaettagea agaatttatc atcttttatc acattcccca tgtttatgtg aacatgtatg acagcgatgg tttgaaggtt icttcagaac tttctgcttg caaatattit gccctatcat ccccttaaat atagttgtac tcatggatai tgctttccaa atttgaaaat aeggtaatta attaettgea tgttgaaata tacataaagg acttgcccac acataagatt ccacctgtaa ttatggcttt gaggagagga gggeatgaag ggctgcatag tctiagtatt aaataattea ttaegetaaa ggagaatgea cgtaaagtca agtggcagga gatgcaattg tgaaagggcc atggccacat tttgtcttgg ggatgtegag ccattgaaaa taaatgaaac agtcactgtg tttaatetea ccagtcttca aaacaattca gagggcttac tgctcatttt tactgataag aagataataa aaataataaa gcattgactt aggtacaagg ctccatttag aactaggttc 11tacaagcc tcacctctaa ttcatgcagc aatccttact caaggtaggt gtttcttgca ttatacagaa gaggaaactg ggtettagag aggtttaggt ctcttcccag ggccacaaaa ctaaacgatg aaacttggaa gaagcccact ittttttcac tgcatcatac taccttgaat atgaaatatc tctgccaagt ctacaa gtgc agtatagaag gttatggtga tggtcatagt gggtggattg aggctgtgtg gtgggacaga cagtggcagt agggatcgtg aggagggggc aegtetaaga gctatttggg aggtagggtg gaacaggcat tggatgttac tatatgtgga aagtgaggaa gacagtggag cigagaatct tctcaggctg gataggaggt ggttetattt acaaaggaag gtattatggg gcagagcagt tttagagggt gaaatigatg ctcaagttac atgagtttct gttgtttttg acacagggtt tctctctgtc acccaggctg gagtgcagtg gtgctgttac agctcaccgc aaccttaact aaccatcctg gctcaagiga tcctcccatc tcagcctccc aaggagctgg gaatacagac ccatgccacc atgcctggct aatnttttt tgagactgag tctccctctg tttccccagc tggagtgcag tggeatgate tcagcccact gcaacctttg ccicctgsgt tcaagtgatt cicctgcctc agcctcccaa gtaactggga ctacaggagc ataccaccat gcttgggtaa ttttitttti tttttttgag ctggaaictc actctatcac ccaggctgga gtgcagtggt ctgatctcag ctcactgcaa cctccacctc. ccaggttcaa gcgaitctcc tgccicagcc tcctgaatag gtgggactac aggtgcctgc caccatgcct gaataatttt ttttrttcca agacagaatc tcgctctgtc 4140 4200 4260 4320 4380 4440 4500 4560 4620 4680 4740 4800 4860 4920 4980 5040 5100 5160 5220 5280 5340 5400 5460 5520 5580 5640 5700 5760 5820 5880 5940 6000 6060 6120 6180 6240 6300 6360 6420 6480 6540 6600 6660 I35M56 Patent specification No. 97丨35019 Amendment date: August 3, 100 gcctaggcrg gagrgcagtg gcgcaatctc gget tactgc aacctctgcc tcccgggttc 6720 aagtgatici cctgcgtcag ccacctgtag aigggauat aggcgcgcgc caccacgcct 6780 ggctagtttt tsiautti tt tagtagaga cagggutca ccatgnggc cagagtggic 6840 ngaict tct gaccicgtga tccacccacc tt £ gcctccg aaagtgctgg gaitatagge 6900 atgagccacc gcgcccagcc taaittttgt act π tagta gagagaagat ΐtcaaacatg 6960 i tgc.ccaggc rggiCLgaaa ttcctgagct egagegatet gcctgcct ig ccctcgtaaa 7020 gtgtggagat tacaggcatg agccat tgtg cccagccaca raagteent laaricargt 7080 rt tct t tgct ggggaagcgi acattgcatg atggattcag atcctcaact tt CL tt Ϊ 111 7140 tctuttttg agaiggggtc team tgtc acctaggctg gagtacagtg gtgtgaicgt 7200 ggcttactgc agccitgacc tcctgggctc aagcaatcct catgcctcag cccccaagia 7260 gctgggacta caggtgcaca ccgccatgcc tgactaatti ttgtattttt 11 tgtagaca 7320 cagggttttg cc atgiaagc caggttggtc tagaactct t gagetaagga cagiccgcct 7380 gttttggcct cccaaagtgc taggattaca ggciaacttt caat t taata aaaaaaat ra 7440 atttgtgcaa ttggttgtta tmatagaa gcctaat t tc tagaatatgg gatataaaca 7500 at t taataar gn t tcacca gttagtttga ttgctttcta aattaggaaa aatgaaaaca 7560 aataaacgat gggcaaaaaa gctgactggg gacagtaagg tetaagaagg cagcctaagt 7620 ggaaaat tag ccct tactca ccatttaggg ttatgggggc tgggagcaac agtcctcact 7680 gcrcactgac raatctttat caatct tat t laaterttat tgaagatgea t tagcai trt 7740 raatttaagt gggtttttit cctct t net tttggtgggg ggtgigggcg gcgggggagt 7800 ttcaatatgt tgaccaggct ggtet tgaac tcctggcctc aagcgattci cccrcctcag 7860 cctcccaaag tgctgggait acaggcatga gccangcac ccagcctm ctat 111 tea 7920 trtcaagagt ttgcttttta agaat taaaa ttgtgtaatt atgacagtti ttattgcagt 7980 actccaagct agagaaaagc Atatataaat taatagtttt ccct tct tct cccacagt tc 8040 tgtctctgt t gt taacact ΐ tgctgagtat tct tcigtac ttgttttaaa tgtett taaa 8100 catataggca gggtttttgt gtgtgtggtg tttnggtti tttttutt t gctgttttrc 8160 ttCCtitgtt mataaaaa caggatcttg cagcctggig ttttaaattt agtagtatgt 8220 cctticaaaa ggcaggtatt tacgagacaa agctgcattt ttaaagcact ggtgaagrgt 8280 gaagaaaatg agaccgatta gggaagaaaa cccgagaagc tcagagtt tg ggtgaccctg 8340 gggargtggg aaggiggtga aaatggiacc ctgagggrag catggaiggt aagigaaaga 8400 ggaaaaggtg taggtttgca taaaagaaac tgatggaatt tggatgccca atagcagacc 8460 caggggaatg ataccagggg aaaagatgga cagttttgtg ggtaaat tag cagtgatt tt 8520 gattcct tgt cttgttagct gctgatggag ataegigtai cagcataaia cctggctagt 8580 rtccatggcc ggcaagagcc agtcctgcag tgtgaccaca tcctgtccat tcigggtctt 8640 ggtggcaagc caggatgatt caggcagttg ggctttatta cgttatccct tcittgccct 8700 ctgaaagctg agtttigaaa tagttaggat cttatacaac atcicagatt cagcatgctg 8760 tgcaggaggt ggggagaaaa gggtacaaaa gaggaaaatg ttcagtgaag gtgnat tac 8820 aaiggagggg aatatgaaag tggaaattga taccitttcc icttgggait taat taagtc 8880 tataaaatta aggtgttgca atacaraatg ictatgat 11 11111 tacca Getetaaaic 8940 tctgagatgg ctgtgrt t ta gagcigcatg t tet Gettat t tact geetg tccir tacat 9000 t tcaaat tea rrcaaratrt ttccaaagta cagaatagt t itgcctagt t gcagtaar rt 9060 icacctagac i tcagggatc ticcatcaac tct r ttatgt ar 11111 ctc ct t tgt 11 rt 9] 20 ccactctggr cactcagt tc tagccaagat agtccacct t at mageae t tgtactatg 9180 tctctgtctc tgtctgtctg Tctgictgtc igtctcictc tctctctctc tctctctctc 9240 4 1358*456 Revision period:]August 3rd, 971350] Amendment to Patent Specification No. 9

11 tctctctc actctgtcgc acaggt rcaa cactatgctg ggcccaacta gctgglcttg attgtaggtg iccctttitc tctcacctat t tggcttcag ataaatcact agtaatgaat tatggggagt tcggat t tct tttat act it tgt t tggcat aaaact t tat aagctttaag aagctacgtg cgggcacatg tatatataca rcictctctc tctgactgaa gtaatccicc gctattttit at 111 tagaa aacttctggg tgaacractg tttgaacact tatgt tatag agagcagaac ttctgacaag tccctgtcac. Tgtccttagg ttgattttta tcccaccacc ttcacactat tttgatttat atgagtgtat gt tgcat tga tgcatgtgca caaatatata iatatatata gtacagtggt cacctcagcc tmttttaa attattattt ctcaagtgat tgcctggcct tggtccaaac aactgatatg aaggccctgt tgtagitgtc caaaagggag aaggggtata tcattccagg agagcagtgt ttgatgactg gttttgcttt ctciaaaiti gggaggtcta tgact t tata tacacacaca tatatatatg gcgai tacag tccagagtag cctgatttig gcagagatga tctcccacct tctacattrt tcacttttct t tacgt i tgt gagtcactgg tagtaatgga aagctagtga tctagaatga tgticcaaat t tccaacatg taaacatttg attttcagaa ggagagcttt cagcctccag ttttgtcatt cacacacaca taat 11 tgag cccactgcag ctgggaccac tttttact£g ggttttg tta cagcctccca 11111 taacc tctggat rca 11 teat tgat gagccagait atgaggeagt gccact tgei tetetaaggt aatttgataa gt taaai tgt gaatgttttc gaaaactaat cagtgaaact aatcttcttt taegettagt cacacatata atggagtctc cct igacctc ag £ tgcacac aggctcaggt tgtrgctcag aagtgtiggg at t tcatagt tarrttctga gcgtctgtac ttggatcaaa ct tct tagga gagaatactc teattettat gtttatgiit tctgcrttaa acagigtctc gggtaatata gtacarttrg ttcacacaca Catatatata iatatatata 9300 9360 9420 9480 9540 9600 9660 9720 9780 9840 9900 9960 10020 10080 10140 10200 10260 10320 10380 10440 10500

tatatatatt tttttttaag accatatttc getetegitg tccaggctgg agtgcaatgg catgatctca gctcaccgca acctccacct cccagtttea agcaattctc ctgcctcagg ctcccgagta gctgggatta caggcatgca ccaccatgcc cagctaattt tgtattttta gtagagacag ggtttctcca tgttggtcag gctggtcgcg aactcctgac ctcaggtgat ctgctcgcct cggcctccca aagtgctggg attacaggcg tgagccatcg caccggcccg cttagtccaa tattttattt tattttattt tattttattt attttttttg agatggagtc tcactctgtc gcccaggctg gagtgcagtg gcgcgaactc ggctcactgc aagctccgct tccctgggtt catgccattc tcctgtctca gcctcccaag tagctgggac tacaggtgcc cgccactacg cctggccaat ttttgtattt tggggtttca ccgtgttagc caggatggtc tegatetett gaccttgtga tccgcccgcc tcggcctccc aaagtgctgg gattacaggt gtgagccacc gagcctgg.cc tagtccaata ttttataatc tgeategtea actagtcagg ccccagaatc tgtgggttca gcatccttgg attetgeate cttggattga aaatatttgg aaaaaaaatt gcatcggtac taaacgtata caggcttttt ttggtcattg ttccctgaat aattcagcat aacagctatt tacatagcat ttacatcgta ttaggtatta taagtaatet agagatgatt taatgtatac tggaggatgt gtgtaggtta catgcaaata ctacactat ttagtacaga t ttatctcaga gaettgagea tctgtggatt ttggtatctg cagggggtcc tggaaccccc acaccctcac ccagactgag ggatgactgt atttacgtta tctaccactc tgatgttttc tttttgcttt agattgccca ttacctcttc atctgtttca tttattcatt caaaaatttg tattgagtgg ctactgtgtc gggcatggtg ccacttgctg gagatacagc gitgaacaag acagacccaa tggggctgcc tgggtggagc ttatgtttca gactgggaag agagtcaacg aacatccaca catatttcag ttgtgagagg tgccatgagg gaagagacag actggctggg gaaagcgtga teaggeagte ttccccagga ggtgagactt gagcccagac 10560 10620 10680 10740 10800 10860 10920 10980 11040 11100 11160 11220 11280 11340 11400 11460 11520 11580 11640 11700 11760 11820 1358456 Patent Specification No. 97135019 Revision of this amendment date: 100 years S 3rd cigaatgatg acaaggagcc agtcatgtgg agactsggga atgtgattπ taagaagagg i 1880 acaagtgcca agaictgcga actctgtigt agttgttagg ggaagggatg gguaccarg ] 1940 ctcigtaaaa argaccattc atatttgaaa Taigaccatt ctgtaacaca gtgiaitgcc 12000 tactggat11 ttctaatgag gtattgggtc icaacattgg aaaigtttga gcagaccrtg 12060 gatatciccc tgaggtcttc tcrgagaaga ggtgggtagg aacta gtgac trrcaataca 12120 gactgtatgt tagaatcacc igggrgat 11 araaaaciac tgctgcctgg accccactcc 12180 gggagagna aaicactcai tggaagigga gcctggcnc agcaigtgaa tcccact tcc 12 + 240 cttagagatg cagccaggst aaagaacccc tcttciaiat ticcaacttg aggactaaai 12300 gaccccatgg gcgtagaagt gtrtagtaag aaaatctagt tccggstgca gtggcicatg 12360 cctgtaatgc cagcac.ttag gaccaacgtg gcgaaacccc atctctatta ggagaccaag gcagatggat catatgaggc caggagtttg 12420 agaccagcct aaaatacaga attagctggg 12480 catgctggca tgcgcctgta gtcccagcta ttcgggagac tgaggcatga gaattgcitg 12540 aacccaggag gtggaggttg cagrgagctg agatcgtgac acttcactcc agcttgggcg - 12600 acagaacaag actctgtctc aaaacaaaac aaaacaaaaa actgggaagt taigagctaa 12660 tacataaacc ttcaitgcac agtctutaa aatttgttgt tictactttc igaaaatgaa 12720 aatattaaat ccttcctgaa aacagaaaat atcaaaaact taactgcatt agacagagat 12780 atatgttaac ttiga £ tgca ttiaattttg tattcttgag tactgtttaa agtgtctttt 12840 aaaagttctc icitaitgtg tctatttatt ttattctgtt Tgcagtttit atgccaactt 12900 tacacatttg taaatagaat atitaaaaag aatt titttt gagggattga tctctaacit 12960 cttggtgact tatagttgtt cttttggttg tacatcttta ctgttttcca acattttaag 13020 gagaaaaagc actactctca aaigtaatat ttaactgctg tgtttctatc rttaaatata 13080 gaattgaaaa tgagaacctg tttatattta tgggagcaat agcaatatgt gtacaataac 13140 agtagcaatt tccttaagaa tgitctgttg cagtttggcg tgggtctgtg atagaaggtt 13200 cagaatgatg ggtctttgtt tttctcttgc atactgcaga gtaatgtgga atcaaatacc 13260 actattgaag agcicttagt caicaatttt tgaaactgaa agaggtttat attgtaagaa 13320 ggatgggccc tgttgataag cctcactgat tgctacttgc tagatggttt taggagatat 13380 crtgaagttg accttgtgtg aggtiactgg atggaaacag catgagtita atcttgtaca 13440 tgacttcttt tgttgagctg gagatactat tgtcttgcag attatctcit tggcacgcat 13500 gaccattttt tttttgtctt ttaaatcaca aactggcttt ctttctgcta aggttggtgt 13560 gettagatic tttaagctcc aaatctcaag aaaatatagg aaggaaaatc aaccattaga 13620 gagagagaga gagagagaga gagagaaaaa aaaaaggaaa aaatataatg igctccaaac 13680 rgattataaa taget tt tga artgttgget ccaragaat t titttttttt ttrt t tgaga 13740 Eggagteteg cgctattgcc ca ggctggag tgcagtggcg tgatctcagc tcactgcagc 13800 caccgcctcc rgggttcaa® tgattctcct gcctcagcct cccgagtagc tgggattaca 13860 ggcgtgtgcc accatgcctg gctaagtttt tgtatcttta gtagagaegg ggtttcacca 13920 tgtiggccag cctggtcttg aacctctgac ctcatgatcc acctgtctca gagtgctggg 13980 agtacaggcg tgagccacag caccrggcgt ccatagataa ttttaaaaat tcataccaga 14040 tctiaattaa tgttggcatt aaaaactaat ggtggctcat gcctgtaatc ccagaati11 14100 gggaggccaa ggtgggrgga tcact tgagg tcaggagttc aagaccagcc tggccaacat 14160 ggtgaaaccc tcictctaci aaaaatataa aaattagerg gaigtgatca tgcgtgtctg 14220 taaicccagc tacttgggag gctgaggcag gagaaactct tgaacctggg aggeggaggt] 4280 tgcagtgagc taagatcact ccattgcact ccagcctggg egagagteit gttctgtctc 14340 caaaaataaa aaiaaaaata aaaataaaaa taaaaataaa agegetgagg tggaaggatg 14400 6 amended date:〗 August 3, 2000

13584564 No. 97135019 Patent Specification Revised gcttgagccc aggaggcaga gactgcagac agccaagatc gcaacactgc actccagcct gggcaacaga acaagactct atctcaaaca aacaaacaaa caaagaaaac ctacggttaa tgatatagtg atctgaacaa cagaagatct cagtttgtca aantttttt tttttttttt Lgagacaggg tctcactctc ttgcccaggc tggagtgcaa tggtgcaatc tcggctcact gcagctttga cttcccaggc tcaagtgatc ctcctgcctc agcctcctga gtagctggga ctacaggtgi gagtcaccac acccagctaa ttttttigta itttttgtag agacagtgtc tcacaatgti gtgcaggctc gtcicaaact gttggactca agacatctac ctgcctcagc ctccaaaggt gctgggatta caggtgtgta ccactgtacc cagcctcagt ttgttaatat tttacaataa ittagaagta gaaccctttc ttaaggctgg gcgcgctggc tcacacctgt aatcccagca ctttgggagg ccgaggtggg tggatcacga ggtcaggaaa tcgagaccat cctaacacag atcgagacca tcctaacaca gatcgagacc atcctgacta acatggtgaa acccccgtct ctatgaaaaa tacaaaaaat tagccgggct tggtggtggg cgcctgtagt cccagctact caggaggctg aggcaggaga atggtgtgaa cctgggaggc ggagcttgca gtgagctgag aicgcgccac tgcagtccag cctgggcgac agagcaagac tccgtttcaa aaaaaaaaaa aaacaaataa caaaaa aaga agtagaaccc tttcttaaga gcattctcag gtcttctatc ttaattactg tagttatttc cagtcatgtt ttataatcag gtgctatttt tcattgtggc- ataataagta atatattttt gtaaatcatg ttgaagtgct tgagacaata caagcaatta tttgctaaaa tttagaccag ggtctcaaaa caacaattac atttttagat aatggtcaca gtaagtcttt tcagaaaaaa gcaacgaaga aagctctaga ccaatgagat tttagtcatc attaatcaat gccaagcgaa aaaatcttaa gatgtattta aatttgtgat gccagtgtga ttcagaaatt tgaaaaatgg atttcaaagt aatgctgtga gcagataggt cattgtataa acataactaa tggttcattc attcattcct acaataatga ttcagtgtca gatttgggtg ttgaaaatac agcagagaac aaacacaaca gaaggtccat atΐtgcggag cctacatttt gtgggggaag agagatgata aacaaaatga atgagttaag tagatagcac gttagatcat ccaaaatgct atggggggaa aaaaccctgg gaatagggag atggcatgtg aagtggaaga aggttatgat tttcaataga gtgatcagag aaagcctcat tgagaagaca cactaaggag gccatgtggc tggaggggac tgagttaggg ggtgaatagt aggtgagacc agaggggecc acatgatgta gcagcttcta gattatcagg actttggctt ttgctctgag tgagatggga aacittcaga gagctttgag cagaaaagtc acaatgttct gcactttttc cttcattgag ataacctctg catacattca agc acgacta agaccccctt cagggaaaag aagttttcat taactcagta tcccatgagg tatatggcat tctcttcctt cccac.catag caggtgttta ataggtggtt atggtattgc actgatttag gctgggaaaa aattaaagat gaagttatta agacagccag ttgtggtcgg gcacagtggc gcacgccggt aatcccagca gttigggagg ctgaggcggg cggatcacct gaggtcagga gttcaagacc agcciggcca acatggtgaa accccatctc tattaaaaat acaaaaaata agccaggcgt ggtggcaggt gcctgtaatc ccagctaccc gggggctgag ccaggagaat agcttgaacc igggagatgg aggttgcagt gagccgagat tgcgccactg cactccatcc tgggcgacag agcaagactc cgtctgaaaa gaaaaaaaaa aaagacagcc agttatttea aaagaggttg gagtagacca cttgttttaa aaataaccac ttgtttgcct aggttaaacc catttactca aaagacactg cgctgacttg cctggttcct tgtacctgaa tctttaccta agtgtcttgt gctctctgtc ctttattctc cataatgcga gctatccagt agaccctagc caaaggggac ataaagacag tctcaacatt gtattactgg uctgtgcta cagttgtcat tcaagttcct gagaaaatgg aatgaatgtc tgttattcat ttatttatta aatctttaga gagcatcatc tatatgccag 14460 14520 14580 14640 14700 14760 14820 14880 14940 15000 15060 15120 15180 15240 15300 15360 15420 15480 1554 0 15600 15660 15720 15780 15840 15900 15960 16020 16080 16140 16200 16260 16320 16380 16440 16500 16560 16620 16680 16740 16800 16860 16920 16980 7 Patent specification 97135019 amended this amendment date: August 3, 00 gtaitatgca tgitgttgga tr tgagt taa tatttgaaat taagtggtaa ct tgataaat ttggctgtgc gatcaggcaa ggctatacaa ggcaacagag gaacagactg gaigtgaacg ggaaaaatgc gaiggatgtg tcgataggag catttgaggg aaattaggaa ataaatgaai rgittgaaat ttggtttcct atgtgaagga atggtgacaa tggagggtag ggctttgaag gacgtgaict tgtgatatt t ccct t ragca cctcagtaaa 11 taatacag taatagtaat caaactcaec aataagtagg r. tatttnaa tactggaaac gctatgtgac atggagaatg tatctgacac aataataaaa ugaatcaga gattttccgg gnacttatt aatatgagt t ct taggccaa ataataacta atgacaagca taaiaatgtg Gt aatctcct ggagagaaga 17040 17100 17160 17220 17280 17340 17400 17460 ggggcaaagt ctgct tgtca ggtgagcctg gt ttctgcca t tgagagcca catgccctcc agaggcagct tgggcaccca tacagacccc actgagcttc aatattctcc tcttttctct gtttccctta tatcatgaga t taaagcgga tgactaacct aaatggaatg gcag gaactc caacacittg gggcaacatg tggrggcaca cccaggaggt agagcaagac ttgccttgaa cact tagagt ggaccctaca cagact teat tgtgtagaaa gcagctctct attcttaaaa ttttgggagg acatagigaa cctgtaatcc aggttgcagt cat tcaggaa gtgtctgtgt gagagatggt gccaaggct t gaccaggagt tttgtatatt cctcagtcta ctgtcctctg tctgattcti raatggttga tgcccati tg ctgttcctgc tgcctcttga aaageat tga tttttgactt tcctgctagc aatgagtega ttagaagtaa ggaagccaag gcaagacccc cact tgtagt ggagttigca rccatctcaa tgcatttgct agaggaaata actatigtgg accccaccaa ggatgaaatc ttgaagacac aaaaaaaagt ccgaggcggg accttgtttc cagctactrg gageegagat gatgaaacag tgttgcagta ttggggccag cagcatagct acctgtgact actcctactg cgtggttgga cactcttgge tcagaccct t atttgttaat iggttcaagt acagggtcaa aagt ΐ tcaaa tagat tctgg aacaattaaa ctact tggta gcagtgtgti gcaggtggat gtctctaaaa cccagctgct gttagctgag aaaaaaaaaa gaatcagtat ggagataaag ggggaactgg tgggctctca t taagattag tcgctatcat tgctggccgg tggatcact t tactaaaaat ogaggetgag cagatcacgc ccigtagaag ttaaatctgt Gggaggtaga atggggaaag gactgtaaca aacaaggggt t tgageette tgaccaggt t tagatgctgc 11 tgagagee gaatgttgag taggat teat ttaacctcca gagcact tag gcaggagagt caatacagtg aatgctgagt aggatgetea ggetaggege cact tgaget aaaaaaaaaa cgggagcctg at tgtgtcac aaaaaaaaag tggttcaata cctagaatct atgtggtggg ccacggtttg aatgagagtg ggtgggctag gtatggtggc gataccagga acaaaaatta gcaggagaat cactgcactc agggaagget tggaatgggg ctgrgttaig aagttgggaa ctgggaggat tgggctcctg gcctaat tgg tcccaatgtc cctgatgccc ctct t tccat tggctgtttc ttttctttct gagctcagat gacataatta gtcctgtggt gcaataaaaa gaggctaaaa agtggctcag caggagtttg atgccaaaat aggtgggaga tgcactccag cagtgcatca ctgagcat ta ccccagattt aaaaat tgta cagactgt tc aacgcaggit aaatagteae icacacctgt gttegagate gtttggcatg igcttgaacc tagcctgggc ggagagagtg tgagagggga ggget tgtca ggeettgett ctgctgctcc tgaattaggg ccctttggft cctgatctct tgeagtet tg actagact tg tctgctctcc cctctgggaa ttacactgta gctttatgtt ciaagacatc actagccct ctgaatcaaa cctgtaatcc agaccrgccg taggcagaca t Ategettgag cctgggcaac aatctgactt gttttccggc gggetccaga tacctcttct aca Ccgagtt ggtcatgcct catagatagt aatcuagca agcctggcca gtgatgcaag cgggaggtga gacagagrga 17520 17580 17640 17700 17760 17820 17880 17940 18000 18060 18120 18180 182.40 18300 18360 18420 18480 18540 18600 18660 18720 18780 18840 18900 18960 19020 19080 19140 19200 19260 19320 19380 19440 19500

8 Revision date: August 3, 100

1,358,456 No. 97135019 Patent Specification Revised gactctgt11 aaaaaaaaag aaaaagaccc tgcagaaatt aaaattgtaa aaatataaat atacaaggaa caggcaccag gcaccmgg ctccacatcc ttgtcatcac ttcatacctt gtggctciag tttgcatttt tgtggctgct tatgaggtcg igcctcttca gtatttacag gcatttatga ctatcctgca ctgaaatgca tttcatgtct ttgctcaitt accartggat tgtttacatt rttcttcctg atttgiaaga gtatacacct ataclcatat tctgtatact aagccttttt agtratttag atatgttgga aatatctttt cctagtccat gggttgtctt tttactcttt ctgtggtatc ctttgaagaa gagaagtita taattttaat ttagttgatt tatcactctt ttgtgtttct aggttgtatt tttctattct taagaaatcc tttccatgaa gtcataaaaa catgcaccta tattgtciic tgaaiatctt atggtttgac ttttataitt aaatctttaa tlctccctgg aattgagtti tgtgtttggt gtgaggtaga aatctaattt aaattttttc ccatgattcc accccacccc ccaataaaat tagccagtga tctcagtacc acaggttact gaacagttga tctrtcctgc actaatticc aatgtgtgtt ttgtgataaa tcaagtttit atatatgcat gggictattt ttggactatt ctgttacatt ggtttgttgg tctattcttg tgcaaatgcc acactgtctt actctiacca ttttaatata agttcttggt agctgatgga ataattcttc ttattttgt t cttccccagg agtcactggc tttggacacc ttccttgctg icataggctc tttgctttgg aaagctctca acattiacaa ggaagtgaca agtgtgaacg aaggcagatc acactgttta tttccgtttc cccaataagc attaaggagg aggatattga gggtctagtt gtggttgtct tagactttgc acatgttttt ataagcaaag cagacaagct ccagcaaggg aactcaattg tctaattaga tgttaccaga aatcttattg gggctgtgat ctaattcttt tttttttttt tgagacagac tcttgctgtg tcatccaggc. tgcagtgcag tggcgcgatc tcagttcact gcagcctctg cctccgaggc tccagtgatt ctcctgcctc agcctcctag gtagcgggga ttacaggtgc atgccaccac acccggctaa tttttgtatt tttagtagag acagggtttc accgtgttgg ccaggctggt ctcaaactcc tgacctcagg tgatctgccc gcctccgcct cccaaagtgt ggcgtgagcc accgcacccg gcctgagcta attcttaaga agtcactttg gaaaaaaata ttatttaagg gcttttcata aagtattcaa aaaggtacaa gttctaatct aacagttcta tttgtgattt ttgaggaagc atatgcgtat ttccacttaa gcatctgaaa tattgcctct agtgctgaac aaattcttcc cttggttatt ttcctcttat ctcagtccct ggaagaataa atgcctgtac taattctcta tatacataaa tggtctcttt aggiataaat aacctcataa tcacataaaa gttaaagttt taatggaaaa ggctgagatg aaatatt tgggatcaca acc taagtaggaa ttaattgctt tttatcactt tacattattt catttttagt attatgaaaa atataattgt tccttttctt aaaaaaaaac cagcgtaatt tgtgcttagt tttaaaccaa aatttttcct atatgtttat agtttatatt ttcaagccaa aatacttgag tttttttcct gtcataatat atcaatatga gaaatgtatt gttactttag aatcttttaa aacttctttt tattcctttt tttgtttttt aagatagggt attgttttgt tgcgcaggct agaatgcaag ggcacgatct tggcttactg tagcctcagc ctcccaggtt caagcaaccc tcccacatca gccatacaag tagccgggac tacaggcatg caccaccatg tccaactaat tttttttttc tttttttttg agacagaatc tcgcrctgtt gcccaggctg gagtgcagtg gcacgatctt ggctcactgc aacctctgcc tcccagattc aagagattct cctgcctcag cctcccgagt agctgggatt atgcaccatt gtgcctggct aatttttgta tttttataga gatggggttt caccatgttg tccaggctgg tctcgaactc ctgacctcag gtgatccgcc tgcctcagct ccccaaagtg ctggggttag aggcccaact aattttttaa aaaututg taggccgggc atggtggctt atgcctgtaa tcccagcact tigggagicc aggcagacgs atcacctgag gtcaggagtt ggagaccagc 19560 19620 19680 19740 19800 19860 19920 19980 20040 20100 20160 20220 20280 20340 20400 20460 20520 20580 20640 2070 0 20760 20820 20880 20940 21000 21060 21120 21180 21240 21300 21360 21420 21480 21540 21600 21660 21720 21780 2.1840 21900 21960 22020 22080 9 1358456 - Patent No. 97135019 Revision of this amendment date: August 3rd, 3rd, crggccaaca ΐagtgaaatc ctgtctcrac taaaaataaa aaaaartagc caggtarggt 22140 ggcacatgcc tatagtccca gctacttggg aggctgaggc ageacaartg crrgaaccca 22200 ggaggrggag grtgcagtga gctgagatgg cgcaactata ctccagcctg ggcgacagag 22260 cgagattcca tctcaaaaaa aaaaaaaaaa aaaaaaattc igtaaacaca aggigtcact 22320 atgtttccca ggctggtctc aaactctggg ctcaaccgat cttcccacct cagcctccca 22380 cagtcctggg attatagaca tgagccaccg cacctggcct aaaactcttt cttcaacatt 22440 aagaaataag acrtttccag tctcttictt aaccctgtac ccTtticttt cicatcttct 22500 rrtatcccct ccctteatta actttacatt gcaataccaa ggacnaatg gtttgtiaaa 22560 aaaatgaatt Ctactcagta gaaaattee! gagaatat11 attaaatgtc actgggagga 22620 aatttcccta agcaagatac aaaacttaga atcaaaaggg aggacigact tatttggttt 22680 tagaaatgaa aaagaacagt ttggaagaaa tagtgcgatg tggaigacn ac aaacaau 22740 artattccta aaatataggt acaatgagtr tatrgaaaac aacataatgc aataggaaaa 22800 aaggacaaag agcaactagt cagagaggat ttgcaagtaa atcagtaaat gggaagagat 22860 gttcaatctg agtagtcagt gaatgtaaat taaggaagtt taettitnt cccartaaii 22920 racaaaaatt ttaaatatga taatatacag tgacaaaatt 11m11111 ttgagatgga 22980 gtctcgctct gtcgcccagg ctggagtgca ctgggcaatc tcggctcact gcaagciccg 23040 cctctcgggt tcatgcccu ctcctgcctc agcctcccaa gtagctggga ctacaggcgc 23100 ctgccaccgc geteggetaa ctttttgtgt ttttagtaga gacggggttt caccgtggtc 23160 tcgatctcct gacctcgtga tcigcctgcc tcagcctccc aaagtgctgg gattacaggc 23220 gtgagccacc acgcccggcc ccaaaatttt taaataatga taatatacag tgtcggaaag 23280 tgtgtagage tagaagtgtg aattgctgtg aactttgaga acgiggattg gcagtctgta 23340 ttaagateta aaatgcatac agtgcttggg cccagcagtc tcacagaagc cataggtgat 23400 tgtatgtcag ttcccaaata ccactcgtta gagagaasca ctgtttaaca tetagtatet 23460 camagacc ctgtttgage atagatcata tgtgtgtgga acataaaagt aatcgaagta 23520 tgctcattct ttttttaaca tatctttcca ggettetata tagttaaata a ataatgctc 23580 cttgacattt atgtatttat ttatttagat ggagtetatt tctgtcgccc aggttggagt 23640 tcagtggtgt gatctcagct cactgcaacc tctgcctttc gggttcaagc aattctcctg 23700 ccttagcctc tcaagctggg actataggca tgcaccacca ttcccggcta at111tgtat 23760 ttttagtaga gacggggttt cgtcatgttg gccaggctgg tctcgaactc ctgaccicag 23820 gtgarctgcc cgcctcagcc tcccaaagtg ctgggattac aggtgtgagt caccacgcca 23880 ggctgctccg tgacatttaa ataaaatcat attttaaast ccagttgtaa gcctatacat 23940 • cccccttatc aettatetet aattcacttc tagacctggt ttgaactttg gatttagtgc 24000 tttcaaagtg tgattttttt 24060 aaaaaaatra tttttctgtt geegtatatt rcagctcttc 24360 aaacaactct gttgcacaaa tcggtcttga aaagatttgt gagccttttt gacaaaaggt ggtgctcatt ttetatiteg 24120 gtggctccag taaagggagc tgctctctca teggatgatt attgccccca gaagtggtcc 24180 taccatagct ttactggtca gttagccaga atttacacat ttactctgag gcttacaaaa 24240 atactgtgit cataaaaagc cctccttcac atttt〇tgaa acagttgcat ggtgatttgg 24300 gatatmaa gtttaccatc acctctctgt cctctgcaaa aataaaaatt gtggaatgra aaggggaact tg 'gtgtagsa aaaaataaci agaaatgata 24420 actacgagac actgcactcc caaattgaag atttaaaaaa attcctgatc gtaaataaga 24480 aaaattatgg agacatttat ccactgcata tctgatgact aaaegettgg tataccccag 24540 ccattgttag gtgccagggt acaaagttcc igccctcagc gggttgacac acttgtgggg 24600 gagaaaggea acaaaagctt aagcaagtaa atgeataatr ttacagggtg atargtgcia 24660] square amended Date: August 3 100 years

1358456 * 97] 350] No. 9 patent specification Revised aaaactaaat aaagcaaggt ggaggaataa caagactggc gggggtgctg gctggggtgg ctatttgaga aargagggcc aggcatggcc trrcagagga gaigatgttg gagctgaaic ccaagiggtc agaaggagca aggtgggaaa aiatttgagc aagatgggaa aatatttcag ttcctgggtc aaaagtaaca gtaagigtaa agatcttgag atgggggctg ggcactgtgg ctcacacctg taatcccagc tgtitgggag gccaaggtgg gcagatcatg aggtcaggag ttcgagacca gettgaccaa tatggtgaaa acctgtctct actaaaaata caaaaattag ctgggtgtgg iggeaggege ttgtaatccc agctactcag gaggetgagg caggagaarr gcttgaaccc gggaggcgga ggttgcagtg aaccgagatt gtgccactgc actgcagcct aggcgacaga gcgagactct gtctcaaaaa aaaaaaaaaa aagatcttga gatgagaatg aactgggttt ttgtgaaaat ggcaaatggc attttgggta ctgcaagcct ttgeggeteg gaactgtgct gtgcactgtg ggactgtgtg gctcaatgcg ggacggttag catccctagt cactgtcatt acaaaaacag tcacacattc tagacaccca ctgcccgccc caacgccaag ggggcagtac tgccttcaac caggacccca aaagactcca gtgtggcagt tgttggggag ggggaatgtg agaggggcag tggagaggga gtcagcaagc aggttctctg agccctggtg agaagtctgg attttatttt aag ccgcctg agtgatgtga tttcatacat stttttaaaa gatcactctg gttattcctt gcagacagtg gaagagtgag ccaagttagg aggetattge agtagttcag gtaagagatg atggtggctt agactgagag agaatctact tgagggtaag aagtgatctg attcagggta tatgttgaaa gaittgetaa ttaattaaat atgggaggca aaagaaggtg gagaaatcag gatggctcct aggtttcita taaggageta ggaagaatgt aaagaaatca tatgataagg agatataaaa aggaataaaa taatatttca cacttaaatt taggagaega aatatttgct tatttgaatt tgaaaattct tgtggatacc aatattgata ctttgtctga aaaataattt taagatgagt ctcctggcca ggcggggtgg ctcaigcctg taatcccagc actttgggag gctgagtcag gtggatcacc tgaggtcagg agtttgagac cagcctgacc aacatggtga aaccccatct ctactaaaaa tgcaaaaatt agccgggtat ggtggtgcac acctgtaatc ctagctactc gggaggttga ggcacaagaa tcacttgaac ctgggaggta gaggttgcag tgagccaaga tcgtgccact gcaagccagc ctgggcgaca gaacaagact ccatctggga aaaaaaaaaa agatgagtet gccaaaatgt ttctcatttg gaagggattc atgactttgc cagaaaaaca ageageatte tatagttata atgetetatg atgtaattta ctggacctaa gttggctacc tttcatgatg cataitaagt gtggagccat atttcttagt ttctgttata aagctaaact gt taagteat ttttaitcci ataaagtcaa acaaactagc catggatact ttttaacatt ctgtgaaacc aactttatcc agtttctgaa atggatgcca gitctttttt tttttttttg agatggagtc ttgctctgtc ccccaggctg gagtgcagtg gtacgatctc tgatcactgc aacctccgcc tcccgggttc acgccattct tctgcctcag cctcttgagt agctgggact acaggcgcct gccaccacgc ctggctaatt ttttgtattt ttagtagaga cggggtttca ctgtgttggc caggatggtc ttgatctcct gacctggtga tccacccacc tcggcctccc aaagtgctgg gattacaggc ctgagccact gtgcctggct ggatgccagt actΐtΐtaaa ccaaagttaa aataattatt tataggaage agttgtgcac Igtagattag gaacatggag actggggcat aaatatattc ttgagetaga attaaagtaa aacatgtgac. tgatggaaat aacagctctc cctgigccct accaiggaac ttggtaagcc tttgttaact cactggcact gctagatcat gctatggtcc ccgagggcca gggaggcaag tgtgctagtc caagtaaaaa gctgatatga tettigtatg aacagaaaca ctgtttgtaa tgtgatgata acgttggttt cttgctcctg ggatattgtg ttctaggtaa agtggtccag agaccaatgg gtggcagata cagggataca gaggtcaact taatataaaa π 24720 24780 24840 24900 24960 25020 25080 25140 25200 25260 25320 25380 25440 25500 25560 25620 25680 257 40 25800 25860 25920 25980 26040 26100 26160 26220 26280 26340 26400 26460 26520 26580 26640 26700 26760 26820 26880 26940 27000 27060 27120 27180 27240 1358456 Amendment date: August 3rd, No. 97130019 Patent Specification Amendment aaagaccrtc tctaaigtct aagagcagag tgaaagrgag caggccatci gaggagagag agacttccct gttggctcat caigaigctr aagcagagcc aaaaagctac ttggtaggga tgtcaaggaa gtgagtcagg tgttttcagc- accgcgactc tgtcattgrg tgcctctctc crtaatacct cagaattaga ataaagtcu gataacagta gtggcaccag tcctgtggtt tgt ΐ t tgcga tgacigigtg gt rgt taaac t tt ctaagtg aaacaccara gtgtcgggag caatgccgac aagcctggcc acctttggtc tacagcagar attgcaagcr gatarcccgt ggccacagtc aggctrggtg attgataaac atr irgattt agggagctgc tttmcaag aaacagaatc acataaacag gatttcaggc cagictcaaa Aaactggaag atttcacaga gccttgggcc cacarttcig tgrggcatca gag^gcraga ggrgaatgag tccrcctctc ctctcctctc cccctcctcc cctccattcc cctcccctcc ccuccccgc tcccctccrt taittttttt tggtctcagt cctgagtagc agagatgggc gcctgcctcg tttttttttt agigcagtga acatctcagc ttaaatttat cctcaagcga ccmcutt tctgagt tar gacatgtgag aaaataaagg gcaggacttg gtataggact ct t tgtccaa ggcaactata gat tatgtgt ttgaaggtag gtctgaacgt tagagctcca tcacccaaac gcccttgggc aaggggctgc acaggaaatg ggggcagagg gctgctcagg gagtaggggg tatctctcta at tct taaga gctatartat actgttttgg 11 ttaigaga tcattgcaac tgggattaca tttcaccatg gcctcccaaa tttttttttt gacaaacaca ctcctgagta rgtagagaca icttctgcct agaaagagcg ctcactatct tt ttgact tt gggaaggaag cattctcagr gaigtttatt agtacacatt algticcact gtcttactca ggaccatggc cacactgtta aaccagaagc ccagaaaacg taacccttta agggaacaac gacaggtcct agaggctggg gtattgacat agagagaata gaaggaian aat taagaag eager t tgct 11 tagcatga cggagtcica ctccatctcc ggtgcatgcc ttggccaggc gtgccgggat 111 tt tgaga gctcactgca cctgggacta acact icact t tacatccca tgaatctcta ctgttcttcc tgattgagai gtggagaggg tctgcctct ΐ t ttgtattag ctnagctgg gncigtgat act ttgtatc t ttctctt tc aataattaci Aaaaaggaai aggatcgtaa gtgcctctgg cagccaggtc gtccagtgta ggatcggtat gccat tuga actgggcatc cacccatact gtgat tcttt tatggctcca ct ctagmt ctgtgtcacc caggttcaag accatgcctg tggtcttgaa tacaggcatg cagggictct gcctagacct caggtgtgca atattggcrg aagtgctgga attcaccaga ctcatttaca gctgacaccc acaaaggaga aaaicttgga atcatatata t〇ctcctctg tat tgarttt accaagcacc t ttactggac taacaactga 〇〇tgctgggc gccccttcat ctgcatcact cagacatgga gataaaatga t〇tagcaatg taaatacatg cccttctgta cacct [gtcc gccaaccata gaagtggcca cac tgaatat caggctggag ccat tctcct gctaattt ta ctLgtgacct agccaccatg tgcgctgtca gctgggttta tcaccacacc gcctggtctc at tacaggca gtccccacca tcatctgtca tcct tccctt ggcgtgtgga acctatt tct taggagtacc tgttcccctg caggtctgtt racgtggcat actgtataga ccagaactaa tggggcacti gggccaaatg gtcagagtaa caaacataat cagcagctaa caggagtcct aattaatgag gatccrcagi acti tgrgcc t tccagttct t taatacctg t tagtat t tt tgcagtggtg gcctcagcct tatttttagi caggtgatcc cgtggct ttt cctaggctgg agtgatcct t tggctaattt aaartccrtg Tgaacct tea ΐ tccatctca ct tacctgt t ctaggaaagg ggatgatage tcatctaaca tggcatataa taaagactga tcctccacca rttttcrtrt tgtcatgcag ggctgtggtc tcctcia Aca cagggciggg ggtaaccagc rggaaggaag ggcaggttga gtcctgagtg tgagi t tega ettetagid agagt igaac ttatrtagga gagctaaaac taagt taggt 27300 27360 27420 27480 27540 27600 27660 27720 27780 27840 27900 27960 28020 28080 28140 28200 28260 28320 28380 28440 28500 28560 28620 28680 28740 28800 28860 28920 28980 29040 29100 29160 29220 29280 29340 29400 29460 29520 29580 29640 29700 29760 29820

12 Revision date: August 3, 100

1358456 蟾 Patent No. 97135019

Ltttttgng ttgttgtttt tgumgti ttgtttgaga cagtgtcicg cictgttgcc cagactggat igcagtggig tgatttcagc tcactgcagc ciacactgcc tgggncaag aaaiicttgr gccccagcca cctgagtagc tgggattaca ggcatgcgcc accacacctg gngatttit giatiittag tagagacagg gttugccgt gtttgccagg ctggicttga acicctggcc rcaagtgarc agcctgcctc ggcctttcaa agtgctggga ttacaggcai gagccaccgc acciggccta aggttaattg tititaiaag caaattattt tgcttttgtg acccaaagca gtactctcag atacttagtg tagcaattta ttactcagat atataacttt ttacaaagag aatcatagca gaaaagaaca aggtaacgig ttgtagggca tatgttctga aggagcactt gaccttatct tctgacatca tgtaaagatt ttggcattta gtgtcatcat gtgcaaccat tgttactitr tgctactgra tcataataat acitagtcgt atcagtttga ttaaatgcct cctttgtatg gttcccagca gcatggctgt agaaagtatt ctcaaattta tcaggagacc caagttttaa ctttgtaaaa aggcctccat tactggaggc caaaiataaa aacttttttt rttttgagac agagtctcct tctgtctcci aggctggagt gcagtggcgc gatctcagtt cactgcaacc tccgcctccc aggttcaagc gattctccig cctcagtctc ccaagtagct gggattacag gcacgcatca ccatgcctgg ttaai111tg gtgtttttag taggga ttcggattcc cagg gttttgctat gttggccaag ctggtctcgg acrcctgagc ttaggcaatc cgcctgcctt ggcctcccaa agtgctgaga ttacaggcgt gagccaccgt gcctggccaa atatataaag tttaaaaata gctcgcttgt gttcattgcc taccacatac tgggtattgt gctagatatt taatatgcca gatagcatat gcctcattag cctatgaagt agaggctttt attatlattt ccacttacat agatgagaaa attgcagcac agaiaaatta atttgtctag cgatggaacc aaaatctcag tcaggcagtg tgacttcaaa gettgtattg atagaagttc tccaagtgct ttaaatatat taactcattc agactcacca agctgtgcat ttttagttta tagagttgat atcagtatta aataggaata tgtatgtgta tgtatttata tatgtatgea gatggtccct gaettaaega tggtteatet taatgatttt ttgactttat aattattttt tgactttata attttttgac tttatataaa ccatattttg ggtgcccaca egtetattet gtttttcact ttcagtacac cagtcaacaa attacatgag ctattcaaca ctttacttta aataggcttt gtgttaggtg atttttgccc aaatatagge taatgtaagt gttttgagea tgtttaaggt aggtgaggct aagtaagctg tattigatag gttaggcgta ttaaatgtat ttttgactta tgatattttt caaactatga tgggtttact aggacataai ctcatcatca gttgaggage atctgtatat gtatgtgttt agatagatat aattagatat ctatatataa tagattetat gctat gggca ttgtaagttc taaattgett cagtggcatt attgtacatt cttacataag attgaagaat tttgigattt tgattaattt atatccttca aagtgaccag gaaggtagag tttgeatgea gaaaatttgc atgtatatta attccataaa taatgtttgt agttaaattt tcattttgtt taaacatttt ttacaagata gagtttactc agtgctgtta tttageaget gtgtgtatga cttcataatt tagggggctg tctgttttgt gttetaagee acgtggctgc tgtggtgact gctttagaaa ctttcagttc cctttgctgt gaaacaggtt teagtgeate gtccctgtgt ataaggtcag gtttcuaca tggactcact ctgtttctgt aaatttgtct gagaattttc aaggcagtgc tttcatggcc tctcctctaa ttttgtgtgt gtgtgtttgt gtgtgtctgt gtgtgatgat gaaaaagtca aaagccctaa aattaaatca gagtttaatc catgtcccta aactagataa gctgctttag accttttcct tatccct tac acgtcgctca 〇taaatact t getgat tgac 11 tcaaat tc agat tact it taegetagea tacggtgg〇c acaaagggtΐ tttttgttta 11tgrttgtt tgagaeggag tctcgctct® tcgccaggct ggagcgcagt ggtgcaatct cggcicactg caacctcctc 29880 29940 30000 30060 30120 30180 30240 30300 30360 30420 30480 30540 30600 30660 30720 30780 30840 30900 30960 31020 31080 3Π40 31200 31260 31320 31380 31440 31500 31560 31620 31680 31740 31800 31860 31920 31980 32040 32100 32160 32220 32280 32340 32400 13 I35W56 Revision date: 100 years August 3rd 97135019 Patent specification rtcctgggt t gcgccaccac. ccaggatgct at tacaggcg acagaaaact gagaagcagc gtggctcctg cgagcgat tc gcccagctga caaacccctg igagccaccg igrrggcgtg agaaccatct cct r tgtagt ctcgtgcctt 11 π rgiat t accicgcgat ctcctggcct ittcagtnt gtccgtgtac ggarrccct t agcctcccaa rrtagiaaag ccgcccgcci ggscacagag cagagtcuc cgaggacgga gctgtgcigt gtagctsgga acggggrnc cggcctccca r taaaaaaaa tataaggtci ictcagcagc aattaagica ctacagacaa accaigt tgg aagcgcigag aatactggia tataccagcc tctctgr tea geeggeagga 32460 32520 32580 32640 32700 32760 32820 gncctgttt ccatgt tat t atcctctggg atttettgag aatgctaaat tctggcaaag agaaaatgcc t tgt 11tt tg agcrcaargc cctccartga tttgattctg tttcttcagg tact tcgtgt ataactgcat gggaaacccg acccagaaag tctcacaaat ctgttttgtg ctgtgaacat cagcgtttcg at tat tcaag 11 π gt cc ΐ g gaaaaatatg aggcccttcc tcgcccaggc tcaagcgat t gcccagc.ta a ctcaaacccc ggcgrgagcc cgaagccagr gtgarteng acaaatgnc tcttatcaat ggaaaaatta aaagtttaii tgagggggcc. gtggagtgga ct let tccaa at tatgaaaa gettataatt gtggamtt taaatgtcaa ataeggagte aaccccgcct aggaagtgee tgtttacagg tgaataaaat gtgtagtttt caacaacatg gamut tg gaaaacacat teaggeatet tctttccct t aaggcgctcc atgt tgcact gcci tgt tat atgactgcct gcaaaaacaa 11 tggacaca iggagtgcag ctccrgcctc 11 iticta 11 taaccnaaa accgcgcctg ggt rr retag ntcatt tgt atcgaatgta gt tttacatt gggagggaaa gacagcctgg tctcccggct taat t ΐ ti11 gaagcaccac tctgt tagat atactcccaa ΐ t tccatggc gaatacaaca tcgctctgtc cccgggtica atagtgtggg aactgtgtct gt tact tgea ggcat ttaag t tatacacca ttgtacttga tggaggaett gttaaccctt tggcggagtg atctgccgct cctgtcttat ctagtttata gtgactaat t aat tetatat

CtttttgiU tggtgcaatc. Agcctcccga tttagtagag tgatccatcc gcctggacac cct i mart igggcrcaac ngctgaaca agagggatig cgtgatggct ggagaagtac ticctgcatg at ticcctga gaaagcttgc tgaattaett agagaaattt tet tgt t rgt gcccaggctg agcaattcgc aggatettrt gtagacaaaa tctcctcatt gaaacagagc gaggaaatgc aatcttccgt tgtaciagt t egagggeata gt tacct 111 t taaagtgaa tagatatcaa get tat tcag tgtgttrttg t teraatgee tgttttgttt ttttgtttct tcggctcact gtagctcgga gfggggtttc gcctcagcct ccattttgaa egeegr regr ccccagagcc catagictat aaacaggaga actgaaactc caggccrgta cactgcct tt ggtcttggit aaataaatgg ctttttctca ct ticactgg tataaaaaai tgugttgtt gagtgcagtg rgcctcagcc tattttctac agcaaaatgt gtcacagtgt taaaaaaaaa ggcgactiag agaaegtaeg ccat tetaat taagttcaga ctgagccctt gatttataat ctiaaagtta aat t tat an t tat taagci ccatgagaaa ttgageggag gcaccctcca gtacaggcgc accatgttgg cccaaagtgc tagcacttac tgtaaget Tc tagcacatag tf 111 tcaaa «ageggat tc rat tgaagia atcccagcac gtgttacctg taacagcagg cagatgaat t tgt rcaaaac cttcct t rgc gtaatatttt gttg t tttgi gcgcaatctc tcccgagtag gcgcaccgta tggggittag tegtai taca acaaaggaca gttctgtgat tgt t tgcatg tctgtaaaat gccatgt 111 ggcttgcttt tcaaacaaga agaaaatgga tcigan 111 aagat igtat tcigat t tag tet rgctctg ccicctgggt ccgccactac ccaggctggt tgggattaca cacagattcc ttoagteng taggtgacga aaggtataaa ttttcaaara tgtcaacata tttaggagge 32880 32940 33000 33060 33120 33180 33240 33300 33360 33420 33480 33540 33600 33660 33720 33780 33840 33900 33960 34020 34080 34140 34200 34260 34320 34380 34440 34500 34560 34620 34680 34740 34800 34860 34920

14 1358456 Date of revision: 】August 3rd of the following year, Amendment of Patent Specification No. 97135019

caaggigggc gggrcaciag ccccgtctci attaaaaata agctactggg gaggctgaga agctgagatc gtgtcaccac aaaaaaaaaa aaaaaaaaaa tatctatcta tctatctatt tcaaattaaa aatgctΐtat attacaacag ccttcgcttc ccatattrga gggctreart tctctcatga agcacccaaa acagtctaat gctgccagat cttgtggact ttatgaaatc ttgcattgee tttgctgtgt gtgctacaag ccgttaaata ttcitcatag cacltartac gtcattcttt taccagacca ctgtgggaaa tataccatat aataatataa acctgctatt agcaccgcac aatctccatt cattgtccac aacttgttgt aatttagttt ttgtctgctt ttaatgcttt ttctttcatt ttgtacacag tgctagttat ccacagttta tccattttit atgaatagtg ctgctctgca etatgagegt gatcacggtg agcgatcaia ccaatttatt cat tggatat tgteagattt tggtacitat aatttgcatt ttatttcgat ttcctaattt cctgtctttt caaaatgatc cctttattct ttgtatgtgt gtcctttgat aaaattctca ttatgtattt ttgtgtcttt tctttcataa ttagttcttt etttgaatet aca〇tagttg ccagggtgaa tattageata aaatetaaga tttttccttt gtacaagagg cataaatcca aaaratgtct icttagatat taaatgaaga atcaccagga ettagtaat t get t teat ta tcaaaaaatc tattatctac aggreaggag itcgagacca caaaa2ttag ccaggtgtgg ca ggagaatc gcti £ aacct acttccagcc tggscaaaag acaaaaaacc ccacctatct ggtetateta tetagataaa tgUatttat ageatgattg acatctgact ettgeageat agttirctaa gccttaaaaa atatagacag cttticttat cttiatctgt cagggacttt ttgcatgcag cacaatttga tcacagtggc actccatgag gttetetett ctcaacctai ctcctgatta tattttttgt tetagtetea tatgtetata atacagaaaa agtgcacaaa catgtagcca ccacccagat tgtgcccttc tccatcgtag aataatttac ttaatlttct tttgaacttt a <: atgaatgg taacattttt rtttgtgtgt ttcattttgt tatggtatag agttgatggg ttttgacttg cctgttgtac atatagcctg gtgtagaatt gccaatcttc taccttccag cagtgtatga taacatttgg ctcaactgat atccctagtt actaataagc atgaaatgee tgtttaagtc tataggagtt ctttgtataa tgcaaatatc ttcatctctg atttggtgaa tgtaattgaa aagaaatttt tccctatgta aacccttcat aactttgagt aattgeatat atagaggett tcacaatagg acagtaggga tctgctcatg aaaaatgm cagtgggtac. aaatgtcaaa acgaaacatt ttgtcaaata catgtgatac agtgaaacta atccaggcag gttaatattc tgaaacct11 tatatagcaa gcctggccaa catggtgaaa tggeaggege ctgtactctg gggaggeaga ggngcagtg agtgagactc tgtctaaaaa atcctatcta tetatetate aataecagtc aactaatttt tttttctata aaaaaggcat tcrtaiaaag agatctcaca aarttcatca traagattar tttc.ttttct tcaattgttg tgatgttgtt ggagccatct aacttcattg tgcattcaai gcttaactat ggagatcctg tcccctatcc tgcttttctt ttgccttttg tctatcacct taacctttct gaaaaacatc catgaatata cagtttaaca gaaggaaata gaatatcata ctttctclgt cccagacaac tttatagttt tatcacacat aataatattg catatattat gtgtgagatt ctccaggttg tatcccattg tatgattgta ctttcattgt ttgggctatt gtgaacatgt ttgcgaattt aacctgcctg tattttccaa gaatteteta ttctcaccat gggtgtataa tggtatccta ttgagcaatt tttcatattt ttcagccatt tcaaatgtta tatatattet ggcccctagt cagtttactc tttttgtggt tttattaatt tttctctttg gggaagaagg acaaaaattg atataaatta ttgtgaccat gagttcttaa attattettt cagtggcttt ttcgctaatg ctgcttaaat tgtaatgagt gattatggtt taaaccagca gcccctggca tcatctgggc ttccacttat agtaacagca tatetaettg cataacaatg gttaagctcc tatttctttc 34980 35040 35100 35160 35220 35280 35340 35400 35460 35520 35580 35640 35700 35760 35820 35880 35940 36000 36060 36120 36180 36240 36300 36360 36420 3 6480 36540 36600 36660 36720 36780 36840 36900 36960 37020 37080 37140 37200 37260 37320 37380 37440 37500 15 1338436 Patent Specification No. 97135019 Revision of this amendment: August 3, 100 ataagaitg agatrcaaai attaatccaa aciacicaea aicactttct ctrcctcact 37560 t rtctgatac ccccacigga gagtgactga tcagtgcatt aictgtcacc tcagagctca 37620 gagigcccct cttttctan caaatacaaa gccattcatt tactrigaig gacaaatagc 37680 cgtggcatta gtatgggtag gggcaastgc tgrtgictct taictaggaa ggagttggtt 37740 ct 11 tctgat ggt igaataa iatacnagg tatagaaaga gacctgagig tct tgaaagc 37800 aacattcttt catttttgtc aatgitttaa rcagcacccc igtgcataia ttatctngc 37860 atatttcagc acrugtatt agacttctac atgtrgtggt ctitgcttct gataagggac 37920 agaataaata ggaagaaaga ataaaaaagc cataatgna agtacatcca ttccatgccc 37980 atagccatac atcacagaag Tcacagggaa ggctctgtga cacgagataa igatgtggat 38040 gtgacagaac atggtagagg aaaaggccac agacaggtgc agagtaggaa gaatgaaaga 38100 attcattgtg gcigtcaaaa tcciatgttt gtgrtcccaa atccratttc ttttncrtt 38160 tgacttgtga igtattgacr gtcaattagt tatcaggtac tatgttcagc ccagtlaitg 38220 cacaagagat cctgaaaatc titaagtagc tcctggactt aggaaggagg ggaagaggga atttgtacat catgacaata catttataga 38280 agacactaaa ataattacaa ratgttac.ta ttatacatga caatatgcag aatgcamg 38340 gaacatagcc aataacrtta cacagagata gcagtttng agctgaattt tagaggacca 38400 agttgataga atttgatgat cagatgaggg gitagggaga ggaagtcttt cagtuartt 38460 taaggctgga gtgaatatia tttttgtaaa tgcaggattr taaggaaaag gacaaaatgc 38520 cagaagacag cagatitcta ttttctgtat 38580 tacactaatt cttgtacata aataattcat ataatgtttg tcutatcag tctgaatrgt 38640 cagctttggt catagggaat tggaaccaag tgtttactga gcatctacta tatgtgaggc 38700 actatattag gtgctgggca tgcagtgatg agcaaaacag ggatgggtcc agctcttata 38760 «gaacttagag ttgagtggga aaaacagaat taaicaaatt tccaratna taattagaaa 38820 tgacatatac atatgaacaa aggctctctc agaacccaat tattcttccc tttcactctt 38880 cricctaatc atactaccag cgttaagttg acagttattt atcaggcata tttagcagcc 38940 agccitacag ttttctcttg cacactgtta acaartactg tcacatggtc actgttacat 39000 gtiagccaat Agtgc ctcac attcactgtg gcttccaaag cttgggcttg gggaagcagg 39060 tggatggtga tatcatgagc tcagatagag atcatgggag aagagatttg agatgl'ttta 39120 aaaaagtgtt ttgagcagat gaagttaaag agrraaaggg aactatggtc aagiggaggt 39180 gctggtaggc aggtggaaat atacttctga atctcaggat gactaargaa aagcaagaaa 39240 atgaacaaca agggactati aatgigtgit atgctgtgcr ratgcatitt gtctggrttc 39300 aaatcattgt atttaagtag ttcttaaagt cacaggagtg aatgagatta agiagaggaa 39360 gaaggaaaag aggtacagat ggagacctag ggagtgccag gcctcagagc agacagagga 39420 agggcacgca gtgacagagc ccacgaagrg tggccagaga gcagtgatga ggaggattac 39480 cgagtggctc atggaaacca gcgtggaagc tttcttattt cttcttctcc ttctgcttct 39540 cttictccct tcctccttic ctccctccct ccctccctcc ctcccttcct tccttccttc 39600 tcctcctcct tctccttcct cttcttcttc ctcctcctcc rcttcttctt crttctcrtc 39660 ttcttccttc ttcctcciic ctccrcctic ttcitccttt ttc.tttmg agacagtctt 39720 £ ctctgtcac ccaggctgga atgtagtggt atgaicatag crcactgcag cctcgacctc 39780 cccaggctta ggtgatcctc tcaccttagc ctcccgagga gctaagacca Taggtgtgag 39840 ccaccat gcc cagctaatgt tttaanrtr gragacatgg gacctcccta t £ ttgcccag 39900 gctaatct tg aacicaagtg aicctccigc ct eager tee caaagigctg ggauacata 39960 tatgagccac igrgcccggc tgtgggaagc tttcaagaac aagagagacc aatgttgcca 40020 gacaggccaa gtaarauag gactggaaag cagctagatt gagagactca caggaacaag 40080 16 amendments Date: August 3 100 years

1,358,456 No. 97135019 Patent Specification Revised aacagagaat tctgaattct aaaatccaca acgctcattt cactgaaagg tcgticaggi cctragccgt ggcggtggtg gaittitttc ttatantcc ttcttcttgt tag cat11tggat atttgattaa ttatcgacca! Tacgat ttactaagaa gaaiΐ11tat gctamtaa agttaaatga tctgigattg cartatttac ctcaactgct cacttaatti tttaaaaaca tcttcaaggc tccttcagag 1111tatgtΐ gataat11ta aaaaatct11 ttcaagtttt ctagaaacat gaataagtac acaataattt agttaatgtg ggcagtaaat acacagttgt gatagtgaaa tgtcttctat gaactagaaa taaaatcatt ataagaaaat agacactraa agttcagagt agagaaggaa actcaaagag acagaatggt tccagggcag cctaactgta cagiacccit aagaaaagta rtcgtatcta tatctctact gcagtaggcc aagtgctgtg gcacacgcct aaaattgtag cactttggga ggctgaagtg ggaggactgc t.tgagcctag gtgtitgagg ccagccctag caatataggg agacccccca tctctacaaa aaataagaaa aattagtcag atgtggtggt gcacacctgt ggtcccagct gcitgggagg ctgaggtggg aggatcactt gagtctggga ggttgaggct acagtgagcc gtgatgacac catcacactc tagcctgggt gacagagcga gactccgtct ccaaaaaaaa aagaatctga gaagcagata ctggccatat tcactgaggt gctaagc agg ggrgggcacc ctgcctggct ctgtagtggr catttctgac aggcctgigt tgtggagaca gacacactag gttttcagag tctgatgcag ΐtacattcga attaggcaaa tctcatactg attctgattc catgttcccc gcaacaggca cccggtaaac tggctttctg gagagtctgc ctttgagcag agaatgtgat tttcccactg tccttctctg acctctcggc agttatacaa ttcttattgt aaaataaagc tctattctgg ttttgtgcat cagtctcctg tgggtttaat tcacatgcaa gagcgtcctc gagcctgaat gagcctggaa tggaatacag tttcccagcc catgaatcat gacctgaaic atgtcaaatt caccaagtta tgctcccttt taaggtcact tggcagacag gcaggtagga actttcctgg tgaaccctcc ctgtatgacc atgcagcttt ccactgggaa cttttacagg ttgctgctat ttttataaaa atgatagact gtaatgttgc cggggacagt ggctcatgcc tgtaatccca gcagttlagg aggctgaggt gggagaaaca cttgaggtca ggagtttcag accagcctag gcaacatggt gaaaccctgt ctctactaaa aatacaaaaa ttagctggac atggtggtgc acacctgtat tcccagctcc tcaggaggat aaggcacgag aatcacttga acccgggagg tagaggttac agtgagccga gatcacgtca ctgtactcca ccctgggtga cgaagtgagg ctctgtctcc aaaaaaaaaa aagagttctg taattgtaaa aatgtgacat aggcattctc taatgtgcaa tgaatagtca tttttaagca tttca tacat tgttcctgta ctgcactggg tctccttgtg ctgaactgca tgggataggc catttccata caatctcatc ctcigaataa ggaaccatga tgctcctaaa gacatactaa atatagatct tgggtaatat tggagtcagt gctggtcatc aatgattttc tctgtgatga tagagggggt ccactatgaa tgatagcatt aattttgctg tatgttcttg catcattggt acataataat tcatagactt cataagttat taatatacaa gttacagaat ttaataatgt aacccacctt tgatatgttt tcatatacat tatggggaaa ccatattttt ttgaagtcaa gaaatgtata ttgcttcatg ttgcaaaatt gtcaaagaag cattgccaga aaatgatctg aaatgtagaa caataaagtt acattataga tgtcttaggt gaaccaagag tgtatgctat aaaaattagt gtcagagtta aaaagatgca agtcaggaat taaggcaaaa cattgaccct atctgactta ggagaattct ggtcatgtga tcttaagaag agagagtaac tgacagttct ggagactggg aagtccaaat caaggcatca gcagattcag tgtctggtgg gagcttgctg tctgcttcac agatggtgcc ttcttaiggc atcctcacai ggtgaaaggg aacaaacagc ctcccicaag ccttttttgt aagggcacta atcccattea tgaaggeaga gcacctactt gtaatactat cgtattcgtt cgttctcatg 40140 40200 40260 40320 40380 40440 40500 40560 40620 40680 40740 40800 40860 40920 40980 41040 41100 41160 4122041280 41340 41400 41460 41520 41580 41640 41700 41760 41820 41880 41940 42000 42060 42120 42180 42240 423(8) 42360 42420 42480 42540 42600 42660 17 971350 ] Patent Specification No. 9 Amendment Date: August 3, 100 cigctaataa ggctscggag tggcagcagg tgagact rac cct tccaccg arugggtgg ggattttagg ctagtccat tt rccrtgacc aagcccaarc gactgagcag tacaaatgca cgggtaactt cct taaagt t gtcggtgagt cttgttcaaa ctcatggcaa cttccttgta tarttcagca atcaaaacag tataagactt aagcrggaaa gccctcatac gtcactttcc cctctggctg tgatcactgg ttggagacat. taaatagata ttgatttgat agagacatag gaggagcagg agtggaarct cracccccag agttcctgag tgttgttttt ragtggcgcg cicagactcc atttttagta aggtgatcca tttaacttit tgatcatagc cccaagtacc gctgaggcta asacataccc gcctcacagt caagagggtg rcactatcat ggtccctcct ggacacagcc t tccaacata Ar tctggtct ttgaaaattt aatrttagag agagactgat ctgcttgtta ccagggctgc atgcagtgca gtatgatact gatattgcag aitcattgac atcitaacat aatacrtgaa atggtggtgg ccttgatgtc cagtggagca agagctgcag ttctttcttg cctgccttcc attatggtac gcacgtgcca cat cgaaggt attgggtgat aaggaaagga gactgaaagc gtggttgcag tttcccutt actagatgtc tgtttttgtt ttctcagctc tgagtagctg gagatggggt cctgccttgg tttttttttt tcact mac iagggcraca gtct tgaact acgactgggt caiggcagaa tgtgcaggag gagaatggca acaacacatg aaactgtatc caaattttgg gtctgaaggt agcrtgggct agacaagtgg gatctgaaag acatctatga tgtgtggcac gacctgcaca ctgatatctt agacaagaac tcttctgtcc caatggtacc aaaaatgtag ggttgttggg caagaatact tgt tcccaca ctgcctgtga gcagfcttgt tactcaccag agc-tttggct acccaagtac tatguctca gaccaaacac acagaaatgc cactgagtca ggcatcccra tctcct tccc ttcagt tcaa tt t tgagaca actgcaacct ggactacagg itcgccatgt cctcccaaag aacagtct tg ct tgaactcc ggtgcatgcc cciggcctca aat 11 an la ggtgaaggaa aactcccctt tgggaaagac ggaattatgg aactatcata gaggacatga tttatctagg ttctrtgtac atgaagatag gacaccaggt at tcatgtac aagtttgggg acctgacaca aaaaaaaaat c.cct tccaca gagcattttc ctgcttctta gatccactgg aagatggtag gagattiata tagaagcaca tggagcctgc Gccctgacag gtgcaacttg aaatcact ta aataaatggc ggcatcccta agttggtcaa cagtggtgat gagtacactg c ctctgcctg tgtggccata gcagtcagca gagtctcgct ctgcctcccg cacacgctac tgcccaggct tgctgggatt ctctgtcaca tgggctcaag accatgctca agtgaiccrc atggacttgc gaccaaaggt tataaaacca cigtccccat gagctacaat cctctiaata acatctggac cagsgaaaag aaacargaag ggaitaaaag aaaargtttc ttgctutcc. agtagggatg ggggccttgg aacataagaa ggtaaagaag ttgtcattti gcaartt tga cttatatctt cagacagggt tgaitagaaa ggt tcccage acagattctt ccct tetgat t taat taett catttttcat acactgttta gettataagt atcctccctc aacagggaca aggeatatga cacatcrgcr gtggaagatg gagacttgtt gigtctccca ggttcacgtg catgcctggc ggtct tgaac acaggcagag taggctggtg tgatcciccc getaat 11 tc ctgcctcagc agriccaggr acatcitaca icagatcrca gat tcaat ta tcaagatgag ctaicacat i agtagcaatg cgtatgn rt atcciaggag aattgigctt ttutagett atgctaiaga gaaatggtac gtcagtccat tetgiagget gcacgrgaga cat tatagee taaatctttg ctgtgtaggc tget taaaaa tttciataca tcccccagag ccagtagaca ggctctggag gcatgcaata tet tat taat t tgcaagcac Gtacat tatg tgggagttgg gcagaaggaa gcaatacctg tet i rcitee gagger tcac tttttgrtgt gg Ctggagtg at tctcctgc caatttttgr tcctgacctc actagttttt tgccatggca gtct tagcct t tgccatgat t tcccaaagt 42720 42780 42840 42900 42960 43020 43080 43140 43200 43260 43320 43380 43440 43500 43560 43620 43680 43740 43800 43860 43920 43980 44040 44100 44160 44220 44280 44340 44400 44460 44520 44580 44640 44700 44760 44820 44880 44940 45000 45060 45120 45180 45240

18 Revision date:] August 3, the following year

1,358,456 No. 97135019 Patent Specification Revised gttgggatta caggcgtgag ccaatgcacc tggctgaggc tggtattttc aaarttcaat tctagcrgtc agggagagag aaattgattg gcccaccagg gaccaggtgt ttgcitctgg tccattcttc tataaccagg gagacattta tatatataaa cttggctgct gaggcccaac cctcaaaaca tagagatttg agcaacatia gaataaattc ttttatttat ggaattattt ctataggcat atgtcataac cttttatttt ctttttaaga aatcaagtct acttaatatg ataataatat agtcaaagaa gtacacagcc acgtatggct ggatttgatt tcttatccaa tagctggatc tgagaaaagg ttgitcagtt acattccaga agcttcagta gcaaaactgc tcttttttcc cccaactttt actitatati cagagggtac atgtgcaggt tttttactga ggtatatcgt gicafgctga ggttttgggt atgaatggic. ccatcaccca gacactga £ c atagtataca gtagtttttc aacccttgct ctcctctctc cctctcacct ctaggcatcc ctagtgccta gtattgccat ctttatgtcc ataagtacct gatgtgtagc tctcatttgt aagtgagaac atacggtatt tgtttttctt ttcctgcatt tctugctta gaataatggc ctccagctgc atctatgttg ctgcaaagga catgattttg attttttatg gc-tgcaiaga attccatggt gtttatatac cacattttct ttatccaagc cactgttgat gggaacctaa attgattctg tgtctttgct attgt gaata gtgctgcgat aaacatgtga gtgcccttgr ctttttggta ttaatagagt ggtttgtttt cttacggata tatacctgaa actattcttg ΐtaagtgagt caacaaggcc cacctggcag aagaggaaac ccaagaacat taaatcagtt aagatggagg ccaaggcggg tggatcactg gagctcacga attcaagacc agcttgggca acatggcgaa agttcatctc tacaaaaaat acaaaactag ccaggcatga tggcgtgcac ctgtagtcac agctactcag gaggctgagg tgggaggctg gcttgggtct gggaggcaga ggttgcagtg agccaagatt gtgcctctgc actccagcct gggtgataga gccagacttt gtatatatat gtgigtgtac atatatatat atgtgtgtgt gtgtgtgtat atatgtaata catatatatt acatatctaa tatatataat atatatgtaa taaacatcat gtatatatga tgtttattag ccctccaatg cttgaaatca ggggttggaa tcaaggctaa ccaactctgg tctggtcacc atcactgaat gcttgcggta gccatgtgaa cattgtttat tgtcgtatac tcctgggaga gtcccaggga tgagctttta taaagttgca gacgggaaag ggactctcac tttggagaga attaagcatg tcacccagtt gcctaacaag ttattgctgt gcaggcaaaa aacagacaaa agactcaccc aactctaaga tttttttgat ggacttctci aagttcatta tgataaagtt aatattatga tttttccagt tctcaatatt ttgggtctaa cccttttttt attactttat gtatatgttc tgggctccgt aga ctctctg gagtgacaag aaaatcttga actgctctgg aaaataaaag gcgaggtcta ttggagagct gttcgtggat gattctgata cgtgctcttg gttaagaatc acttgactat atattgtctt gtataaatga ttttcttccc agtgcctctt acccaccact gttagatcag ttctttaaac accacttaaa ctcccacttt tgtcagcaac ctcctcttga cagtcaagct ccttagtctg gcatgtagca ctcaccatta cttggtgtga gtcctgaatt ctgagcagcc agtgtctcct tatctgicac attcgtactc atttttatga ctttgcaggt cttgctgaaa attcttcctt aacttgcctt gagaaccacc ttttccacca agcattccca atgaatgtag ctcgtggtgt tctttccttc caaattcctg ttctcttatc tctacigctt ataacccaat agrcttttct atcaaagtag atgttcatrt tcttaggagg aggaatgtct ttggtatcct gtacaaaatc tagcatagcc. tggtactcaa agtcacctta atcatacact aaatggtatc tttattgatg ggttgtcgat aaacctcctg ctttatcctg tarccaatta aaatgatccc tcgtcagitt ttcctctgat tcaaacattt taccccacat tgtttctgca attagacaga aaaataagca tctgtgaagt caaccnttt gcttttttta ctctgaagtg ctgctttttt ttttcagtaa gttgtggttt taaaaaaatc 45300 45360 45420 45480 45540 45600 45660 45720 45780 45840 45900 45960 46020 46080 46140 46200 46260 46320 4638 0 46440 46500 46560 46620 46680 46740 46800 46860 46920 46980 47040 47100 47160 47220 47280 47340 47400 47460 47520 47580 47640 47700 47760 47820 19 TT58~455 — Patent Specification No. 97丨350丨9 Amendment of this amendment date: August 3, 00 said cagttatttg aatgacattt anatrin〇cagiiaataa argiatftta agrnrraaa 47880 tccacagtgt agataaggcc ctagaagcaa gtgtagacii cgrccacagc tgtactccat 47940 cggccactga cagtcttait gcattaitic aacggcacaa gcaatcarrt acacttgtta 48000 .ttacccaggg gcatttcaaa ctgttaciga aatgcatcca icccrggagt aaccatctgt 48060 gaatggtaat gccataaggt agagagacta aatctaattg ataigcaaaa aggagaattt 48120 cagctgtcca gctatggaga ttcaaattga acctnaata ggctgaggat ttcagctaaa 48180 tiutaaaat catgatatct agttcaggca ctcatctut aggtttctca Cagattaaag 48240 tacagccgtc itccttgaag taagaacatc rcaaagtcaa aaatact rgt r tat tgtaaa 48300 acaaaatgct acagagaaag gaaagttctt gtaaaataca aagagatcgc ΐΐttgttgct 48360 atataataec aaagcagctg cacctttcct tggtttttac acttgtttgt gcctcaaatt 48420 gcctgaaaga aaaaaaggga aaataagaaa atgctttc ag atttcagtig cattaaaaca 48480 taaaaaaaat tgggagcaac atttgttaag atattaagat atagtcant acattaagtg 48540 gttttataaa agtgatttat aatcttttaa agttatctcc ccctttctta tgacacgtaa 48600 ccctaaaaga gccatttaaa ttagctgtca ggcaagatgt accaggcct t tccagtgatc 48660 ccagcccacc tggacatatc tagcaattct gcagaccagc acatacttct ggaaagatgt 48720 tgcatggtga tttatagatc tgigtggaca cataacacct ttacaatgga grgaggrctr 48780 gaaatagccc tgctgttgct gcccattgag agataagtat tctcctgagg tattccccaa 48840 cagctggaaa tgaagtagca gctcttgtca gtctgtgaca ggagiggatt atcagacatt 48900 tgtaaagaga caacagcaga atcaggcctt tttgcaataa aattgcacac atagatatta 48960 ttgctcctcc agcgttteat atgcagtgtc aaggeaeget acagttcagg cagcaggcaa 49020 gcagctctgt itgaatggtg ggacaaacat acctctgtgt gtgaggtgcc tgcacttgcc 49080 ctgctttgtc agggaggaca caatgccact ttctctgctc ctcagcatag ctcaattcca 49140 gcicccggga tgaaltaata aagagatata geegagggea gtcrtagug gggctcaggt 49200 taccagctgt cacattactg aaatctcagg atatgcttac agtaattgaa ggaaagcaca 49260 ttagggttat attgactcag aatgaggeae t ctctgggag atcaccgtga acagcatm 49320 gggagcaacc tagaicat11 cccctaaaat tctgacattt gctttttggt cttctgggct 49380 ccaggtactt attactcttt cctgaagagc rgttaactgg ctgtcaagtt tacattitga 49440 aatagtgcca tgaiggeate cciatgcttg gtattattta ccccacggag gagatgtgtg 49500 taitgcagaa cactcatgtt tagatca〇cc aagagaactg cttggaacaa tcctagaagc 49560 aggcaaagct gcattttatg ttcttcatat attatugaa aattactagt ggtcaagaaa 49620 cattccaact gtttgaattc tcctctccaa acaggaaaat tctgtaaaat tgt111teat 49680 atatatatgt ataacacaca tacattttat aacacataca tacacatata agcatatact 49740 aaatgagtta gtaaatatac aacacittga actgttgcct gggatataat tactggcata 49800 attacaigig ctcgttatta tttttctaaa tcaaaggtct ggttttcata ggcttaaaaa 49860 ataataaaat t £ gatgttaa tggtacaagt tttgaaaata tttgatattg aitcaggaga 49920 tgaaactgtc tagaaattac tettgtetat tataattaag tccagagtct tattttcaga 49980 gataagtact igatccctac ttttgtgtgt caarttgaat rtaarttttr aatgcatgtc 50040 trnaatact accctttatt atagatgeag acgttaatga agaatccagt cccatttgta 50100 caaatgccaa Ggagtttacc ctcta Ttgaa gggatgaaat gttggtagag caaatgcagg 50160 tgtattatta tgattacitt tggaiacitt giattaacaa attttcagac acattcctaa 50220 agattctggg gggctggagc aagcaggcaa acagaggtcc acatactcta igtgtaaata 50280 ctaaaagiga tcaatcaagg gtgctctcca ccctttctgc ttcttctgga agctaccaag 50340 20 Revision period: 〗 August 3

1358456 ψ No. 97135019 Patent Specification Revised attccigggt gcccaaggat acctgttggg tggt tgcagg ggccacctaa ccccaaattt ccttgccacc atrcccttea tcctctcagc atgacagctg gtttcctaci tttcctcttc ttcccccut tttcigtctt tggccaaagc ttagtgaatt naccttaga gauttacit tiaacctatt cccatatttt aaatgmcc acgtattcac tgcagtgtgc tgatggttgg aggtggtaat acagtttctt ggttaaggtg tggtctttgg aatttgactg cctgritagg tcctggctcc ccactattag ctgtgagacc ctgggcaaat taettaaett ttctgtggct caggttccag atgtaaaatg aaatt11taa aaaagcaaca cctttaagtt ttcttaagaa ttaaatgagg ctgggctcag tggctcacac ctgtaatccc agcactttgg gaggcttaca caggacgata atttgagcct aggggttttt tttttctttt tttttttitt ttgagatgga gtttcactct tgttgcccag gctggagtgc agtggtgcaa tctcagcicg ctgcaacctc cgccicccgg gttcaagcga ttctcctgcc icagcctcct gagtagctgg gattacaggc gcccaccccc atgcccggct gattittgta cittttaagt agagacaggg ttttgccatg ttggccaggc tggtcttgaa cttctgacct ccagtgatct gcccaccttg gcctcccaaa gtgctgggat tacaggcgtg agccaccgtg cctggcccaa gcccaggaat tgagatcagc ctgggcgaca cggtgagacc ctgcctgt at aaaaaagaaa aatttaaaaa tttaaaataa aaaaaaatta agtgagitaa tatgtggaaa gaatacctct ggtatatagg aaacactcaa caaatattag ctattctttt tcttggaact ctgaaggtgg cagacttgct ccctcttcct gtgtggagag aagcccatgt actttatttg tggacagtca tctgtgattc tealgaatgg ctttgcttcc ttctcatgtg gctttcacac ttatgeagag ctttgttaga acctctgctg catcctgcag tgtgaaattt ctctccatct acattcccac gggggccaat aacttgtatg gnatttgta ccattggttt gtgagccctt caaaggcaaa aattgtgttc tttggttttg ttttcctagg gccttgcaca gcacttgcca ctcttgatta ageatgetta agaaatgett gttgagtgag tgcgrgaaag cgccatcaaa cttttttttt tgagatggag tctcgctctg tcgcccaggc tggaatgcag tggcacaatc tcagcgcact gcaacctccg cttcccgggt tcaggcaata ctcttgcctc agcctcccga gtagctggaa ttacagtcgc gcaccaccat gcccagctaa tttttgtatt tttaatagag acggggtttc atcacgttgg ctaggctggt ctcgaacttc tgacctcatg tgatccaccc accttggcct cccaaagtgc tgatttacag gcgtgagcca ccgcacctgg ctcatcaaac gtttgattta teggtttcct ageatataaa etagetgega agatgtgtat ttttttgaga agccatgtgg agagagtagg ggacacagaa tctgctcttc aggeatgetg acagcaaaaa gtgactac ta gtaggccatg agggatggaa gagagaaata ctataaaaag catagttgtc tggggctatt taaggaagac acaataacac actgcacatc ccaggacccc tttcaggcat cactataata gcatggtgta agaactgtgt cctctcagtc ctgtteaget tcagccacta ctatcctttg tetattaata ttcgccagca ggtgcgattc tggaattgtt tggctgccag agacccggta tttggtgtgt ccgtcattac tgggtgtttg tgtccccaag ccagagtcat catgttgacc atcctcctga actggggctc tggttggatt cccacctgtt tacctggtgc atcttgccat acccttcctg gagaggaaag ettaaegtte ttctccactt cagcaccaac cact tggtcc caaaggaacg ttctggcgag aaatgtgcag agagaatcag aagacaatta atttctacct gtagtttggg ttctccttca agagaaatta caaaactgcc tgccttggac ccagagcttt ccttctttag gatggtttgg gcctgacagc ctgaggtttg aatctggici ccaccattrc ctagttcata ttcactctca gcaaatattt aactctctaa gcctcaaatΐ tctcacccac aaaataggga taataatatc ctgugttgt gcccttagat gacgcatatg gcatctaaca catacttagc atgtggttta gtctggcaca tacttagtat tcagcaaatg gtagctgcta cccctcccac ggccatgtcc 50400 50460 50520 50580 50640 50700 50760 50820 50880 50940 51000 51060 51120 51180 51240 51300 51360 51420 51480 51 540 51600 51660 51720 51780 51840 51900 51960 52020 52080 52140 52200 52260 52320 52380 52440 52500 52560 52620 52680 52740 52800 52860 52920 21 Π5Μ56 Amendment date: August 3, pp. 97130019 Patent Specification Amendment this cagctactgg caggcagcct gccticcatg ttatctrtaa ttagaaaiat tcatuaict ctgaaaacca tcaaattact ggtgcccctt ttattatata tttattaagt ttcccctctt ctatctaaat cattaaaaac aacctttagt agatccggaa ctttaacatg tgtcaaatca gccgtataac tcaaccagag ctgacatcat aattgttgaa ccagtttcaa aaggttaaga gatggtatcc tcagagattg cctcaactag tttgtcattc aataattttc ttttagagtt gatacittcg catgaagtaa ccttcgtgag aaicccacag aaggagtatg aaagaagttg t tacat tcca aaaataacrg gctgtctgaa gggtatcatc gcctagcaga atccrtattc taaaatttsa aatagctcac cggctaatcc £ CCIgttttg aatgtaaagc ttccacaaat tgaaatggaa ggtggaaagt tttattcctt aaaatigctt caaggtagta t tcaggtatc attaaaacn ttgctttatg acacatttat ctggaagcct agaaaagtga act tactgag t tgcccatca aaatgaaagg acacagactc gatigtattt ΐ tatagccat tttgtcttta tcaataaagt actgcccagg taaatataat actgtaa gct tatgccargt taacttttca ataccaacac caggt tccag gggaatggac caggcttgat gcatgtgtct aaatgtgcag gaatggatgt t taacagtct acatggataa gtcaaatcct t ΐ tct tcaaa gtgcctggct t tcaaai111 ggiigggtat tcrggatat t ct tagagatg acaagatgn catcgttagc atggctaaaa gtgcctcact gutttcagt atcatctgat ttctgtcira aggigggtag aiacacacat aacacatgaa tgcagcaaga acagaatagg taatgacaca tataaatgtc cccccaacat tagtgctgag gagctgacac cgttaatggt ttttcttcat tggccgagaa 11 tgatatct ggaccaaaca gaataagatg cagaat tgaa tcttaagtgc ctatcacctg tgaat ΐ 11 tg tgccataata aaccagcaaa actgcaact t ggcagcaaca gattggtgga gtttraatat tgagtgccaa t tggaagaat atgacatgag ct tccacctc atatggct rt aatggtaat t tgttttcctg ggiggctcat gncaci ter tccccacagc tataat tctc taagctagct taaatgtaac iiuttitir atcaagtgtg atgaaaatct rairear tea ataitcctgt acacagatac ggtagataat ctatgatata tiaactctgt etaatateta attatgtett ggtaaaagar tagtaatctc tagaaagaac Atgtcaatat etttaggaga agtcttggat aaactcctga ttcagtgaat taatggaagc t tcatatagi agggaagtat gcaiagaagg ttcaattttc aaaaaaag ct ggaatgcccc ctggtagcac gccatccctc tictaaacca tccagcctct tctactgtat gtaatatagg gcagtgarta tatgggaaic gaggaataaa catcaataga gcaggaaacg gcctgtaaac ggaaccaagc aagggaatct caggttgtta taaaaat ret cactctigga taatggagcc gtaaataaga gaatcatctt rteatgeage t tgtgacigt acacatgtgt atttcaaitg accttgtaaa ggeteterga atat tgccta gagactcacc citagcctga tccaggctga artagtgaaa gaccaattat gaacagtttt gttuacatt teataaetta tgtgaat ter aggcagaact tatmgtra atat n tact cactggatga tcatauggg grcaagarca t taccatacc catcacagag ggtctcacat ccctcagaaa gctggaaaga ctat tctact cgaagatttr agratgggct cat uccaia taagaaaaac · ggt tagetat gagartettt cca £ cat ΐir ccacctrtgc ctgciagcat agaaaaggt t at tgtatacr gaggcaatgt tcaatacagi gctaactgat gaaatacagt aat r tagggt tgaaacattt grtitgtttt tact taagea tarctaacti gcaatatctt taact tcvtc taaatgcaat aaacactcct aagatggcai tcaatatgat t tccacagca act taaccgt Gttatcgtta ccaiagtt tg agaaatgcct tgaagagcaa at ΐ tetget t tgteat tgta atai1111ig aagctgccag ggaaacrgca cgicagcacc aagggaagtg ccccct Ttgt tgtagctgca aggcttacag tcct taaagc tcagtgccaa ccagagtgat tctataaaat agtaegatat tatacitcca aar taaaaat ggcagaccga 52980 53040 53100 53160 53220 53280 53340 53400 53460 53520 53580 53640 53700 53760 53820 53880 53940 54000 54060 54120 54180 54240 54300 54360 54420 54480 54540 54600 54660 54720 54780 54840 54900 54960 55020 55080 55140 552(8) 55260 55320 55380 55440 55500 22 1358456 \ Revision date:] Amendment to patent specification No. 97130019 of August 3, 00

ggcaggagga tcgcitgaat tcaggagtrt gagaccagcc igggcaacat agcaagacct 55560 igctctgcta aaaacaaaca aaaaaattag ccaggcgtag tgataigtgc ctgtggtccc 55620 agctactcag gaggctgagg caggaggan get igagtn gggaggtgga ggctgcagig 55680 agctatgati gtgccattgc actccagaci gggagacaaa gtgagactct gtcttaaaaa 55740 aataaaaaat aaaaaatttg atarrrtata aitttaaait atggttttaa catat t tagt 55800 tgaaaaggac tcttccaaag cctcatgaat atetet taca catgitaaat gataacgcag 55860 gggtcttgag t tctgaggat tgttccagta tttctacttg etttuatia gctccacacc 55920 taagcaaccc caaat tgaga acgatittca t tataataga ttttcatata acattttatt 55980 at t taai tct tcctgccttc uttcattaa tttatgeage atttgagggt ttatiatgta 56040 ctagggtact gaggtggata ggtacttctg ΐ tt tat t tga atgatataaa ttcttatttc 56100 ttiaataata rttttaitat aagactaata catgtttatt gtggagaau tgacaataaa 56160 caagtgtata gagaataaca t taaatcacc tataatccca ctctacaggg ctgttggtag 56220 caaagtgata Ttttcctcta gtgtttttct tgcataicct taettittag gaagacatta 56280 tgtattcagt ttggtatcct gcttgttcac tcaagac tgt at tatgagea tgtttctgtg 56340 ccat taaata ΐ tct tggaaa acattttaat ggettgatag tcttttatta taigaaatat 56400 aaaaataiaa aaattgctgt ttcccgrttt ccagtattgt agtcatgtct ttggaacata 56460 gattctggtg ctcaccaaai attccatgtg gccctticta tttcctgcct icctgttttg 56520 ttgagtiaga atcatgagac tgatatgagt cagtggccca tgaacagaat ccactagtac 56580 cactcacagg ccaatggtca gaacccaaga cccctgcgt t atcatttcac atgtgtaaga 56640 gatgttcatg aagctttgga ctagtctttt tcaactaaat atgetaaage caaaattaaa 56700 aactatcaaa tt tcaaaatt tttntttat tttctgtttt ttaagacaga gtctcacttt 56760 gtcttccagg ctggagtgca gcagcacaat catagctcac tgcagcctcc atctcccgtg 56820 tgt t tcctt t cttcccttct tctct tagtg aaacgaact ΐ agaagtggca tatggcgaat 56880 gtcacagcta taagttggag gaggaactac cagtctact t tcaactttac ctagactgat 56940 gt igagtcaa atcat igaga ct tacagat t tgtetat tat ageagettgt gttaattatc 57000 ctgataatgt atagaatgta Tcttgtttac caatggtat t gatttattgt tatatttttt 57060 aaggaatct t tgcagtttta atggccatgc tattatgccc caattctcat tagcgcactt 57120 aaaaatcagt tct t tccacc ctgtaaactg aaaataaatc agaatatatg gt tcaaaagt 57180 gaaagactaa agaaagttta ctaccacgca atcctatct t tgtetet t tc tctittttat 57240 tggcgtcaaa ctactcagta ttttagactg caaaat t tee actgcatgga ggaaagtaaa 57300 tggattggga ttat t tcctg caggtaaatg aaactttatg gtatttgtta tggaggcaag 57360 tagggtact t agagaaagcc aaatataacc tgtccctccc tatcttttcc ttagttgtga 57420 gggtcaaagg ggcacattac agtctggatt cagaaacccc tttcaacagc aegtagatag 57480 ttaaagagaa agattgrtct tcaagggcct ctaaggacaa aagtgaatcc actaacactc 57540 taggaagcag tgtgactact ggaagaaaga cattcaagag gtaaaatgga ttttagaagg 57600 tcacaggagc caattgtcag tgt ttgtact cttcatcaaa attattttta atgagctccc. 57660 tgacaacLgc gcatcctgac agcacgggtg aagtggctca tctggggtca tgcccgtgcc 57720 tgacactgcc ctaattagct gacactgctc tgctttgctg aagcacaggg aggteteteg 57780 agaaagatcc agaagggacc atgataaatc gggcaaaata ttccttgaga gcctgaggtt 57840 cacatgagag ctcagaggaa ttacaataaa Gatggattag gaaaatggaa tattaggagg 57900 ggaaagacta gagt tactag aagagatatt tg aaaagaga ttccaggatt tactggacag 57960 git tgtt taa aagtatttga gttggccggg cgcggtggct catgcctgta atcccagcac 58020 ntgggaggc cgaggcgggc ggatcacgag gtcaggagat tgagaccatc ctggctaaca 58080 23 1358456 No. 97135019 Patent Specification correcting the present date correction: 100 on August 3 cggtgaaaca ΐ tgtagtccc gcttgcagtg gtcacaaaac gctactcggg gcigagatgc aaaaaaaaaa t taggcaacg ggat icatct agaagtacct tgttactcit ccatgttgat cagt rcagag tttatttati tgtcacccag gt tcaagcga atgcctggct gtctcaaact caggtgtggg atgcttctgg ggacagccaa gcttgagtta ggagaataaa acagacaggc cccagat tgg aaagagggca atcagtaagg tatcaacata ggtaatgggt ct nataata ataaai tcta aataatcaga tgtiat taga agcaatgaig acatatttgt aactgggaag tgtcgcccag gt tcaagtga atgcctggct gtctcaaact caggrgtgac gggrgctaag t tctggagcc ccgtctctac agcractcgg agccgagatc aaaacaaaac aggctgaggc gccactgtac gtatttgagt aaacct Tgcc gt tcaaaagc gtggaactgt tcttgagttg catactatga ctgt 11 tact tatttattta gctggagtgc t tctcctgcc aatt tttgta cctgact tea ccaccgcgcc catctagtgg caggaaagaa aagtaaacct gct gtccaca gcctgtctca aatcct tgac taaragtgtc. atgtggcatg gaaataaaat tttaacttt £ acataaitca aatgttccct lattttcagc atgaaataaa catttatgat gttttgctta tggctgagaa gctggagtgc ttctcttgcc aamngta cctgacctca ctaccgcgcc tgattgaggg agget tcct ΐ tgaaaataca gatgttgagg gagccactgc aaaaattagc aagaiaattg tacagtctgg tgatgctctg tcaaactcat aaaacatgat tcaggagtcc tttctgtgaa ageagagatt ccitctccct ttiatttatt agtggcgcaa t tagtctccc. tttttagtaa ggtgatccac aggetatetg gtagaageta tcatccagtc gataacctgt tttgtaagcc gtgagatcat cgaaggcaag tettgeetta gigcctgaca tgaaaagata tttcctagat ettgutraa tctattttcc tattacctaa aatgaaaaat agactggarg gactttaaaa tcauctn t agtggtgaga tcagcctccc rttttggttg ggtga'ictgc tggcctatca aaacccagaa gtaccaaatc aaaaaat tag caggagaatg actccagcct tgggcgtggt cttgaaccag tgacagagcc tcaaaactca t iccaactca aaaacaatgc taaaggggci t tacgaaaaa giagagat ΐ t gggacarrtg tatttatttt tctcggctca aagtagctgg agacggggit ctgcctccgc gagacatttt gaggtgctgc tcaaatgtcg At r taaatga tctaccaagc agcatcagta ttctcaacct taggttttgg a tet t tagat cacacacaat tttaaattit gtegaticag agagtcaagt ctcatgagtg aaat tget ta ataggatttg ttgtttcttt ttttttaatt tctcagctca aagtagt tag aaarggggct ccacct tgge ttcriatug acagcittgt tcagccctac aegggegigg gcgcgaaccc gggcgacaga ggtgcgigcc ggagteggag agactctgtc tΐ tatcaaga gcgggtttga agaacacctc cat tetaagt ggcctatctc rat taaactg gcaatgrctg t tggagccag ctgcagcctc gat tacaggc tcaccacgtt cacccaaagt tgattgtcac taaccaicct gtagtgccca ataaaaggga acagtgcctg atcccigtac ctctaagact tgaaaat rga gcccaataag gtttgcat tg tccaccataa gaaget tetg ttagat rate tgtggaatgc tcaarattct tttttgctga ttetatgage ttigagaegg ctgcaacctc gactacaggc tcaccatgtr ctcccaaagt acagggattt gttgtggtta cgctaactag rggcgggcgc gggaggcgga gcgagacicc tatagtccca attgcagtga tcaaaaaaaa ggattrggtt agatgtgcaa aaaaccatag ggaaaattai agtgaacaga ccatacttct gagacat t ta cgtitcguc tgtttccrgg gtctgccacc ggtcaggctg gctgggatta aactgggggg acacigcaca ggctgagaaa taagactagg atgtgggatt Cgtatgtagt cagttacaaa ataagaaaac tggtagctag gttatcct-tg cacgtattgc attci Atatt tagatcaiga tgtggctt tc gagatagcaa acttattcar acatagcaat agtettgeae tgcctccigg gcatgccacc ggtcaggctg getgagat ta ccctat tget acagcacaga cntttgact 58140 58200 58260 58320 58380 58440 58500 58560 58620 58680 58740 58800 58860 58920 58980 59040 59100 59160 59220 59280 59340 59400 59460 59520 59580 59640 59700 59760 59820 59880 59940 60000 60060 60120 60180 60240 60300 60360 60420 60480 60540 60600 60660

24 1358456 » Amendment to Patent Specification No. 97135019 Revision Date: August 3, the following year

icagtgaagt rtettaaett ccttgtgat t atittcctca ten tgaaaa aggaataatg 60720 icctcaaCag gtaacatgaa ggttaaaagg agatggcgtg tgtgtglgtg tgtgtgtgig 60780 tgigtgtata cttgtgtaic tcatccciaa acaaagcctg gctcatagta ggccctatat 60840 aagtgcrtgt tactatgatt gaaagttgga ratat 11 tta aaritctatt 11 tcaatct i 60900 ttgcaaagaa ggaaaacaca actttgataa aggtaat ΐΐ ΐ ggtagacatt ctctaacatg 60960 taaactgct t gtgiaaactg ggaaatacca gat tgeteta aat t aat tag uctatattt 61020 gttcaattac actggattgt gttctgtgtt tttattitgt 11 tgt t tett gtttictact 61080 cacatggtga gaettggett gggtgagtca tttcntgaa gacccicagt tcatactaag 61140 gggcaaaagc agatgagggt ccagggcaag gcatggaagc caactgctea gtggittcaa 61200 cccgggct tc atgggaaaag gatgggaggg tggggttggg tgteettgag attgaggtga 61260 gaacagttgc ctgagaacag gaaccagaaa gtcctaacag eggiegatea ctgataacat 61320 ttgtgctgaa aacatttcag gcccaaactg tctcagccat gctgagcaag gcaggaactt 61380 gggatgtgaa ccactctctt aatcgggtcc actgtgtatc caaagttgac ccttgagggc 61440 caggcacggt ggctcactcc tgiaatccca g cactctggg aggccaaggc aggtggatca 61500 tctgacgtca ggagtttgag tccatcctgg ccaacatggt gaaaccctga taatacaaaa 61560 attagccagg tgtttgtggc gggtacctgi aatcccagct actcgggagg ctgaggcage 61620 agaatcgctt gaacccggga ggcggaggtt gcattgagcc gagategege gattgcactc 61680 cagctigggc aacaagagcg aaacttcatc tcaaacaaac aaacaaacaa acccaaaatt 61740 gaccattgag aaaaaccctt gctttgtgcc catctgitgt gaggagatgg gacagccttg 61800 cccctgcatg gaatctgctc aggagettta gtttctgtag tagaaggtgg gctctgtgat 61860 taactctgtg gagtttaagg atctgggttc agtgagcact caggctctga tggggaattg 61920 tacctggaac ggttaattat ctcgtaaaaa gatcaatgga aaaattattt tcaagaaaaa 61980 taatagataa aatttaccta ctctgatact tagcacaata aatatttatt gaactgttga 62040 atcttttcta ggtatttgaa gttttatttt caggctagtg gcttttgaat tctgccacag 62100 gagaat tcag t tctccttct gaggeettet gaggagggga gagagtgaaa ggaagggaag 62160 aagcagcitg gcctggaccc attttttcca ttaaiitttt ttticttagt agagaegage 62220 tctctgctat gttgcccagg ctggtctcag ac.tcctgggc tcaagcgatc ctcccgcctc 62280 ggcctctca a agtgttggga ttacaggcgt gagccactgt gcccagcctg gacccatttt 62340 atatactaga cttttctaga aggttctct ΐ tgaagaaaag ttttctctgc taaccacact 62400 ttgaaaaatt atttctgtag gaaaatgata tattatcctt tgataaccta ggtcgctgga 62460 cagcttttgt taaaaagttc tacccatgtg getttagett ccaaagatac acttcctttt 62520 tttgagacag agtctcactg tgttgcccag gctggtcitg aactcctggg ctcaagtgat 62580 cctcctgact tggcctcagc ctcccaaagt gctgggatta caggcatgag ccactgcgcc 62640 tggcccccaa gatacactt ΐ caccaaactg tgtttcaaag ttatgctttt aaattgtatt 62700 taaagt teat ataagaacag gcttagctgt gacactgtag aggegagaat gtggagttga 62760 cacgggtcct tttcacactt gttccccaca cagggcccac atgaaacctg tccctgagtt 62820 taatcctaag aaaaaccttg ittcactagc aaaraat tee ct tetetgag aaggcaaat t 62880 aattatttta tttccaactt tetet tagge atcctgaaat tetgagetea gtttcatgct 62940 ctgaaaaaga aaaaataact getagagtea cagaaatggt at tgact 111 tggat tggaa 63000 tatttgtm ctctgt tcct tacctgt t tc Cccctatttt tettact tee tttccatttt 63060 art ΐ tgtatg octet ttgta agctgcct ta aatgcttt Tt ggaatgagge aggatataca 63120 ttcaataaat aaaatatgtc tgagccactt atgaacaaaa ccttcttggg ccagagccta 63180 aacattactt atataaaaag acctgat tee tcacct teta caacaatat t at t tagreat 63240 25 T358456 Amendment date: August 3rd, 2003, No. 97130019 Patent Specification Amendment trrcctgcar tgtacrcaac rctttaaagg tiaiagaart grasttagcg tarragaagg 63300 crcatggatc tagattctat gtcctcagca ggtgaagtct tnitacaca aigccactgt 63360 acggattgta gagttcttgg gciggcataa t {ttatgtga ccaaaattig gcaaaggstc 63420 itatcagttt gaggagagat tagtggagca ttgaatttea gastugaaa tgacattaga 63480 ganatctgg tccagtgatt ctcaaccagg gagacatttg gttarttccg gagataint 63540 gtttccttca agctgctttg gtgaagaaaa aaggcttcag cagtcattcc ttatgtcact ttatgaatgg cattcarttg aataagactg atcttgactc agttgttaaa gtgcctgagt tggtcacaac gaacccgaca agccctgatc caaatataag agaaatttcc agaagittac ttgaaagcag cacgtcacga tctgccagtg Cccgaaggcg cacatigtaa ggrgatgctt ctrctgtggt tcctgctatg tgtitaaaaa tgggaggccg tggtgaagcc gtagtcccag ugccctgag cicaaaaaat taaaactgct atcaattttc aegaatg eae ctgaaagaag aagtagctgg atatagagat gggaaatiga ctgatcttaa cagaatctag cttgccccct agctcccaag tgtttagicc ggtaggacag gaactgggga gctagacati attetettte actaatacca tgaggtgggi gtgtacagga tagccaatcc atttaatan ct tcaaaaci tgctcctcci acatggt tac tcaggtggga ttccagggcg atgctgtggg attaggatcc tcct t teer t tcctcagt tg actgagatgg attataaact aggeggatgg cggtctctac ctacttggga ctaagatcat acacacacac gacattgagc tctgcctctc acat tgctgt agggaatcag gaaaagacaa ttigcaagca cactttgatg agcctttccc auctcttat actcaggccc tccagggttt gitgttcatc tccactgcta aattatat ta ggcatttttc acaacaiaaa gctactggct cagcccccac tgtcartttt taattgccca gagaacaaga ggggatgcct ttgactigtt gac.t tagtaa tggcaggact acctggaaat tggggagcgt atcact rcaa gggcaccttg caatateagt aggetaggea atcactctag taaaaatgta ggctgaggca gccactgcac acacacacac attatacagt cctccgttcc ctggcttgta tgctagtgaa tctagggatg accagcatgt cagactccag aat teat tct caaagatgtc ctcaatagag tgggcctatg cacatgcctg gccagcctgg aaaget t Tgc ggcactaggt gtctgcagac tctggagtac gcttttcttt cagtggctca grea ggaget aaaattagct ggagaattgc tccagcctgg acacacacac aagacagat t ttttctgtti tctatgtggt ggatataggt gctagtttgg ctcaaaggaa ctccct tact agccctccag gtagatctgg cacagcitta cctgacatgc icagtgitac tgtgct race ataaggtet t cagittatgc ccagcatcac tcaccasccc gaggicagga cactactgcc ggagtttgtg taaaaiatag laitatgata aaat tctaca aaatgtgaac gigtcccatg tcttggagtc tgttgitt ta at tct tatgc acagccttca acagtaaggc gttggtggtt cacctataat ggagaccagt gggcatggtg t tgaacccag gtaacaaagc acacacacac ttccttcctt gcttctactc aagtctagaa tgtggttaac ttttatacca ccttagct ta ctaaactcac agaaaaggta ttgaartcac agtgttttaa aettataggg tcicagaaga atgtgccagg tgetettaag cctaagccaa caggttgaca gctcagctcc aagctgccaa gaggaegaga acctgaccrt caaaatgatg gaccgt tci t trcccgcctg agaggcgaca cccttuccc acagctgggc aaaatggaat agagetagat gggegrterr tatgccacag tttatattta ctcagcacr t ctggccaaca gcgtgcacct gaggeggagg aagact tggt acacacacac gtttctttgc aggaerggge tgatcagt ta tggagi tccc gatactagt t gagtet tgea aettgaatet gtaagagatc ettgrtetet aggagtggaa gagtccag Ag tgctgacctg cacagt tcca gagarrccat gctatcctct acataaccca cagcigactg 63600 63660 63720 63780 63840 63900 63960 64020 64080 64140 64200 64260 64320 64380 64440 64500 64560 64620 64680 64740 64800 64860 64920 64980 65040 65100 65160 65220 65280 65340 65400 65460 65520 65580 65640 65700 65760

26 Revision period:] August 3rd of the following year

1358456

V 97] Patent specification No. 35〇19 Revised ccccggagtc ccgccctgtr caggcagagg cagagtttrt rttttrgitr trrtrggaga cagcgtctca ctctgtcgcc aggctggagt gcagtggcac gaicgtggat cactgcaacc tccgcctcca gggttcaagc aattctcctg cctcagcctc ctgagtagct gggactaagg ctcaccacca cccctggcta attttittrg tttgtttrta gtagagatgg ggtrtcacca tgttgcccag gctggtctca aactcccgag ctcaggcaat ccgcccgcct cggcctccca aagtgccggg attacaggcc tgagccaccg tgcccggccc aggcagagtt ttaattgacc accatccctt gtccgactcc tagaaacttt cacctggatt ccttaaagtg atgccttgct gacctgattg gataacicag taticattgc tgagtagctg aggtaagcgt gatgttcact tatttctcag ciatctatga gagctgtagc ttacattgtg atcattctgg taaatguct ctaagaaaga aaacgaaaaa ataatggcta gagtcatgtt cacciagttt taacaict11 agagttttgc ttcttctcag ttcagtagct caaagagaga aaaaacaccc aaagacagca attcrtcact ctaaacccaa tat tct tcaa ctttctagaa attat tagcc acttaattta ctttgatttt catcictgaa aaagtattca gacttatata tagttgccag atgtgrtcat caaacacttc tctaagaaat ttgtatattt ttggaattca gtcaacattt tttggataaa tgaatgtgaa Cactttagga attgctt att ccacaaatga tttcttacca agatttccag aaactatttt catattgaaa caaaaacaaa acaacacacc actctgcttc ttcccacaga gttctgagac agcttttaca taatgatctt gaacatattg taatcttgtt tatgacagaa atgaaaagct gtcatcacat ttctgttttg gagagtteat tgttttccct gtgaattcat aggagttcit tgtetattat aaatattatc actttgtctt gaaaatagct ttcccttctg tactctttct ctgtgggctt tatgeatett ttgtcttata aaargtatga tgtctacaga gtcagatgta tctgtttttt cctttttagc gtctttattt tttgtttaac acaaaaacat ctgccagttg gtaagttata gaaatattct taaatttett ctaaagtttt aatatigtat ttttcagtta aagtgtaatc cactgagcca ggcgtggtga catacacctg tagtcccaac cacctgggag gccgaggtgg gaggattget taagcccagg agtttgaggc tgcagtgtac aatgttcaca ctactgcact ccagcctggg ccacagagca agaccctgtc tccaaaaaaa aaagagaaaa aattaatcca ttggattact ctttgttttc ttctagttaa acatccattg tgteageata atcaaactat cttgccctat gaaatgagtt getatetett gtctatattc. acatcttttc ccagattttc tgttctattc ccactgatgt atttacaggc cagtatcaca acctgtgaaa gcattgtctt cagtggaaat tttaaaatag taattactcc tttcattatt tttttcataa ttttcttggt tatttccaga tcttt acttt tcaatgaaca tatttttaaa tcgcttaaat cattcagatc tgaaacctca ttggcagtct aattggagtg aatcttctga ttcacaagca tgaaatgtat gtatttctgt ttattcaaac cttcttttag tattttaaat atgcgttttg ttgtcttttt catgtaggat ctataccttt cctaaatgtt ttatagtttc ttgtaaatag aattttaaaa ttcccattct atctggttat tgtaactata agacaaagct attgattttt ttcctcttta ttttctagca tttattattt gcaagcattt attagttgac cttttggggt ctgttttctc ttttgaatgt gtaagcacaa ggtagatcat gtttatcttg tttactagtt tatccccagc attctggcag gacaaatgaa tgaatgcatg aatggatatc tgaaaaagcg tttgagagga gattcaacaa tctacactac tttccctttt cttcttttta ccttgtgttt ctaacacata ctaagctttt tttctttttc ttctgaaatg gggttttget ctgtcaccca ggctggagtg cagtgtcatg atctaggctc actgcaacct ctgcctcctg ggttcaaacg attttcctgc ctcagcctcc egagtagetg ggattacagg tgcacgccac caagcccagc taatttttgt atttttagta gagaegggat ttcgccatgt tggccaggct gctgtccaac tgctgacctc gggtgatcca cccacctcgg cctccccaaa gtgctgagac 65820 65880 65940 66000 66060 66120 66180 66240 66300 66360 66420 66480 66540 66600 66660 66720 66780 66840 6690066960 67020 67080 67140 67200 67260 67320 67380 67440 67500 67560 67620 67680 67740 67800 67860 67920 67980 68040 681 (8) 68160 68220 68280 68340 27 Ί 358456 Patent No. 97135019 amended this amendment date _ period: August 3, 3 gacaggcatg agccaccaat cccagcccat tciaagct it taacaiccii agailactgt 68400 tccaaatacg ttgggaaggt cccccaat 11 tnccttaac ttutaaaag caacn tat t 68460 gaaaratati rtaiataica taaaaatcac ctatttcaag aigarntag tancaataa 68520 111 ttagiag etttaergag tgatgcaact gtaatgtaac gaiagatgu caggt t taga 68580 acgt 11 teat cctcctaata ggatetetea tgrccatita tagt taatcc cigiicgcac 68640 cmacccct at tcacaagc aatcgt taat naettettg 11 icagtgga 11 rgcc.tgt i 68700 ctggacattt catataaatg agatggtacc atatgtgaac 11t tgtgiCt gactgctitc 68760 get tageata atgttttcaa ggttcatcta tgt tgtegee tgtgtcagta t tetet tcct 68820 ctgtigctga ataaiat tee ertgtatgea tgtactacat 11 tgigtaic tgttcat tag 68880 rttrtggaca igtaggttgr ttcracttt t tggt tat tat gagtaatget ccagtgaact 68940 tcacatgtaa gtctctgtgt gga catatgt 11 teat t tet ΐ t tcagtagg tacctaggag 69000 cggaattggt ggttcatttt atgttttttg agaaat tgtc aaactaii π ccaaagtggc 69060 cacaccattt tatatttcia gcagtaatgt atgagggttc ctat tcctct 11 tet taaca 69120 11 π tc.tcac agt t tat tga tgtatgat tg aggtatcat t tacattgagg tataact tac. 69180 atatgataaa atgcrcagat cr raagtgra cagt tcaat t ai111 tggac acatgtarac 69240 atgeatgtat acaaccactg cgtcaatcaa gatacgaaac at t tgcaica t tetagaaag 69300 tccct tgt tc ct tgccctca gattttgatt tctatcattc tatcatactg ttttgatttc 69360 tatcat tgta gatiagtgtt tattccagaa rncatacaa atcaaatcat acagiaigta 69420 ctc.ct t tgtg t tgtettet t tcactcatcg taagggmc gagtttcatc agtgt tat tg 69480 tgt t tatctc asttgtttgr tcctttttat tgctgagagc actccattgt atgaatgtcc 69540 cacat ΐ 11 tg t ttatccagt tacctgttga tggacatttg agtcattttt cat t tgtagr 69600 tattaggaac aaaggtacta tiaaacattt atataccagt ctttttgtgg acatgat t tc 69660 atttttcttg ggtgaattcc caagagtgta attgctgggt catagggtag ttatatgtta 69720 cttactgttt tttatctagr attaagt eae tttacaaaat tctttaagaa t tacagt 111 69780 ttggccgggc atggtggctc acgcctgtaa tcccagcact ttgggaggct gaggcgggcg 69840 catgcct tga ggccaagagt tcaagaccag cctggccaac atggtgaaac cccatctcta 69900 ctagaaatac aaaaattagc caggcgtggt ggtgcgcacc tgtaatccga gctacttggg 69960 aggetgagge araagaatet ctrgaacccg ggaggtggag attgcagtga gctgagaica 70020 caccaiggca ctccagtctg ggcaacacag ctagactcag tctcaaaaaa aaaaaagaat 70080 gacagt t tet aaaatatcgt gtcittgatt ttctaaatta ttatacaatt tgctgatagg 70140 tataaitttg agttagatct ttatctgt tg atctggagga gtttctggga ctttttmt 70200 11 ttaaagaa gcacacaagt tgcccagaaa tgtatatagr ataatccaaa 11i tgiaaga 70260 caaacaataa catgtatgta taigttcgcg at tetatagg caaaagaaaa gatgtgaaag 70320 atgttcactg gcatgctaac catggttrcg tggctggagt ggcggaggtg gttaagggga 70380 ggtgtagagg gttgagttta caaaaaaagg aaacagggat aaagaaaaca cattattaaa 70440 gt taaatgat ttagtagagt ataaatatat aaatatatit atatatt tat ataaaatata 70500 Tataaatatt ttaatatata tttaatatat aaatat t tat aaaaatataa atat t tatat 7 0560 aaaatataaa atai t tat tg caaaaact 11 ttaatgataa aaatat tgga accagcataa 70620 agatgagett accaaagtta tt tgcagctg rtaaaaarag tgatatacgf gtgtrtagaa 70680 tgtatgt iaa aucaaatrc agai tgcaaa gcagtatgca t tetatggee ctgactactt 70740 Lgtgcraata tgat igtgat taigggeatt tugtttact ttttaaaatc ttatggggga 70800 aaaaagcagg agnatttet agaagtaiga atcactgaaa cacagtaata t rcct taaat 70860 ratacttttc ttaggatage Tgtaat tata taagarttag tcaaatcttt aattagatgg 70920 曰

28 Revision date: August 3 of the following year

1358456 97 No. Π5019 patent specification Revised taggctsatt gagggraggg atccctcaag attctatttg tcaccgtcag agctcagaat aattcrgact cattcataac atgaagagar caccgttgaa cacagrccai aggaaagtaa gatctcagca ttaaagagat gcaggtatga gtgttaaaga agagcaggcc ctggtcagag tattctccaa ttgacgicaa tcagitctcc acttgattga cctggagagt actttgacag ggcctgctct tcattiacat aggereggtg cctacct111 gcagctgaac aggctcggcc ccagttettg ctgggtteta agctacagtt tcagggaaaa ggcagaaagc caagataggg caggaatggg atgaaagggg actggcctgt tggctaggtc agcaaatttg tctgtgattt acagcactaa gctcaggatt tgaettgatt agaatttgat tgcctttcat ttgattcaag ttggagccac tgctccgggc tgttetatet agtggatgga ccatagaagc agggatetea tgaettagea atatlaaaac ctcaggcagg tggcttgttg etctgagcag cctctaaatt tgtacaaaag cctggiggct ggctgggttg gtaaaaatgg cagttgtcct gcaigctgac attgggagtt actctgcact getgeagget gtcctggcac actgcaggcc gggcatcatt tcatggtgga ggacgtcact cagttttgca tgaggetett gcatcacatr tgtatttaag gaattcacac ettat11tag ggaaaacatc tgttccttgg ttaaaacagc attgeaettt taacagagcg gccaccttit tccaca tacg ataggacagg ttttggatat atggagtatt aactgaaaag agcactatat atttcatagt tetttaaaga ccattgatat gtaaatcaat gtgtaagaag atatcgttta agaggggtta tggcacatgg tggaaggaat gctgctttgc atttatccgt gtgaagtaat ctgcctgtgc atctgaagaa acagcaggcc ccgccgcaag tgatgaagea gttctgtgga gaaacccatt tacaccagtt tccagatgct attccaccag aaataattee aagaatatac ttatatttta aataaatgat aaaatcaatt tccagatgaa gtgtacatta caaagagaaa cttggtatta ttatgtatta atccatatta actaaagttg aacctgacat caaaatattg atcccttctt aaaatagaca aaaatac.ttt gagttaaatt gutttette ctatttgtgc tagccggtgc ttaaagtcia atgatgtgat aattgaatag taaaggaatc taaatctcta etttettgat tcccagtgtg ctaactttac taaaattgtg ggaataagea aaatattttt catagcagta ataaggam ttaaaaatta tgtgacaatt gtgtattaga ctgaagtaat taataccttt gtcacaggga ccgggtgcaa tggctcatgc ctgttatctt ageaetttgg gaggeegaga caggcagatc acttgaggtc aggagtttga gaccaacctg gccagcatgg tgaagcctca tettactaaa agtacaaaaa ttagctgggc atggtggtag gcacctgtaa tcccagctac teaggagget gaggeaggag aatttcttga acccaggagg caaagattgc agtgagccga cattgcg cta ctgcactcca gcctgggcaa caaagcaaga cacgctctca aaaaaaaaaa aaaaaaaatt ggeatgagae taaagaggat ggatttcctc gcagtaggta aagaagcaaa gccctgttta ttcagagcct gagctcagac ttgaatttct 111ttagact ttcattttct ccctttatga agtggcaaag tcagttaagt atagatgtgg ccgtctatgt ccctgagctt ctgggttcaa taatcagctc tgcgactcct cttaaagaat ccagaggatt tcctgcctgg accttgaagt cacctccccg ctacatattt cccagctctg gttttccacc tcctcaggat gaatgtcttc ttgaatgtcc tctggaagag tgtcagctgc aettaaaett ccatcaaaag ggggactcag aggeettaaa ataggeatea ggtacacatt ctattiatga ttctgggatt aggcctattt ttaaggtgga tttggcattt cctgtggtca aatttrtaat ttctgaactt tateggattt ccaaagatac cgtcccttgg ctgtcttcat tgaittcttc aaaggatttc ctcggcaaag ttaccctagt cttaactgga agageatgge tcccttaaag agtctaaaat aagccttttc ctttagtgac tcccagctct ggtcttgtca ggttgcattt ttctcctaac ettettettt cctaatcctc actcactaat tcaaaaatgt tattctgcct tccagaacat cacacntgt aaacattttg ttaataataa 70980 71040 71100 71160 71220 71280 71340 71400 71460 71520 71580 71640 71700 71760 71820 71880 71940 72000 72060 721 20 72180 72240 72300 72360 72420 72480 72540 72600 72660 72720 72780 72840 72900 72960 73020 73080 73140 73200 73260 73320 73380 73440 73500 29 T35M5 "Revised date: 8August 3rd, No. 97丨35019 Patent Specification Amendment aagctagcat gatgt tattc catctgtatc gcaccaaatt aataaatata aaccagaaat aggtgcttat gcagtttggg ccaacgtggt gcgcctgtaa cagaggttgc ctctgtctca ggtgcattat tctaacattt gcaataaaac caaattcagc aaacataat tt taacagaga ctgtgtgtac gattgcaggg agaat tgtga get 11 taat t at t tat tcca teat tgtaaa atgggaagca ttttctrttt citgctctgt ctcccgggtc cgtcaccatg caggctggtc ggaaatatag ttctgtcctg ggcattgtgc aagtatgaga ttgttacaat aatttgtgtt aagagatagt tgcagccttg acaggtgtgc gagtcitgct tcggcctccc aattttattt tttttttttt Tcct tgaata at taaggage ccagctuta 111111111 a tttttcaatc taaettaaga aaaaaaat ta aggeegaggg gaaaccctgt tcctagccac ggtgagcaga aaaaaaaaaa agttctggct gaaatcatta agetegttat taagctagtg agattttctg aaaacactga ctcatcaat t aaagaagcag tagtaat tgc agergetaga tigcaaataa ccaagttcag gaaaaacctg tet t tet t tc tgcccaggct caggcaat tc cccaggtaat t tgaactcct gcatgagcca ageagatgat ataataaata aattgctttg ttatcatgaa tttttctttt gtettgetet acctagactc accagtgcac t tgt tgccca aaatcctggg ctctgtgttr ttagtttttt ctggttttgt atttgctttc acagtitgt t attttattgt catct ttacc aigtutigg cact 11 tgge gggtggatca ctctactaaa cggggaggct gatcacccca aatt tact 11 acaaaateaa aaagttacta ct ratgeter attctatcag agcaactgtt cctatgtaat cagcaaaagc tcagctgatr tetaagatge aargaaaaac ageagaatt t aaaggtggtg atttcctatg tttctttcit ggagtacaat tcctgcctca mtgtattt gacctcaagt ccatgccccg tcacttccag tatactggca agaaaatcaa atttagtgag tertitettt gtigacaagg gagcaatcct icagctcar t ggctsgtctc attacagsgg ctacaggcu tgagacagag aagetagati ttaggtcigc actgctctti aictuagag cagaaat tga catttggaga cgggcagagt ettgaggtea aatacaaaaa gaggeaggag cggcactcca t tattataaa acaat t tat t tcaggagcct atatgaaggg aaaaiatcat get tataatt 11 Tagigcaa aaaacctgat tgtctgggcc at tctgt t ta tgicagggta aaagaatatc gtaaatatct acacagacca tttttttttt ggtgcaatct gcctccctag t tag tagaga gatctgccca ctgttttcta agaaaaggat aatacataai agggttagaa tat tacagag tctttctttc ctggaatgca tccacctcag gttttantt aaagtcctgg tgagccacca naggccatt tettgetetg arctcat t ta aacatcagtc cctatcatat gagtutagg aaiattacit catgcataca ggctcacacc ggagrtegag ttagctggga aaicgct tgg gccigggcaa tttgtcatat t ttaaact tg cicat 11 tat laatan t ta ttttcactca ggaatttgct ctagaagtcc ataaaaccgt caaagactaa igcttgttag aatgtaaaac gaatgratcc ttgcattctg ttaaattttt ti 11 tt t tt t cagctcactg tagctgggat tgggctt tea cct tggagtc catttctttt ettrgeatte ggtagtat ataaaagaaa ct ttgiacac ttttittnt stggtsrgat cctccagact tiaaargtlr cctcaagiga cacctggtci ttactaataa tcaccaggct accctgtgat acrcctcgcc tctcitgtgg ggagagtaaa ittatagiag aatactaaag tgtaacccca accagcctgc gtggtggcat acctgggagg cagagcgaga t taatgccat aitttttitc gcatataaar agtgcatt 11 ctggcttrtg tat tatcat t ciccttatgc crgtgcagca tt Ggtgtctggc cattgcagct aictacctga aggaaact tc trttggtttt tattgrattg gagacacagt caacctccac tacaggtggg rcargr tgge ccaaagtact atatgiaaat cctg Ctgtct t tat t tataa atlaaaagca tgggitagaa t tun tt ta cacagatcac agctggaact tgtagagacg tcctccct tc raggt t tet t nactttttt ggagtgcagt 73560 73620 73680 73740 73800 73860 73920 73980 74040 74100 74160 74220 74280 74340 74400 74460 74520 74580 74640 74700 74760 74820 74880 74940 75000 75060 75120 75180 75240 75300 75360 75420 75480 75540 75600 75660 75720 75780 75840 75900 75960 76020 76080

30 Revision period: 100 years August 3曰

1358456 * No. 97135019 Patent Specification Revised ggigcgatct tggctcattg caaccgctgg ttcaagcgat tctccigcct cagcctccct agiagctgag attacaggca cgcgcgccat cacgcccagc taattmgt attntagia gagacagggt ttcaccatgt tggccaggct ggtcttgaac icctgacctt gtgatctgcc cacctcggcc tcccaaagtg ciggcatrat aggcgtgagc cactguccc agcctgctaa tagcmtaa aaaggaatat igattttcat agtigtgtgg cagacacagc tgacaccact agctaactia agcatactct gagaaigacc ttgcaiggca gatgcacctg acacaaaatt taagcataac ctgaggatga ccctgtagcc taagaagaat gtgtattcag agttcccagc taataaatcc aggaaggcca actgggagag tcattccna tctgtgagta acatctgaac cctcagccca tcctgtggaa cacaggccat ataggggatt gaggccctit gttttgggtt agatagaggt rgctagggg £ agggtgctaa gcaagaatgc tgtataaact gcatgcttri tacaagcagt tgccattgtc tagtccagcc cgtcaccact ggaccaccct giatgtaaai cctctcagta aaccttgtct catttactgg ctccaggtct ctttgaaagc ctctcaaaca tggcgccatc cctattgcag ccaitagagt ccggcgtggc agtggtcagg actgttgaag aaggctgaga atttagggca ctgtgaagtg tttaatcatt tatcaaggta tcaatttagt gtctctcaag gaaaaaacat atttgttgat ttgatttcat gccaacactg atgttttttg ctactctatg gccttgaata gtcaggcatt gactgtaacc aaaaggatgt tcagaaaaac aaagtgagga tggtaggaat cctttcgcct atggaaaata attgttttct tttttgagai ggaatcttgc tctgtcgcca ggctggagtg cagtggcgcg atcttggctc actgcaacct ccacctctcg ggttcaagcg attctcctgc ctcagcctcc cgagtagctg ggattacaga cgcatgccac cacgcccagc taatttttgt atctttatta gagatggagt ttcaccatgt tggccaggct gctcttgaac tcctgacctc gtgatccacc cacctcggcc tcccaaagtg ctgggattac aggtgtgagc caccgcgccc ggccaaaata attgttttct atccitagtg aagagctaaa gagaatttcc ttagaataac agcaaaggaa cttaaagtgt gaaactttgg aaaaaggtgg atgaattaca actaagtcat cttttagctt tgctttcttg atcttccttc aaagtttatg atacctaaat tctctcttca actcataaaa tgtgitttat ggtttaatag aaaagctata agcacatgac aaaattagtt cttattagct atatgcctac agaaccaatt ttgtggtttt caatatgata tgttcaattc cagaaggtgt tttataaatc agitggtagg aaccigtttt atgtgtaagc rgtgtccaga tggatgtitc tttacccttt tatgtacctg gaccaatagt accagaaacc atgggagcat aaccacccca caagaactcc acccctgcca cagccttcac tatttggcag gggaagcaga gactctgcca tcttcaagcc actggtagag cccctttcac atgacctggg aggtaatttc acaagcaaag aagtctaaag gaaaggttgt acctaattta aattattgct tttgtcatat tctctaccac tcacaggaat gttttattat taatcacaaa tcataagcaa tttatactct tgattatttc aaaagagcca catccactgc tatggttttg aaattattac attatacatt attagtcagc ttagactaaa ttatgctgtg gtaacaaacc ccaaaatttc aagggcttac aacaataaag gtttgtcttt catgctgtac attcattgca ggtaactaag acactattcc atgtcactgt cartctgaga iatgggctga aggaacatcc tctccctgag gctttgctag tgtttcagta gacagaaaaa gaacgcaatg ggaacacaca caatggttct taaagcttca gettcaaagc agcacatgic atggcactca cactttacaa agcaagtcag acggctgctc tggggacctg cagtcgtgca ggagaggggc tcccaaatca gacagccact cctggcatca atgacgcagg gatetatagt cct11tatgc tgaggggtgg tgaatccacc acagttaaca aaatcugag acttgccata aacaaattct catcrgtttg tgtgatgagg tccagatgat ggcccacttc agtagcaaag acagtgcact gtgctcacca cgccatttca tcttttccct gggttgatag gaagaiggee ttctcaaccc 76140 76200 76260 76320 76380 76440 76500 76560 76620 76680 76740 76800 76860 76920 76980 77040 77100 77160 77220 7728077 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 78720 cgtgtggcac ttccagacct agctcacaaa cgtggcaaaa tccactctcc cccaactcct 78780 igagcctgtc tctccaaati gctgcataga ggcaatgttt ccaggagaac ctcacciggc 78840 cagaaacatc igccttgaac atggttagaa caaatgaaac. tittttgtat taaaacacTi 78900 gagaitctgt ggctcttcgt tactgigrta ccctaiccig accttgctit gLggtttart 78960 raatgatgca caittacrag agtggtgtac aitcaatagt gaggtggcca caiacaacat 79020 acccctaaaa cattgctgaa agtacacagc caittciacr ataaaaatat aagtatatga 79080 grgaagaact gatttttgaa itttgcttta attaatriaa atttaagtgg tcacatgtgg 79140 gtagtggcca ccgtattgga ccacagaacc ttaagcagta ggaagctttt tgctacgtga 79200 tgtattataa atctttccac tgictcagca atctaaacat aaaaccaaca tgtctaaart 79260 tcacactttc tagatgatga agagtcataa aaigaacaga aagtctttat atg gtgtttc 79320 agggggacag ttgtgacatt ggagtgctgg tcaaagttct ttattatm ttam'gtn 79380 ccaaatatgg agtgcagaaa accaaatggt ggaatggaca tttttgccaa agtataartg 79440 tggtctttaa tgatgtaaaa taaaatacca tattcatttc igaatttttt tcar.cgtgaa 79500 gtgtgtgaga tgtgacttga caactttgca aatgtcgtgc ctctgctraa atctctgcai 79560 tatatttatg gaaatgtttg agatcctgga aaccatttag aggtgttata aaatacttta 79620 rttcttgagg tccaaaagac ttcaaaatag gggctgagtg atataatgga aagaacactg 79680 gattaggagc cagaatatct gggttatgn gcctgctctc tcactaactg gctcagtgaa 79740 tttgggcagg ttatttgaac tctctggatc tcggtttcn ctatggtgag ttiatgggct 79800 tagattaatc acccacctct aaaattccag gicttttctt ttttctgact ttaggtcagg 79860 tcttttcttg tgaagtatta aaactgagcc cacccatgtc aarataactt aactctttgr 79920 iccacgaaat tcgtgcccag gaagataaga cagtaaatta ataaataaat tcactgtttg 79980 ctttaggaaa gtcttgcaaa tcaatrrate aggacaaaca gtttgctcat ctgggcaaac 80040 agttgtctta ttaaaacaat atattgetea cctgggcaaa cagcttgaca agtttgtgaa 80100 agaatgteae tatgeattgt ggttttgaaa Atgaatetat gggctgggcg eggiggetea 80160 cgtctgtaat ctcagcactt tgggaggccg aggcgggcag atcacaaggr caggagttgg 80220 agaccagcct gaccaacatg gtgaaacccc gtctgtacta aaaatacaaa aattattegg 80280 gcgtggtggc gcgctcctat aatcccagct actcaggagg ctgaggcatg aaaatcgctt 80340 gaacctggga ggcggaggtt gcagtgagcc aagattgtgc ccccgcactc cagcctgggc 80400 aacagagcga gactccatat caaaaaaaag gaaaaagaaa aaagaaaatg attetargga 80460 aacagcagac actggggaci ccaaaagaag gacaaagaig taagaaciac ctattgggta 80520 ctatgtttat tatttgggta aggaattcag caggaaccca aaccicccac atcacacaat 80580 atatccatct aacaaacctg cacatgtacc cctgaatcta aattttgitg ttgttgtigi 80640 tttttgagac ggagtetege tctgtcacgc aggc.tggaat ctactataaa tgcattntt 80700 nttutaga eggagteteg ctctgrtgcc caggctagag tgcaatggca cgatctcggc 80760 icactgcaac ctccgcctcc cgggttcatg caattcrccc accrcagccr cctgaatagc 80820 tgggattaca gaaacctgcc atcatgcctg gcraattttt gtatttttgt agagacgggg 80880 tttcaccatg igggctgggc tggtcttgaa ctccigacct caggtgatcc acccaccicg 80940 gcctcccaaa gtactgggat racagtcatg agccacigcg cctgg Ccaac taraaatgea 81000 aititattta ctautaact gggagtagaa taicitagta tgtaagteta ggiatiittc 81060 caactagcac aacacttcag atagttrata tattggtgag attaattaca agattagiga 81120 gcacatcata gacattgagt taattatgac aaggtgaatg aacaaaacca attrictgtg 81180 32 1358456 Amendment date: August 3, 100th 97] 350] Revised 9 patent specification

tcaaacgtag 11 tacaact ΐ tatstaaaca 11 tatcgtat acai tgtaag aaattcagt t 81240 1tctgiaaaa aaatacgtag tct taagt 11 acaat tcaaa acccaiagag gt tccctgac 81300 at tacctgcc aacat t taag agctacttat tagtttgaag agagacagag tatgtgcaca 81360 11 taaact ta aggcagaaat ttgtgtctgt tggcctaagt guctttgtt cactgggctc 81420 tgaagaccat caaataaaag taat tct taa cttagtgtu ttggcactga atcttgaat t 81480 cctttttnt 1111 tgagac agagtctcac tctat tgccc aggatggagt gcagtggtgc 81540 aatct tggct cacigcaacc tccgcctctg gggctcaagt gattt tcctg cctcagcctc 81600 ccgagtagct gggactacag gcgcccacta ccatgcctgg ctaatttttg tatgttttta 81660 gtagagacgg ggtttcacca tgttggccag gctggtgcat cctgaattct taaataacca 81720 gtaccaaagt tattittctt gaacct tctc actaagtatc 11 tatcgcac atgagt tctc 81780 tctttaattt taactaaggc ctaat taaaa tattticaaa tttataattt Tttatttctc 81840 atgaagcctg ataggaaaag ctttgccctt aggctcatag tttiacctga ggaaat tcaa 81900 caatggatct gaaagcagct tattgaggac atgcagttag aacttaagaa gaatgtgcci 81960 ttaaggagga ataaccciga gaaat agttc catgacattt aaatictatt gctctgacag 82020 agccat tctg acaggtttta agtttcaaag ttatcagaca atgtgcagac aacctcacca 82080 tcicctgagc t tcacctcac tgt taaccag cctatggtaa tgtctttctc tt tt tctcct 82140 cctct tcctc ctactcccta tccttgccct gtcaatattg gatataatgg caggtcagaa 82200 atggggtgag gcatgaggtg aaaaccaaag agaactgtgc agaaggttaa gggttaaata. 82260 acatcaggca aaccagccaa gtataactag acattagaag ttcagctcta gtataaaagt 82320 taaaagacaa aagtattaaa aatcactata cctgcataat ttgttgatga atacacagta 82380 taaaaaggtg taaagtgtga catcaacacc atagaatggt gggtggggga taagtaaaag 82440 tgtagtaatt tttttttttt ttttttgaga cagggtcttg ctctgttgcc caggctggag 82500 tgcagtggtg caatctcggc tcactgcaac ctctgcctcc cgggttcaag agat tctcct 82560 gcctcagcct cccgagtagc tgggactaca ggcacgcacc accatgccag gctaattitt 82620 gtat t tgtag tagagatggg gt ΐ tcaccat gttggccagg ttggtctcca actcctgacc 82680 tcgagttatc tgctcacctc cgcctcccaa agtgctggga ttacaggcgt gagccaccgc . 82740 acctggcaag tgtagaattt ttgtatgcaa ttgaagttga gttgttacca gtttaaaca g 82800 aatgt ΐ t tgt ΐ ΐ tatgtaag gtccatggta accccaaaga acctacct11 agtagaaaca 82860 cagaagataa agaaatgaat caaagcatac cactacaaaa aaaaatttaa agtcacaaag 82920 caagactgta agagaggaag aaaggaacaa atgaactgca aaacaaaaca aaatagttaa 82980 gccct taact ctcaataat ΐ agt t taaatg taaatggat t gaat tcccca accaaagata 83040 aacagtggcc aaatggatta aaagaaaacc caagatctaa caatattcgt gtgtacaaga 83100 aattcacttt agact taagg acatacatag gctgaaagta aagggatgga agaaaatatt 83160 ccacgcaaat agtaatcaaa agagagcagg agtggcttta 11 tatatcag actaaataga 83220 ctttcagtca aaatctgtca cagaagacaa agaagatcac tatataataa taaagaggtc 83280 agt tcatcaa gaggatataa caattataaa tatatgtgca ccccacat tg aagcatctaa 83340 atacataaag cacatattaa cagagctgaa gggaaaaaca gacatcaata caacaatagc 83400 aggatgcctc agtacccct t tcaacagigg gtagat tatc. cagacagaaa atcaatgagg 83460 aaacagtggc ctgaataaca ttatagacca Agtggaccta acagacatac acagaccatc 83520 tcatccaata gcagcagaat acacgttttt ctcaaggacg ct tggaacat tcacaagggc 83580 tagat tatat gttgggc Cac aaaacaagac t taacaaait taagaagat t ggaatcatct 83640 ccagtacctt t tctgatcat aataacatta gaaat taata acaggaat ta tgaaaaatgg 83700 acat atgtag acat taagca cacactcctg aacaactact tggttgaaga agaaatcaaa 83760 33 1358456 Patent Specification No. 97135019 Amendment of this amendment period:] August 3 曰agagagaita ggaagtatct tgasgcaaat gcaaatggai acacaacata ccaaaagrta 83820 caggatgcag caaaagcaat tciaagaggg aagtΐiagag ggataaaggc ciacattcgg 83880 aagaaagatc itaaacaacc taaittcaca ccccaaggaa ctagaaaaag aagaacaaac 83940 iaagcccaaa grcagcagaa ggagacaaag attggagcaa aaagaagcta aggagacagt 84000 agaaaagarc aacaaaactg agaittgttt tttgaagaga aacaaaattg acaaatccit 84060 raictagctt laccaagaaa aaaagagaga actcaaataa atgaaattat aaatgaaaga 84120 agagatacag gcataccrtg gtrtattgca ctttartgta ctttgcagat attgcattrt 84180 ttacaaatig aaggtttgtg gcaaccctgc Atggagcaag tctgttggca acgtitttcc 84240 cgcatgrgct cactctgrgt ctctgtgtcc cattrtggta attcacacaa tatatcaaag 84300 iitttcaua ttgiatiata tatataatai iatgtaiata taatatgtaa tataia taat 84360 acgtataiaa tatataatar argttatata ttatatgna tatgcaatat atgnatata 84420 taatatatat ratatataat acatatatat tatgaiatta ttatatcaca atgctgattg 84480 tgatcagtga tctttgatgt tacaatagta attgcittgg ggtatcacag actgtcccca 84540 tgiaagaagg tgaatuaat caatagatat catgtggtct ctgactacta cagtgtgggc 84600 icigctactg ttctgactgg cctttccctc tcaugagcc. tccctaucc ctgagacaca 84660 acagtattga gaitaaacca attaataacc ctataatggc ctctaattgt tcaagtgaaa 84720 ggaagagtta cacatctctc actttaaatc gaaatgtaga aatgattaag cttagtgaag 84780 aaggcatatt gaaagcccag ataggcctat tgtgtcaaac agtcaagttg tgaaggccaa 84840 gaaacgttct tgaaggaaat taaaagtgct attccagtga acacacaaaa gataaagcag 84900 gccaggtgcg gtggctcacg cctgtaatcc cagcactttg ggaggccaag gtgggcagat 84960 cacaaggtca agagatcgag accatcctgg ctaacatggt gaaaccccat ctciactaaa 85020 aatacaaaaa aaaagragcc aggcatggtg gcacgtgcct gtagtcccag ctacttggga 85080 ggctgaggtg ggagaattgc ttgaacccag gaggcggagg ttgcagtgag ctaagatcgt 85140 gccattgcac tccagcctgg gtggcagagc gagactctgt taaataaata aa taaataaa 85200 taaatagata gatagataga tagatagaca aataaagcaa aaaaacctat tactgatata 85260 cagaaagi11 gagtcttctg gatagaagat caaaccaacc acaacattcc gttaagccaa 85320 agcttaatcc agagcaaggt ctttcttcag ttctatgaag actgagagag gcagtgctai 85380 ggaaggagag 11tggiacta gcagagactg gttcatgaga 11taaggaaa gaagccat11 85440 ccatiacata aaagtgcaaa taagcagcaa argctgatgt aggggccgca gcaagtcatc 85500 cagaagatci agctaagatt attagtaaag gtggatgatt rtgaggggtt caagacttea 85560 gtggaggaag gaactgcaga tgtggtggaa acagcaagag agetagaatt agaagtgaag 85620 cctgaagatg tgactgaatt gctgcaarct gaggaraaaa tgtgaatgaa tgagtacttg 85680 irtettatgg atgaacatcc ttcrtaaaga tggaatctac tcctggtgaa gargctgtgg 85740 atattgttga agtgacaaca aaagatgtag aatatttcac aaacttagtt gataaccagt 85800 ggcagaant gagaggattg actccaat11 tgaaaaaagt tctactgtgg gtaaaatgct 85860 gccagacagt attgcctatt acagagaaat ctttcacgaa aggaacagtt gatcaatgca 85920 ttaaactrgt ettatittaa gaaattgcca cagccacccc aaccttcaac aaccaccaac 85980 ctgaicagtc agcaggcctc agtaatgaga caagaccttc taccag caaa aaagattgtg 86040 acicactgaa gacttagatg atcattatca ttttttagca ataaagtatt 11taaggtat 86100 giacatigt t gt 11 tagaca taatggtat r attgcacat t actagactac agtatagtgt 86160 caacataact neatargea ctgggaaacc aaaaaatgga tgtgacttgt tttattgtgg 86220 tarngetet gttgtggtgg tttggaactg gacctgcaat gtatcagagg tataccrgta 86280 iraragetaa taccaaataa atagaatcat aagagactac tgtgaataat tgtatgccta 86340 34 1358456% correction Date: 1 Amendment to the patent specification of August 3, pp. 97130019

caaattggat gaatcataaa tcaaaaacct tgcgtttaaa gggaacactΐ ggacactaca acaaaatacc gaaatgtaic accacattaa tatttgacaa ggaatatacc aatggtgaaa tcaccact tc gaaacaaaag c ΐ ΐ ati caggatacaa aaattaagaa gtggctcatg tgggattttg aaat tagccg gagaatcgct ccgcctgggc aaataaaata aaaatattaa gaggctgcag aaaaaaaaaa agtggaatag gcgatgccta tttgtatgga gctggaggaa tctagtaatt aatagaaaga caagaataca atctatatgc gaattgaaga agcaaaaagc ggcaacaaat caaaggaaac gccaiatgtt cacataactc tggacatitt attactaatc tataatgact aacctggaag tata aaaactagaa ccagcaaaga taagaattaa ccaaattcat agaaaattcc agcgaaccra tctgagatgc caggatgagg tattcaacat tcaacataat agctaaaagc tgttatacat acatccaaat aaccctaaag aattaacata aacaatccta cctgtaatcc agaccagcct ggcgtggtgg tgaaccggga aacaagagca aaatacctag tgaaagaaat taagtcatga aaaaaaaaat t taatattgt tcaaaatttt attgcaaaag ccacttcctg aaaacagtat ctagaaataa caatggggaa aaaagattga ct taactgaa tcaaccttgg gcaaaaataa aatcaacaaa tgataaggag at tagcaaga tccaaagaag atgagagaaa ΐ tatcaaaat aaatggatca aatataaacg aaaaccccaa ca ccaatcct tttatgaggc agatcagtat at tcaacagc aaggatggtt gataaaaatc cctt tcatga aaaggccata tttrcctcta agtactagaa tagggaaagc aUccacagt caaatattag tttacaatag caacattttg gaccaacagg cecatgcctg ggtggacgtt aaactccatc gaataccaag tgaaggctgg ttgtgccact tgaagacaga taaaatgtcc aatggcattt accccaagta gtttcaaact ggaactggcc acccaaacat aagatcatct aattggaccc tgtgagattt tcttggcaat tgaaatggga attaaaagac ttaatatcca aaacataaag acatacaaat tgcaagtcaa gacaagagat attcctagaa accaaataag actagatggc tctcaaactc cagcaacacc cactgatgaa acactaaaaa caaatatatg acatgatcat ttaaaaacta tatgacaagc aaaccaagaa gtcctagcta taaatagtct tagaactaat ttgcatttct catcagaaag ggaggccgag gagaaacccc taatcccagc gcggtgagcc ccaaaaaata aaggtgaaag ggcagaagga gcactgcagc aataaatgga atactactga ttcacagata accaaagcaa acttcctggt taaaaacggc atatggtcat cttcaataaa t tgatttaca gaaatcgtaa gattttttig ctatgttaaa agcctaaaga aaatatataa cccaat t taa ggctgacaga aaccaccatg agtaagigtt acatacaacc taaggagatt ttctttggtg ttccaagaaa cicataccaa catagatgca catcatacac caaat ta gta ctcaatagtt ttaacaaatc tcacaactaa caagagaagg gagcaattag ctgtttgcag aaatgaat tc aataaaaiag gtatactgac cataatcaat aatgigatat gcagaaaaag gggggtggat atctctacta tactcaggag gagatcatgc aaataaaaca atctgtacat ttgcgtgatt ctgtgtgaca aaggtatcct aagcaacata tcagaaaaac tcttgagaaa ttcaaactac cactagggtc ctaatcitig tagtgttgga acatatacaa aagtcttgga gaaatgacaa ctaaaaaaac atgggacaaa ggaat tcaca aaacggacaa catgtgaaaa agctatcacc ggcgaggatg tacaaagatt aaatgagtca agt tctacta itcgagagga agccagataa aaagttctca agatacagaa catcctactc atgcccacac gcaagaaaaa atgtcaigat agtaaagttg aactaaccag gccaggcgtg cacatgaggt aaaat acaaa gctgaggtag cat tgcactc aaataaaatg tgaaaactgt ccaggagttt gagtgagacc ctgttcaaag cagat tcaat aatcctaata gaaggacaaa attacaaagc actgggacag acaagggtgc aaaactggat caat tcaagt agaaaacatc caaaagcaca t tctgcacaa atat t tgcaa taaaggat tt aggact tgaa gttgcccaag ttgcacctgt tggagaaaag 86400 86460 86520 86580 86640 86700 86760 86820 86880 86940 87000 87060 87120 87180 87240 87300 87360 87420 87480 87540 87600 87660 87720 87780 87840 87900 87960 88020 88080 88140 88200 88260 88320 88380 88440 88500 88560 88620 88680 88740 88800 88860 88920 35 1358456 Revision date: 100 years S 3rd, No. 97135019 Patent specification Amendment agaattttig atggacgt tc gSgatgaaat at tcacaata gaaaatgtgg atttgcaaaa gcaagacaaa aacagagtag agagtgtaca gtgaatatag grcagcactg gattgtggta atatgtacaa gccacactta ttcaagattt cgatctcagc ccggagtagc tagaggcggg tgcccaccti aagattttac agctaaaagc aattcatatr caaagaagga caaagtaat t tgacaaccaa catt tctgag tatgaracag 11 tatagtcc rcaacaagct aaaaaaaaaa caaggcgggt cctcgtctct gctactcggg gctgagatcg agaaaaaaaa ggcacagact tatatatata gtcctccatg aaaagcagcc t tcngcttg ttgagaggtg ttcnaaaat cictctcctc tatattgttg t tccaaaat t aaaatctgtg gccaagatat tgtgtataca acagaaacga tattgttttg aaiggtggtt aact Tr tagt t tgacgatac caaccacaca gtcagracac cttttctttg ctcatcttgg tact 111111 tcactacaac tgggattaca gtttcaccat ggcctcccaa ttatatttta attggcaggg grttgaagaa aaccaaaagt t tggctct 11 t taatatgta gtctgcacat atcagcaata cagt argccc gtgagtgact aattgccagg ggatcacctg actaaaaatg tggctgaggc teccartgta attatactga ttttagtaaa tatatatata gtcagagita attgtacagt t taatctgct cttccaagcc ggtcctccac ctgccgtcaa gtggaaatat raaaaaaaga tcrtgaagag ggaaacaacc caatggaata accrggagga tct tacttat gccagggtct t ttaagatga tgtgtttact cagaigataa actgtgtatg ttaaataagt gaaaagcrat ttttttttga ctctgcctcc ggcatact tc gttggccagg agtgctggga aatgtctaca ttatgagttg aataatctgc cttaatattt accagggatg tagct taagg ctgaagatai cgtaagacag gagttttaca ctccagcaca caccgtggct aagtggggag caaaat tagc aagagaatcg ctccagccig tgatttgggg tcttatgagg tat tccaaaa aggtcagggt t tgacaggcc tcccctatcc tacctatttt tct tatgact gggtgttgct caattigtac gctaccatat acatctgcac taagtatctg ttartragcc catgatggta atgtagaatc gggSgtgagg ataagt tcag tgaaat taga ctgggtggtg tatatcaaat act t taaaat cagicat t ta gacagagtct caggt tcaag accatgccca ctggtcrtga t tacaggct t tcttgaattt gggtggaaat ttataattat tct Tagtgat ct tcatataa ctatgactgt tataaactag aaagggggt t tattgtgaac aagcrt tgag catgcctgta tt cgagacca cgggcgtggt ct tgaacctg ggcatcaaga gagagcacca ggatgat tat atat tggcaa cagggatgaa tgtgtgaata ccactct ttt aii taccact actgat cagt t tat tctggctgtt aaacctatca aggaat taic gaiccagcca cccatgitea tcagccaatg atgaagaagg agraaaataa taaaaagt tg gairagggga tggatctaat taagaagata atggatatgt catcatgt tg ΐitacaaaag aagcaaagca caggctagag agattet tat t ttt actccrgacc aaaccactgc caartcttat atttgggcct ta aaagiggagg aggagggaga at tctgcaag ctaggagatt icacccagca 11 tgctaacc tatcaagcat atcccagcat gcctgaccaa ggctcatgcc ggaggeagag gcaaaact tc aataccct ta gggaataata aaataatgaa tgt tgcat ta tcctgcr t tg uttrtattt tcctcgt rag tgtacacaag tccicaacct aaaaaacagt tcccact tct tagcagcact aatgaataaa aaaicctgcc gccaaacaca aacrcuagt gatat tagtc gt tcaacatg gat maagt taguaat ti taegeettga acat t tacaa tcct t teer t tgcagtggca gccicagcct gtarttttgg tcaggtgatc acctggcctc tctacctaga gtggaagata taatcaggcc aagtaactga acaatt tcct aaatagat ta tttatgatga agagttagga rtcaccttta gcatatagta tttgggaggc ratggagaaa tgtaatccca gug Cggtga gtctgaaaaa aagt111 ?ac tgeatetate gaacctgaaa gttggcaata tagctgagtg aatctggtgg η itrtgggc aacrgtccac gaagctcct t 88980 89040 89100 89160 89220 89280 89340 89400 89460 89520 89580 89640 89700 89760 89820 89880 89940 90000 90060 90120 90180 90240 90300 90360 90420 90480 90540 90600 90660 90720 90780 90840 90900 90960 91020 91080 91140 91200 91260 91320 91380 9) 440 91500 36 1358456 « Revision date: Amendment to patent specification No. 97135019 of August 3, 100

ccacatcct r ct tgccagct cactatcagt catttcctga gactgacatc acaaaagagt 91560 cat tagat 11 aagccctggt ttcagcaatt aciggacctg ttgtgattct agacagggtt 91620 cttaactttt aat 11 tccat gacatnttt cccttgacat cccagiccaa gctgttgact 91680 ttigcat tta ctgctcatt t ctacct naa tattccattt tcctctgtta atattatatg 91740 ctgtgaaacc caggagaagt cagcat tact atggtcttgg gtagaactga gagagataaa 91800 gacatgaatt tgaggctgtt gggggatgag ttgeagagag gcataaatac gaggeagaaa 91860 ataagt tatg agtgagaata caacttatta atagett ttg taaacttctg gcaaaaaaag 91920 atatigaaga iaattagagt tgaaaaatta tataagacat cacttacgai tgggattcaa 91980 tcacatt tta tagaaaattc aaataagagt tget taagea tgaaagaagt tcagaggtaa 92040 gtagctcagg gcttgtatgg caactccatg gtcacagggg gcccaggttc cttctcacat 92100 tgt t ttctcc carccttggt gctggcttac atgccaaaig tctcctcatg accacaagat 92160 gctcctggtg r tcccagacc aaactgaggg ttgggctgct atttctcgtg gcccaataac 92220 gagaagcaga tgaactgggg aggaagagtt tttatttctg caactggtta tggggggaag 92280 gcctggaaat tatcaccaga ccaactcaaa att acagtΐΐ tccagagctt ataiaccttc 92340 taagctatat gtctacgtgt aagtgtgcat teatetaaag acataagtga ttaaettett 92400 ciaatctata gctaaggtct gagtcctgaa gaccticctc tggagcctca gtaaatttac 92460 ttaatctaaa tgggtccagc tgctggggtg attaccctta ttatgtctcc tgcttaaatc 92520 acggaggttt ggggagttcc ttcagacctc caataaactt gtttgtggag gtctggggag 92580 ΐ ttct tcaga cccacaataa aactcgttta atcctaaatg ggtcctgtta agaattcctt 92640 tgitattttg ttatgcttta aggcccagga aaagcctagg caaaactctt ggtgggcttt 92700 cgttacattc cagcctt tgt ataagggcac tggctttttt aact 11 taat atttaaetta 92760 accactcagt cagtactgaa acagttgtta tggaggcctg cgttagtgag agctggcctg 92820 ccacactggt gctccagcta ttatgtccac gttccaagat ggaagaaagt ataatggcaa 92880 aagtacctat ctctcagctg aatcagtttg ctttaaaggg cttccttggc ttccatccac 92940 ttctgcttac act tccttga acacctccag aaaccaagga ggttgggaaa getttagget 93000 gaggacat ta tcactccaaa taacatattt ttaagteagg aagtgggaag agiggatatt 93060 gtgtaggcaa ctcacagtcc cttccaccat agccgaccag gacagagata Gctggatgat 93120 ggtt tgctct agttgagcct aaacaagctc atggctccct ctcctiaaac tacttttata 93180 ttttctt tct ctaagt tcag agcaaagcit tcatattatt ttatgaargt ttct taacaa 93240 gctcatcgtt tctggigttt tgctgcaatt ctgcagtaga tagtatggta tatttggtgg 93300 acagattcag ggccaccagg ct ttgaatag cagtggtgct act tagaage tgagaggtta 93360 tgaacct tat agggaatagt gttgttacta taaataatga ttgtactgaa 93420 ccttatatgc aatagtgaat aatgttatta taaataatga ttgtactgaa ccttatatgc 93480 atgcaaccat aacataggga ataatgttat tataaataat gattttcaga ctgaggcagt tttctaaaaa 93540 t tcaagtgaa agatcacatt actttacatg aggaccacaa ggcacattca aaagataegg 93600 t tgat tcact ttgttaaaca ataagaatat aagtgtccaa atacagaaca aaggaaataa 93660 tatgtccaag aaacattt 11 ctttgcttaa tactaaaagc ctcttgatct- gtttcctata 93720 tcctagtcac aactgaat 11 taagaaagtc gaggtcatgt tggtaacicc atgtcaatac 93780 tgctttgtgt actaactgca agatcaggaa tcgtccctca ttacttccat ct tggctttc 93840 aaaagagcct actgtaat 11 Mt tctga aatagtatga aataact tt t ticctgaaag 93900 aaaatctcct ΐ tctatggtt ctttcttctg aaaca Agget ttcct tetet gaget tccag 93960 ctagaataat t tcctctgac atactctgat ctaggaggat tgtagtgtgg tcacaatgcc 94020 tcagctgat t tcagttaatt ttettgaget gaatcaaatg aatgtcttaa caagitgtcc 94080 37 1358455 Amendment: August 3, 100, 971,350, 9 patent specification amendment u taaaagga rrcaracaat tcagtaaata taggggggaa tgtgaaatgt t tct tcctt t agmaaata aatagt t tac atctggagaa ctgaatagac tact t tccgt gactagcttt tatataatac t tatcactgt catggacagc aacaagatca cttcaagggg ttacaggget t tatctatat tatattcctg tttcatttac tttcaaagn cccaggct tg agcagtcctc tgtctaattt gaacacctgg gtgagccacc caggtacccc gggacattat ctggcactcg gattat tcgt atttcaggga agtataegag ataaggcaaa acatcgctaa atgtgiggca tctaagaaga gactgattcc sttgccaggt ttttagaaac agtcccctcg ttctttggcc acatgtaact tagacgtgct gtaatgaagt Ttggagggaa attattttrt at tactttca tatttacati aaaatttaca cratatttta tttatttcgg atai tctgc-t atgctgat 11 taacacagcc ttatggaaca gccaacaaaa tgccagcctg gatcctagtt cccagtaggc aggtgagaaa tttctttaac actaagct tc agar tgccat tattgtttat ggtac agtgg ccatctcagc ttatattttt gcicaagaga gcaccaggcc ttttttctca aggatagcct acatcagtgg tcagaaaata gatiaaggga aatagctt ta ggtttggtca aagagtggga ggcacacctg atgtgtgttt t tgtctatga gaaggttgca ggtagtggtt agaagcccta tctcgaacct aacaattagg 11 tatacaaa ct tggtat tc ggaggatggt cttcctgggg aact tgagga t taatgataa rtttaatgat tacgtgtttg gttataatag aagcaagcaa ttaaagtgtc agaagaagct gtggttgccc agaaaaacta ggcagatggc tgagacccaa aattgtggga aggtaatcca aattatatat atcaatatgt taggatacct t tat t tat ta tgtgatcug ctcccaagta tgtagagatg tctgcccgcc caaagt taaa ggggaactgg agaaacagaa gataggaggg at tgaaatgg cttaagttat tgacctrgga t tgagccatc gagaaaaacc acagcaacaa ggagttctca ggaacatctg ggaggggagc cgtccatcca tatctcat 11 gtgcratccc aaacagaaac acrtgcat 11 cagcgau rg ggaaagaaag ataggtttca cccagaatat agacactcat aaagacactc tnaaaaaaa tcagaaaatg tctcctctta tgiarttggt gaigtgaacc accatttttg ggaacctggg gtctstrtgg aacctggtga aaaaatctgg aggggtaata attact Iaaa atttgcttct tagtaatgat ttaitttgga gctcactgca gctggaacia gggtctcgcc tcagcctccc ataact taat ctcctactta acactcacgt ggtaatacat atctgtact t aaaaggcaaa ggagggaagg t taaaatcaa acacactggg ccgaagcata gctgaggaac aacccccggc taagtaaaaa gcctgctacc gccagcictc taiccaacic ctgtcrtua aaatgaaacc gcacctaaat aaagggggag π 11 taat tg aact tatgat tggccaagac at tggccaag aaaaacacaa tgtgccttta gacigct tgc tggiggcttt ageagaaata aacccaagat gaggaettag t tgagacaga gtaagaacaa aggtcctgaa tttttttctg ggaaaaaact tttatacaaa gtccagt tat ggcagggrct gcctcgacct caggtgtgca atgt tgccca caaatgctgg gaataaggtt gatatet tat cagtgtgatt taaaiggtgc cat t tcatac act t tgaaac atttacaaat ggaaattact agaaaatatg cccrgagaar ctggtagtgg ccat t tegga t gc tatai aa actggaccgc ggictctrct aataggggtc gaatgtggga actagacitc gcataggcac cagggaaaat ggaaatgtaa gatttaagtt ccagaaaaaa acccagaaaa tcir tgaaaa agttitgctt tgagcacata agtaataaga acacigatca rtccigacat agagaggaag t tcaccagga gtgttcagga Cngcccaaa ct 111 tggtg etaggtetra gtaacat rgt gatgeagata tactgtgrtg tccaggctca c.caccatgcc ggctggtctr gattatagge tggatgatgr gaccat tagt t Aiggetaag atgggaaat t acaaaaatca m tggaaai agtgt taget tcatcaaaag tgccatacat gaccctatgg ccaacccgga ttaaaggagg actgcaiact tgcataigta ttggccicrc iggcacaaia ct ictct tea 94140 94200 94260 94320 94380 94440 94500 94560 94620 94680 94740 94800 94860 94920 94980 95040 95100 95160 95220 95280 95340 95400 95460 95520 95580 95640 95700 95760 95820 95880 95940 96000 96060 96120 96180 96240 96300 96360 96420 96480 96540 96600 96660

38 Revision period: August 3, 1 year

13584564 No. 97135019 Patent Specification Revised tcaaaagcac tgtaaaatga gttaagaaac aacccaiaaa tactigagga agaracttgc caiacatgta actgacaaat taataaagga aaaaggtaci ctggagaaaa atgaacaaaa gccttgaata gaaactacac agaagtggaa atgtgaggtt gggcgtggtg gctcacacci gtaatcccaa cattttggga ggcctagaca ggtggattgc itgagcccag gagtttgagg ccagcctggg caacatggtg aaaccccatc tctacaaaaa aatgcataaa ttaactgggt gtggtggcag acatctgtgg tcccagctac ttgggaggct gaggtgggaa gattgcctga gcctgggagg tggaggttgc aatgagctgt gatcatgcca ttgcactcia accigggcaa cagaggagac cctgtcaaaa aaaaaaaaaa atgaaaatgt gaatggtcaa taaaaatgtg aaactactta acttcattag taatcaggga aatgcaaatg agaagcacca ggtgatactg tttcacactc tccggggcgg ccaaaatttt taagtcttaa caaacaaccc taacaatgta gagtcacaaa caggaatcct tagacactgc tggiggcagt tgaattagta cagccacttt ggagaactct gcagccttgt caggaagagt tgaagctgtg tgtaatccac aacactgccc acactccaca gcaatgcttc tcaagcctgg cataatatat tagcatccca aaatgagcat gttggaaata cttacacctg gcccttaccc cagacctgtg attctcaaat ggtatgccaa gatgccctgg ggaaccacag caaac tcaca gaagacgat £ ggatatctta aatgttcaag gggaatgcag tgatacttgg catctgttga acgcagtgtg aattactagc tcaagacact tcagttcagt ctcaatgtta ccccacgcat catccctttc tattatgcga agctggattt tcagtggttg ctgtaacaaa aagcagatat catgaaaatc agtatggaag aggaaataag ggtgatagag tccaatatga ttccaaagtt taagaagttg tatagtgccc aacgagtgca cacattccat taataagtaa ttgaggttat ttaagaatga aataaaactt ttttctttgg cagatttttc aaacagctac tgcattgtta ggacaaaaaa gacttgttaa cttttttgga cctaactact taaatggaat tgttaggaat ttgttctagg ggtgcctaga accctgaaaa aattgagcca cttagtagtg tattticata tcccttcaac tgagaatatt tgggaatctc tttcccaaat tagttaactc agaatggaga tggaatctct atgtctttgt ttttaaaaag ctccccaagt gattctaatg ggttcgtaag gttgagaacc actgcttgag agactcttgc acatgtgact taggataatg ctactcaaat tgtacctggg ggccagcgct ggtttgcaaa ttatttccta cagatctgca gcaagtttat atgaatcata ctttcagtga ataatggtac agtttttgta atcttttgtc ttctgattaa atttactgaa atataatttt atgtcaaatt ttataatgga aaaattgagg cttgtacttt gtgctttttt ctcatatttt tctaatattt atgattttac agctttgttg atgtataagt gat caatttg cactctttaa atatgtgcaa tatattatat gtcaattttg acatatgtat atacttgcga aatcatcaac acaaccaaga taatgaacat atccatgact ctctaaagta ttttctcatc cctgtgtaat ctctcccati tggccctcca catcccttca taatcctcca ctcctgtccc cgccccagtg caaccactca tctgcctgtt gtcactatag attagtttgc attctctagc atttcatgta aatggaatgt tactgaatgt actcttgctt ttgtctggct tcttttacit agcataatgt tttgcaatlc agccatgttg ttggatatgt cagtagttta ctccttitta ttgccgatta gtattccatt gtatggatat gccacaactt ggttttttat tcaccaattg atggatattt gaaatgtttg cattttggct gctatgaaca tttgtgtgta aatctttatg tgatcacgtg ctttcatttg tcttggataa ataaatacct aggagtggaa tggttggatt gcatggtagg aatatgcata tagtaattta tttttattgc atttcacaaa taaaaagcat tagcccacaa ggattagaaa taaaactctc ccaggccggg agcaggggct catgcctgta atcccagcac tttgggaggc taaggtgggc tgatcacctg atgtcaggag ΐtcaaggcca gcctggccaa caaggtgaaa cctcatatcc acraaaaata caaaaattag ctgggtgtgg tggtgcatgc ctgtaatccc 96720 96780 96840 96900 96960 97020 97080 97140 97200 97260 97320 97380 97440 97500 97560 97620 97680 97740 978 00 97860 97920 97980 98040 98100 98160 98220 98280 98340 98400 98460 98520 98580 98640 98700 98760 98820 98880 98940 99000 99060 99120 99180 99240 39 T33B455 ~~~ —— 971350丨9 Patent Specification Amendment Revision Date: August 3, 00 said agctactcag gaggctgagg taggagaatc acttgaacct gggagargga ggttgcagtg 99300 agccgagatc acgccactgc actccagcct gggagacaga gcaagacicc t tctcaaaaa 99360 aaagaaagaa ggaaagaaaa cicttccttc agcaaaigta tittgaaaag tactagccta 99420 agttaaatgc ccaacagtgt tcacagctac attgttiata aiagcaaaag aciggaaaca 99480 atccaatcat ccattgrcaa gagaatggat tartaaiaig aagtatarat ccagtagact 99540 actttataac aatgaaaact acattgatgt agctgcagtt tatctactac artaatgtag 99600 ctgcagctac attaatcaga aigaataaac ggaatttaaa gttgagticc aaaagcaaat 99660 tgcaaaagag tgcatatgga aggattteat catatgaatt ttacaaacag tattttacta 99720 caatattaaa tagcattna ttracagaaa catacatata iggtaaacia taaagaaaai 99780 ggtgatacaa aatgcaggat agtgtttact tggggagtgg ccgaaggtac aatgagagag 99840 ataggaccaa ggaggacaga cagaggcctt tgagg ctagt gggtcttggt cccgttctta 99900 aactatagga artcatttta atgttacatt ttgtgtttat attttgtcat aaartttttg 99960 tgcatattca atatgtaacc acaaaataca aaaaaactct caacagttga caagggagtt] 00020 tattaagcaa atagaggtac caattacaaa ccatcagggt tagaaaaaaa atccaggctt 100080 taagtaaata taaatctaag taataggcta t tgactatta icttagaaaa act tggggia 100140 ttacaccagg ttatcacaga atatttagtt gagaagtatg gaaaatatga tatgctat11 100200 atttgaatga tactcggtag gcatgtaatg tgatgattaa atcagttaag aatatgtgat 100260 agattttttt taaaaaaaca tctcatttaa aaigcatgtc tttrgtttir atgattattg 100320 aaaaatggtt ttcagaatac aaaatgasaa tcaaaaattg gtaattagat attctgtgtt 100380 tctcaaatgg acggacttta taattgggtg gagttatgtt aaaagctaga aaaactgaag 100440 aagttaagaa agaattgaaa attcccatta agagaaaaaa gaaaaagctg caaccutgc 100500 taatataaac cgiaagagcc tatgcctctt gaaatttctc tgtgtttgtc tttgtacatt] 00560 tttaatgact taargagaaa aaagattcat caggactcct ttcctagcag gaggtttagt 100620 gtttcacaaa tgagtaggga gctgctctca taatgaggta aacggccacc tgattcttgg 100680 ataagtccaa Ggaaaa cctt tacaccagag gaagcaacag cttgccagtg ttcaatctga 100740 gactttccaa ggtcagaaga gaggaggatt ggtattgata tttaataagc atttactgtg 100800 tccaaggcat tttggtacga attttatatc tcttatctga tatcctrgcc ttttaggact 100860 aggctgtttt tacctttaag gtagaigtta ttatictcai tttacacatg aggtaactga 100920 aacatagaac ttaaaaacct tgccaaacai t tcagaggag gcagattiaa acccagatgc 100980 atttgcatta aaccccaatg gaittgattc caaagcacgt cgtcttrcig ctaataatag 101040 ccaacagtca ttgagtactt actatattta taccaaggtc tgttccaagt gatacataga] billion i100 ttttctcttt taagcctcgt ggcagtatga gaaagaagct attattatcc ccattttaca 101160 gatgaaaaaa tggagtcaca gaatgttatg taatttgccc aatgtcacac agtaagtggc 101220 agagttggtc cacctcagga gcccacactc ttaacctctt ttggcctttt atgagtacat 101280 ctgccctctc aaggatcagg cttgagtctg tcagggaggc cicatgtctc ctartaactt) 01340 ttgagccata cgcatcatgg aaactggttt ctcctggctg ggtacttctg agttgcctgg 101400 cctcctgtga gctcttcttt tctaattgaa tctactctct aagacrcttt gcrgctggaa 101460 tatgcagcag tagtugaga gacacttctc agtcagttct aacatgt t Ta gctaggttc t 101520 tcctattttt tgrgcticat cagatcattt gggctcagtg ttttcutct ttuatttn 101580 ttcnttttt ttgagacagt atctcacgtt gttgcccagg ctgcagtgca gtggtgcaat 101640 ctcagctcac tgcaaccctg cctcctgggt tcaagcgatt ctccrgcgat rctcctgcct 101700 cagccitcag agtagciggg attacaagca cctgccatca cagccggcta atΐ 11tgtat 101760 ttttaataga gatggggttt cactatgtig gtcaggtgga ccttaggtga tccaccrgcc 101820 40 amendments Date: August 3, said 100 years

1,358,456 No. 97135019 Patent Specification Revised tcagcctccc aaactgctgg gattacagac gtgagccacc gcgcccagtc tgggctcagt gtttttcagt ggaataagga tgaaicatta gaagagcrtt catacctctt aaactctcaa aitccatgcc ttaataagga ttutattaa tacitcatrt ccatttgatg tgattataac aaaacaaaca gtaattaagc aicattttaa tcatatgctt tctactccaa aaatatttga agtagaagaa accaatacaa tgggataaac acaaaaaaat gcagaacaat gtagagaaaa cagagataat tatacaaaac cttaaggtat tttcgttatt gcrgttgagc atttaatgct gaatttcctg gcagctgagg caacagaaag gtaattggic agataatttt tgttatatgi tcaaataaag taaactagtt cattggggag gatagggtac catgtcaggc cactagccaa ccctiitctt cctacaagtt aaattatatc igaatatcct ctggagcact cagatcttaa aatactttag aagagactgt aaagaactgc cagtgattgt ctttaaagag gcgtcatggc agtgctgtaa ttcttgctta gcaacactta tatctaagct ttcttctcrg agggaaaggc caggttctag gtcactccct cactttgttc cagtctctgc ccaaaggtca cctcttccct gactgccctt tctatatgag gitcccaccg aacgcatctg ggttgccctc tatccctgtc caacatagta gtcactagcc atatatgaca attaaaatta attaaatgac aaaataaaaa attcagtact ttggicatac cagccaca tt tcaaaagctc agiagccatg tgtggcaact gggcatattg gcaacacaga tacgtcatcg cagaaagttc cactgggcac tgctagccta tgctcttgcc ttaacttttt caacactatg ccatgccatg cacctattga tttgtttatg ttccaciaga agtttttttt atacatgctc tggatcaca® agataaaatg atattaaata taciagtcaa ttttgttttc ccagaacata gctgaatcct cagtgcctaa agcagtgcct gacatagtac agtgctttgt aaatacttgc cgagtgaatg aacaacaaat gaatgaatga attttagtat tattttgcag tttcaaatca aaagtatttt gtctaatgtc cctgggtgac ctagtacacg ttctgccaca gtttitgaga tgaaagaacg aaaattctgt gatcaaagag aacattttaa aattttattt cttttatctt ttatattatg aagaataatg ggtacgaaat ttctgtttat caattaacgt atcatcctga atatgaacac agaaaatatc aattttcttt gcattaagaa gtcatgtaag tagaaggaga aaacaaagta cttattacat agctaactgg acttacagtc acatctaatt taaagcaaat ttgctccatg caatggaata tactaaaagt aatattgtgc aattatagct acagacatga taggaaatca taatacattc taaaagtata tagaaaaatg tcagtttact tcaacttatt ttaaacaaaa attacccatg aaatgattgc agtacctaaa aagaatttgc aatctgaaca aaatataact agaagcacga ctaccctata ictcctataa atacagattg aagctagttt tgtgat ttca gccaaagatg cagcttcagt aaccttgaaa aacattgttt cctttctatt gggcctggct ttgtcaggag atactcagga ggtgatggtg aaaggaggta cctggtggag ccagacgagt cgggtaaatc agctttaaca agcagccaga tgatagatgt cagttgggtg tcatgcccaa ttctagttgc tgacaattag gaattagatt aaaataggag tgttttctcc ttcaccctcc ctttcttaaa agcagccatt ttctgagtag tgttagttct tagttctcag tggatttgca aatgcagatc atgaggcacc tctagcttgg gcaggattgg tgttattitg ctatttcaag taaaaaacat gatggttagt gtccttggat aacctcatat actttcattg tttttcaaat caggtccagt gaagggccaa gitcttcata aatatcatgg ctaattttgg aaacccatat gttcagttaa ggtttctgaa actggaataa atatgaatgg aggautatc aacatttgga tatttgcaat ttcaattctt gaitcttttt tgaaaatcia itxtgggtct acatctgaaa tgtttatctc ctttggtgct agatccagag tacaattttt gaaaacttta aatcaagggt ggaacaataa attcacttgc tcttaagact itaggggttg ttttagctgc caagagagca ttgcctgtgt gctgcgaaaa atacgagagc cacagaatgg ccaaattatt gcttttactc aggcagagtg aagaaaatgg 101880 101940 102000 102060 102120 102180 102240 102300 102360 102420 102480 102540 102600 102660 102720 102780 1028 40 102900 102960 103020 103080 103140 103200 103260 103320 103380 103440 103500 103560 103620 103680 103740 103800 103860 103920 103980 104040 104100 104160 104220 104280 104340 104400 41 1358456 Revision date: August 3, 100, No. 97 Π 5019 Patent ^^月书改本本ccctgtgaca aaaaaaaagc acitgactat cactgtgggg tacrgaat tc catcatctgc ggaaatctga aatat 11 tac gcttagggac catgggrttt aatttaggga aatct 11 tct gccraatct t tamtam cicggctcac agtagctggg acggggtttt cctcagcctc. cat 11 taaat cangaatat cagtgt rtca acittitgtt aaaatactac cataatcata aacctaaata gatccaatct cggaggagtc 11 tgtacaat tgcat 111 tg ttgttgitrt agtggcacaa tcagcctccc ΐ t ti tagtac gatgatctgt acccggcccc gatctaagtr actgttcttc acatcctgt t crgtaacagt tat tat tgta tatgt taatg ggccartgga ttaaatgcat gacat ttcca cagctggggt aiagtgaggg agagggagag agaaftgacc aaagataatt ctactcaaat ictgtatgta catcttttga cagtgttttt ggagtaccag gccttaaggt itcatagatg ngagacaga tgcaacctcc at iacaggca gccacgttsg ccaaagtgct t tcaaaatgt agtatctcct ccaaatciar tgaaataaca ac tgattnc gtacagtgaa acttatttca agaatcccat 11 tctataat gtcc.ccagn acaacaatac tgtnttgit tctcagctca gtgtagctgg agacagggtr ctcccacctc cagtgtaita t tggtcact t ccamgaat icicatcata tatragtgtt at tctactgt iggatatata agcccct tea g \ tgtaactc gt t tcctgta tct tgacaca arcciΐ tgea aggctgicag tcacagaatc ictcatciai aagaat ttet cagatggaca tttigatccg ttgtttttgt cttgtttttt ttataacaaa atagegtage gtet tget 11 atctcccaga tgcacaagca ccagactggt gggattacag aataaaatca tggtgttcat caactctrtt aaactttctg atgtaccct t ggaaacagaa gtttgccgat acaacact ta tttcacgact tgggttigtc cactgaagtg ttggagaagg ctgcaacctc gaccacaggc ttgccatgtt tgtctcccaa tatgagaggg agataatgtg taaiaagtac ct t ΐ tgccca tgctaaatgc aaggaagage attagt tacr gacaggctcc tggcatcaca catagaaatg cagt icatgc ggatgatgat aaccttcccc tgatcat tac tcaigagiac gtegagagae tcgatactgg tgtcaagart ttttgrttia ataagngtt tgtgaaacta Ccagaagcaa gttgcccagg t icaagtgat cgcccagcta ticgaacgcc gcgtgagcca caagt tatgc gtccttatgr aaggeagaga ataact teas gatacagct t attgacgitg tgtcctacta c t tgtcacgt raatactttr tgatgt 11 tc atgt tgtgcc ggtcrccatc cgtctctcgg acacaccacc ggccaggctg aaagctggga tacatgatgt gtgtctacca tttgtgggga itaatrttag tgataratπ tgtictt tct ataattttii tgtcrcctt t agatgtgtct gggaaacagt taauttaaa ctgtigaaga tccagaggcc tgatgcaaga cigigcttat tgaacaagcc aatatttctg etaaggeagt atiictgtn tcttacaaig agt t tcacag tatgctgtga ctggagtgca tctcctgcct arcrttgiat tgacctcaag ccgrgtccag cagaaagcca tettatataa ctacatttat acttagaaaa ccccagatgt atacaatagc gtgtcctttt cttgttagtc gaagagtccc t raggataag ct tcccaatg tgttgccctg gtrcaagtga acgcctggct gtet tgaact ttacagatgt cagtatgtct ggtttctcca gatgctttaa atactar tga tatrtccatc tctgctattt tctcaaaata tgacatatcc ggcttattrt tgtgaaaaaa i tgtactaat cicagcaggc ttitaatgga gcaaagrcaa caccacatct aggcaccagg tctcactgat ttaaciaaga ctgtgagtgi attaacacai gt taaticca cattttaiit gtggcatgar cagccaccca tttaacagag tgatccacca cctaccgtga ccgtacttct ctctgtgtgc t tat 1111 ta aagttgcccc Taccatct ta atcactaact taaagtccag teatetagte gaccagtgat aattagetta tttrtt Grtg cctggagigc t tctcctgcc aatttttgta cctgacctca gagccaccgc cat tgctgt t ctgcaaagt t gactctgcaa tgancr tac at tcct teta attgatttat ictcagart t teat tatet t gcrccagccc 104520 104580 104640 104700 104760 104820 104880 104940 105000 105060 105120 105180 105240 105300 105360 105420 105480 105540 105600 105660 105720 105780 105840 105900 105960 106020 106080 106140 106200 106260 106320 106380 106440 106500 106560 106620 106680 106740 106800 106860 106920 106980 42 1358.456 Amendment date:] August 3, 2003, 97] 350] Patent Specification No. 9 Amendment of this tagaatcagt aacttctcca aagaccctag ttctttttac tgtagactgg tatttagaaa 107040 caaaatcigg gtgctggata tgctcaitgc tactggtata icattgcttc taggccctct 107100 cagcttacag tgctaggaaa taatgtgtct gtatatccag acacatgtit ctctctccct 107160 ctctctccat atctatatgc ctatgactat ctacctatta aaaacaataa gtttatctac 107220 ttartaatac ticcacttac aattcaatac cactagtttc cttttagata tctctttcct 107280 107340 107400 107460 107520 107580 107640 107700 107760 107820 107880 107940 108000 108060 1 08120 108180 108240 108300 108360 108420 108480 108540 108600 108660 108720 108780 108840 108900 108960 109020 109080 109140 109200 109260 109320 109380 109440 109500 109560

tactcgtggc tttttctcca acagttagaa acctggcatt cattatcrac aatatattta ctiatttgct caaccctagt atatatgtaa agaagtttca gaactgtgat ttccataatc ictatgagaa acaagtttac caacaagact aiatagcatc caggtgcagt ccittttgic tttagtctta aggtatataa taaaagtact ggtitccaaa attaggttag atattttcti tcttacctct ttcatggtgg ctgitgtut ttacttgtaa tacagctagg ttcitttgtt actgttcgtg ttccattttg ggttccccca acaccgagag gttggtnta attaitcttt attaggggga tgtgaaacat gattattgtt ctcagagtca gaactctgtg aaaaggggcc ggtcgtggrg gctcatgcct gtaatcccag cactctggga ggccaaggtg gtigaatcac ttgaggtcag gagtttgaga ccagcctggc caacaaggtg aaaccccttc tctactaaaa ggacaaaaat tagctgggca tggtgatggg cgtctgtaat cccagctaca tgggaggctg aagtaggaga attgcttgaa cccaggaggc. agaggttgca gtgagccgag atcataccac tgcattctat cctgggtggc aagctagact ccatctcaaa aagaaaaaag aaccatgtga aaaggcattt cagaaaagtg tcattccacc tcatcccttc tgtcacgttt cagtctccca ttcttcccat ctaccccgta agtgaccagt ttagtttcta cttttttctt ctgtatttct ttttgcacaa ataaacaggc acatatatgt titcttatac agagatgata ttcagtgtct itttttgtgt ggtactgggc aatttaaatg ctgtttggta attttaactc ttaaggatac tgtΐtataat tgatctgtcc ttaatgccaa tgtattagaa agcacactaa atgattgttt tcttttttgt aaaatatttg tgagattttt taaaaaatga aggtgacatg aattttgatg ggcttattaa cactgaacta tttcttgata agagttgtct aaaaaaatga gaacatatgc caggcgcggt ggcttatgcc tgtaatccca gaactttggg aggctgagac gggcggatca caaggtcagg ggatcgaaac catcctggct aacaaggtga aaccccgtct ctactaaaaa tacaaaaaaa aaaattagcc gggcgtgttg gtgggcacct gtagtcccag ctactcggga ggctgaggca ggagaatggc gtgaacccgg gaggcggagc ttgcagtgat ccgagattgc accactgccc tccagcctgg gcgacagagc gagactccgt ctcaaaaaaa aaaaaaaaaa aaaaaggaga acataaagca agtaacaatg tttttcaagt tttctttaat gcattacatc tttttttcac aagatattΐt aaaattttat ttttccttat taagcgaatt gaattatttc aagcatcagt gagagctgct agactgttat atttcggggg tcttgcaggg tagcttttct tacacatata agcagaagaa aacattttcc caagtcttaa aagagggtta tgatgcattt cattgtgtac tctttttctt cccaiatact ctgcaggcat ttgggcagtc cttctccatc caccggaagg ttgctgaaga tggagagact cgggaggaaa cgcttctgca ggagtcagca tcgaaggagg cttactat ct ggggaagatc ttggagatgc agaacgagct gaaacagagc cgggctgtgg tcactaatgi acaggcagaa aacgagaggc tcaccgcagt cgtgcaggat ctgaaggagg taaataaaca aattccctat gagagatttg tgagagggag aaataagaaa gttctctcca tagcagagag gaataacact tttgttttaa tcagaggagc tgtattaagc acgaaactac taatacigag ctagcaactt ttctttttta gtgaaatgat agctagcttg itctgagatg agcitncrc tcttttattg tttcttgaaa artaagtttt gtatgtattg cggacttcgg aattggcctt actatttctg caaaggtatt ttaaaaatac agtgacctta gcacttcctc cctgcattag ctggtttaat acaatgtgga gaagaacggt tggctgtaat 43 Π5Μ55 of No. 97135019 Patent specification correcting the present date correction: 100 on August 3 gcrctgtarc tgcctgarit ccagcrgaca gtggrgrrgg ctcaggacac tgcrcatagg 109620 gaaigacagc ctaggcgagt gtcctgagaa gtctttgagt ctggtgatgc agatccccaa 109680 aggatttttc tggitataga gaaggcagca aattaiggct ggtatgaaiΐ aggtcaggga 109740 gtctctcttg ctctgtgagt grtgagcatc caccaaacrc agtaitccti gtragct111 109800 ccaaggcagc atcacctgcc atatcatttt caaactggca gagtcatcct ttagtggagg 109860 Ggigaigng gaaacagaga tagccaaaag tagcttcatc cai caaaccc ctgiaagaac 109920 atuttggaa gctatattca atcattcact ccgtattttg atatgaaagc tatagaagag 109980 acgcagacgt cciciaactc ctacaccaat gcagtgatca irgacaggtc cacaaccaag 110040 tgggcreact agttgagcat ittagtgata gaaatatgta ggatgaaaat aircttcaai 110100 atigtaaagt ataagacaag caatccacat ttgaaataag tgacatatta caaatagggc 110160 ucaciatta taagatataa gttgtccaga autattgga anttetaga raatttacgt 110220 ttacacatgt ccatattaca atgaactaaa tgaatactga cagcaaggtc aettatgaga 110280 taaggtttac tiatetegtt arctttggat atgcccaaar atagcaatat gacttgtgaa 1i0340 gacagagaaa ggatctaatg aagtggaagt tagtgttgag tactaagaag aagatgagac 110400 agtfrrcagg ataccaggac ctcctcat11 ccctccaacg tgaacaactg ttaaaaacag 110460 agctactctc tggttccttc tttctgagac. agggtgtcac tctattgccc aatctggagt 110520 gcagtggcac aatccagcat ccattgcaga agtggacaga gggtcatgtg gagccaaagc] 10580 ccaccattct ggat taagga agtcaccaaa catttgcagg gagcaacctc ageageegtg 110640 ageageaggg gttggeagag aggatgtggc atgggcaacg tgaggaccgt 110700 gtgcacacgc atgcaggtgg tttat tcatgtgcaa ggaga agaatgtgac caatgagtcg agtattcrtg 110760 atggccagtt ggatggatcc tctgaaagct gcaatcccca ttgtgtgtag cagctgcagc 110820 tgagccaaga acagccaagg ttgaggatgg ggcagggaat ccacagatgc ttttctgtgt 110880 gagtcaacgt ggtgatgatt aatggagcat cctcacttac acagccacgc ttgaaggcag 110940 ΐtccaatgag tagatttatg atgeatggea gaagttaatt aattaageat gaagttacaa 111000 gttaggaatg aatggaggca gcaaaagaaa aaaaatttga ggggcctttc attcagatca 111060 gttctcaaac ttgaaggage atetgaatea cctggagaac tcatcagacc atgaacacgg 111120 ggccccctcg cagagattct gattcagtag ategaggrag gacccaataa tttgcatttc 111180 taacaagttc ccaggtgatg tgggggctgc tgctctggaa accacatatt aagaaccact 111240 aat ΐ tagat t 11 ttggcctg cccaaagctg aggaaggctc acaattggga cat tgetata 111300 agcaccatga tctcctgaai aaatcaattg gttgigattc ttcaattttt argcatttta 111360 catagtagat itgcagtaag agaataactr gttatatcca catttaggta ttutgatet 111420 aaaacagctt gaggcactit agcctatgaa tgtgtttatt cagatttgtc aggiaactaa 111480 aagaaaaaaa agatcttgtg tttctrtgtc ttctatgtgt gccaataatg tattigtiaa 111540 tgtictttct gatgagtgag agctggtgai attactataa cccigagttt ttgtttttgt 111600 ttttaatcca gcagatacat tttattttgc tgtacctaag agaattatta itaacaitta 111660 gagctaacat aaaaggagaa taggaataaa ttctattrti tggtgtattg atacacactt 111720 rtaatggttg gtatlaagtt gaaatctcag atttgatttc ctrttaggct cagttttati 111780 tΐtigtacta taageattaa ctgatgtaca gtgattggaa gagagatcat gtaacttaga 111840 acagttatga catgatggac catgagaaat atacaaggat aaccaaccca aaataiagta 111900 aatgatcagt ttgacagatg ctgtgtctct aagaacttaa ttaatgggat aautttctt 111960 tactgaaagg Actcarttcc tgttttagta ggattgttgg tcctggcaaa ggtgtgtgtg 112020 cgtgcatata tgrtgggtgc atcgrgaaag atttacccat gtgtgtgtga ttacaatgic 112080 aaatretett ccataaatag tagttacagg atagtatggt ggaaaatgga aaaartgctg 112140 44 Revision date:] August 3, 00

1,358,456 »97] 350] No. 9 patent specification Revised aaitaggtat iagaaaatca atatictagt cagctctgct gaaagittta gtattaaatt caigataut giaaaattta igtiaagati atattgatat agagtacata cataaacata agcaattatc attaataatg ttctgcatac tccaaaaata tcattgacga tatgactcat tatgiagatc tatattctta gggtaaagaa acatgagata aatatcrctg aatttatcac ctcaaaaatt ctttctcttg igatatgaat caggcagtag aattacacat ttttatttci gccttgactg ttaagaagct ctgcggctat gettaagtat aaaaaaacta acctagattt itttcatcta aitctcactt ttaaacgttt tgattagcci tattgtatat atgtttttaa tggtaaactg ctttaaataa ttttatatac tatactacaa ggctacagta accaaaacag catggtactg gtaccaaaac agagatatag atcaatggaa cagaacagag cccttagaaa taatgccaca tatctacaac tatetgatet ttgacaaacc tgagaaaaac aagcaatggg iaaaggattc cctatttaat aaatggtgct gggaaaactg gctagccata tgtagaaagc tgaaactgga icccttcctt acaccttata caaaaactaa ttcaagatgg attaaagact taaacgttag acctaaaacc ataaaaaccc tagaagaaaa cctagccatt accattcagg acataggcat gggcaaggac ttcatgtata aaacaccaaa agcaatggca acaaaagaca aaattgacaa atgggatcta attaa actaa agagettetg cacagcaaaa gaaactacca tcagagtgaa caggcaatct acaaaatggg agaaaat11ΐ cgcaacctac tcatctgaca aagggctgat atccagaatc tgcaatgaac tcaaacaaat ttacaagaaa aaaaccaaca accccgtcaa aaagtgggcg aaggacaiga acagacactt ctcagaagaa gacatttatg cagccaaaaa acacatgaaa aaatgctcac catcactggc catcagagaa atgcaaatca aaaccacaat gagataccat ctcacaccaa ΐtagaatgge aatcattaaa aagtcaggaa acaacaggtg ctggagagga tgtggagaaa taggaacact tttacactgt tggtgggact gtaaactagt tcaacccttg tggaagtcag tgtggcgatt cctcagggat ctagaactag aaataccatt tgacccagcc atcccattac tgggtatata cccaaaggat tataaatcat gctgctataa agacacatgc acacgtatgt ttattgegge attactcaca atagcaaaga cttggaacca acccaaatgt ccaacaatga tagactggat taagaaaatg tggcacatat acaccatgga atactatgca gccataaaaa atgatgagtt catgtccttt gtagggacat ggatgaaatt ggaaatcatc attctccgta aactattgca agaacaaaaa accaaacacc gcatattctc actcataggt gggaattgaa caatgagaac acatggacac aggaagggga acatcacact ctggggactg ttgtggggtg gggggagggg gagggatatc tttaggagat acacctaatg ctaaatgacg agttaatggg tg cagcacac cagcatggca catgtataca tatgtaacta acctgcacat tgtgcacatg tgccctaaaa etttaagtat aataataata aaattaaaaa ttaaaaaatt taaaaaaaaa tgtaaaatgc ttccaacagt gcctgacatg tggcaaaaca aattaataaa cgttatctgt atcacaaaaa ataaaaaaat aaataaataa ataaataaaa ataaataaaa ataattttat aggeegggea tggtggctca tgcctgtaat cccagccctt tgggaggccg aggcggctgg atcacaaggt cgtgagttca agatcagcct ggccaagatg gtgaaatccc gtctctacta aaaatacaaa aaatttagct gggtgtggtg gtgggtgcct gtccctagat gcttgggagt ttgaggeaga gaattgcttg aacccgggag gcagaggttg cagtgagcca agattgegee actgtactcc agcctggcga cagagcgaga ctctgtctca aaaaataata atgataataa taataatttt ataaaataca gggagtataa acaaaaactg atcacccaaa ttggagaacc aaattaatag ttaatcttaa cctaattagg agttaatcct acagggccaa taataggcag agtgaagaaa tctctgagtt ctcttgaccc ageattattt ttggtaagag cataaagaaa gcagattgct ataggattta aatagatatt tagtaaacaa gtttgaattt cattttttct alcticaacc tgtaggtata atatactaga 112200 112260 112320 112380 112440 112500 112560 112620 112680 112740 112800 112860 112920 112980 113040 113100 113160 113220 113280 113340 113400 113460 113520 113580 113640 113700 113760 113820 ]13880 113940 114000 114060 114120 114180 114240 114300 114360 114420 114480 114540 114600 114660 114720 45 1358456 Patent Specification No. 97135019 Amendment of this amendment date: August 3, 100 agatagccta aaatttgggr aatatttact triatactia maiactaa actaaactaa 114780 aatccacatr aatgaaatca taaaaiagga taaigaaact taaiacract taattctccc 114840 aauaciagc taatgictca aaiataagat atgitagaat taactgcaat aittacaaag 114900 taiacaaasc. aatiatgcag cattcctaac cagaattggt atatatggga taaaaagafg 1] 4960 tcacataaga taggcccctt caggtggaai gcagaagait ggagtiatca aargaattat 115020 cgaccttagt agagattaag cciataatti aaagtgaaaa taacaacan tatigagtgc 115080 cagacactgt tctaaatacc ttacgtgcct laacigctga aicutctaa caaccctact 115140 gaggcagttc ctattatatt Atacccctat tttactgatg gggcacgtgg atcaaagaga 115200 ggtcagatca tttgtccaga gcacaigggt accaagtgac aggccatgat ctgaactcag 115260 gaacaciggc tctgatgtgc cattctttgc catgtcaccg tagctgccaa gagcataggt 115320 ttcc ctcttc cgaaccctgc ctcaagcaat gaaatttcta gaaaagtata tgaagtttta 115380 atacgatagc tgctatggtc tgaatgtgcc ccttttaaat tcaigcactg aaacnaatc 115440 atcaatgtga taatattaag aagtcgggcc cttaggaggt gaargagatt agcgagttia 115500 tatgagggct ggagggagct agctaggcct mggccctt ttgtcctitc cagcgtatga 115560 ggacaaggca ttcatcctct ccggaggaca cagcaacaag gtgccatcrt ggacgcagag 115620 agcagctctc accagacact gaacctgcca gcacctraat cttagarctt cagcctccag 115680 aactgtgatc aataaatttg tgigttttta taaattctaa tgcaaggttt cttctataag 115740 gitattttgt ctatgtrgaa aatctatgtt ttagtnagt ttacctttat caatgatctt 115800 agctagatct gctggatcac ttgctgcatt cagttaaaga catcagcact tgctacttea 115860 ccttgcactt tatgttatgg agatggette tttccttcga cctcataaac taacctctgc 115920 tggtttcaaa ctrttctttt gcagcattct cacctctctc agccttcata gaattgaaga 115980 gaggcatccg ggtgtggtag ctcacgcctg taattccagc aetttgggag gccaaggcaa 116040 gtggaccatc tgaggtcaag agttcgagac caggctggcc aacatggtga aaccccgtct 116100 ctactaaaaa tacaaaaatt agctgggcat ggtggcgaat gcccgtagrc ccag ctactc 116160 gggaggctga ggcggagaat egettgaaeg tgagaggcag gtgttgcagt gagccaagat 116220 cgcgccactg cactggagcc tgagtaacag aaagagacit tgtctcaaaa aaaaaaaaaa 116280 aaaaaagaat caaagagagc ccrtgctctg gattaggett tggctggttt gatettetat i16340 ccagacct11 crtcatgrca gaaatgagac tgtttcgctt tcttatcatt catgtgtcaa 1) 6400 tggagtagea cttttaattt tcttcaagaa cttttccttt gcattcacaa 11tggctaac 1] 6460 ttagctaact iaacttggct aatttggcat argetiaate autcttcct ttccttgaaa 116520 gtaegattet ttcacttgga cactttgagg ccactgtggg gtiactaatt ggcctaattt 116580 caatattgtc ttatgtcagg gaataggaag gcccaaggag aaagagatgg ggaatggctg 116640 gtcagtggag tagtcagaac acacatgt11 atgggttaag tttgctgtct tatatggaig 116700 iggttcatgt caatataaca gataaaataa taatgaaaaa gertgaaata ttgcaagaat 116760 taccaaaatg tgacacagac acacaaagtg agcacattta atgtatccag taaaaaccaa 116820 agigtttctt acagtctctg atgtttcctt ctgagtaatt ggtcattggg agctgtggtt 116880 acacatagct gagigaageg gacactrctg tgaaggcatg gettggetet tgctgggaag 116940 ttttctgttt cctggcct〇 t tcctgtctct ctt ctcctct ccatacttgi tgggaatgga 117000 cctcatacct ctctggaatg atgeagtgea ccaaacagig aagaactgtt grtgttttra 117060 actgatttac ataaergata ataatatcat agctaacatt lattgagcic accaiatgcc] 17120 aggtatgaag cttagcactt tactacgttc attattgeat uaattetet caacaaacii 1] 7180 gcagcgcata tgegattcca caggagagag crctatirci tuggttgaa aagtretttc 117240 taatacttgc tgagctacag taaacaaata tgtctattaa tgccattggg aaittggaag 117300 46 amendments date: 100 in August 3rd

13584564 97] 350] No. 9 patent specification Revised caaagtctta acaaaatata gacaatteat utrgaataa ttgigatitg anaigcitt tggggaaiat cagattaaca aagtgggttt gtttgtaagg attagtrtgc aattcaggct catagaattt ttgigtgtgt gtatacagtt giatcgattt tatttiattg agatggagtc trectctgtc acccaggctg gagtgcagtg ttgcaatctc ggctcactgc aacatccacc tcccagattc aagegattet cctgcctcag cctcctgagt agetaggatt acaggtgtgc accactacac ttggctaaat tttgtatt11 taatagagac ggggtttcac tatgttggee aggetgatet cgaactcctg acctcaagtg atccactcac taaagtgttg gggttacaag tgtgagtcac tgcgcctggc cagttccatg aattitaact tgtaaataga ttcatatagc cacagccact atcaggaggt agaccagttt caccacttea gaaatctccc ttggtcagtg ctactctttg tagteagage cactcccacc tcagcctctg ataaccaatg atctattctc tattactata gttttgtttt atttttttct tttcaggaat gtcatataag tggaataaaa cagtatgtaa cctittgaga iigggtcctt cagcatgatg cctrggagat tcatataagt gtcaatagtt tgttcctttt tattgetgag tattattcca ctgtatagat acattgtggt tgeattaate agttcaccta ctgaagaaca Tgagttaitt tcagattttg gtgatiataa etagagette tata tgttacatgt ageatt catgtacact tacgttttcg tgaagttttc atttttctag agtaaatact taagagagtg gggaiactag gtcatatggt aagtgtatgg ttaagttitc cagagcagct gtaccatt11 gctttcccac tagcaatgtg taaaagttcc tgttgcccct attctttcca gcccttggta tttgacagtt ctttttttct gttttttttt ttittttttt tagaeggagt tttgctcttg tccaggctgg agticaatgg catgatctca gctcactgca acctccacct tccgggttca agtgattttc ctgccttagc ctcccgagta gctgggatta caggcaccta caaccacacc eggetaattt tagtagagac gaggtttcgc catgttgacc aggctggtct caaactcctg gcctcaggtg atccacccac ctcggcctcc caaaatgctg agatttcagg cgtgagccac tttgtatttt cacgcctggc cttgacagta tttttaaaat tttagcaact ctaataggtg tgtagtgata tctcattatg gttttaattt gcatttcact attgactaag aatattgaac atcttttcat gtgcitgttt gccttccata tattetettt ggcatagtgt cttttcaaga cttttgccca tttttaattg ggtgtttctt ttcctaggta agtttttttg ttttgttttg tttgtttgct ttgagacgga gtctcgctct gtcacccatg ctggaatgta gtggcatgat ctcggctcac tgcagcctcc acctcctggg ttcaagcgat tctcctgcct cagcctcctg agtagctggg actacaggca catgccacca tgcctggcta atttttgtat ttttagtaga gac agggttt caccatgttg gtcagciggt ctcaaactcc tgacctcagg tgatccacct gtctcggcct cccaaagtgc ttggattaca ggcgttagcc atcacacctg acctattttt aaattttata ttaatatatt aaclggattt ttgtcaaata gagaattatc tttaaataac catctcctca cttcacactt agtcigggaa aaaatgagag caaatttetg tgcatccagg gageatatea ccaaccaggc atgaagetta aagggagagt gcaggctgag tggccagcag gccatgggca tcccacaggg ccaggccagg acccaggctt cagcgaccct tctcccagcc cacctagtgg ccctcaaatc catgatggga cagacatgca ttctcctgtc ccagttgaga agccccttet agatggaagg gagaggagaa aagccatagg aaagaaatcc cagaaacact ageaggtaag tacaggggct tcctccccag ctgcggtgac cttgctcctg ataacaccca acccctggag ctcitcgcca gtgtgcctgg ggctggagcc tggcggggaa gggaatgtgg gctcacagtt tctggatgtt ggcctcccac agettggeae agaccagggg aaggcatgtg aggagggcct ggggaggtcc tcggggaaga taacacagct caggaggttg agtgtaaagt ggctgccaga ccaagggagc tggatggact gtgaaggagg aggtggctgg agagcctcct ccatgtaaag ctactagagc aaaaatagaa 117360 117420 117480 117540 117600 117660 117720 117780 117840 117900 117960 1) 8020 118080 118140 · 118200 11826 0 118320 118380 118440 118500 118560 118620 318680 118740 118800 118860 118920 118980 119040 119100 119160 119220 119280 119340 119400 119460 119520 119580 119640 119700 119760 119820 119880 47 Revision date: August 3, 1855456 No. 97135019 Patent specification Amendment this caagggggga cacccgtgcc ccagaggaca gccctaaaga tggtaacggg gagcacggcr gagcagcgcc ctggaitcig agctagtgtg gaaagctggg ggccaggggc ctctctcttc cttcatcacc agttgctggt aactttacag tcagatttgg aggaggaaca aggccctcca tcgcctcccc tagcctctga tgctgcccca aggggagggg laagaaiggg caaagagggi gggaaacagg gaggtgggag ggagtctact gggicttctt attncagag sagggggctg iaatagtgta gtggcagagg ctggticcta ggtargtagg rgngigrgg gttgcctggc actgacaact gcttctgtgg ctctggcttt ggctgccaga gcagaggggc. caatggggcc acigaccaga ggttccatga gcccagatag ggcagtggca gggattgcag gcatcccata gciccatcca tcaigggagg tcctggatag aactcagatg gggactgtgg Attggggtag ccaggagggc aaaggtacat tccattggca actggcagag gaaagacata ggcicrgttg ggtatgtaag agtacccgta gcctccattg ggggcctcgc ccctggag〇c irgaaatgcc ac ctggagca ttcaitgtcc aaactgctgt aaggttaact tgratgaacc ccagccctcc cagccatctc ccgcttcacc ctrcactgtt cuttgaagi agttggcagc aaacaggcta gttgatctca cagtccttca tcaggtgaaa aggcaicacg aaggct tcai ggagt ret tc. ttettggaca gaaagatgat cggtaagggg taaggtagac gaigccttic ttggiccctt tgaaggactc. tggcacattc ttcttgtcat tgaatgtaag trccacatgg acgraggaca ttaggatgtt crtggtgttc ttgatcactc tgccaccctt tgagtgattc ttgrtgagea cgatagtctc ttggaaaggg gtcctaagac tetegatgea gggeettgag ttcgtttrtg cataaaggag ttggtttaga tigaggtrcc tttttttggc atataaatgt ccaattgtcc atttgttgaa aagactactc 11tctccatt gacrtgcctt tgcacitttg tcaaaattta ttggccatgt ttgtgtaggt ctatttctgg aatctgtait ctgctctatt garctgtgtg tctatccttt caccaataca cactgtcatg aagteagaga ggtaacagga agccagatca tgtagggccr tgtagaccat tgaaaggatt tcttgagtga aatgaggage tacaggaagg aggaggaacc tgactrratt gaggcaagga taggaatgtg aggttaerge agtcatccag atatgcaaaa atggtggatt ggaccaggat gatgggtaga agtggtgaaa agtagteata ttctgaataa ttittgagag tagccccaat gggattttct aatgggtt taggettita tgctgggcaa ga atgtagagaa tgagagatag gcatgagaaa agaactctag tctgagggtt tagcttgacc aacgtgaaaa atggagttat caattgagat gggaaaacct tcaaatgaag cacattttag gaaggaaggt cagaagttca gtttcgaaca tgttaagtrt taaattteta ttag'aggtcc acctgtggat gttgagtgaa tagtgggtga taagggctaa gagcttggga gagaggtctg ggaatggagg tatacarttt ggatccrggc ggggcacctg ggarcacgcc tgtaatccca gcactttggg aggetgagge gageggatta ct tgaggcca ggagittgag acgagcctgg c.taacatgac aaaaccccat ctgtactaaa aatacaaaaa attageeggg cgtggtggtg catgcctata atcccagcca cicaggaggc tgaagcaaga gaat tget tg aacccgggag gtggaggitg cagtgagccg agattgtgcc actgcactcc agtcttggcg acagagcaag actctgtctc aaaacaaaaa caaaaacaaa aaatttttgg atccatcagt agatagatec tatgiaagge catggcattg gtgaaatcac caagggcaga tatgiagaga gaaaagggca agcactgagc cctgggtcac rgcagcattg agaggtgggg gacaaaaaaa gaaaciggta aaggagacta aaaaatagta gtgaggtaga aagaaggiag acaatgcttt ctgagagcca aataagaaaa tgatatccag gaagtaaatg atcaacagig cggatgctgc taataagtea aacaagacga ggacatatat tgaccattgg gtuacgaac aaggggtcat tggtcacctc agt Gagagaa gntccatag agtgttggga gaaaaaggct gaggatagta agtttaagag agaataaaag gagaggaau gcaggcagag aatagaagcg rttttcatgg 119940 120000 120060 120120 120180 120240 120300 120360 120420 120480 120540 120600 120660 120720 120780 120840 120900 120960 121020 121080 121140 121200 121260 121320 121380 121440 121500 121560 121620 121680 J2J740 121800 121860 121920 121980 122040 122100 122160 122220 122280 122340 122400 122460

48 Revision date: August 3, 1st

13584561 No. 97135019 Patent Specification Revised agictgtrtg caaataggac caaagaaatg aggaggtagc taggggacga gatgggctca cgtgcaagtt gttgggtiit attccttttt aagatggaag aaataacatt tgtgaatgct aatggccatg accccataaa gtgggaaatt ttaatgatgt aagaaggaaa gagaagaaag cctagagcaa ttgatitcct tgagtaaagg agaaaaggat ggaatctagt acaaaaatgg agggattgcc cttagaagga gctagaaaat ttaatatatg gtaacacttg gaaaagcaga atatgtggar gtggatgcca gcatatgggt agatagatgt gagtgaagca agtccrctrc agtctgcttc catctcctca ctgcggtgga agcaaggtca gcagctgaga gggaaggtag gggaggggct gagatttgaa gggacaaaag tgggcgataa tcacctggga gagtgaaccg taggagtcat gggaetgagt gcctgccata ggagagaaga tccctcaaaa agaggaattc agggctggat gcagtggctc ctgcctgtaa tcctagcacc ttaggaggct gagatggaag gatigcttga gcccaggagg tcaggactgc agtgagccaa ggtcacacca ctgcactcca gtctaggcaa cagaatgaga ccctgtctca aataaataaa taaataaata aataaataaa taaaiaaata aataagcaag caaataaata aataggaatt caagaattga gatcatctgt gtgggiaitg agaatgccag gaattaagac cagaaattci agagatgatg gcaatggcaa tgagaaatga aggggaatga gttgg tgttt gctacataac agtaacagtg ctggatagcg gatgatagaa tctgatgaca tgaggtltaa agcacagaat ttttagagag gagagaagga gaatgctctg aaagcagcca cgtggagcaa aagcggcgtc igtctcacct cactttccag ccatgtggag caaaaggggc atctgtctca ggcccagtgg catgggagtg aaatagcact tcagagagtt gcaggggaaa cagtgtcccc aagggagagt caggttTctg ttaaaggaag gtgcattatg cacatctgtg aaattatcat gactgctgtc atcccatctg ctcatagaac cagtgaatat tgattggtca taaaatgcaa gcattatttt aaggagcatg gacatttaat ttctctttta aggactggaa ataatttttt ccatgatttg gaaagtgata ttatattrgt caatgagaaa taatgtaata gctttttaat agttcacaaa atgatgtcag ttgctcttta ttcaaaaata tctttagcct ttttgaggtt attttgggga gatgataagg acaggcatct ccataatccc aaatatttgg gagaaaactt caaaaattaa agcgtattta ggctgagcat ggtgactcat gcctgtaatc ccagcacttt gggaggtcaa ggtgagtgga tcacttaaac ccaagagttt gagaccatcc tgggcaacat ggcgaaactc tgtctctaca aaaaatacaa aaattagcag ggcatggtgg cgtgtgcctg tagtcccaga tactcgggag gttgaggctg cagtgagctg tgatcatacc actgcactcc agcctgggtg acagaacaag accctgcccc ctaccccctc ctccaaaaaa agcatattta aata ttccca gaatccaaat gttgaacatc atttggacac agcttcaaaa tggtaccaat tcttttaatt tgtgactgct ttatttattt atttaittat ttatttattt atttatttat tattatactt taagttttag ggtacatgtg cacattgtgc agattagtta catatgtata catgtgccat gctggtgcgc tgcacccact aactcatcat ctagcattag gtatatcccc caatgctatc cttcccccct ccccccaccc cacaacagtc cccagagtgg ggttccccit ccigtgtcca tgtgatctca ttgticaatt cccacctatg agtgagaata tgcagtgttt gtttttttgt icttgtgata gtttactgag aatgatggtt tccaatttca tccatgtccc tacaaaggac atgaacicat cattttttat ggctgcatag tattccatgg tgtatgtgtg ccacattttc ttaatccagt ctatcattgt tggacatttg ggttggttcc aagtctttgc tattgtgaat aatgccgcaa taaacatacg tgtgcatgtg tcttiatagc agcctgattt atagtccttt gggtatatac ccagtaat.gg gatggctggg tcaaatggta tttctagttc tagatccctg aggaatcgcc acactgactt ccacaagggt tgaactagtΐ tacagtccca ccaacagigt aaaagtgttc ctatttctcc acatcctctc cagcacctgt tgtttcctga cittttaatg attgccattc raactggtgt 122520 122580 122640 122700 122760 122820 122880 122940 123000 123060 123120 123180 123240 123300 123360 123420 123480 123540 123600 123660 123720 123780 123840 123900 123960 124020 124080 124140 124200 124260 124320 124380 124440 124500 124560 124620 124680 124740 124800 124860 124920 124980 125040 49 1358456 Revision date: 100 years S 3rd, No. 97130019 Patent specification Revision this gagatggtat ttttrtcatg ct tcacctac ecagat tctg tgtaggt rgc aartagatcc gaagtcct tg tatggtttla tgtaaggaag tttattaaat ggggccgaaa at iaagccag taaigtagaa aatcttgctg ggccaatatg gggcacatgt ggaggaggtt gagictgtct t tcaaggtca cagcctact t tgtcctctct cttccctccc tctcggacca ctaaaaatag cttetgcagc ctggacaatt ggcaggtcta gattaatcta aggaaacata tatatacctc actgtagacc laagi tagaa ct tccatatc tata 11111 g ctcacgcctg ggttcaagac gccaggtgig act tgaacct gggcaacaag aaaagcagaa ggagttagag ctgcaacctc agtagctggg Ctcactgtgg tgtt ttrtgg 11 mgatgg gaiatcagcc ctgt tcactc catttgtcaa cccaigccia ggtcaaacgt ggatccagtt agggaatcct ct ictggcct cgccaaatgg atggcaactc ggaggccaag gtgaaacccc aaccccggct gcagtaagct t taaaaaaaa ttacamtt 11 taaaatgc ct tgcctccc tccctccc ct taagaataaa ctcaatt tgg ctggtaggcg naatctm gcctgatraa aaaatcaagg tact tgagca aaat tacact taactggatt cactatggat accacttgtt gt ttcactaa taatcccagc cagcctgatc gtggcicatg gggaggcgga agcaaaactc uataactaa tctctcactc cacctcctga actacagcca trt tgatiig ctgcaraaai ggttgntgt ctttgicaga tgatggtagt r 11 tgt ct 11 tgicctgaar t taagtct ti tcagcrttct r tccccatga gatatgacag aaaaitaaat tggcacrgac gcgggcatat aicgctacta actctggagg gagattgtgc aaaaaaaaaa atctgt tat t ggaactcgta tccctcccgt ttcciatct t gatctgtgca 11 tcaaact t ggcaagtaat ttttacgtct gat tctgt tc ataccagaat acctaatgaa ttttaatgca agctgtatta ctcataaggc caggaacat t gacagctttt actttgggag aacaiggaga cctgtaatcc ggrtgtgggg cgtcicaaaa acaccacrt t tgt tgcccag gtggaggtta tgtgccatca cat ticictg grct icncr titmcttg tgagiaggri 11 ci 111 gc t tgt tgccat t ggraarggct aaiccatct t acatatggct ctgct t tati tgacatcaac ggaaaatggc ataggtitaa cacttgaggt aaaatacaaa ctgagacaag cattgcactc gtaggcttac gttcaccatt tggtgractt tcttccccct ctgagtaggg caatccattt 11ictcccac gcatagtcag tgacctctat aggcat t taa ctactcagga tgagcttagt tatccaacaa gtagatccaa aggctatata aaaagtactt taaaaagcaa gccgaggcgg aaccccatct cagctacttg agccaagatc aaaaaaaaag ttttttcrtt gctggagtgc ctcaggcaat cacctgaata atggccagtg gagaagigrc taaantgtt gcgaaaaitt grgcagaagc gcttttggtg aggrtrtctf gaangattt agccagt tit tctgcat tag ctct tgtgta agagagcait aaaaattatg caagaat teg agttatgt tg agaatcgcti cagcctggat acataitccc taaaaataag ageatatata tcctcctcct tcaaacacca tgtacatart cctaagttca cattccatct ttccaaagag ttctcctaag ct taact tet gatategtaa aaatattttt atttaacttt ttgattacct ttttagaaat aatiaggcag gcagatcacc ctactaaaaa ggaagctgag gcaccactgc aaagaaagaa ctturtttt agtggcacaa cctcctgcci at nttatat atggtgagca tgt tcaigrc tgagt teat t ictcccat 11 tcutagut trt tatacat ctagggttit ttgtataagg cccagcacca acaataagaa giagccigtc gcccaggaca niiaaaagt agaccagcci gcatggtggc gaacccagga gacagagcaa tttacigttt cagtggaaag taaggatttc tccttccttc gt tctctact Gat tet tgga ggttttgttc gggatgetta catcccagtt ggaaittaca tgaaggr tat tgaattttta aaaaacaaat caatttgaat agt tagccag agmtctga ggcgtggtgg ggaggtcggg tacaaaat ta gcaggaaatc gctttagcct agaaagaaag ttttitttct mtggcttg cagct tcctg tttttgtaga 125100 125] 60 125220 125280 125340 125400 125460 125520] 25580 125640 125700 125760 125820 125880 125940 126000 126060 126120 126180 126240 126300 126360 126420 126480 126540 126600 126660 126720 126780 126840 126900 126960 127020 127080 127140 127200 127260 127320 127380 127440 127500 127560 127620

50 revised period: 100 years, August 3曰

Patent Specification No. 1358456 97135019 Revised gacaggatca ccccatgttg cccaggctgg tctcaaactc ttgggctcaa gcagtctgcc tgcctcagcc tcccaaagtg ctgggattac aggigtgagc cactgngcc agcctaaaca tctcgtctga ggctatcaca atatatacta nctccagcc tacagtagat tatagacatc tagaataiaa aaaittgttt cctgataggc nggcacaca atattcctac agtcctttga aaacacacat attaacagag tgacaatati tacaggcaga attactcatg tgtcttattg tagcttacag 〇agagtgtgt ctgtctaaga atggggtaga ggttggtttg taaaaacagg tgtcccacaa gctttcttgg atagttaact cagtagttag aatgaaggat gtaaaataac ctgtcaggat aacacctgct ctcttgccct caacaattaa tgaraatgaa aciaggcctg aagaggaata aaaatcttgt atcatctttg aattagtctt ttgttggtcg tgcgttccaa tgaaatgatg ittcacaacc ttttcttcat tatcatctct gaaaagatcc tttatggcta tttttttuc ctagttgcca caaaattaaa cacaggcaia ctgtgtctta ctgtgctttg ctttcitgct citggaagat attgtgggtt ttttttttta caaattgaag gttigtggca cccctacatt gagcaagtct actgggacca ttttcttttc aacagcatat gctcctttta tgactgtgtc acattttggt aattcttaca gtatttcaaa ctttttcttt tctttttttt ttttttttta gacagagtct cgatcagcc a cccaggctgg agtgcagtgg tgcgatcttg gctcactgca acctccgcct cccaggttca agtgattctc ctgcctcagc ctcccaagta gctgggacta taggtgcatg ccaccacacc cagctaattt ttttgtaitt ttagtagaga cagggtttca ccatgttggc cagactggtc tcgatctctt gacctcgtga tctgccctcg gcctcccaaa grgcigggat tacaggcgtg agccactgcg cctggcccaa actttttcat tattgttata tctgttatgg tgatctgtga tcactgtctt tggtgttact attgtaattg ΐttggggatg gcctgaactg catccatata acacttaatt gaggccaggt gtggtagttc acgcctgtaa tcccagcact ttgggaggct gaggtgggca gatcgtgagg tcaggaattc gagatcagcc tggccaacat agtgaaaccc catctctact aaaaatacaa aaaaattagc tgggtgtggt gacgcacacc tgtagtccca gctacttggg aggctgaggc aggagaatcg cttgaactgg ggaggcggag gttgcagtga gccaagatca tgccactgca ctctagcctc agtgatagag caagactcca tctcaaataa taataataat aaagacttaa ttgatactta atccataaat gttgtatgtg ttctgagtgc tccacccacc agctatttcc catctttctc ctcctcctca gacctcccta ttccatgaga cacaacaata ttgaaattag gccaactaat agccctacaa tggcttctac atgttcaaga gaaaggagga gttgcacatc tctcacttta aatcaaaaca tagaaatgat tatgcttagt gaggaag gca tgttgaaagc ctagataggt caaaagctag gcctattgtg ccaaacagcc aaactgtgaa tgcaaaggaa aagttcttga aggaaatgag gagtgctatt ctgttgaaca cacaaatgat aagaaagtga aacagcctca ttgccgatat gcagaaaatt tgagtggttc tagatagaag atcaaaccag ccataacatt cctttaagcc aaagtctaat tctttttttt tttttttttt ttttttcaga gtcttgctct gttgcccagg ctggagtgca ttggcacaat ctcggctcac tgcaagctct gcctcctggg ttcacgccar tctcctgcct cagcciccca tgtagctggg actactggtg cccgccacca tacccggcta atttitttgt atttttaata gagacagggt ΐtcaccatgt tagccaggat ggtctcgatc tgatctcctg accttgtgat ctgcccgcct cggcctccca aagtgctggg attacaggtg tgagccacig tgcttggcca ccaaacccta attcagagca aggccctaac tcccttcaat tcactgaagg ctgagaaagg tgaggaactt gcagaaggaa agcttgaagc caatgggttg gticatgagg ittaaggaaa gacaccatct tcataacata aaagggcaag taaacagcaa gtgctgatag agaagctgca gtaagttatc cagaagatct agetgagatc attggtaaag ctggcttcac caaataacaa atettcaaat gtagatgaaa cgactttgta 127740 127800 127860 127920 127980 128040 128100 128160 128220 128280 128340 128400 128460 128520 128580 128640 128 700 128760 128820 128880 128940 129000 129060 129120 129180 129240 129300 129360 129420 129480 129540 129600 129660 129720 129780 129840 129900 129960 130020 130080 130140 130200 51 1358456 Revision period: 100 years August 3 曰 97135019 Patent specification Amendment t tggaagaag aaagmcaa gact ttgagt gatactaaat cgtctgrtra gaaaaaaagg gcrctgaaag gcagccaatg t tataaagat gaaaaccttc acatgaacag agacttcagt agcgggtgga ictcctaaaa aaatagcaag ctcatgataa ttcttgggag aggatttaga actgcaattt tcagagaaat taagaaattg aaggtgggca cccatttcta ctacttggga ccgagatcgc aaaaaaaaaa ccgaggcagg cccgtctcta cagctacrtg gagrcaagat aaaaaaaaaa aatcccagca agcctgatca tggcgcatgt aggaggcaga agtggtgcga tgttttttga tgatctcagc cccaagcagc agagatgggg gcccgcctca tcaagcatti tacagtaiag atgccttcag gggacaggcr igaaggcaat gractctact tagagtggtt ticcittcaa tataaggaga gatccaggag atagctgctg Tggaaaggat gagit tcgaa agagcaggct tcacaagcat aggat ttut agaactagca aact tgaatg ggaatctatt atatcccata tgaaagaagt ctttcttcac tcagccgggt gatcacctaa ctaaaaatac ggctgaggca g ccat tgcac aaaaggctgg tggatcatga ctaaaaatac ggasgctgag tgcaccactg aaaaagaaaa ctttgggagg acatggagaa itgtaatccc ggttgcagtg tctcggctca gttggagttt tcactgcaac rgggattaca t ΐ tcaccatg tcctcccaaa tuaattaag tgtaaacata gctaggacu rtrgrcccn gctcat rgaa tgiactctat tatcaaacgt aatattactg tgactgttgt tcatt t tgac tagatagtga tcacaattct gaagt tgat t gggcatggtg agagt tcaag 11 taagact tt taagaatga gatgaggagt cctggagaag aact tagctg tgtaccatga aaaaggaaca gtggtggctc ggtcaggagt aaaaaattag ggagaatcga tccagcttgg gcgcagtggc ggtcaggaga aaaaaaat ta gcaggagaat cactgiagcc gaaaggaaat ccgaggcagg accctgtctc agctactcga agccgagagc cgatcgttag tgctcttgt t ctctacctcc ggcatgcacc ttggtcaggc gtgctgggat gtatgtattt act 11 tgtat icatagctgg gggcicngt cattctaaaa taatgaaaca ttaaagcctg ctcat tgaca 11 tcatacct tttcaagtct ncctcigat agatactgt t ccaaacctca gcctataat t accagcctgg cagtagagga agct taaaga tgcttcttat acactgtgaa Ataaagcagg gtaaaatgcg attgglgcag acgcctgtaa t taagaccag ccgggcatgg ttgaacccgg gcaacaagag tcacgcctgt tcaagaccgt gct gggcgtg ggcgtgaacc rgggtgacag tgttggccgg cggatcatct tactaaaaai gaggctgagg gcaccattgc cgttttttaa gcccagcctg tgggttcaag accacacccg tggtcicaaa tacaggcatg tttagatatg gcactagaaa agaggagaag raggggctaa atccragggc acaaagtctg ctgtigagac gtgtacctgg gctaacacaa tar tatataa ggatctgggc. gggaggaggt tggtgacttt ccagccct Tt gcaacacagt agtactcgta tgigactgaa ggatgagcaa agttgtcgaa ggcaggcttt atcaaacagc caaaat taat tcccagcact cctggctaac tggcacgcct gaggtggagg caaaactctg aatcccagca gctggctaac gtggcaggig tggcaggcgg agtcagactc gcgcigtggc gaggtcagga acaaaaigag caggagaatc actccagtgc cactcaagtg gagtgcaaca tgat rcrcct gctaat 11 tg ctcccaacct agccaccatg gtattgaaca ataaaaant tcaatgci tc racagcrtgt cct aatgacagca ciaccactca tcacccaaga catccactgg gaaatacat t aaagtctat t caaat tatca gagggcttta ggaaggctga gagaccccca aatatggtgg itgctgtaat aggaaatgat argacaccat gagaggatcg attgcatgct tttcttattt ttgggaggcc atgctgaaac gtaatcccag ttgcagtgag tctcaaaaaa ctttgggagg atggcgaaac cctgtagtcc aggttgcagt taagaat Cgtctcaaaa ttacgcctgt gt i tgagacc ccgggcgtgg act tgaaccc agtggagtgc tttttggnt agagctggca gcctcagcct tat rrt tagt caagtgatct cctggcccac ct taa〇agac catgigactc 130260 130320 130380 130440 130500 130560 130620 130680 130740 130800 130860 130920 130980 131040 ] 31100 131160 131220 131280 131.340 131400 131460 131520 131580 131640 131700 131760 131820 131880 131940 132000 132060 132120 132180 132240 132300 132360 132420 132480 132540 132600 132660 132720 132780

52 Revision date: August 3, 100

13584564 No. 97135019 Patent Specification Revised actittitga gatarttgct rtatrgcagt ggictgaaac caaacctgra atarctccaa gaiatgcctg tactgaagag taagattttg tcagtlagag tnaaictig gaaagaciac aaaccactgt aataacctaa gcattatttg attccccaag gaccaatitt cacccctttg ggggccatat iaattntta tggctgctat accaaagtac tatgaatttt atggctgaaa acagcacgaa cttattccct tgtagttcta gaggccggaa atgcagttea ctgggggtaa tgtcaaggig lagggccata cccccaggaa ggctctgggg aagcgtacat ttcctcttcc agcttccaic tttttctggc ttccagactt gcatrctgtg tgttcactga ctcatgtctg cttcctccat ctttcaaagc cagcagccgt gtageatett gtttcaatgt cacgttgcct ttttcttctg tcaagtctcc ctctgccigc ctctcatgag gacagtgtga ttacacttag ggtctacctt gctaattccg gataatetet gcalctcaaa atccttaait tgcaaagctt gtgttaccat ataaggtaag agtcacaggt tcccaggatt aggaactgga tatctttggg gaccaatact cagccacaga ggtgatacca ctccccaccc cttaaaaatg catgttctac accagtaagg aagaaagaaa ataagaaaga agagtaaaag ataataaata tgtaactttg gctacaaatg aattctttat tataictcat tctatttggg gcaciigcta ttagaacaaa gagagaagat atamaaa taategtate a ttaataggat tcagaagagt agagttgatg atgttcacct cattgcgatg tactcaccca ttcatttatt ttgcattacc cttcctgcct ggggccagtc ageagaggag ggcagtgagt cactccaagg tcagacagta ttattaccct cttattgtga tgggcaaatc caccattaag cttcagattg agagaaacac cattgagttg gcaaatgctt tcgatgtgta cgtgcagaaa gtcatatgta tctacaattt tccagacagc ggcaaagaga aatggaaact ctgtgctgta ttttaattgg ctgcaaaatg tttccttcag aaattaccat tccattaagc acctactctg tgcaaacgct ttgcaaacac tgctgggaat agctgcatgt ataagggeat gcctaccttt attagactgt tcaggggaat aaaatgaagt tacaatttat tctaatacta gaatgcagtt ctctccccat ggactgcacc tttcaggata gtggcctgaa teagageaga aaacacctgc tggatatcct ccaagtacac agtctgatta gtgccctctg ggaaacatgg aggcagatac tacttggctc tccagcctaa gggaagtatt attaattaaa aacttaaagc caggttcltc tctgtgtatg gttatgcatg tcctagatgg ccttgaaatt gatcigttci ccattagcaa tctgtgaatt gtactcctgt ctgaaattga gtagaggtca gagetatgaa ggttgaattc aacaagaatt tttatgaagt ataactagag ttagtgctct gctctaactg cttttggaga cagactttee ccagtgtatc ccatcaaatc acagactaaa aacagtctat ttccccttat tettggcc ag ataggaccta ggcacctgaa ttttttttta aactagattt ccaggaaatt ttattgaagg ctaacagcat ageattteat gttggataaa gaagatgeae aagacgggac atggtaagac acacctgtaa tcctaccact gaggcaggtg gatcacttga gctcaggagt tcaagaccag cctgggcaac atggtaagac cctgtctctc caaaacaaac aaacaaacaa acaaaaaaac aaaaattage tgggcatgai ggtgtgcacc tttagtetea gctactcggg aggctgaagt gggatgatca cctgagccca gggaggtcaa ggctgcaatg agccatgatt ccatcactgc gctccagcct aggatacaga gtgagaccct gtctcaaaaa aaaaaaaaaa aaaaaaaaaa aaaggccata tgcagtggc.t catgtctgta aicccagcac ttggaaggat tttgggaggc caaggcaggt ggatcgcttg aggteaggag ttcgagacca gcctggtcaa cattgtgaaa ccagtctcta ctaaaataca aaacaaatta gctgggcatg gtggcaggca cctgtagtcc cagctactag ggaggccaag gcaggagaat tgcctgaccc caggaggcgg acgttgcagt gagetgagat cgtgccactg cacittagee tggccgacag agcgagactc tgtcttaaaa gaaaaaaaaa aaattcacaa aagaaaaait gtattaagta caatttaata taatttcita caagtttatt acctaaaact 132840 132900 132960 133020 133080 133140 133200 133260 133320 133380 133440 133500 133560 133620 133680 133740 1338 00 133860 133920 133980 134040 134100 134160 134220 134280 134340 134400 134460 134520 134580 134640 134700 134760 134820 134880 134940 135000 135060 135120 135180 135240 135300 135360 53 1358456 Revision date: August 3, 100, pp. 97130019 Patent Specification Amendment t tgcaaataa aagtggaaai aaaggt nag gccct t taag cactggctat tcgaicr tgt aggat raaat ctgggtgagt gtai nagga gcagtggtac tctcagcctc tnttitttt cccaaactcc ggcatgagca t taaaat r ta naaatttat gtgtgccaaa ggtttgttat tgtttttaaa atatcrtrcc tcatttctac gtttgatgtg gtcccagtgc giattaatta ttiataggta atagatattt aaatcaatac tccaatctag cart tgaccc caatcaaatc gcitgcctgg caggctgtca aacccagctg ccatttttic atggagtctc ctccacctcc ggcacgtgcc grtggccagt igctgggatt aagctcttct gggctcagaa tnccaaecc atgtatttct ttgaagttag Cct r tccact tgncctgt t tatgcacaga ecacatgt ta tagciattaa gagtcct tac gt tagctatt ttncttttt gatcuggct ccaagtagct ΐ 11 ΐ tgtat't tgagcicaag actgcgtctg t tgatccaga at t tcatcaa aaat tat tga tttccttttg tgtactgatt ctctcct fee ctgt t ttcgt tggaacag ca car t tacagt met tat tc agaagactca tctgaaatga taagtttctt tttittgtct rgtgtcictc aicatagcaa lacccaatac ttaattggag acaggtacac itaagtet ta actctgicgc tgggttcaag accatgccca atgatctcaa acaggtgtga gaaccarata tcaggcccca tcagtttttt 11 tgaatatc aaget t igga ggtuaut t titaaatcia tt ttgcaaat gctgaataac gigggaataa atgtgacata gtattattat ttttttgaga cactgcaacc aggat tacag tttggtagag cggtctgcct gccagggt ta aatataat ta ttttacacat ttttcttaat attttatttt gtttcttagg let rccct tc ggett ttata agagagttta gtggtacccc aaact tacca ttctttatct aatatggaaa t tgtatacaa getaataggt tt tgeett tc ggitttcatc arataatctc ttacctccaa aaggggcata gttttctctt caggctggag egat tctcct getaatt 111 11 tet taatc gccaccatgc atatgatgt t ccact tat 11 catctgtata tagtagtat i it i tgt ttt t cct 11 Rgat ΐ ctgatcgt 11 gcat ream crtaggcaag tgacaancc ct tgaaatag ttcattgctg cagggrctca tccacctccc gcacgcccca acagggt π ΐ getttggcct tttcttaggg aaaataattg ttgttaggtt cgttttctat acttttgaca agattcctta actctrctca ctttcaatgt aattaaaaat tcctgtaata gtggc attta gctatttcaa acaattam gatagccaat gctcagtatg cccttatgaa attttttatg tcttcaggct t tgcciact t gcccaaat ta gatataggat tgcagtggca gcctcagcct giaittttag tcgtgatct〇ccggccgaca t taaaatata tcaatggaat atagggataa t taaaaatca agagettaat ttaitttact ct tatgagat icttarttgc raaattatcc. taactcaagg tacctsstgc tttgeatata ctct t tgccc aggctcaaga ccatgcctgg gccatgt tgc cccaaagtgc atageat tee atcaaatggt ttaatgtttc gagtagaaat ccctgaaggt gagtgccctt aaactataaa gttcatctac ct tcccctaa agaatat tac agaaatcatt aattaaaatc ttacaatgag aatacctagg aeggagettt aataagctga gaatgtcagc gcaacacaca ct tat tetat catgtaatcc tttttttttt cgatctcggc cctgagtagc tagaaatggg cctgccttgg taggetartt gacictgaag ct rgtctgaa aaataatagt gataactaga cct 11 tctgi t tgacaccct tccitagagi cagggmaa tctctgggcc gtctgttgtg agagttaggg 111 ttaaaat aggeeggagt gatcctccca craatttrtt ccaggcttgi taggat taca agaaatataa agaagact 11 tactact tgt cctttccact ttagtgttcc taageagaga aatataatac atgagattia atggctaaat at tet tatcc agitcagttg attgtctttc acttggaaaa cct aaaacgt tet tgaggac cccctacatc ct tgccacct gcact tgagg tcctatcaaa ataaatctci ttttmgag tcactgcaac tgggactaca gt t tcaccat cctcccaaag tttaaaatgc acaaagacct tet tgtaatc aaacaaataa at tatataac 135420 135480 135540 135600 135660 135720 135780 135840 135900 135960 136020 136080 136140 136200 136260 136320 136380 136440 136500 136560 136620 136680 136740 136800 136860 136920 136980 137040 ]37100 137160 137220 137280 137340 137400 137460 137520 137580 137640 137700 137760 137820 137880 137940

54 Revision date: August 3, 100

1358456 ▲ No. 97135019 Patent J specification Revised tctatgtgct ttatttttta cttgtttgct gggaatcaaa gagcttagti ttgttttttg tttttttttt ttttgagacg gagtctcgct ctgtccccca ggctgsagtg cagtggcgcg aictcagctc actgcaagci ccccctccca ggttcacgcc artctcaaag agcitagttt aagctcaati caagtgacta tttgaggcct ggtcaggata tctgctgtta tttggaacac aagctgtttg cccaggacta agatcaagtg attttcctaa agcaaacagt gtattgaatg taatccaaat catcagcagg aacaaaggag gccatatagc ttagcaatta aggcatggga tctgaagtca gagagacttg gatitgaatc atggccctga caagttacgt gcctctctct gcctgagtti cttcatctgt tagaigagca taatattgca atatagtgtt actttgagaa ttaaatgagg taatgcaaag ctcttagagt agttactagg ataagtgtcc aattaaccat agtttaagaa aaaggataag ctgggcacgg tggctcatgc ctgtaatccc acactttggg aggctgaggt gggcggattg tctgaggtca ggagticgag accagtctgg ccaacatagt gaaacccctt cictactaaa aatacaaaaa ttagccaggt gtggtggcgc acacctgtag tcccagctac ttgggaggct gagatgggag aatcgcttga acccaggagg cagaggitgc agtgagccga gatcgtgtca ctgcactaca gcctgggtga tagaatgata ctctgtctca aaaaaaaaaa aaaaaaaaaa aa aaggaaaa aggatgaaat cacaacttgg agcaaaaaaa cccaaaggca tatttaaaga 11 tgcgtat t gggttaaaac aagttttaac atctggaaag aaaaagcatc catcaacttt tctiatcaag aaatatgaat tatagccagg tccagtggtg tgtgcctgaa gtcccagctg cttgggaggc tgaggcggga ggatcacttg tgactgggag tttgagaaca gcctggggaa catagtgaga acccatcagg aaaaaaaaaa aaaaaaaggt tgaitaaaaa aagaaaaaca aaagaggcca ggcacggtgg ctcacacttg taatcccagc attttgggtg gccaaggtgg gaggatcgct tgaggccagt gattaaagac cagcctggac aacatagtag gactccatct ctataaaaat tttaaaaatt agccagacat ggtgccgtgt gcctatagtc tcaactactt tggaggctaa ggcaggagga atgcttgagc ctggggggtt gaggctgcag tgagctgtga · tggtgtcaat gaactctaic ctgcagtaca gagtgagacc ttgtctcaaa aaaaatcatc tttacagtta tttgattatt tgcagatttt cagtgtttat tglttttact ttccttgccc cactattctg cattcatcaa atattcattg aacactgtct gactgctgta ggcacaagag atacagcaaa aaacaagaca aaacccitgc tctcatgaaa cttacagtca agtgtgtgag atggacataa acatagtact gtgctgtcat gttgtaaaat gggacctctc attgagaagc tgggttggtt tgggggtggg gagtatgaca tcaagagttc tgttttgatc atgtttag ttttgccaga tt caagatgcct gttatggtca ggcaccgtgg ctcacacctg taatctagaa ctttgggaga ctgaggtggg tggatccctt gagttcagga gtttgagacc agcctgggca acacagcaaa accttgtttc tacaaaaaat acaaaaatta gcccggtatg gtggtgtgtg cctgtagtcc cagctactag ggaggctgag gtgggaggat cactigagtc atggtaacag actcgctctg ggtttcgctc tggatgacag agcgagaccc tgtatcaaaa aaaaaaaaaa aatgcctatt agaccttcaa gtggtgaaga caagtaggta attggataca caagtctggg ctcagggtag aggctgggct agagaaagaa atttgggagt catcagtgaa tagatgacat tttaagccat gggcttggag gagataacct aaggaatgac gagaatacat ctgaagatcc agcctcagac actctggtgt acagaagcag gtagagaaaa ggagaaacca ttaaagacct ctgttgggcc gggcatggtg gctcacacct gtaatcccag cactuggga ggccgaggtg ggcagatcac tcgaggtcag gagttcaaga ccagcctgga caatatggag aaaccctgtc tctgctaaaa atacaaaaat tagctgggtg tggtggtgca cactcacttc actctagcca gtagtcccag ctactcagga ggctgaggca ggaaaattgg ttgaactgtg aggcagaggt tgcagtgagc cgagattgca ccactgcaca ccagcctggg 138000 138060 138120 138180 138240 138300 138360 138420 138480 138540 138600 138660 138720 138780 138840 13 8900 138960 139020 139080 139140 139200 139260 139320 139380 139440 139500 139560 139620 139680 139740 139800 139860 139920 139980 140040 140100 140160 140220 140280 140340 140400 140460 140520 1358456 Patent Specification No. 971350丨9 Amendment of this amendment date: August 2003 3 曰 caacagagca agactgtctc aaaaaaaaag aagactgagt gtgarggctc acgcctgiaa 140580 tcccagcact itgggaggcc aaggcaggcg gatcacctga ggtcaggagt icaagaccag 140640 cctgaccaac atagtgaaac cccgtcicta ctaaaaatac aaaaatia〇c cacgiggtgg 140700 tgcgcacctg taatcccaac tattcgggag gcigaggcag gagaatigct tgaacctggg 140760 aggtggaggt igcagigagc cgagatcgca ccactgcaci ccagcctgag tgacagagcg 140820 agactccatc aaacaaacaa acaaacaaaa aaaacaaaaa cccaagaaga cctctgtctc 140880 ciagagcagt cacctagaai cctagagaaa aatgtciΐtc caaaaggaag aaatgcagaa 140940 ctgtgtgagt Aaaatgaagc taagaattaa ttactggatt tggcaagatg gaggttgcig 141000 atgacttggc aggagagttt ccctgaggtg ataggaacca aggtctgatg agagtaggct 141060 gaagagcaaa tgtggagaaa cagagatggc aagaatcaac agttcatatc aggattttgc 141120 tgigaaaggc agcagaggga tggggtacca ttattttcat tttgttttgt tgttggittc 141180 tgctgcagtg gtagtttatg ttgagatgta tatrttaaac tgatgatcct iaaagaagga 141240 gaaattgatg aaggagagag gtgggaggga taattgcaaa aatgaagrcc t tgagcagtg 141300 agatctgctt ccttatiatg catatagatg aaacattaaa argtaaaaca gacictfgtg 141360 ctgattttaa gaactctaag ttagaagagg gtggggagaa ctgggaagcr ggggagccca 141420 agatgcagga tittggctct ttagctcagc taggttcagg ttcttgtctc acaaccagga 141480 ggaattaggc acgtggacac cagagggtga gtagagtaga atttattaag caaaaggaaa 141540 gctctcagca aagagggggg tctggaaaag caggttgttg gctgccccct tcacagttga 141600 atactgtgct taaggcacaa attcctggcg gctccacccc atccttccag igcgcatgtg 141660 ggcccttagg gtgagccact ccatattgat ttacttccct tactgcacat gtgttaagga 141720 atggaatttt ccactgcggg catgtttagg caagccccct gtgcaagttc ccacatctgc 141780 acaaaatatc tggtgiaagc atttgtgggg cgggttggag gtictccagg gacccttccc 141840 ttactgtctg cctaaagcaa gctggctaac ttcttacacc tgtgtattat acagcaccag 141900 tctttaggga aaggaacttc aggtgggtag ggtagagta t agcaatagct ggcaagaaaa 141960 aaaagatttg aagaaacaaa ctctgtggtg ccctagggag cagatgtggg atggaaaagr 142020 gaggctgggc cttaaatcac aagaagccca aggtgtacag ggatctctit acaacagaac 142080 gtgttcttat atatgagtta tttgaaarag citaattata ccactatact gtcattaata 142140 atggataaat gtacttcaaa gtaatttait agtttgtcrg tgaatatgtc. tticcttgic 142200 tcttttcccc cttacctaga aigtaaacaa gagagaagag aactccagat ctgattttca 142260 tggaggaagg tgatacagat cattatggct gtaaggggag gartcttgtg tttcccaggr 142320 gtcctgaaac cattcacatg gagcctaagt taaaatgctc tgggttcggg agtgtcrtcc 142380 tggagatcac taagggcttc aggactcctt gagatggagt titcttttct ctctctctct 142440 tttttitttt tagtatttta aaatgtattt cgttaattag cagcagratg ccaaagttgt 142500 tccattatia tattttgttc attcttrtgt acaagtgtct tccaatgtga titgataatg 142560 ccaacaattt gcaagtgatt ttattgcagc atgacrttgg ttcccaggaa tgctgaagca 142620 caggtcctag aacagaggct tgaaaaggaa ataaaaggga ittgatcata aaigcttctg 142680 gggtiggcat accagatcat tttgagctca aataggagac aaaagaaagg atgttgggaa 142740 agctgtatgg tggagagg ct gaacigttgg aatgaaaaga caagaagcat at tat tatgt 142800 iaattccagc accctagatc tgcaatgctg aaaggactgc caaaactaaa gcttgtccta 142860 caccacgrtc atcacaaaga aattcigt11 agacgttgag ttaaactttc icaactgtat 142920 tcagtacagg attaagtggt tgagatgggc cattctgcag ttacactgit tccgttccag 142980 tctgggtctc ctcatgtatt agctgtgtgg accugggca ggtaactcct ngigcctca 143040 aagaaatgga gatgacgata atacctaccr cagtggggtt angtgagga taaaatgcga 143100 56 1358456 4 correcting said period: Amendment to the patent specification of August 3, pp. 97130019

ttaatagaaa ataattagaa ttttattatt agtgcactgt gtaatgcaca 11iatcatcc cattgaaigc tcagggatga ctctcattag gtatccacct gacatattct cagtaaattg tggctcatgc ctgtaaicct acgagt tcaa gaccagccta aaattagcca gargtggtgg gaggattgcc tgagcccaag tcactctagc cagggtgaca tgaaatcata agcttaggtc tccttttgga attttatttt ttatccttaa agtitgccat tatcttcttg ttgttcttat agtgaaatag gaatgacata catgctatag aagtaaatac gettaaagca acacgaatcc actgggtgaa aaattaagge atcttttcct tgcccttctc gaaatgttia atgctccttg tctitiatat acagctacat gctccctgtg ttaatggagt ataaataata tctttatact gttgttcttg gtgtagtttc ttttaaattg ccttctcaaa catatttcca cacggttttg ctttaccact atatatataa tggtgcctgg gatacaiact getataatag gatggetate agttaattga aagaggtagt aaaatgagac aggttttatc acttttcaaa attgigttat aggccaccat atggaagtgt agcactttgg gaggetgagg gacaacatgg aiaaatcctg catgtgccta ragtcccagc gaggtegagg ctgcggtgag cagtgagacc ctgtatcaaa ctagttcttt rgagtgagtt tctaatgttt acctcattat tacaaaggga attgtaette atatattttt aagitatata aaaataaaat cttcctcctc ttaaattagt ttgctgtaac atctcatag t tgtgtagctc atcagcagga ctggtttctt aegttetaga ccccactatt atttttatca cctaattgta actgttctac tatatggatg cttggtttat tttcaagttt ttcatattta tgcattttga caggtaaagc aggatgtaca agacatctat tatctttccc gggegetegg gagtttgttt tatatttata atatatattt gctcattaaa cattgtarat tagaaaacat catgcaattt gatgggacag tggtggcaga ttgttttgtt ttatttttgc trtaatcttt aitgcataca aaggatgaag ccaggcgcag tgggcgsatc atttgagcct tctctacaaa aaaaatacaa tacttgggag gctaaggtgg ctgtgatcat accactcact aaaaagaaga agtataagga agaacctata taaaattttc ittctgacta taatagaaaa tttaaaatgc caattaaaaa tgcatatgtt aaaatattta actacctcaa cctccagtcc aaattaccac aaactttgtg agcattciga aatgcgtctc cctggaggct ctagggaaga aacactcata tattgtttca tattttctag aactctccat caccagatgt tatgtgtcca ttattttcat aaattgeate caaacagatc catgggataa tttacacttt tgataettet tccagtgatg agtaagagtt tttttacaaa acttttaaaa ataataaata tcatatattt 143160 143220 143280 143340 143400 143460 143520 143580 143640 143700 143760 143820 143880 143940 144000 144060 144120 144180 144240 144300 144360 1444 20 144480 144540 144600 144660 144720 144780

ataatatata tatatttata acatat tata 11 tataataa ataaatatta tatttataat ataitatata tatat tatat aaatattata ttatatattt atttataata taatatatac ataatatata aatat tatat tatatatttt tttataaata attatatat t atatatat 344840 144900 144960 tatatettgt atatattata tatataaett ctctttttac ttcgtttcac ttgagttata 145020 aatttgccat gtttggaggt 11tcgatggt cctagcaaac cagtttccct agaagcaact 145080 tcccttcagt ccgattcaca tcaaagatgt gacttcaata ccatctgatg ttcaagctat 145140 ttattttagc agtggtctta ta caagtcggat agtgggagca ggtgggtggc atgggccaga 145200 ttcaatcaga ggtcagatga ctgcctgtcc aggagggtct ccatctggag actattctca 145260 gagtttggga gattcttccc atttetteta cctgcattta gttcagtcaa ttatcaggcg 145320 tttctttcat aagaggaggt taagctagtc ttataagggt aagctttgtt aaaggtttac 145380 gagatttgea tccgtgatga ggtggcctta tgtcctggaa atccctgggc cagcttggaa 145440 atccccaggc caggtggcct cacgctgcta agtggcacat agtgtcagtc. ctgtgagagc 145500 ttgttaatgc ettatageta teattaatet tgtagtcatg atatgtctcc tataggatgc 145560 tacacagttg gttttagcat Tttactatcg ttttgttgtt gattactttt gttttctttc 145620 gttttttgit tcrgttttig agacagggtc ttactctgtc atcccggctg gagtgcagtg 145680 57 1358456 of 971350 Shu 9 patent specification correcting the present date correction: 100 August 3, said gcaigatcat ggctcattgc aacctctgcc tcccggguc atatggaagg cagagganc 145740 tcccacctca gcctcctgag ragctgggac tacaggtgca caccaccgca cccaggtaar 145800 tutgcatit 11tgtagaga ctgggttttg ccatgiigcc caggctggic ttgaactcct 145860 gggctcaagc agtcggcccg ccttggcctc ccaaagtgtt gggattacag gtgtgagtca 145920 tcgtgcccag ccagcatcit actatgtt ta ttagccattt ggat tcctt tt tct t tgaat 145980 tgctgcttgt iaataiang gccctnttt crgttacau attaataatg ccaggaatta 146040 tgciagttgc latgcaagat gcagacttga ggaaaacctg gtcccagctt tcaaaatgci 146100 tact ticcaa aicigactca tcgt t tgact ttaatgcccc actggacuc tciaacagca 146160 111tccat11 tccctttcaa aaggactcaa aatatacaaa tttaatttga tgataagagc 146220 tcaagaaagg ccgtggattc rrtrittttt ratttttata gtaaaagtga tcagacrgtt 146280 tcctctttta agaagaaaaa gaaagcagag gtcaatatta agcrtccaat taatgcttat 146340 tcatcacaaa tagtaagtaa ataatgacag aaataaticc ttagtcactc tctagcacac 146400 ttctttttta tttttaacat ttticactat gtgagatttc ctagatttgr tttattttct 146460 gtitccctct aactgcaata caagctcttg tggactggaa ccacacctgt catattcatg 146520 ctgratctca cctgtcatat rcacrgccaa atcccacctg ccaiaatcac rgccgtaicc 146580 cacctgtcat aatcactgcc gtatcccacc tgccaiaatc acrgccgtat cccaccrgic 146640 ataatcactg ccatatccca cctgccataa tcactgctgt atcccacctg icatatttac. 146700 tgctgtatcc cacctgtcat aatcactgcc gtatcccacc tgccacattc attgcggiar 146760 cccacctgcc ataatcactg cccatatccc acctgccgta ttcactgccg aatcccacct 146820 gccataatca ctgccatatt ccacgtcata ttcactgcca tatcccacct gccatattea 146880 c.rgccgtatc ccacctgcca laatcactgc ccatatccca cctgccgtai tcactgccga 146940 atcccacctg ccataatcac tgccatattc cacatgtcat attcacrgcc atatcccact 147000 tgccatattc actgccgtat cccacctgcc ataatcactg cccatattee cacctgccat 147060 attcactggc agatcccacc tgccataatc actgccgtat cccacctgtc atattcactg 147120 ccatacccca cctaccatai tcactgctgt atcccaagct iccagagtag getet ageat 147180 ttgtaggtgc tcagtgaata rttgctgaat tagcaaaata gaaaatttaa atctcttaac 147240 aggtaccacg ttitgacata atcacttgta acatctattt agaaatccat aggcagcaca 147300 agcacataaa taaaaacctg accttcccca agatctttcc tcctctgttc agcatgctgt 147360 gtcaagagca gcacattgtg tggtcactgi ctcattcaat tgggacagtc gcatcatctg 147420 ccccttgctg aatcgagcct rtgaattaga tgaaggaaat ttgggccaag tcttctggaa 147480 tltagtgact actattatet agtttccctc tggtscaatr agaaatgage aatgaaccaa 147540 tatataacct tgcttaaaaa gcaatttcct tiactattct ccttgtttaa ttagteigit 147600 ttgttctccc tgagetegag aggcattttt tctcccaaag cagaagcatt aagtaagatg 147660 cattcagtgt tttcatgaga ttcattcatt ettertggae aagatcttgg ccactgtaft 147720 agtctgcttg ggctgccata acaaaatatc acagaccagg tggcccaaac aacagaaatt 147780 gatttctcac agttctggag tctgagaggt etaagatega ggtgtctgct gatttggttc 147840 ctgctgaggg ccctcttcct gcrtgtgaca gccacctici tgctgcatcc tcacgtgact 147900 tttcctctgt gettgeatgg agagaaagag acaacaagac aganegetg atgtetette 147960 atataaagge actgaticca tcaggccact gatccc atca rcccccagcc tcaiagcctc 148020 aiccaatccc atttaattcc caaaggccct atctccaatt accatcacat tgggaactgg i48080 ggettcaaca taggagtttg ggggaactca aacattcagt rcataacagc caccatgtgc 148140 cagtcatctg gacagaggtt gaaaaagccc tatccatgcc aaaatcttac ctcitaaggt 148200 agtagaggea tactgctaat gtgaacct11 aaaaargctc amatteta cagatattee 148260 58 date of amendment:] August 3, 2000

1358456 Λ No. 971,350〗 9 patent specification Revised ttgtitatgc catattactc actggcttaa aaatcttcta atgatgaggc atggaacttg gagaaaccac ccaaagtttc taccaigtic tgcaaggctg tgatcaggca cctgctiacc tctcacactg ctccagccac actggcctgc gtgctgctgc tttctcccu agggcctttg ctciggctgt tcattctcci tgtggtgcit tgccccagat agctggctca ttctcatcat tcaggtctca cttaagtgic aictttcata ggacatccci gatacccaat cagaattact cccttggcca gctggcctgt gccagatgct ttgctggata tgaagacaca aagatcagta gtgcggccag gcgtattaaa atattaccct taatcaatgr tgactcgaca ttaataatag agcatat taa tgataatatt at taat tat taat ttatcaatag agcagatat ΐ gaacacttac tatttgcaag gcattatgct aagtctttgc cattattata attattgtta ttuattttt iattctttta gaggtagggt ctcactctgi ggcccaggct ggagtgcagt ggtacaatca tagctcactg caaccttgac cccctgggct caagcaatcc tcctgtctca gcctcctgag taggcaggac tacagccatg cactaccatg cccagctaat tttttaatti tttgagacgg gtttttgcta tgttgcccag gctgatctcg aacttctgec ttcaagcagt cctcctgctt tgaccttcaa aaatgctggg attacaggtg tgagccacta taat tat Cgccctgccc tttgccatta tttatcta at ttaaccctca cagccatcct ctgatataca tatgattatc atccccactt tgggtcagat cataaaaccg aaccttaagg aggtcaactc acctgccaaa ggccacacac aggaaagtga tagagctgag atttacccag ttttgttgag cttcaggttt iaaagccaga aagatttctc itttagaaaa tgataaagaa aagttttttt attttgaaaa attgaacaaa taatagataa gaaggaaaat tgtaaaaaga gacagtgatg actaatgaag ataaagttgt tttgtaatca gacagaccct ggtttgtatt ctgacccagc caccaattgg ctgtgtcact gtggattcaa cacttctctt atctttgttt tttatctgta aaaaggaagt tatgagcatt acacgaaata aacactgaca tgaacagatt ctcattcaat gttagtttga ttttattgaa taatattaac aaattacagt atctaattat gcagttcatc atcagacaca aataagcact taatttcttt ttaatgatat aaaatctttt ctggctgggt gtagtggctc acgcctgtaa taccagcact ttgagaggcc aaggcgggcg gatcacaagt tcaagagatc aagaccatcc tggctaacat ggtgaaaccc cgtctctgct aaaaatacaa aaattagctg ggcatggtgg caggtgcctg tagtcccagt tacttgggag gctgaggcag aagaattgcc tgaaccgggg aggcggaggt tgcagtgagc agagatggca ccactgcact ccagcctggt gacagaggga gactctgtct caaaaaaaaa aaaaaaaaaa aaaaatcttt ttaaagcatc actaggatca gaaatgcaaa tttttca gaa atttcaaaaa tgtggagaaa aggttggaca ttttgttagg gaagtaaaag catatacata taaaattata tttgttctgg aatataaaat atgttatttg tattgctcac tatagatcta gtgattgtaa gaacttatgt agcattitat caagcctcca tatctctttg gagacttcaa agactttaga aaggtataga taatatcaaa tgttggtcaa gatggtagtc aacaggaact ctcaaacatt gagagtaggc atgtaatttg gtacaaccat cttgaaaaac tgtttggcct tatciagtaa agctaaagat gtatagatcc taagatctag caattccagt tggaggtatg aaccctagaa aggcttgcac ttttgagtca gaagatgtag acaacaaaac tcacagcagc actgtΐtgta acagagaaaa ctaaaaacaa cggaaattac tatccacagt aaatagaatg aattacagta aatatggtta tacaatggaa ccttatgttt gtgcagttta ttcaagtggt tgcatgtggc cacagttcat tttgttctca atatatataa tatatagatg aiacatgtat gtgtgiatac atatatttca ngtgtgact atactacatt taattrttcc artctgttgt caiitgacgt ttcagtttca gatagttagc tattatgaaa gagctactat gaacatcctt gttcatgtat mggagcat gtatatgagc atttctgttt attatacgcc tagaggtaga atxgcagcag agtatgcttg ttcagcttta 148320 148380 148440 148500 148560 148620 148680 148740 148800 148860 148920 148980 149040 149100 149160 14 9220 149280 149340 149400 149460 149520 1495S0 149640 149700 149760 149820 149880 149940 150000 150060 150120 150180 150240 150300 150360 150420 150480 150540 150600 150660 150720 150780 150840 59 1358456 Patent Specification No. 97135019 Amendment date: August 1980 3曰gtagagacrg ccaaacaati uccatagtg gttgtaccag tagacaggcc caatatgtga 150900 gggtttgcri actccacagc ttcaccaaca utggtaitt meatuca atacitactt 150960 tcattttcat ittatatnc atttcaaaac mcatttca giatttiagi tcauttgat 151020 gcartticat tgiagrcaci ctagtgagtg latagtgata ngtactatg gtncaacti 151080 gtatrticct tatgactaat gaaatcgaag acctttiaat atgtgigttg gtcattrgat 151140 atgetattat titaaagtaa taaaiaiagg gtccagacct atggggctta gcgggtgttc 151200 tctccgtgtg tggaaacgag agatetaaga aataaagaca caagacaaag agaiaaagag 151260 aagacagctg ggcccggggg accactacca ccaagacgca gagaccagta Atggccccga 151320 atggttgggc gtgctgatat ttategtata caagacaacg gggcagggta aggagggtga 151380 gtcatccaag tgattgataa ggtcaagcaa gtcacgrgat cataggacag ggggcccttc 151440 ccrtata ggt agetgaagea gagagggaag acagcataca teageatnr cttetatgea 151500 cttatcagaa agatcaaaga ctttaagact ttcactattt ctictaccac tatettetaa 151560 caacttcaaa gaggaaccag gagtacggga ggaacatgaa agtggacaag gagcgtgacc 151620 actgaagcac agcaccacag ggaggggt11 aagcctccgg atgactgcgg gcaggaatgg 151680 araatatcca acctcccaca agaagctggt ggagcagagt gttccctgag tcctccaagg 151740 aaaggaagac tccctttcac agtctgctaa gtaacaggtg ctttcccagg cactggcatt 151800 accgcttgac cagggagccc tcaagtggcc cttatgtggg cgtaagagag ggctcacctc 151860 trgccitctt ggtcact tet cacaatgtcc ct tcagcacc tgaccctata cccgccgt ta 151920 ttccttggtt atattagtaa cacaacaaag agtaatatta aaagttaatg attaataatg 151980 tccacgatca tetetatate taatttgtat tataactatt ctaactgttt tctttattac 152040 actgaaacag 11tgtgcctt cagtttettg ccttggcacc tgggtaatcc tccacccaca 152100 aataaataaa ggattattgg aaaaattact taaraagatΐ gattaegate tatglaaagc 152160 aatgtatcag tggactgagg cttggttatc ctaacagtga cacatgactt gagaatetea 152220 gtagettaag gcaaggttta actcttgrtc ngetgearg tctacttcca a cagtcagtg 152280 ggtctgctcc acatcagcat cattctggca gcttctgtga agggacagcc tcaatatggg 152340 gcattgctgg tctccaggca gagagaaagg agagatggea acacaatggg ccacacacaa 152400 gttcttagaa cttrggetea gaagtggcac acacttcact tacactcaca itteattgge 152460 caaaggagat cagatgtcca agactgatgt tagigagtgg attatataat ctaaaggcaa] 52520 gggcttgtag gaagaggcag tcaatattt〇tgaacaagag aaigatcagt aacatctttc 152580 tgcagagtag gcttataa £ a gtattactgt aggatagaga aaacaagctg tgtgtctgtg 152640 ggctgttgtc aacacatata tatacactac acacttttrt tttttttttt tgagatggag 152700 11itgetett attgcccagg ctggaatgca gtggcttgat cttggctcac cacaaccrct 152760 gcctcccggg ttcaagtgat tcicctgcct cagcctccca agtagctggg attacaggca 152820 tgcaccacca cgcccagcta atttttgtar ttttagtaga gacaggattt cttcatgttg 152880 atcaggctgg tctcgaactc cccacctcag atgatccacc cgcctccgcc tcccaaagtg 152940 ttgggattgc aggeatgage caccacgccc agcctcactt tttttctnt gttttgttga 153000 actggttgcc aacgtttaaa aattatgaca tttaacaaag atgeagattt ctggcttctt 153060 ttggaaatcc taagetatag caagaaicat ttggaactga gttgtagctg cccttctggr 153120 gggatgtgca ctctctggti ttccatgact gratctgcct gicttetetg cagcagtgcc 153180 tucaaacat tttttacgta gctcacaata aacaatacat iuacattgc taccaaggac 153240 tcgcatgcat gtgtgigtgi ctgcaucat atataggtat agataigcat atacaratac 153300 attccaaagt aaaatacatc aaggaaacag tgettaccai tactcattga aattgtctgt 153360 tetattetat cctartgtat retagtaerr trurrtttt rnaatgctg gaatcaactc 153420 60 amendments Date: 3 August 2000]曰

1358456

A 97] No. 35019 Patent Specification Revised cctaaariga tttcacaaac cacrtctggg tcatasccca taggttgaaa acatggttgt ctatcaigtt acttgtctgi ttctcctcta aatgctatig gttagttttc tagcctggai tcctgtctaa gccctttagg gtttcaggac aattcactgt gtgggtgagc agcatctgct taaacctggg caattactgg ttttgcccaa gggtcttaaa acttaaactg cttgaataic tggcagtttc cccgctgact tttcccttgt ctgatttcct atttcaataa aaatagcctt gtaggcgaat atgccactga ttcggagaat ctcagtttcc tgactgggct aggcaatcaa gggcaaatga tcccticact aagtgagtcc tgttgtacag gaaggagagt ictcagatga tgaggatggt catggggact ttgttaccga aggaggccca agctcatgat ticacaggat tgattcctcc atctcactga tcatttaaca aatacttatg gatgacccat gigccagacc ctgtgctagg gaactcatcc aaaacitaca aaaatttctc c.tagatgcac agacgatgaa tagtaattac ctcttcctgt gttttaccct tcctatttct tcttticttc ccttgaccca gaaattcatc aattgcccta gggctgttcc ggcttagtgc ttguggtca gttggatgtg cccitctgct caggtctttg tgggctctca ctggtgttcg tatgcatata gaatggatgt ctgcatcaca ttgtagggac agtgtatggg gatgtgaaga caataagtga aagtctgccg cccactaaga cacaagcagc attgctataa actccagtgg aaaaaggtga tattataggg aaggaaaacc gtattgtcat attrtcatgg aattcagtga attgcatitt gaggaccagt gccattttga tgctggagga ttccaccacc tttgtggtgt tgtttcctgg aagagattct actactgaag tggtgttggc agcaggtgta cccagcaaaa tcaggtagca aggcctggtg gaacttggca gaaaggagct cactggggcc atcagagaca gtagtgaggc ccccttgtgc cagttagggg gcagcagaga cccaaaagtg gattttacca gaaagggttg aagcaggaga ggaaggaaat ggcgaatgcc trgacaggcc atgtttgtga gtccaggaag acaactcatg ggagctctca gaaataattg tggggtgagg tgagtgcata cttggataga gatgttacag tacctgacag gggcaagacc cagtaatata tgggttgtta ctattaaacg tgaccccatt ttaagtcgtg ggtttatata acaaggttat ttatgcttgt tatatgcttt atgtgcatta cctataaatg tccttaaact tttatcacag tgcaaatgca gctcattacc agaatccgtg agcactgtct tcaaaccctc cccattgcct tgacattggc tttttcttaa ttctgtctct ttitttggcc actctgctct tgatcttgtg tctacatctg agcctgaaat tggagagtcc ttggctactc tataatctga gtcttctact tcctgctttc cctattcagt ctcccatttc cttctccagc cccatccctg gtactagcaa gtccctccct gatgtcttca ccatccgttc ctttcagaca cctgccaccc ttcacattag caaaatgaca aaaaataaga ataaataagg tgagtatagt agattgcata gtggccccca aaagatacac cacagagctc cacacatact aacccttggt ccctcagaat gtgacttatt tggaataagg gtctttgcca atgtaattaa gataaggatc tagagatgag tccatctcct gggttacagt gagccttaaa gccaatgaca agtatcctta taagagacag caaaggagaa ggtggccatg tgaagacaga gacagagatt ggaattctgc tgccataaga caaggaatgc caggggcacc agaagcagga gctttctgaa ggtgcatggc ccctgccagc accttaattt caagtgtctg gcctccagaa ctgtgagaga acaaactctg ctgtttaaac caccaaat11 aggctgtgag tggtggctca cgcctgtaat cccagcactt tgaaaggcca aggtgggcgg atcgcttgag ctcaggagtt tgagaccagc ctggccaaca tggtgaaatc tcgtctctat tgaaaaaaaa aaaattagcc aggtgtggtg gtgcacgcct gtagtcccag ctacttcgga gagaggatca cctgagcccg ggcagccaag gctgtagtga gctatgatct ggccactgca ctccagcctg ggcaacagag tgagagccgg tctcaaaaic aaacaaaaaa gccactaagt ttgtggtaat ttataacagc agccctagga aactgagaca atgggtgacc atacagcacc aaaggacttc tatttcatga ttggtgaaca 153480 153540 153600 153660 153720 153780 153840 153900 153960 154020 154080 154140 154200 154260 154320 154380 154440 154500 154560 154620 154680 154740 154800 154860 154920 154980 155040 155100 155160 155220 155280 155340 155400 155460 155520 155580 155640 155700 155760 155820 155880 155940 156000 61 1358456 Patent Specification No. 97i35019 Amendment Date: 100 years August 3曰itttaaaata agaaaaggcc aggcatggtg gctcacgcct ataatcccag cactitggga 156060 ggccgaggcg ggiggatcac gaggtcagga gncaagacc actcicgcca agatggtgaa 156120 acccigcctg tactaaaaat acaaaaattg gccaggigig gtggtgggca cctgtaatcc 156180 cagciactcg ggaggcigag gcagagaaci ggttgagccc gggaggcaga ggttgcagtg 156240 agccaagatc acgccactgc actccagcct gggtgacagt gagactccat cccaaaaaga 156300 aaaaaaaaaa aaaagtatta cagaaaagaa tgtgagaaca tgtttcaagt atraacaaat 156360 aaaagaatgc atgctaaata attattigca acacaicata gagccagitc tcacctggca 156420 ataaggtact ccaaaagttc attcataagt aaattgagac tcagaatgca tatttttcct 156480 Gcaggagtca tgtgatatat tatggatgtt ttcaaatait aatccataat aatcatttta 156540 agttaatcat atgcggacta tagtrttctt gaagcgaggg attgrtctac acgtarttaa 156600 gtcttgctg t ctagcagagt gcntgcatg ggtagggcct ccaataaatg cttgatgagi 156660 agtagttcat iaaaaaatic tnaaaattt tttttaccac aaaacatctg caagtagagt 156720 agucattrt ttaaagcacc atacactaat atttaatagc agctgtttta gagtcagatt 156780 gcaaggcnc agatcctggc tctgccactt acagaatgca aatcattaag caaatttaca 156840 taatcrctgt gtgcttcaai itatrtgtct aiaaaattgt gatattaata cctatctcac 156900 aaigctgttg tgaggagtaa atgaattatr atgtactaaa tacttagaac aitactrgca 156960 tgtacggatt caaiaaatct taaatattgt tattagctct taagtatatc tcclcaacta 157020 aattataaac tctgaggaag aggcaagatc ctatcctttt taaaatcccg gcatctacac 157080 aatttcttgc atattgtgtg cactcagtga gtatttgttg aactactaaa aggaatgaat 157140 gattggctat atgtttacaa taccttctcc ataaaaaata catatagaat tgataacatt 157200 ctaacatrtg ttacagtaaa aaatguttt agaaattaaa tagaattttt 157260 agigtcttgc tgrgtcgccc aggctggagt gcagtggcai gatgtcagct cactgcaacc 157320 tctgcctcct gggtccaagc aattctcctg cctcagcctc ccaagtagct gggactacag 157380 gcacglgcca ccacaccctc ctaatttttg tatttttagt agagatgggg tttcaccatt tttttaagac 157440 gttggccagg ctggtctcaa actcctaacc tcaagtgatc cacctacctt ggcctcccaa 157500 aatgctggga ttacaggtgt gagccaccat gcccagccta aatagaattt ttaagatgtc 157560 agagcaaaaa ggaaattatt accagtgtga aattcttcac tatattttag cccctaagag 157620 gcagagacct tgtcctgttt ctttgtaact gctgcatttt gcgtgatgtt ttgcagaata 157680 ggcatgtgcg accttgtaca cagaaagggc ttaagcaaat ccttargcag attcctggag 157740 ttarttttct gtgctggtcg ctcctttcca gaattctact ctgcaacttc cagctgcctt 157800 agccirctga actcagagcc ccctctcctt acctccacga ggcctctggg gtctctgggt 157860 ttcccctict tgcacttgca gtttatacat tgcciccaag cagaaggccc aggtgtitct 157920 catgctcatc ccatctgttt cccctciaac agagattagt cltacaaggc ctcgtgttea 157980 gtctgaaaac agetget tee tgtacttcgt tcagtictct aattgctcac aataaaaagc 158040 laagteettt cttacttcat catggctaga agcagttccc atgegaatgt cttggttaaa 158100 ggagaaaaat gtataaggta actataaact aagactttca catcaattca gttggttctt 158160 ttgnaagaa ttacagggrt gggcacgatg gctcacacct gtaatcccag aacttrggga i58220 ggctgaggcg ggaggatccc trgaggccaa gattttaaga tcagcctggg aaacatagtg 158280 agaccccgtt ictacagaaa aaaaaaaaaa aaaagtaaaa attaggcaca gtgtcgcatg 158340 cctctagtct cagciacttg ggaagctgag gcaggatgat caatcccttg agcccaagag 158400 ttcgcggtta cagrgagcta taattgtgcc actgcattca gcctaggrga cacagcgaga 158460 tcctamaa aaaaaaaaaa aaagacaaaa agaaaagaaa attacagtat aatnttctg 158520 tgttgaagag cttcrgctgg acaaairttc agtcttggtc ggcagtttaa ctcaagaaca 158580 62 1358456 • k fix the date:] 2000 8 May 3 said No. 97135019 Patent specification revised gactcttcta aiaaagaaig gcatgatgaa agtctataga acagact tcc t tcctct tcc aaacctgcag tatctactgg aaattttact gcgactatca ctctttaait aaaagcaaac tgcatggtct ctttgggagg acatggtgaa gcctataatc gaggttgcag ctgtctcaaa tcacat tcta tggctctgag ggtgccagca atctcat tgt cgaaagatca ttatccctag aatgaactgt tttcttgtga ciactgtatc tgctgggtga ctattcctag cagaagtatg t tcttat tta aacccatct t Cagtgaatct aagttttttt atggctcact ctgggactac aatggtgtct gtgtcccaaa tttatttacc ttatgtatca ccaatgtcaa gtgcctgcat tgcaacttct tcucacttc tacactgttc taagcgtgtc gactit eat t teatetaage taggteatag caatggtgga agaattttct aaaatgtggt gtaatagige aggacctaac igccaaaaaa caaatggaag ccaaggcggg accctgtctc ccagctactc tgagccaaga aaaaaaaaaa gtaagaaacc gi ttgaette caggagtggc ttagtgtctc cacacctgat cctt tcaaac aattaaataa gttcaagaaa cctagcactt atccatacta ttagaggctg gaattttaat agaaattctc tcccccactg gtttctaggc agagacaggg acaccctcta aggcatgggc tactgtgtag gcactgggat attatttatt catcccattt cagaagttgt tcctgcccat ctcggagaaa cagcttacat tctgccccaa atctctctcc gcttctcaca acagacacga ccctgtagtt aggaggggaa tgtcttagaa cattgtcaat tggaaatatg tcttggaaac teatettaaa ataatgacag tggatcactt gggaggctga tcacgtcacc aaatttagaa ancctcct t tgt iatgtac tgatgacaga ttccitggta actactatgt tttctccttc actacataat gcagagatct ataatagtgt aatataaatc gtcttttcat gtagttaaat tgctgcaaag atctgcaatg tctctatttt tctaactctg actcctgggc catcacttct cccagactgg tacaggtgtg tttaattget gcaagggttg ttttcttcct cagggtacta acaaaataaa aaattagaat tracacatct atttatugt aatttgttta tttctattta ctatcataca cgggagtcai acactagaaa ta taccaaaaat tgtaacag ataacaggcc tccttcatgt ccgcatcatc ctaagataga gaggtcagga ataaaaaaat ggcagaagaa gcactctagc tgagcacgaa gtgggaatta tgacagtccc ggctgacatg aatgetetet gtctatccat tggatccctg t tact tattg ttgtagtttt gtggcagaga tttgtcaatt t taetttatt ttatcaatcc tgataaatat acatttttgt gtttcattgt ttgcccaggc tcaagtgatc ggctaattta cctcaaactc agccactgca ggacagtttg tttgtcttgt tegaagagaa tggacactga aaataegtea ggagaagaga gtctcacggc gcatccattt aacttttaat ggtcatttct tagactgtct t icatcagaa ttatattttc gggctttcct acattctaaa gagctgccac taaaagttat atttagaatg gttcgagacc agccaggcgt tcacttgaac ctgggcaata gttaatgaat gagccctgcc cattacgctc tcatgcacat gataggtgtt ttgcctcttt catatgtaca attaggtctc tttgttttgt acaagtactc agtatatgtg gtaaatgatg ttattaaget gttctggtat tgttaattaa ctgactatcc tggagtgcag cgccgcagcc aaaagtgttt ctggccttcc cccagcctat acaagtccag tcaaaggaca gggatgegee gccccagata ttggtccatg attetaaagt ttgttaggea ttaiatccat agtgatatat gtgeagteae at tttaatag agatgeattg tggaaat ttc tt tcaatata aattcatttc aacatcatct tttggcaaaa agccc cagca agcctggcca ggtggtgcat ccaggagatg gaatgagact aatacctcag cccagaaccc atggttccat cattctgtct accatgcaat cctagacatc cagtgtatac ttttaaacta attttaatta agtaaatagt tgagaaatat tt tgaatgaa atttttttgt attttcttct cttttattac tttttaaaat tggcacaatc tcctgagtca tttttgaaga tcccacctca cctatttatt tttgagetag atgagtacaa aggatggaga tgaacagatg ttcaactgcc 158640 158700 158760 158820 158880 158940 159000 159060 159120 159180 159240 159300 159360 159420 159480 159540 159600 159660 159720 159780 159840 159900 159960 160020 160080 160140 160200 160260 160320 160380 160440 160500 160560 160620 160680 160740 160800 160860 160920 160980 161040 161100 161160 63 1358456 Amendment date: August 3, 100, No. 97135019 Patent Specification Amendment catcgiaaaa caagcaagaa catgccrgta t tcaagacca ccaggigagg acitgaaccc Gggtgacaat tgacaaaaag caacctact tt tct ttggac agtttttgai gtgatgttga gcccacagct agtagtatat rrggaaatag agtaatatga t tact t tct t ggaactat ra gtctgtact t art t ragtaa at icccaaca gccattataa at tgt tgct t trtggcctgg tg agcagggt catgagtttg aattagccag agaattgcrg agcctgagcg tttiatcttc tatggtatat atggtactat aattcacatt agtataaaag aagt rtgna cacatact 11 actaaaatgt tgaraagat t rtgatictga acat rt tctc ca £ gcaaaaa ctccgtataa cagtggggtc aagaaataca attagaagci atct ragcgc gctiagccaa tggtgagtgc aggaggcgga aaaaataaat ttaataatta atgagcatct tact tgtcaa ΐtgtaggtct tactgctggt gcattatttt at taatactg gcacaigaat aiat tgtcct. acattgtgaa agtgagaact aacaact tgc gaaatgctaa gtr 11 at aga acctgatggc tcagttttta taaiatctcg ggctcacgct ggcccagcct gcgtggtggc aacccaggag acaaagccag tcratctgtt gaatagtaat at rcgtat ta t taaaagtcg tttcgttgtt tgggtggaac gattaattaa taaacaggta trt raaaaag atatgtattt aattagtcat tacatcattg agger tctct ncaaggaac teartggara tgiaaaaata tt tgggaggc catggcgaaa ctgtaatccc ggttgcagig aaatgaaatg ttangtaic gttttctgga actgtagtgt gggatgggac ictgggacca ttttttattt aatgacaagt at 11 Tgaact ccaaaact 11 aact tagage rtaacagtaa aaatttgctt aarcaaaaag tgaaatttta tgagacactg aaataigget ggtcccacac tgtaaiccca ggccaacgta acgta cctat gcggatgttg actccctcta aatgagagag aaaataatat tagetgatre atcagtttca gtagacacca tgattaagtg atggtgaata agacaaaaag tgaaacacca tataatat 11 utcaggttt gcct t tgiat tcictgcaaa aacatagaga agcaacrrca agatggaat t caaggcagst ccccgictct agctact tgg agccaagatc. aaaataaaat taat t tctgg tgaget tcaa gaatcagagg t tgagaat 11 catttrgaga tcccaagaat tagaaagata taaaataaat gatgatagag atattet tee t tctccatat ttatccaaaa ataggtaaat agttctctgg gtcgatcacc taantratg ataigatcat gcacmgga gcaaaacccc agtcccagct cagtgagcca aaaaaaaaaa actaaaataa aataagatgt tttacaaaaa ttttttctgg ggtcctaata aggtaccact agaacttgtt gcaattatta cccatacaca cattggcctt at tgcctaag aictt tgaaa ctgaaaggga gcagccgctg r tcaaaagtc ttgagctggg ggatcact tg actaaaaata gaggetgagg gcgccactgc aaggiggaat acaitgaata ccgt tgcaag agtt taatac gcttitucc aactitgt tg taatgtcatc gat tign ta gtttcagtga 111 ΐ g 11 rct rcaggcctaa gcaaaaaagc ggaagagaat amaaggaa gt tataactr cat taggaat 11 tgcttaaa tcacaattat aggeegaggt atctctacta actcgggagg agaiggcacc aaaaaat tar t gatgaagaa arctccaaaa gcagtcttgg agaatgttag aaaacaagta gaagaat taa t taarctcat caagE tttta ctgaattcat gacccacaaa atgetaattg ggeetterga ccctgtgtgt gccagccgga agrgccacag cacggtcgct aggtcaggaa caaaaat tag cagaagaatc actccagcct t ΐicacccat gctcataagc tggai111 tc agatigctga aagt tcccat tcaataatgt agat t taaat aaagataata 1111 tat taa rtaatgtgaa gtactgtata armiacia tagagaaatg tcattgtagt getttetgat atatgetaaa attggtttgt catatcgggc agacagatca acaataaaaa ccgaggcagg acrgctctcc ta 11 a 111 ag aacat 11 taa tetgaateta ct tactggaa ct t tactgaa aaagaagaaa agatatetea tattcaagtc cgtaaaacra ttggctggta ctaaacacag aaattcaggg rgggaccttg gaagtgtgt't agccaccatg 161220 161280 161340 161400] 61460 161520 161580 161640 161700 161760 161820 161880 161940 162000 162060 162120 162180 162240 162300 162360 162420 162480 162540 162600 162660 162720 162780 162840 162900 162960 163020 163080 163140 163200 163260 163320 163380 】63440 163500 163560 163620 163680 163740

64 Revision date:] August 3, the following year

13584564 No. 97135019 Patent Specification Revised cgctgtccic aacagagcag ctccaggcrg rargaccccc aggcaattag gcaccaaaag aagatgctca cactΐtccaa aattctttcc cagggctggg ggaagggagc cagacttgga gcccctatgi ggaacttagt ctccaaggaa agaaagcatg ttctcatcct acaaacactc catmctcc cigaattagt gtcctttctt tgaaccagat gagacttcgc tcagagctgg aggctatggc cccttagttc tgtttccaca gtgcttccag ccctctcccc agtitggagg cccccaaaat gaggcgctta tctctttgat τttgtgaaag aaaatgcaca gttcgtctat ttggggcttc igaaagaigt taggccctga agaaggttga ctgggagaci gagtggggag tgacagacca tgaccttaat tactgacctt ttgttataga ttaacttcct tcctatttta ΐtgttcctgg cccagaccag atagcacttg agataaaaga icccttgatt attacatcct taatgtggaa tgttaaatac tcccttcccc caaggaatca ctgcctaaaa ccagtcagat tgctgcgact gtgcactaac crtgtgtgga aaatgctgtc atcctgttaa gettccccat accgtgcctg tataaacaat cctcaaacct cgctgcttca gagcactaac cccatctttt tggagtcctc ctgggtgacc ctcctcaaac tttgtgctca gtatΐΐtaat cctattgcct ggatetegat ttaaagttga taattttcag agaattette attttctctt tgcaiatttt attgittcct ΐtccatctgt t tttctttta cttactgcct gaagccaaga gacaatgtca aggtgtctta gtgaaaggag ctcatactta agggttcctg ggtcaaaacc tacatctctc atttettage tetatgatet acctgtttcc ttaatctctc tgggcctcag tttacccatt attgtagtaa aacatgtact acaagttact ttttatttaa etaettatge catatttaat tcccaaccac taatattaca tattagitat atattgttaa atcataatgt tctttcacta tttcttttat gactgagaaa tttcttttca atgtataaat catatacatg ttgctcctgg acaaaactga gggtcaggct gctacttctc ctggcccaat aatgagatgc agacaaactg gggaagagag gttttatttt tgcatttggt tacagggaga aggcctagaa attgtcacca caccaactca aaattacaaa gttttccaga gcttataaac cttccaagct gtatgtctac atataagtgt gcattcatct aaagacataa gtgattaact tcttttaatc tataactaag atctgagtcc tgaagacctt tctctggagc ctcagtaaat ttaettaate taaatgggtc caggtgctag ggtgattacc ettatettgt ctcctgctaa atcacagagg tttggggagt iccitcagac ciccaataaa citgtgtgtg gaggcctggg gaatttcttc agactgacaa taaaacttgt ttattccagt ctggccaaca tggtgaaacc ctgtctctac taaaaatacc aaaaagttag ctgggcgtgg tgacgtgcac ctgtaatctc agctactagt gagacctggc ctgccacaat gtggttaagg aaacatatta aaacattttt aaaaatcaag attttccatt tcaatggcct tgtaattgat tgaaaagttt attttgagtc acatggigtt ctagactctt gtggagggtt tagattggaa aataagtaat gacagtgaag cagttgttat gttcgtataa aagaaagaaa agaaaaaccc acaggacttt atttggtm aaaagtctat ctgcaaagat atagtttata ggaaaattca attccaaatg tttctcattg cictggagtg tgtgaagaag aggcctaaga atattettag gaaggcaaaa actttcagat gcagttcata tgcttgacac ctctgtttea cttttggctg acttgtgtag tctgattttt ggtcactgac aggctcagca tcatgagtgt gcaagacgta agggaggcag gaccttgtct tttcaatggt gtcttcctgg gtggctgcca gaattcatca ttattgcact ctactctcat agcctcgatt tctgtttttg tttgctttta ctgaaattgg agtagtgaca cagagtcaga tcattgaaaa gactcacaag attccaaagg gtatactggt agagtataaa ctggaggata aggtacagcg ggagaaagca agtaccagca gacacagagg gggctgagac tcctgcaagc agcgcctttc. ctcaggctca ctggatgtgc tctgtgtttg ggtgtgaacc accaagatgc atgeatgata tctgttttca gggaagccaa gatacaagtg tacagaaaag ccatiatacc cccgtcacat tgctgaaact 163800 163860 163920 163980 164040 164100 164160 164220 164280 164340 164400 164460 164520 164580 164640 16470 0 164760 164820 164880 164940 165000 165060 165120 165180 165240 165300 165360 165420 165480 165540 165600 165660 165720 165780 165840 165900 165960 166020 166080 166140 166200 166260 166320 65 1358456 Patent Specification No. 97135019 Amendment date: August 3, 100 ggargattaa accacgtacc aagcggtgtc taaatrtcag taataatgar cagciagt2g 166380 agggtgcctc aaggcagttt casacttiaa ataacatagt agaaatcact agciagtcca 166440 tticaicctt atcattgttg cagaactttc tccitagnc agctaaaacc gggucugi 166500 cacacaaccg gaaaagatta ggctcaggga cacaiagaag ggtgaggggc agaatuan 166560 gggtgaaaag gaaaaaggaa aaagaacrcr cagcaaagcg agagggagtc ttgccaacag 166620 gccctccacc tcacagacig aacaccaggc caccacacag gaactgaaga ggccaggcic 166680 ctccccgctg aacaagcgta aacttctctt ggctccaccc tcttccccca gtgrgcaggi 166740 gggcattatt cagagagaat cagctgagaa agggcaggct natccggga Ccagcagtcc 166800 agttcttcag ccttcaggct ctttiaggct tgaaggcagg gtttcgtggg ggaccttggi 166860 aagaagaett cttttcgaca ctttaatgta gattgtaaga ggtagaaaaa aattgatcac 166920 attta acata tagttactta aaaacacaic tttgagttrt ctagacttct aataigattg 166980 tagaaaatca gcgtggcagc caacttaaga cagatcaata cctcgaagtc 167040 ataagaacat cagaactgaa attctatatt agttacccta ttgiactcac agtcatggaa 167100 tacagaacag gaaagattct ggaaacacat tttgatagtc agggicacag arartgctct 167160 grttcagtaa ccaggt11tc tacttatgaa agttatttaa aaggcaarga ata tgtaacttta? tcaaaa 167220 tgtgagcagc tattgctacc attagctcca gaatcagttc tgaagaattt gtaggaagic 167280 atcttgaaaa taataaagca atatattttt cagaaatagt atccactaaa tcataaictg 167340 aggccactti actgaggcgt rtatattiat atitatarta atrrgttatr ttacacagaa 167400 agggaaacta tgacciaaag acagagataa caataatctg attagcaua gccaccccat 167460 rccaacaaca aatcacgtta ataaggcait tttagaagta gcaaagcata gtggttaaga 167520 acatatgttc tagaactaga cagtctgagt ttgactcctg ataccacm ttttattcia 167580 aaacttttgg caaattatta cataacctcc cttgcctcag ttsgccaagc tgtaaaatgg 167640 gactaataat ggtgtccaac rcacaggatt gctatgtagg ctaaaaggu aaaagagttt 167700 tatatttcta aaacaatgtg cttgtaatag tcrtggcaca rtgtaaacat tgtgt aagtg 167760 cttattaaaa ataaatteat gcttgtaau gaagategee atatgagata cacattetag 167820 tgatetatat gtttatcatt agatatatga tatatacaca cactcatatt tcagtcccct 167880 gagggattaa ct11taatcc cttgatttgc aaatcaagtt gtaaattaca cgtataaata 167940 aaataccttt gtagtgatrc gttcattata aaattatget aactatgttg gttitcaigt 168000 aggeataage tggetetata aataaagttt gaaaataagr aaggtataaa ggaaccctgg 168060 egggatagat aagatactag gaacagtggt ttgggagiga ggatgggaag tagactgaig 168120 tggaacaaga tgggagtgag actttttita gtcaccgtct atatrtt tat aat t tciggg 168180 tctggaatca gtatctcctc atcctaactt gttcatatga igagttagag icatatctgc 168240 ctgctgitag ttttttcaaa gaatcttcaa atggggcaac cccctttggg tcccctccct 168300 ttgtatggga gctctgtttt cactctatta aatettgeta ctgcactctt ciggtccatg 168360 tttgttacgg ctggagctga getttegett gccgtccacc actgctgtrt gccacrgrcg 168420 cagacccgcc getgattccc atcgccgctg actcccatcc ctccagatcc ggcagggtgt 168480 ccgctgigct cctgatccag cgagactccc augccactc ccgattgtgc taaaagcug 168540 ccattgttee tgeaeggeta agtgcctggg ttcgt cctaa tcgagctgaa cactagtcac 168600 tgggttccac ggtreterte catgacccac agertetaat a〇ctcatcgc atggcccaag 168660 attccattcc ttggaatccg rgaggccaag aaccccaggt cagagaacac gaggengee 168720 accatcttgg aagccgccca ccaccatcrt ggaagegget tgccaccati ttgggagctc 168780 tgtgagcaag gatccccggt aacattttgg cgaccatgaa gggacctccg aagcgutgt 168840 ctcttccaga attgaaactg aatggnctt caaatgga〇c cccagatgca 168900 66 1358456 4 taaaactaca Patent No. 97Π5019 amendments to manual correction date:] August 3, 2000 gtccatgact aagaiccacc gcagacccct ggaccggcct gctagcccat gctccaatgi 168960 taatgacatg gaaggcaccc trccggagga aatctcaact acacaacacc tactatgccc 169020 caattcagca ggaagctgtt agagcagtca ΐtggccaacc tccccaacag cactigggtt 169080 • ttcctgttga gagaggggac igagagacag gactagcigg atrtcctagg ccgactaaga 169140 atccctaagc ctagctggga aggtgaccgc atccaccttt aaacacgggg cttgcaactt 169200 - agctcacacc caaccagaga gucactaaa atgctaarta ggcaaaaata ggaggtacag 169260 aaatagccaa tcatctattg cctgagagca cagcgggagg gacaaggatc aggatataaa 169 320 cccaggcatt cgagctggca acggcaaccc cctttgggtc ccctcccttt gtatgggagc 169380 tctgtlttca ctgtttcact ctattaaatc ttgcaactgc aaaaaagaaa aaaaaaagaa 169440 tcttcaaatg gctattgatg ctaaagaaag ttctgaagga gcattctcca atgcagttat 169500 ttcctacaga agattttaag tgatttttta aaaaactgcc tctmctaa aaatarttca 169560 gcttttattt tagatatggg ggtacaiatg taggattgit acatgggtat attggatcca 169620 ggtagtgagc atagtaagca ataggtaaaa aaatgacctc ttattcaaga gggtacctca 169680 ttactattta caaagtgcit tcaaacattc tttctcattt tttctgacaa ctctggacgt 169740 • ccccccctac tttiagaaga aaactaacag tcccaaaaat gtittggtgt aagtcaatat 169800 atgaacccag gtccatgtcc agaactgttt accactcacc tctttataaa acggtaactg 169860 tggccaggca cggtggctca ctcctgtaat cccagcactt tgggaggccg agggaggtgg 169920 atcacttgag gccaggagtt caagaccagc ctggccaatc tgttgaaacc ccatgtctac 169980 taaaaataga aaaattagtt gggcatggtg gcacgcacct giaatcccag ctactcggga 170040 ggctgagaca ggaaaattgc ttgaaccggg gaggtggggg ttgcagtgag ctgagatcat 170100 gccactgcac tccagcctgg gcaacagagc aagactctgt c ttaaaaaac aaaaacaaac 170160 agtaacagtt acttctctga agctattatt ttttatcctg ttacatatat caaagacttc 170220 atttgggtaa ctatattcac gattatttta agctttcttt ttcattacca atagttgggc 170280 taacctttat 11tctggatg gtaaaggtgt tttatagcaa caaaaacaaa cagctaagtc 170340 aatccgtcca ggtaccctgt taaagcttca aagactctgg atcagaatga tctctgctat 170400 acacacatac ccaaagaata aacaaaaatg ctattgctaa tatcictcag tcccttgagg 170460 gattaacttt tagtcccttg atttgcaaat caagctgtaa actatattaa ttcccccctt 170520 tctgtacctt tcctttcgga tgatgctcat ctagcatttt gctgtcttga ataccttctc 170580 _ ctttctcatc cctatatatt ttcattcttt atttgagtat aattccactt taacacatta 170640 ccttaatgca aaccattatc tccatttttg ctcacttctt tccctttcac agcacctctt 170700 ctcaataaaa gtctatatgt agtgtgttcc catggtgatg ggaactaaaa ttacttataa 170760 tcaatggt11 ttatattgtc gctgctgctt atctcttggg ttaggcctct ctttgcagcc 170820 aggtcacagg taagtctatg aaggtgagat gaaacaatat ttaccagaga tTgaactact 170880 tctggaatat ttgtgaatcc agccttcacc attattgcac catctagatt tcacatctgt 170940 ttagtgtatt accaatattt cctttticca tataatgaat tcttttattg tagtaattgt 171000 'ggtatcaggg caccatggat attcatagtt ataagaagat attatcatag aagaaaattg 171060 tcatgccatc attcattatg gtgttttgca tctttgaatt ttaaacagag aaagagaaag 171120. aacagtcaag ctagtaagca agagataacc aatctact 11 gggaaatgac caatggttct 171180 tgatitcagg gtagattata gaaaagagaa aagartatag tattttatat ctgcaaaact 171240 tattccaaaa caaatcagta aatccaggiΐ aaaataccca ggtcagacag tcacattttt 171300 actaataaaa attaactagc agcccgggcg aggtggctca tgcctgiaat cccagcactt 171360 Tcggaggccg cggccggcgg atcacgaggt caggagatcg agaccatcct ggctaacaca 171420

Etgaaaccct gtctctacta aaaaiacaaa aaaaaatiag ccgggcgtgt tggcgggcgc 171480 67 1358456 correcting said period: 100 August 3, said No. 97135019 Patent Specification Revised crgtagtccc gcttgcagig gtctcaaaga tgaact r taa gtgctggaca tgctgcagca ctgtt taaaa gtccaaaata gggatagaag tctaggtgat taaaaatcat gataaagtga ccacccaat t gitcnttgc at t rat 11 tg tcaaggt 111 caggctcicc tcaaattcat tgaaaat tgc gggtggatca tctactaaaa gggaggctga tcatgccat t taaaraaaaa tatagaggag aaacttatat gcacatgaaa tatatatct t tggattatag aagataaggg aggtgataaa taarggtgtg ctccattgct gtcctgaagt ctcacccct t tgaigt tcca tcaaaatgct ataccatatc atccagaaga tagtgactca tgrrctggag agatctt 111 cttgctacat agctactcag agccgagatt aataaaataa atgatcatgc aatgccagca aagctgtcta tct tacagtt ggcaaatcta cat tacaggg agaaatgttc tcaat tgtar taccaaaaga aaaatgcaat Acaaagaaga caccat t tat gcttargata ttggcttcta tgtaggagaa cagggtcagt ccggggtcgg atacaaaat t agcaggagaa gcacgccagc taaagtgaaa gaaaaat t tc aatacagat t gtcctcacaa ttagaigaag gcagtaaat t atattttagt gatgt tct 11 1111 ta agta t tcagctcta cct tcact tg tttacagccg t tcagt tctc tmtaaaag ttgctct tac aaaaacaagt cagaaacact tcaiaattat atatttcttt ttactttttc gaggctgagg gcgccactgc ataaataaat tacntgiga caatscagia tagacticaa tcaaaggacc taaagataga tcagggcagt taaaitgat t act t taaatg aagatct tcc gtcaatacgt aaaaatagaa ticaactgt t aatgt ttgaa atggaggcag ttaacccttc ggcitacgcc gagtrcgaga agccaggcat tcactigaac ctgggcaaca at tatgcagt tcctctacct aatagaagag gacaatgaag aaatgataaa gtgaggaagt aagtt tgtac tcttcctggt gaaaggggga aataatcagt 11 tactcact tccagcccta tacagt tgga gacaaaggtc agagtcrcag aigtaact rt ccgtagaact ctccccctt rrncitccc ctggrtatrg caggagaatg acgccagccr aaataaaiaa aatagaatat ctttgctgai aaaacaaagg acatat tcta aaatagatta gaccticcci gcggtggtgg agagaatigt ccaaaaagct attcgt t tat atcagaatgt taaaataaaa gtgacactga gtatcccatg gtggtgccac tgtaatccca ccagcctgac ggtggcacat ctgggaggcg agagtgaaac atgggtttca t Tct tacaatc aagcaiacaa acccaaagaa 11 tgtgaaga cactaaaaat agatctatt t acagggaggg ggtcaaaagg aigccaaagt cgt tgctaat tgctt tttat agggictagc ttgtggtcaa tgcacactaa atttaaccta agcctctgca at taccttat gaacatgtt t cccagttgu gcatgaaccc gggcgacaga ataaat tgca cacattacia atagtgtgga natatgagc tgauccatt gtggttacct aaaagataca tcacaactai aaatataiga t tcccgtaaa 11 tatrgctt aagaagacaa gggccgat tt aatgtgaacr ggacagatgc 11 tct tcata gcactttgsg taacatggtg gcctgtaatc gaggrtgcag tgcatctcta ctgtagtttt tctggctagg attttattat gtgaccagaa agtgataaga atagaggggg cagagtcaat cacctttctc. cr t tcctgca ggcatattit caggacttga 11 tatgccat ttgggctacc atcagtt tag carat 'taaag atatitccca gaacacccta tactcit tcc gt t ttaagcc aagtctggat ggagggcgga gcgagaccct gcccat tgag gatctgttgt aragat 11 tg at taaccaaa tatargaaat gggacttgcg gaatitat 11 gtgacaatat gt tatagctc aatacatgt t aaaataaigt gtcamaig targctgctg ggttgtgaga ttgtattgci tgaattaaag aggctgaggc aaaccccaac ccagctacr t tgagccaaga Aataaataaa actactcitg cctaagaat t aattttacti gtagtaaact caaagcagtt aaactaatgg tccaagictc ctggaaattt tctgctat 11 ggggtggcac tcatct t igt tat t taaatc 11 tgtat tgt cgaaiggt gc gr tctgagaa aactttutt tgggaaatgg cagciatgac acaat tcaaa fgccctggga 171540 171600 171660 171720 171780 171840 171900 171960 172020 172080 172140 172200 172260 172320 172380 172440 172500 172560 172620 172680 172740 172800 172860 172920 172980 173040 173100 173160 173220 173280 173340 173400 173460 173520 173580 173640 173700 173700 173820 173880 173940 Mooo 174060

68 1358456 Revision date: August 3, 100, revision of patent specification No. 97135019

agargctgai aitigtgaig aagacaatcc ctggccctca ccttacagtg ataaagtata ttttaratgg tgaaaiatgt tcccagct 11 gtggaataca ccgt tactga acacacaaag agtgtgacca agttaggttg gagacagctg ttttutttt agtgcagtga ccact tcagc ttgtattttt caagaaccaa ctgagctctt tttgagaatc ttgggaagtg tagaggt tga tgtctgggaa agaaagagga ctttgacgag tagatgt tea aagatgggac aaggtgggga caaggttttc aact tgetat t ttgagagat ccaaat t tag ggcatttgac cagctgaaac gageatgeat aat taaatgt accaccgt tg gaagagegag agt tat tggt cagatcacct acatccaggg tacatggtgc catacat iac tcctgcgtcc ttaattgtaa gataagtttg aatacacatg gcctgctttg ctgtaccctc cttcaggtca aggagcgtgc caacaigc.tc aaatcaaatc agiggetget aggatcctag ctgcaaaaac tttttttttt catggtctcg ctcccgagta tgtagagtea cagaaggcca tcaaggaggt atcagcacgc aggaaacagc gcagagacga gccacacgag agatacagag accaggttca tgaccgtaga ttactgtct t tagaagccat agggagggaa actgtgaaca tcaggactat ttaataccga cactccactc tagtccccag agagaaggea gtttgcaagt tagataatga tggtttgatt Gataacatga gtgttgagaa gtcccagcct tctgaatacc tgcccaacag atcagct tgt ccaac cctaa teagataett gaatggatgt tagatatcct cttcttttgg ccaccaatcc atggggtgct teatggetet ttgataaaca giagaaggaa tgaaaagagt tctaaagcaa ttttttttga gcccactata gctggaacta gggttttgcc gggaggggag cagggcaagt aaggaggtat aaaaggaggg ggggactgca aaagtgtt tc gtggccaccg gtgttctttg agtggaaata taaactgtct atctccttgg gatggactga tgtagtatga ttgttttttt agteaggate cactccactc tcagcacaga gagagttagg cagtaagtat gcaaartggg ggaagaagtg caaatgatat ggtrgaggat tet tgt tc t tgcgttctt agaattgggc tattggctgg gagagttaag tccttagtgc tt caccaataag ttutttttc ctgcccagct aatccaggct cttctggatc tagatetagt ct 11 tcagat tggtcttaga gtgaacaagg gacccagctt cacagggtct gcctccacct taggcacatg acgttgccca caaagtggat cgcatagggt ctaaagctgg gcttggtaca aagaageage caaaagcaac atccaatgac ggaggattga tgaatataaa gcagtagaat ggtttttttc ctgtaggaag ccactggaca taagtccatc tgaacccggg cactccactc tctgtcattt ttttatgacc gegatgatgg gatcaaagga cagagcctga gggtgtgagt tgagaagtet tacaaaagag tgccagtagc ttgcctcatt caccacagag ttgtatcagg atatttttta ggittttaaa aatctatgaa aagctcatc c ggaagtgatg ctggggatat gggggaaaga cactaaaatc aagctgcttt agaaagaaat caggtcttet cactctgt tg cctggactca ccaccacacc ggctgcacct gagtgggaga ttt £ ttaacc aggcctggat gacctggatg caggcaggta acatgctgtt aacgtgcaag ggaggaatgt ggttaaggtt ggaagcaact cccct taagg aggaagagag gtatt iacag actcitatca gaegtettge cactgcctct ctccagttct aaaagagaga tgaaatcaaa raggaaacgt tttggaagaa ggctcatgtg gggcctgtcc aaactcagag tcicciaaag gcaatitcag atgigittct catgtgtata aagagaiaga cactggagaa ctcaaatata caacaacgct agactgagct agtggt taaa tagccaataa agattatgig tggagatgac ccaggcagag tctitttttt cccaggctgg agtgatcctc cagctaat 11 tgaagtcttt aggataette ctgacgtgga gaggttgcct gctcaacct t agagttcaga gaagaagccc ttgt tgatga gatttaagaa tgtttgtttt aatgaaaatg aaatatgagg agaagtaaat cctat tagaa gtgatittga teagagtetg ccacgagtta cctcagctat gatgagacag gaagtgaaga tgatgaggtg tcagaggtgc ggtacaggag catggatctg cctgtgcccc 174120 174180 174240 174300 174360 174420 174480 174540 174600 174660 174720 174780 174840 174900 174960 175020 175080 175140 17520 0,175,260,175,320,175,380 175 440 175 500 175 560 175 620 175 680 175 740 175 800 175 860 175 920 175 980 176 040 176 100 176 160 176 220 176 280 176 340 176 400 176 460 176 520 176 580 176,640,691,358,456 No. 97135019 Patent Specification Revised correction saying: 100 on August 3 tggaatttic aaataaagca rgtgcttgrc ccaaggtarg gagaaiagcg gccgigcagc 176700 caataatgtc actgggctca cttgggctaa agtgggtctc ccctttcctt ccctgccctc 176760 cctctacccc gaaactttcc tiaactactg aagatcaggc cttcttggcc ccaacacaga 176820 aatccctgig gggtgggggg caaggagaac tgtigtccac tcctgictgc aacaaaagaa 176880 gagncaitt ttggccaaat gaatgacaar gaaratiagg gtcttggact gccagaacic 176940 ccrgccagig gcactccctg ggagagaagg cctgttccca cacccctctc. tccagcutc 1.77000 rccacctgga ccagatcagt igttctccct tacrcccctc taggatccag aattcctggt 177060 ttgactatca aaagtaacac tacttataag ratttatagg aiacarcatr gaclctcaca 177120 rtcactttat tataaaartr cittttctct aacaactcta ggtacittta ttgttaitag 177180 gccangttc cttactcttt gttitcttgt attatcacat cagtcagcea ccaaatcctg 177240 ucattcraa ctgagatgit ccccgatcrg tcccciccgt attcttcatg tcttctctca 177300 tgttgggcat tggagcagct gcttaatttg trctcmga cctttcttgc taaagtccac 177360 cctcgcaaci ctcaacagag tcacttggca aaacgtaggt ctgatcgtgt ggctgttttg 177420 cttaaaagtc trigatggtt ccccagaitg ctttgitaaa caaaggaatt tctactttaa 177480 aagtagaatt tcctgcggaa tctttctcaa gttactrtgc tccaaccaca ctaaaccgca] 77540 ccgttcccta aaccacagcc tagttaagaa crrtaaagat tccaagcact gactatattt 177600 tggttcctcc cactacttea gaggrtegeg acactagact aatttaacat 11tattctac 177660 aaaatagcac egaaertagg catatgtgga aaataactag ctgttticca gattttrctg 177720 titctgtctt ctcttttctt tigatcactg ctccaggctt gctggggctg taaggaaatg 177780 ctcagtctaa ctggagaatt ttagcattgc cttcaacaca aatataagge tacttctgtt 177840 tgaaggttta tctctggctg gaaaatctgc cctcctctat ctccatttag ttaaccttta 177900 cttttccttc aaggttctac ccaatgataa cttcctttat aaagtgttcc ctggctcacc 177960 caggggtaat caattgctta ggctrttgcg tgtgaacttc tgctcgtgtt accataaatt 178020 atctgtatgt ctagcatcct tgctcatttt accatgttat atcattaaat cctcataatt 178080 ar catgtaat cttaagtatt aggattcctg 111tgcagat agtaaacagg ggittgttac 178140 ccacctaacc aagetattat taatatctaa tgtgaca.atg ggtataatta atttataaaa 178200 gactaagagc attaaaactg gaaggcagta ttatttttaa tatattgact ctgtgtggtg 178260 acaagcgttc atctgtattt tttcttcttg ccaatagtga agggaattta tgattcctac 178320 ataaagaaat ctttttaatg ttaattaaac taaactgtaa gaatgctgct atgctcaggt 178380 gcaatgcaaa taatgaggig acrctatccc tgccatcica ggctaatccc cictcccctg 178440 aggagetgag actcagctcc ctggaggtga aaagctaaag cattcccctg ttgtgccatt 178500 ttcttccctt tcrctcaigc attatttttc ttactctggt tattettgat gggaattnt 178560 agcagagctc agcgccatct tatcccagga agaaaaaaaa attgtaggag ataaatgtai 178620 gatgaatggi gcaaaacaca acagttgcaa tettttaaat ttattgtgaa attaaagaac 178680 atgcccctag aatataateg ctggcaattc aaaaagcaag gattrttage aaaataaata 178740 agaccagttt tcttcctctg ggccttgtgt ctgticatct cagtgagtct ttcagcttaa 178800 ccagtgttgc agcccaagct citccttgtc cttaauagc atcaggagtt ΐteattagtt 178860 attttacgag ttgrtagiga tcctcattag ctttgctgtg gtcttaaat t trcttgacat 178920 ttactgtttc actgcataag attttatggt taattcccag agtatataag ccagaitatt 178980 ageegttata ttttttacaa tgtatatatt cccatttcag aatctcttgt atcttaacat 179040 ttnctttac aattrtatat aaatgactgt catccagttc gttgggcttc ctgatatctt 179100 tutatacat aitaaataag gaaaaataag taaatatata tatcattcac tcagttgata 179160 gaitrtrcaa gaaagaaaaa aattaagata aratgtttct acaaaaaaag aatgtaatga 179220 70 date of amendment:] August 3, 2000

No. 1,358,456 of 97B5019 Patent Specification Revised aatactgtaa titgacttta tagccaaatt aggggaacac tactattttt cattctacaa itattccaca ctargctgca agtartgccc. Aaggaacaga aggcagaaac caagtaactt gacaatatat tagagaagaa taacaagtca agttatttig aagatttagg tgtatttiat ticaaagtgc attgttctcc ctttgtgcct ccttctcaaa taacacaaca caggaagctg tcatccatgt aaiatatatt ttttggggga ttaatcactt gtatacctgt tttattattc atrccatggt cattagggcc taaaatgtac caggiattag ggacacagga taacaaggca gcaaaggatc attatartca gatgcaaaag gaaatgtaat aaatataaaa tgtataaaaa gtaagtagcc agntcaaat aataatcagt gtcattctgt caacacttai tttctaagta tgtactccat gctaaatact aatctataaa gtaactctga tgggtgagtg gagggcgagg ggagctattt latattagti gctcagggaa ggtttccctg aggagatgac atctgaaatg agacttaaat aacaagtaaa cacagaagag tttttcagct gagtttctgg gagrctgtgg atagatttca ggaggtctat agacttggat cagaaaaata attacatctg tattttcact caactcagac tgaaatttag cattttcttc tatttgaatg tagacaacaa atctcagtag tactagtagc acttgttact ttgttaccag tagaaagtat agttttttta aattatatct cagttttcac aggigtcttg aaatgtta tc attgctttga aattatgaga tttcttggat gtgatactag atctgattct aattgtgtta ataaagaagc acatgtatta ctgtattgat tatgtattac tgggtaatga atgacccaca atttgggagc tttaaacaat aacccatgat tctgttggtc agcaatttgg gctgtectca gctgggtggt gttttttttt ttgttttttt ttttgagatg gagtctgtct ctgtcgccca ggctggagtg cagtggcacg atcttggctc acigcaagct ctgcctcctg ggttcacgcc attctcctgc ctcagcctcc caagtagctg ggaclacagg tgcccgccac cacacctggt tactttttta tattttttag tagaaacgag gtttcaccgt gttagccagg atgatctcga tctcttgacc ttgtgatccg cccgcctcgg cctcccaaag tgctgggatt gcaggcatga gccactgtgc ccggcctcgg ctgggtggtt cttaaggact tgccaggatt gctcatgtgg ttgcagtcat ctgacagccc cactgggcca aatagtccaa gatggccttc ctcccatgcc cagcagctgg tgctgactgc aggctgggcc acatggctcc aacaggctac cctggggctc ΐtcacatagt cacagtgtta caagacagca agagcatgag ccacaaagcc ccgtgaggct caggctcaga actccccagc acttccactg tcttctgtgg gtcataacaa atccaaaggc cagctcagtc agtttgagag ggaattccat gggttgtgac ttcagggaag tgtgattaat tgggggccat taatatactt acctgtcacc taccaagtcc taattttttt. tttttttttt ttttt ttctg agacagggtc tcaclctgta gcccaggctg gagtgtagtg gcatgatcat ggctcactgc aggcttgacc tttggggctc aagcaatcct cccacttcag ccccctgact agctgggact aaaagtgtgc accaccatac ctggctaatt ttggcatgtt ctttttttgt acaaaataat cttctggatg gggctcacca tgttgcccag gctggtctca aactcctgga ctcaagtgat cctcccatct cagcctccca aggtgtgggg tttacaggca tgaaccactg tgcccagcct atgtcataat tttaaaaatt attataataa gttggccggg cttggtgact cacacttgta atcccagcac tttgggaggc caacgcaggt ggatcacttg aggtcagaag ttcaagacca gcctggccaa cacaacgaaa tcctgtctct agtaaaaata caaaaattag ccaggtgtgg tagcaggcac ctgtaatccc agctacttgg gagactgagg cacaagaatc acttgaacct gggaggcgga ggttgcagtg agccaagatc atgccactgt actccagcct gggtgacaga gcaagactct ttcaaaaaaa aaaaaaatta tagtaatttt aacatgttcg gtgttttctg taattttgtc ttttacactt tttaaaatat taitctgaga agaggracat agecttcagc acattgtcaa agagggtcaa gcacattatg aganaggag cccttgatct aaaggcaggg agttctggaa agaggagtat 179280 179340 179400 179460 179520 179580 179640 179700 179760 179820 179880 179940 180000 180060 180120 180180 180 240,180,300,180,360 180 420 180 480 180 540 180 600 180 660 180 720 180 780 180 840 180 900 180 960 181 020 181 080 181 140 181 200 181 260 181 320 181 380 181 440 181 500 181 560 181 620 181 680 18174018180071 correction Date: August 2000. 3 Shu said 1,358,456 patent specification No. 97,135,019 Revised agaagcctca aggcagaagc aagctggcat gtccaatggg aiagaggagc agaaggaaag cicctgcggc cagagccaaa gattgagggg cagagiggtt ggagacagag gtagggccag atcatgtgac ttctttgaaa gcttctgaaa cttgcaaagg gacctccact tccccactgc accataccca cagagtgiga aagtaggtai tgtargtaaa tigtarttta tgaurtttg gggtcattgc taactmtt cagt tatct t ggcagaaata agaaaaitci it it tgctat tccaiaiatc tattgtgata tcagagtctg ttgtttgtrt gtgtgtugt ttgtttaaga cagtcttgct ctgttgccag gctgaagtgc agtggtgcga rctcagctca ctgcaacttc tgcitcccag gttcaagtga ttctcctgct tcagcctccc aagtagctag gactacaggc gcgtgccacc acacccagct Aattntgta ίtcttagtag agacagggti tcaccatgtt ggccaggaig gtttgatctc tcgaactrgt gatccgccca ccttggcctc ccaaagtgct gggattacag gcgtaagcca ccgcacccag ccccagagtc tgttgtttat agaggatgat tgggcg tagc 11tctagagc tgggaaaacc acctttaaac agtattatat accaatattt actatttcat aaaitcaggc atatttgctt aaaataatct cctgtagaga ggcaagaaac agaagcccat ttttttgttt ttaggaaatt catagaagcc 11tggtaagg ttcrtrtaag ttggcaaact ctattttcag aagacttcta tgttgacact tgtgacctac agaattgctt taagaggtca gcactgataa aaacagaggg aagctgtaaa gggaggaua ggctaaagtc aactggtgga gtaggcatag gtgaattact aaagtgttga tgaaatgact ctgttggagt taccagttta ttataatgag agctaaagtg aaaaacgcca gacagcctag aagcattctg aataacaagg agcrccaacc ccttatatai aaatgaggtt acatatagta ggttgaaagc aggtttccaa aacaaccaat tagtttgtat agcttcagct tcaggattga tgattacatt ccataggata ttacattaaa trgatgaaat ctgcacgtct ctggggaact ccttacaagc tagccagtga gcttttatga tgataagata cagaatggat aaaaatcttc tgatgccaaa aaagctttgg ccctgcccaa gttaggatct atattcatat tatcaccagg taaagtgtct tgcaaact11 cttagctttc attcctatca gactgcagtt catgactgtg aggtgtcaaa gacictc.tcc ttaaccaagc ttcagtcatg ctctgctaat gtctcttttg gaccaggctt caagcttgct ccacccccag ctttggcttg cccagcccag ccttagcaag gaattctgct aagtcatclc ccaac cctag atatctaatt acccttgata tctgatcaag ttcttcatcc tccaccmt tgatgtctaa gtccttggac tgcctttagc aagagtcctg ttaggccagc ttagcaagaa ttcccctgcc cttgatgtgt tcttttagca atttcccatc ctttgacatc ctcatgctgt tcttggctat aaatettcac ttgetettgc tgtttcagag ttgagcccct tcttttcccc cctccaattg caatggt111 gaatgaagtc ttccttacca 111taacaag tgteagaata atttttttaa catctgtctt tacaccacag tcaacaaccc cttatcctcc ccaaaactct gagetaaege cactacttag agattacagt gtctgcctat mat tagct ggaactgcat cagtgatttt ggagttgaat ttttcattrt ttacatgaaa gattatgtgt ttataatttg ttgttttcac atatgeataa acagaactag gaagagctgt actcaggagt caagtcagaa gaaaaaacat caccatgttc aaatagacaa ctgaacatgc ctctgaaaac cagagacaaa gggagttatt tacagttaac atetatagaa tatgggccgg gtgtagtggc reaegettat aatcccagca cittgggagg ccaaagcagg aggattgett gagcccaggc attcgagacc agetlaggea acatggcgag accccacctc tataaaaaat ttaaaaatla gctgggcgtg atggtgtgca tctgtaggcc cagctactca ggaggctgag gtgggaggat cacttaagcc aggctacaat aagcigtgat taaggcacct gggcaacaga gcaagaccct 〇cttctacca aaaaa tgggaggtca aaaaa tatatattaa atttgtagaa gtctgggcac agtggctcac acctgtaatc ccagcacttt gggggctgag gcagaaggat tgcctteaeg 181860 181920 181980 182040 182100 182160 182220 182280 182340 182400 182460 182520 182580 182640 182700 182760 182820 182880 182940 183000 183060 183120 183180 183240 183300 183360 183420 183480 183540 183600 183660 183720 183780 183840 183900 183960 184020 184080 184140 184200 184260 184320 184380

72 1358456 Amendment date: August 3, 100, pp. 97135019

agtttgagac cagccigggc agccagttgt gctggtgtac tcacttgagc ctgggaggrc aigggtgaca gagtgagaac atgagagaca tttgaaagca gttaggatag agaccutaa aaagataaca gtgcatttac ttagggctgc cgtaacaaag gttctggagg ccaaaagtca tctagggaaa ggcctttcct igttccttgg cgtgtagatg tttccctgtg tttcttcaca tgtgtggctg aatttcccct aatgatctca ttttaatttt cttttttggg agacaattga attgtatgta gtcttttgca tgttgcaata gcagtttcta aaattatggt gtgaaggcca gtattacata agaaaatgtg gtttgaatag gaaacaaatc tΐtccatgac tatgaatatg acattttgaa ctaaaacata ttttacttaa ttgattgatt cttgttgtta aaaaaaaaat cctctcctta tccctgtggc ttttctggat attcttacaa gtgtgtgttc cctgtatttc ttgcttttca catttaataa ctcctcattc tttttttctg gaagtggcct gatctcggct cctcagcctc ccaagtagct tttttttttt ggtattttta aactcctgac ctcaggtgat tgagccacag cgcccggcct ggatgcatga taatgtgttc taagtataca tggatttgtt atttttagat gttgaattgc actaaattgc cattcgaaaa ttatttttaa ctaccaggac gactgittac tclgttgttt aggatgaaat ccgagaatat tggaagaaga aaatatcaca ggtuaagaa attttttgrt aacatagtga aataccatct acctgtagtc ccagctactt aagactgcag taagccgtga atgtctttaa aaaaaaaaaa tatgtcggaa agtcaggtat aaigittcta gtgcttgcag ttctgtcact gtagattagt tctgggtggc tttaaaacaa gaaatcatgg tgtcggcagg tgccccttcc tggcttctgg ggtcacttcg gtctttgcct tagtcttccc atcccacatg ttΐtataaag acagcagccc tgcctttgta aagaccctgg acctacatag catgtttttg tctggcttat ttcagtcaat ttcattgtca gtcctaccta aatgcatcat gacttatttt gtt.tttggtt tctatgatac taatiaatcc ttaattaaaa ttacatgtat aaatgtttat gcttatactt gccatataag tatatcctgt aactttacac tgaaatgatc cagaaggaca ttgcccagtc taattcttta atattttttc tgacatggaa taacatacct gggatcctaa tatattgtga ctacatttcc tttttgagat agagtcttgc cactgcaacc tccgcatccc aggattacag gcgcccacca gtagagacgg ggtttcacca ccacctacct tgacctccca ttctcgtttc ttaaaataat cccaaatagc aaacgtttag tctgtttcta tttacttcta tgggtaatat atatgtgctt aatgcagtaa caatttacac tttacacctt gtaaaatcta cagaacaatg agatggtgga aagttccggg aggcacggct ΐtgcagaaac tagtgtccac atactgaaga tggatctaca ctacaaaaaa tacaaaaatg aggaggctga ggtgggagaa tcatgccact gcactgtagc tctgtggact aigaagcaag acttctagag ctggcic tct atgtcaccct accctcctgc tttgcccagg tattcttttc cagaaattta tcgtctcaca gccatgctcc ctctggcagc tgtttgctgg caatccttga ccatggtcac gtggccatci cagaagtatg tgtcagtnc tatcggattg ggcctcctct gagttaggac ttcaacatgt aactttacat gcagaatcat atattagtga gattcatctg ccactatatc aaggctctgc tttcgcatat ggatatctag ttcttcccat atttctcttt gaaaactttt atatcccatc atctgttatg tggtcattat tttatggaaa aagttaaata ataagtcctg gtaatacaag taaaatcaaa cgaataggct taagtcaccg ctattgacag gtgtgcatgt atctgtgtat tatgcatact aatctatgac atttragtac aataaagttt tctgttgccc aggctggagt aggttcaagt gacrctcctg ccacgcctgg ctaatttttt tgttggccag gttggtctca aagtgctggg attacaggtg tttataatgt tccgrtcaat actgUtcca attttttgtg tgaaaacata cttaagaatg ttaagtttt.t gacagatacc cccatgaggt gtitttatta caataagaga gttatatatt gctacagaga atacggatga ccttcaggac tatactgaat gttgaagcag aaccaggtaa tcltctgacc actagggtta 184440 184500 184560 184620 184680 184740 184800 184860 184920 184980 185040 185100 185160 185220 185280 185340 185400 185460 185520 185580 185640 185700 185760 185820 185880 185940 186000 186060 186120 186180 186240 186300 186360 186420 186480 186540 186600 186660 186720 186780 186840 186900 186960 73 1358456 Revision date: August 3rd, No. 97135019 Patent specification Amendment aatctccaaa cttgtcagaa tacigcaatg tcccaaccct aagtagtata gtgtacacra tagctctgtg itcaittatt tictcattaa aagcctgagt crtgggaggc tgaggcagga agat tgtgcc actgcactcc aaaaaaaaaa aaaaagcctg tcactggtct ctcactccct aatggattat gaagtataaa gtggttcatg cccgtaatcc caggagtrtg agaccagtct aattagccag gcatgttggt agaattgctt gaacccagga cagccigggt gacagagtga tgcctgtitt ctttttcagc atttttttgc tgtaatgggg ttttcagaac tattaataat agttgaatcg agtagttaat gcttcctcag cgacacctct aacagcctat gtgccaggtg attcttgtcc tctgtaaact cctgagttgg tatctacatg agagggaaaa gaaaaaaaat gatttctttt ttttittttt tggcatgatc tcagctcact gcctcccgag tagctgggat tcagtaaaga cagggttgta gatccgtcca cctcagcctc ccaaaatttg Atttctgatc atgtaagggg acagtttcae tgcctcattc cttccgtaag gaggctcccc aggtcttgat ttagaaaaat acatttgtaa tttttgtitt tttttttttt gca gtggcgc gatcnggct cctcagcctc ccgagtagct ataiΐΐttag tagagatggg tcatgatctg cccgcctcag ctgacctaag aagggtat11 ggatttgaaa caaatttact ctacactcct cacrgctctc gccttccctg accgcatgtg tttatTgtta ctctiitatc cctatttcag ctaaaatata aagttttart gaataagaaa tcataagtca aatgiatcgt cttagccggg catggtggtg gaatcacttg aacccaagac agccttggtg acagagtgag ggtctgtaag cttgtctarg taaaattttt tctgtaaatt tcaagaagag caaaattata cagcactttg ggaggccgag ggccaacaig atgaaacccc gggtacctgr aatctcagct tgcggaggtt gcagtgagcc gattccgtct cgaaaaaaaa tgtaacctga ctacaaagat gtttgatagc ttaatittcc tattgaatct gtaattttag taagcaaagg tgaattggat attctggtct aaacgctgtt ctgtgctagg ttggacagac tagaagccag cccagatgta atacactgat tgattgattg ccagaagaga aaaatccatg tgcgacagag tcttgctgtg gcaacctcca cctcctggtt tacaggcatg agccaccaca ccatgttggc caagctggtc ccaaagtgct gggattacaa attgccactt cccccagatr tccatcaaaa aagggctact cactgaatcc ccatatgtgt ttggctggga taagtgagct agatgcttct cgaatacttt ttttgagaga cggagtctcg cactgcaacc tctgcctcct gggactacar gcatgtatca gtttcaacgt g ttagccagg cctcccaaag tgctgagart tcttgtggtc cttΐttttgg tgaagtgcaa ctatttaaag tagagcatgg tgagagcacg gagactgatg gactcaggag ttcrctcrat aacautaig gaaggaaaaa atacacctgt aagaat11ia gittttaui aacaaatΐta acctgacaac tgticctgta atcccagcta gtcaaggtag cagtgagccc acrccgtctr aaaaaaaaaa agct tagggt ctccctacaa getttcaaat cgtagagggg agaaaaagag gccgggcgtg gcgggtggat cacctgaggt gtctctacta aaaatacaaa actcaggagg etaaggeagg gagattacac cactgcactc aaaaaaaaas aaaaagaaaa tacattegta catitaaatg tgattggitt gcaugtgga aagaatttat ttatgaatac gttegagitc mtcaaggr gccacctctc agttcagatc acaagaatcc atagggcatg tgcttttacc tcactccctt attgatagat ataagggrta tagiggcaca attaaaattt ttgcccaggc tggagtgcag caagcaattc tcctgcctca cccagctaat ttttgtattt ttgaactcct 〇agctcaagi gcacgagcca cagcgtctgg rggagtgctg gggggaaggc ggagtaiccc catgtgtttc gctgagggcr ggccattcca cacagtggag aaargtagac t taaaataag aaggggt 11 ΐ ctccgtcacc aggctggagt gggttcaagc galtctcctg ccacgcctgg ctaattr111 atggtctcga tctcctgacc ataggt £ tga gccaccacgc ttattgatga aacaca taga tggcccttee ticccgaric arcagcagcc tccciggaga giraargaag gccagiatra 187020 187080 187140 187200 187260 187320 187380 187440 187500 187560 187620 187680 187740 187800 187860 187920 187980 188040 188100 188160 188220 188280 188340 188400 188460 188520 188580 188640 188700 188760 188820 188880 188940 189000 189060 189120 189180] 89240 189300 189360] 89420 189480 189540

74 1358456 Revision date:] August 3, the third day of the patent specification No. 97135019

gatattcttg igggagaatr gaaacatgga trttttattt caaaatcatt aatgccacaa tttctttata tttrggggtt aatctcggct ggattacagg t itgccatgt ctcccaaagt t taagtacaa gcattcggtc gtccttcagc tagitcaaag aagtacagtg attccatttc taaataaata atctcagcac gggcaacata tgcacacctg aggctgaggc agaccctgtc aatatgaaac atggctgatg ggagttcgag agaaat tagc aggagaatcg ctgcagcctg ctgggcatgg acctgaggtc aaatacaaaa gaggcaggag t tgcactcca aatatcataa taaccggtat cagtcactgg aatat taaag ctaagctctg attaaactat tgctitgatg tct tsct tcc aaagactgcc tgractgtca arccaatggt ccaacatgcc t tctgcacag gtctctccca gatgctagca t tct tgagac cactgcaacc cgtgtgccac tgccctccct gctgggatta tattgtatgt acaaaat tgg ctggtttgat aattttccct taaitattgt cttccattaa cttgttgaaa tttgggaggc gggagacctc tggttccagc tgcagtgagc tcaaaaaaaa at t tcctcca cctggaatcc atcagtctgg cgggcgtggt cttgaaccca ggtgacacag tggctcatgc tggagttcga ttagccgggc aatcgct tga gcctgggcaa ggtaatatca ttcaggggta ctcaaagagc ccacatgita aaaggattat gaagttgcca t tgtct t taa tctsct t tsc aaggtatccc ttcctgttgt taactcagaa at atgctaat agcaccattc gctaagaaaa tctatcataa agggtcttgc tccgcctcct catgtccagc atgttgccca caggcatgag acaaatgcca actgtgttac gtttctctaa tctgaagtat ttaaaaaaca catatagcac gaataagaaa tgaggaggat atctctacca tacttgggag tgtgatcaca aaaatgggaa atgtcaggta cagcactttg ccaacatagt gacaggtgcc ggaggcggag tgagactccg ctgtaatccc gaccagcctg gtggtggcac acctgggagg caagagtgaa taaaagacct tctctctatg ttgtagtccc ggtttggcaa gatatctaac taaggaatcc aatatcaaac tggggctcta ttgagtartc gagt ttcccc gtittitaaa tttcccaatt tggtttattc tgctgtgm actctctcta tctgtcaccc ggtcttgtga Taatttttgt ggctggactc ccaccatgcc cagagtittt tttgtactga acagcaaagc tatttttctt cctcttacit ctacgataga actggccagg cacttgagtc acaacaaaaa gctgagatgg cctctgtact aaaaaaaagc ataatatata ggaggccgag gaaaccctgt tgtagtccta gttgcagtga atccacctca agcacttggg accaacatag atgcctgtaa cagagat tgc actccatctc aggaaatgta agatcatgta aatagggact cacagggata cttgaccgtc taataaagca accagttttt atcacatggt at taacccag atgcccnct aaggaggggg aagtatctaa cctgaaat tg gt t rccagta atcaataaag aggctggaa t ctcggcctcc atttitagtt aagtgatcgc cggccctaat taaagagatg agt tcccaat tactaccatt ttagttattt tctataaaga gcctgatcca cacggtggct caaaagt t tg aaat taacca aaggattact ccagcctgag aacaattcag agaatatcac gtgggcggat ctctactaaa gctactcagg gccgagatca aaaaaaaaaa gaggccgagg agaaaccccg tcccagctac agigagccga aaaaaaaaaa ttcagttgtt ct 111 tagag cctagcaat t gat taagatc atgtagttaa ct tat 111 tc aagcacct tc. gcagcct tac atgccggitc cccagtaat t 〇acttacaca ttaartcatt ggggaactga gtaactgatc nttitggn gcagtggctt tgagtagctg gagacagggt ccacctctgc taatgaagtg acaatgagta acgt tgiata tiaaaatgct attattttct gtctatttac cagtagatat catgcctgta agaccagcct agtgtgatga tgagcctggg cgatagagtg tcacacttct cctgggtgca cgcgaggtca aatataaaaa aggctgaggc cgccactgca aaaaaagagg cgggcagatc tctctactaa tagggaggct gatcatgcca aaaaaaaaag ttatttcatt acaaaagata tgtgtaaatg tt tagagr tc aaataaagtt ctatggtgac ttgttccgtt aacaacggca 189600 189660 189720 189780 189840 189900 189960 190020 190080 190140 190200 190260 190320 190380 190440 190500 190560 190 620 190680 190740 190800 190860 190920 190980 191040 191100 191160 191220 191280 191340 191400 191460 191520 191580 191640 191700 191760 191820 191880 191940 192000 192060 192120 75 1358456 Patent Specification No. 97135019 Amendment date: August 3rd, cagaaaggag igargagt11 gcctcagtgg gcaccaaaga citcagirag gargagartc 192180 itaacitagg tgnaaaaga ggaataagag ttriccagat gacagcciu tcccaggcgg 192240 agaaacatga aacagctggg tgaatagtag gagcitgtac cacatugae tgagtggtgt 192300 gagtgaagct gcccagacag aaagagatca gggc.caggca cggiggcica cacctgtaai 192360 cccaacacti taggaggcca agtcacgagg atcacttgag mgaaacca gettgggcaa 192420 caiagtgaga cctcgtctct acaaaaaaac aantaaaaa atgaggegag aggatgactt 192480 gagtccagga ggttgaggct ccaatgagcc atgattgtgc cacrggactc ctgcctgggt 192540 gacatagcaa gagatcgggt cttacaggaa Gtctaggcca tcaangaat aaatactacr 192600 gaattttaaa ctctgcagtg caaactaaat taatgtcttc aagtcaagac. cagagtrage 192660 aaactttttc tgtgaagggc cagatagtaa gtatettagg tttcataggr cacatgatct 192720 ctcttgegae tacccagctc tgctctggta gaagcagcca tagacaacat gtaaacaaai 192780 acatgggagt gtgttccaat agaactgtct acacgaaaat aggtggtggg ctggatugc 192840 teeggaggae atactatttt tttttttttg agacagaggc rcgctctgtc gcccaggctg 192900 gaglgcaatg gtgcgatctc. agctcacrgc aagctctgcc tcccgggttc acgccattct 192960 cctgcctcag cctcccaagt agctgggact acaggcaccc gccaccatgc ctggctaatt 193020 itcttgtatt ttttagtaga gacggtgttt caccgtgtta gtcaggatga tctcgatctc 193080 ctgacctcat gatcctcctg cctcggcctc ccaaagtgct gggattacag gcatgagcca 193140 ccgtgcccag ccaggacata ctattattgg acaacctctg gtcraggcca icagrttaac 193200 aaagattgea gcaaaacagg tctacaatgc aaactaaagt aatgtctgca aatataaget 193260 tatcacataa tctggggcag tcagagggtt gsttgaaata ctaggaaagg ttggcaagag 193320 gigtcctatg ttgtccaggg aaagaaaagg aaagggttga gaggaagatg actttacagr 193380 attttttttt tttttttttt tttttttttt ggagacagag tccagctctt ttgcccaggc 193440 tggagtgcag tggaagcaat cctggctcac tgcaagctct gcctcccggg ttcacgccat 193500 tctcctgcct cagcctcctg agtagctggg actacaggca cccaccacca tgccca gcta 193560 aatttttttt ttttgtattt tiagtagaga cagggtttca ctgtgttagc cagtatggtc 193620 ttgatctcct gacctcatga tccacccacc ccagcctccc aaagtgctgg gatracaggc 193680 gcgagtcact gcgcccggcc caactttaca giattiaagc aggcctgaaa gaaaccatga 193740 cacaaggaaa cacacigcig tctgaagcaa 11tccaagtt gee111c11a taaccacact 193800 gagggcaatc cttgcttctc ctttcataag gaggtaaagg cccttetgat ttccatactc 193860 cticatccca agtcacctgc aaagcagtaa atcatgttga gcatgcgm ctggattcct 193920 ctcttcctcc acacttcatc ctcagtttcc ccctgcttee tggctaacaa attgagattc 193980 ctataaicag agaaigaacc ttrcaittca ctaccagaga taaagtaaaa aatgcatgtt 194040 rttgcttgaa gtaacaacct agttgaaatg cagtcagtca gcaagtataa aggaaaggtg 194100 actggatgct ttagtgtggg aaaggttgtt tgctcggtgg aaaaggttgg agagagteag 194160 tcacagggca ggagcagtga actcaaatg2 ccacaagcag ettataaata gcattaagta 194220 caagatgtaa acaaaaagta gaggeegagi gcagtggctc acgccrgtaa tcccagcact 194280 tegggagget gaggtggaag gattgetteg gtccaggagt ttgagaccag cctgggcaac 194340 atggtacaaa accttgtctc tacaaaaaga aaaaaaaa gc caagcatgga ggtatgegee] 94400 tgcaatccca gctacccagg aggctgaggt gggaggattg attgagactg ggagatcaag 194460 gctgtagtga gctgrgatca agccactgta ctctagcctg ggcaacagag caagaccctg 194520 tcacaaacaa acaaacaaaa gaaaaagtag atggaaaagg aacagccagi gctcacttac 194580 aggtgattn igtgctctgt gaaggtgggc ccagtgttgc ctgaattatr tatttatttt 194640 tatttaetta tttttagacg gagiettget ctgtcgccca ggctggagtg cagtggcgcg 194700 76 1358456 correction □ period:] 2000 Amendment to the patent specification of August 3, No. 97135019

atctcggctc tgagtagcrg agagacgggg ccgcctcagc ttttgattti ctaaatat tg tciataggct ctgaattggt aatgcaaact ttattaggtg ccatgccatc gcaatttt tc aaactcctac ttttgttata attctaaata atcagggaca ctt t tgtaca ccacccagat cccgagtgat cacctggcta tctcaaactc agat tacagg ggtgagcaca ttagaaacat tttcggtgac atttctcagt tcctcgcagc gtaact 11 ta acatgatcaa acagaggaag ctcctgtcta acgcctgtaa gaaatcatcc caggcgtggt cgtcaaccag gcgacagagc gtcactcttg ctaacctttg gagaaatata tttaaaattc rttgtattag ttctccatag catgaaggaa acigcaacct ggactacatg it tcactgtg ctcccaaagt 11 taaaaaag gcaatcaat t cgatggtcta ggaagggaca acagggacac tcccaggcca atgtttgtaa tcccatgaag ttgattagaa tttattcaaa atggatatta tgttgaaatt taatgtattt tggagtgcag cctcccacct attttcttat ctgtgctcaa cctgagccac ttctttcact ctgctataca cagtgagtgc tttttcctgg caaatggcat atgtccttaa atggcaagcc agcctggctc cctccatact tcccagcact tagctaacat gacgggcact gaggtagagc gagactccgt cttaggrgtc cgagacaaac tgatgatgat aagttcaaac catctaatat ttctttattc cactgaagca cigcttcctg cacctgccac ttagctagga gctgggatta aaatcagaag ccaaaagttt tgggcacccc cgggagcaca atgcctttga ggtaataact catgctattt tactcataat gacagttatt tgcatattca taaataatgg ccaatgacca cttttttttt tgacaccatc catcctcccg tttttgtaga gcaattcacc cgtgcccagt gaaataacac tatgtcttta tggtttacca gcccagtgct aagactagta agggagacag acctgagata ctggatgacc gt tacataag ttgggaggct ggtgaaaccc tgtagt.ccca ttgcagtgag ctcaaaaaaa tgtracarca cattgcattg actggtcaat taatatatat catgatgact agcaaatgca ctatgaggag ggrtcacgcc cacgccccac tggtct tgat caggcgtgag mtcaaatg tataacgtgt trgtgatctc caccagcctg gcaggtagta ccttggagt t atagtgccca cttaagtaat ggtagtatgc tggtagaaca tctccaatat tttttttttt ttttttccct agggctcact aaiagctggg gagagggttt gagattacag cctcataatg tatccatatt tgagttgcat tcagctttca gcccagagta ccagccaatg tgtgctcct t gtatggtcta tcatggagca agaaaaacct gaggtgggtg tgtctctact gc.tactcagg ccgagatcac aaaaaataga gccaggctac agattatata gttccciat t gctaaaataa ttattttact cattgaacag caatgaggtg at tctcctgc taattttttg ctcctgacct ccactgagcc tttgtgaaat tacaagccaa tgcttraaat gggagcccac Gat agccagg grgaaaagta gttatcattt gtagttgata cattgataga attagcactt tgactctttt tttttttgcc caagacaggg gcagcct tga actataggtg cattatgttg gcctgagatt catttcacac cacatataca cctat tagag t tgttccctt aaggctacat atatataaca attttgtgcc gactagaagg gagat tccat ctggctgggc gatcacaagg aaaaatacaa aggctgaggc gccactgcac aaaagttcca atcccaacta aagggaagtt cttcagtttt atatgaaact tt ttctactt cagaattctg gataaaaaag ctcagccttc tau ί 11 ag t cgtgatccgc cagcccgaac caicagtttt ataaagcaca cart tgatgt tagagtacag gcctgtcaag tatttcant ttcccaaagt tgtaacccag ttigttaatt tctagttttc gagtaattct ttagaggcat cctcactctg cctccctggg cacgccacca cccaggctgg acaggtgctg accatagtgt actggcattg caccacagtg ctgacggtgt tct tcactcc agtgatgtgg accgct taga ctgtacaaca gaggaatctc gtggtggctc tcaggagatt aaaaat tagc aggagaatgg tccagcctgg tct tgactaa aatctctacc gggggagaaa taaaatat 11 aagcacatag tattttttca 111 taaacac tacttacttt 194760 194820 194880 194940 195000 195060 195120 195180 195240 195300 195360 195420 195480 195540 195600 195660 195720 195780 19 5840 195900 195960 196020 196080 196140 196200 196260 196320 196380 196440 196500 196560 196620 196680 196740 196800 196860 196920 196980 197040 197100 197160 197220 197280 77 1358456 Patent Specification No. 97135019 Amendment of this amendment: August 3rd of the following year cictaaggag aitacagtgr acustggag ataaaatgti tcttaaaagg tggcatgtga 197340 taagtgccat ggaaaggatc ccaaggaggc atetcggcic agaggagaca tccctgtcac 197400 ccgtgggcct tcatgaccaa attrttattg gagattgttt gaggaggtrf gagcccggga 197700 ggttgaggct catrtcaaaa 197460 gaatattacc tcaataacaa catatggcca ggtgcagtgg ctcacacata taarcctagc 197520 act Itgggag gccaaggcca gaggat tgct tgagcccagg agttcaagag cagccigggc 197580 aatacagrga gaccgrcrct acaagaaaia aaaaiaaaaa ataaaaaaaa ragccaggta 197640 tggtggcaca tgcctgtgai actigaggag ctgaaarggg aagatcactt gcagtgagcc atgaicatac Cattgcaccc cagtctgggc aacagagcga 197760 gaccctctct caaaacaaac caaccaacaa acaaacaaac aaaagcaatg taggtat111 197820 tigttactgg atagtttatg taactgttct ttcagattct gtcratcctt taagcacaia 197880 acaaigatct ttgcattttc atcttacict caaacatttt actgagaita tgttattata 197940 atcgttaaca aatitatctc tgggtataaa aarttcctca ttattaataa ggaaataaaa 198000 caaagtaatg gtgatgaiac aatcttttct tagattgcaa atattctcat aagttaitac 198060 aaaaaatatt ccctatttat igggcaaaca gtgccccctt ttgaccactg gatcctaiga 198120 aagaaatcct aagacaatag actcttcaic tctgctaaaa attgaattat aiagagagtt 198180 atatagatgt atattattag aictaartat atataacatt tatgrtatat cactaraara 198240 cctaatiata tattitatat atggtatata atttctaaag aaactatcct atataacttr 198300 aaggatatat tgtgtgcttt ttattatua tttntagac tcatgttgta ttrtgttaag 198360 tganaggtc cactagagtg trtaarggca gitngtaag aiccacattt tagttttaig 198420 aalcttcttt atcctgtctg aticaggttg aatacgaagg cttaaagcat gagattaagc 1984S0 gatltgagga ggagacggta ctgctgaaca gccagctgga agatgccatc cgatigaaag 198540 agartgctga gcaccaactg gaagaagccc tcgagacm aaaaaatgaa agagagcaaa 198600 agaacaacct gcggaaggag ctctcccagt atatcagcct caatgataac catatcagca 198660 tctcagtaga tggactcaaa tttgccgagg atgggagtga accaaacaat gatgacaaaa 1 98720 tgaacggtca tatccatggg cctcttgtga aactgaatgg agactatcgg acicccacct 198780 taaggaaagg agagictctg aaccctgtct cigacttatt cagtgagctg aacatitcag 198840 aaatacagaa gt tgaagcag cagcttatgc aggtaagaac tttgmagg gccgctagag 198900 tgaatttctt gtagattgca ggtagcatgt tgtgggactt ctgattctcg catticactt 198960 ctagatttct tttctttttt cttttcttct citttcnti ctgttctttt cgagacagag 199020 tcttgctcca tcgcccaggc tggagtacag rggigcaatt tcggcrcact gcaacctccg 199080 cctcccaggt tcaagigau ctcctgcctc agcctcccga gtagctggga ctacaggtsc 199140 ccgccaccat gcccggctaa tttrtttgta ttrrragtag agacggggtt tcaccgtan 199200 agccaggatg gtctcgatct ccrgacttcg tgaiccgccc gcctiggcct ccaaagtgct 199260 gggattacag gcgtgagcca ccgcgcccag ccccagcm cttttctaaa xattgctict 199320 tcagctagaa acttcgaaag tgcagtattt tagaaagaca tgacagaagg agcgttaaag 199380 agaaatgcag tctctcatit gcatcacttc aagaaatgaa cttctgagag ccacaaattg 199440 agctccaatg aagtctgaga aaagacagaa aaaagttcct tgggccgggc gcggtggctt 199500 acacctgiaa tcccagcacr ttgagaggct gaagcgggcg gatcacc tga agtcaggagt 199560 tcaagaccaa cctggccaac atggiaaaac cccatcgcta ctaaaaatac aaaaaattag 199620 ctggacgtgg iggtgggtgc crgiaatccc acctaactca ggaggctgag icaggagaat 199680 cacttgaacc cgggaggtgg agattgcagr gagccgagai cgccattgca ctccagcctg 199740 ggcaacaaga gtgaaacgtc atctcaaaaa aaaaagaaaa agaaaaaaga aaagacagag 199800 ccrtaatgca itictgaua acaaaagaat tcaaaagcn taiatacaag taaaargatg 199860 78 1358456 correction Date: 3 August 2000] Amendment to Patent Specification No. 97135019

gaaaccatgc agtntrcat cacaagcaac rgrgrttata gcrtccagat ttatggttac 199920 amcacagg aatacttgaa gccitaaaag acgtaaagga cttcctatgt acaaatiatc 199980 caggataccg tatgartaaa aatacagaac aggtataatc taagaccaaa ggattcttat 200040 tgcaacatga gttaaaccu aaatttttag cgtcttcaaa acaaatgtct tgtgaagatc 200100 ccagccttga aaaaarcgct ttctagttta gagtcttgcc ttcctgccac atgtaatgga 200160 aatgttgttt aagaaacagc agcattacca tcacctgggg gcttatttat acaaattgtg 200220 gagctccgtg tagatctact gaactagaaa ctgaactaga aatctggtat aacaagcttg 200280 ttaagtgatt aaatttgagg cttaatcttc aatctcaatc ttatctctcc aaggttcttc 200340 atgtatagct gataattaga ggcrgttaag cctctggcag tcatctgcct ccacggaaat 200400 gatgactgga aaagtgaaat tagcagaaat aagtaagaga acagagagcc aatgatgttg 200460 atttgtiaac aggtttaitt tctatgtctt tttgctcagt ttacactaat atgactagat 200520 tgattgaaac agaaaacata tttccttgtg aaaaagtttt acatgacaga tgtattcata 200580 agaatttgtg ccccccagat tgaataccat taaatagaag ttttatgagt tttgtttaac 200640 tctcatattg gtggctttga gataaaaagt tagtgggttc aggctttttg tttattccti 200700 ttgttttggt ggcagtgcag aagataatag gaaaagaggc ttctatgcat gaaacagcac 200760 aacaattttc aagcaggtca tctattggct gaaagctcag agctgtgctc agatttaatt 200820 ciaaatgtga tctgaattgg gtaatacaaa agtctaaaaa agatgaaaag ttcaattaaa 200880 agaatggtgg aaaacaagta agtactcage tggagactgg ctctcctgag ttctcaatag 200940 actgtcgttt tcgtttggtt taggcggttc ctcattgcca gagaatgttt tcttccttga 201000 gaaggtttag cgtctctgat cccaactcat gagatgctgg ttacatttcc tcagttgaag 201060 tgatgaccag aaactcccca tgtatttcaa atgetetgag agtcagccac tagttgacag 201120 teattettag aggacagcac tttactitcc catggaatgg gatacataat accttcctcg 201180 ttagagtgtc atgaaggt11 atgagttata tgcagagtgc tgagaacagg gactagtgca 201240 cagtaaatgc tcattaatta tgaactgtta tcattatttc aactccattg gtcctttaat 201300 ttattaggea ctcactttat aataatttag ataattatta ttaactatta tttttgggct 201360 attagctcaa ggccaatcac cccaaaaggg actgatgtgg atactggiag gaatatagaa 201420 aaataacagt taagtctcat ggtgcaagaa ggtctgaaaa aggatattca tttagcaaaa 201480 tgrtagggtg agaaaaactt tgctggataa accctccatc agtctattga gaaagctgtg 201540 tcccttcaaa tetttettea acccttaact gatgttgaca gtttgcaaag atgtagaggg 201600 gcgcaggtag gtccttatat cccaaagttt gctccagatt tagttgtgaa aaccaggttc 201660 aacacaggaa gggctttgca gettccaatc tcatactaac aacactaact gtaaattttt 201720 ttttaggtag aatatccatt tatettettg taatcagcgt ttttaaaaag catgtcagct 201780 tttcctaaga atatatttta ttcaaacaag tatattcatg agaagtatac cttctcatga 201840 actatttttt tgcaatacag ttttttcctt agccacacat ctttttgggt taaatttatg 201900 taaataaaca cattacaaaa acattacagg atacattgcc tagaatttat tgtaattggc 201960 tttgatgtta ataaggatta aaaataatat ggcaagtctg atcaatgaga gtactgtgca 202020 cctgaagcat atatgtgtca gtaccattgi tctggaaatt atgaagagga accaatcaaa 202080 tgtactttaa gtatagetat ctggaatgct tgggaccagg tgtgttttaa aaattcaggt 202140 ttcagattgt agaaaggtaa tatgeageat ataccacata gattgtgata tctccactgg 202200 gatcagatgc agcatccggt gatcaaataa tattaacatt tctgcagtga aacatgagta 202260 ttcacactaa gaataagatg aggaccatta aaggccttac accagtcagg tgcagtttgg 202320 ctgccctggg agtttaggac tgtctgaata ctgccaagtg agttttatca taatcaagtg 202380 aailatgata aaaettgatt tegagettΐt tggat11tgc agttgeagge gttgtaggaa 202440 79 1358456 correction date: 100 in 97 Shu 350 Shu 9 patent specification revised August 3, the present tagcacigtc ctgtigggcg cttggaacgt gacagittgt gggtacatgt gcacaatgtg ctgcacccat laactcgtta tgtattttca tagttccttt atgggagagg ccgccttgtg agtgtaeagg ggcacaggca ggmtcttc cttctgatca caacacagtg actgtagtta agtgttctca gtgttetaga caaatactga cacatcagtg acattgiggg agaggcaatc tgtgagtaag gcagctgtgc ccgcagctca atcagacttc gttctttgaa aggaaaacaa ttaatcaatt attagtgact aggaagaaaa ggacaaagag taatataggc tcagltacat aattagctca atttccactt atgtacaatt tttglcagtt aaacagtata cctagtccat atgcccatga tttatgttti aaaatgcctc tgtcgacgaa gagccaagta tgagtgacca gcccaaggtg gtcggggtac ttaaatacat ttaagaaata actttgggag gccaaggtgg catggtgaaa ccccatctct tgcctgtagt cccagctact ggaggttgca gtgagccgag tgtctcaaaa aaaagaaaaa ctcacagcgg gggcttccag tgagtttgtc Tgaaggcgtg tgtggagacc aagttttatt aggttgtaaa atgtttctta ctggatctgg a aaggaagga ggattittcc cacaagagac tggttitctt tcrttgccag aaaacgcatc cgatgagaat aggaatttgg gcaagataaa aggaatgttg agtgaat tgt attagcccca ccatttgtct aacaaaaatc aggtctcct t gctgtcagit ttgcgcacct attucattt rtttttatta caggtitgit acatatgtat utacartag giatatcrcc atctcttagg atitctcctg cctctaatcc aacagctgtg aggcigtaac tccctgaacc agtacccct t tgatggagta ataacaatgt attgtattga acccctaaat gtaggtccac cttagcagca gagaaaggtg ggtcaaatcc tacctgcctt aggagaatga aatcccccaa iggatgccat caaggaggtc gttcattaat cttactggct accglctacc gaatgactac . aaaggaaaat aagtaaaaaa caccacaaac atgataagta tgcctacata 11tcaaaaca aaaataaata cattaatttg ataccctttc ggcc.ttttct cccatccata ggtatttait gcaagtcaaa ctctgtaaaa tggcctgtga catagccctc agcttggttt tatatatttt cattgggccg ggtgcggtgg gtggatcatg aagtcaagag actaaaaaaa atacaaaaat tgggaggctg aggcaggaga atcgcgccac tgcactccag agaaagaaat acattggttt gctataggta aatttaaaca ggatcaatgg aaagaaaatg gtgcagagga agctctcaga ttgcacttag aagggtgcct aggaaaacaa agcggggaaa tttgcagggc aatttcaagg tatcagattg gaaagtaa ct ttatggtrtg tagggcatga aaaaaatcag atcttagtcc tttgcttctc tgaggctcat ctgccaigcc tttgtrggaa cttgaagcca tcatactgcc eagertacag tgtcaacata ttatiatact rtaagttcTa acaigtgcca tgttggtgtg taatgetate cctgacagit gcctggatcc aaaacactgc cttagctaac agctcatgac aggtgatatg cagcagttea agttcaagag arctatagta aaaiaaaaga gtagatttta gtgttggatg ggeagtaage tattcatttt tccaaaaaig tgaacgtaac tgggggtttt tgatcaaagt tgtttgtgtc tgcatgacct aaggatcatt gccagggtta ggatgcaaag gtgcaagcag teatgeatgg caaacgttta atgattttga tgtcaggtca tgcatgtcat tcatgttgta catgataaat ttittaaaga actccttrga tctc.ctacaa ggctcaatgt taacctggtt ccaggaaaaa tattttaaga gatttattet aggaggtcct gagaacatat agggaggeat gagacatcaa ctcacgcctg taatcccaac. attgagacca tcctggccaa tagctgggca tggtgatgca atcacttgaa cccaggaggc cctgcgacag atcaagactc ggttcagaaa ggtgggacag ttttctggtt gacaattggt ttcaggttaa gataaaggat tagetgaett cagagagagc ggetettage tgattatctc ggggattctc tacagaatgi tatggcaagg aaatatattt cttgatatac agggttaaat actccccaga cccct tagat tcacctctgc crtaattaic tcaa Aagggg aaggtaataa ctatggaaaa aacaaaacaa atctgctggg aaatggtaat 202500 202560 202620 202680 202740 202800 202860 202920 202980 203040 203100 203160 203220 203280 203340 203400 203460 203520 203580 203640 203700 203760 203820 203880 203940 204000 204060 204120 204180 204240 204300 204360 204420 204480 204540 204600 204660 204720 204780 204840 204900 204960 205020

80 1358456 % Revision date: August 3, 100, pp. 97135019

aacaagtata tacaacctgc ttgtgaggac at tat tang cctgtgtata agcctgtatc gaat tgtatg catgctaagt tgat tcacct tgtcatcctt ttttggtgcc agtcaaatac taactaaatt ttgataaata ttggattitt agtaatgtt t aaatatattc atgattgatg ttttatatat ΐ tatcttcat gtcaaaaatc tctgcttaaa ttcitgggtt atggctaaac catacctgta tttgagacca attagctggg ggattgcttg tccagcctag atcatacaat ttcgtccatg ctccatggta ttgtttgttt gtgtgcacgt tatggtaatt accatmtt acacttgtta cat tatcatc t tatctgctc t tgtct 1111 ataaaagtga tcttgatggt actatgt tgc aacatttata agacttctgc caaatgggai tcctggaaac aacggtcaai taaaitaggg cct tcctagg t tcacataat cagtctctat tattcatgag ctcaagaccT cttaattagt acttaatcaa gcctctaact tttttcagta ctgtaaaact atattatgtt ttaagtggtg ttgcttaatt attatagata tagtaagtgg cactcacaga ctgaaactta tattacagat atcccagcac gcctgggcca cacggtggtg agtctgggag gtgaaagagc gtgtggtctt ctgtaatata tgcagatacc t ΐ t tagctat atgttttaat ctatgt tt ta tatccccacc t tatgtgcct ΐ Tgact tgta 111 tatatct at t tctgagt 11 ratgat t ΐ gtcct t tgar ccaggctgga gctactacaa attgaagccc gg taaatatg tgccatcagg acataaatta agagcttttt ttatggaata acagaaacat aaact tgaca agaagttttt cattat tica tttat tagaa tttaaaggtg ttacatctgc ttatgctggg aaaat taata ttgatccact atggtaattt ggttgctgct gggaaactga agt tgctaca atatttatag aagtgacaag tttatagtta ttcggaaggc catggcaaaa cgtgcctata gaggtcaagg gtgaccctat ttgtgactgg tcagcact tc acatttcatg tatcaataaa tcccggggga ccttctgagg agcagtgtat tttcaatcat 11 tcct tgat tctgtggaaa tgaaagtgtt gcaaatat tt gtacaaagga gtgcagtggc 11 taaatagc tggtgataat aaactgtgta rttcgagatg taaaaagtai ctcagaataa aaatacagga atacacaaaa atagtccttg cagagtatta aaiaggttgt tgaaaataag tcctgtargc atagagtcaa tatataattt tat tctgt tg ctattaaagg gctatatgtc tataacaact ggcatgactg cagagacagt gatgacatta tataattatt gagattacaa tgaggcagga ccccatctct gtcccagcta ctgcagtgag caataaataa cttctttcac attttcattt taaccat tea gctgctatga gttaatacta aactgctagt gagtgttccg agccatcctg ggctatgatg aatgtgtatt ett tactgat tctcccattc gttttttm tattcatagg acctcctgga gccatgccic Taagtcataa ccaagaaggt gggaaaggca attagagtga atatttiaaa aatacagtaa atagtgaata tcggataaat aattgacat t tagattctgt ttgtgctgaa actaagcagg cacatgtagt catcctcatg caattttagt ccataagagt gtatggggta tgttatgtca cgaacaagtg atgaaaacaa tcctagtaca actagctggg ggatagcttg accaaaaata ctagggtcgc ccatgaccat ataaaataaa ttagcataac ctttctgttg tcagttgatg acatttgtgt gaggtggaaa tttgaaaaca atttctccac gtggatgtga ttgageatet cagattattt ttggatacaa tgtgggttgt ttttaaaaga cacaatcata gttgt t tgea ctctgtagaa catutataa ccccactatc agtggtggta atattttact ettagetaat gaaaacattt gttcaatgag tattttggtt ttccagtggc ctggaaatac atttctgtct ggaaaactct atgagaaaac gatgtggaag tttttctata tcaaagcaat gagagtatta ttagttcaag aaatatiatc gattggttag aagctgacaa cgcagtggct aggccagggg cccagaaaaa tgaggtggga gccactgcac aataaatgga attttaaagg tcaaataata gacactttag acaagttttc tgctgggtca aatcgagtgi at tctcacta agtggtattt tt tcatgtgc tttgactggg atccctcatc cttttcactt gatgggtctc gcacactgca 205080 205140 205200 205260 205320 205380 205440 205500 205560 205620 205680 205740 205800 205860 205920 205980 2060 40206100206160 206 220 206 280 206 340 206 400 206 460 206 520 206 580 206 640 206 700 206 760 206 820 206 880 206 940 207 000 207 060 207 120 207 180 207 240 207 300 207 360 207 420 207 480 207 540 207,600,811,358,456 Patent Specification No. 97135019 correcting this correction Date: August 3, said 1〇〇 gcctcaaacc gctgggacta rcragtgrar atctaaggtc lacatt tagg aacattacta ttctattctr cctggacict caggcgcatg ttttttcttt atgaacat tc tctttgatcc it ϊ tacacgt tctr tccccr cctggcctca ccactatgcc tgrtgtrtgt atggctaggt attttgacit gggcarccag ar tgaattar agcaatcctc cagctaaaaa gcttftggtg tttccictaa aat 111 tgaa t tgtcccagc ctttgtaccc ccacctiagc aactttttaa teatacaaaa gagt 11 tata tatgatatga accatttgtt t tgtccaaaa citctgagta tet tgatgtg ctgttgtcta gt t tatetet ggaagagatc gaaaagacta tcaactggtc atagatgtat tgtttttatg aggaaagtu tcct ttgeer tgaaattctg aacattcagt catttcutc ttegtetaga actrtgagta catgagatag catecttgta t tcgagacca ccgagtgtgg gcttgaaccc gggcaacaga tttttgccca agetagaatg ttttttrctt catgatcttg ctcctgagta tttaittttt cctcaggcaa gcgcctggcc tcacaagttg ttttattatt tgtatacatg atctcctaat ttccccttcc ctgtgtttgg ccatgttcct gtatatgtgc agtctttgct gcatgattta t tetagt tet acagtcctac gtttcctgac atatgggctt atttetagae tttcaattct attccattaa titatatgtc ccaatactat agtatcttga ttatagtttt ttigtagcaa tttttgaaat getagtien tttcaagaag tticttcagg actgtittgg etattetagg ttccatataa attttatgac catcttgtca atttctgcaa agaatccagc ttggagtttg cattgaatat gtaaataaat ttgggtagta ttgccatctt ttrttgaccc agaaacaggg gctgtttatc cctttattta ggtcttcttt aacaatgcit tataattttc agagtacaga tggtccttga cttgtgaatg ctittttatt taacaatggt gttaaagcaa taccatttag tggaaaccai cctatacaac tgttctgttt ttcattttca gtacagtagt caataaatta taaacatttt attataaaat aggetttgag tggggctggg cgtggtggct aicctagcac tttgggaggc tgagatgcgt ggatcatctg aggtcgggag gcctgaccaa caaggtgaaa ccccgtctct actaaaaata caaaaattag tggtgtgcgc ctgtaatccc agetaettgg gaggetgagg caggagaatt aggagccaga ggttgcagtg atetgagatt gtgccactgc actccagcct gtgagaccct gtctcaaaaa aaaaaaaaaa aaaggctttg agttaeaiga actgtaggct aacgtaagtg ttctggac ac ttttaaggta ggctagacta tttggtaggt tatgtgtait aaatgcattt tggacatgat attttctttt ttttgtttga gatggagtet cactctgttg ctcaggctgg agtacagtgg gctccctgca acctccacct cctgggttea agegattett gtgcctcagc gctgggaata caggcacgtg ccaccacgcc cagctaattt ttttttattt agtagagacg gagtttcacc atgtcggcct ggctggtctc aaaciccrga tccacccgcc tcagcctccc aaagtgctgg aattacaggc atgagccaat ataettagga tattttcaat ttacaatggt titattgaga tgtaacccca aggageatet gtatacattt tgeaettett ttttttttct tittttaaaa ataetttaag ttttagggta catatgcaca acgtgcaggt ttgttacata tgccatgttg gtgtgctgca cccattaact tgtcatrtag cattaggtat gctatccctc cccacictcc ccaccccaca acagtccccg gtgtgtgatg tgtgtccatg tgttctcatt gttcaattcc cacctatgag tgagaacatg tttttttgtc ettgeggtag rttgctgaga atgatggttt ccagrttcat acaaaggaca tgaactcatc attttttatg gctgcatagt attccatggt cacattttct taatccagtc tatcattgtt ggacatttgg gttggttcca gtrgtgaata gtgccacaat aaacatacgt gtgcatgtgt ctttatagea taatcctttg ggtatatacc cagtaatggg atggcrgggt caaatggtat agatccctga ggaatc〇tca cactgacttc cacaa tggic gaactagttt caacagtgta aaagtgttcc tatttctcca catcctctcc agcacctgtt tttttaatga tcgccatrct aactggtgtg agatggtatc teattgeggt 207660 207720 207780 207840 207900 207960 208020 208080 208140 208200 208260 208320 208380 2.08440 208500 208560 208620 208680 208740 208800 208860 208920 208980 209040 209100 209160 209220 209280 209340 209400 209460 209520 209580 209640 209700 209760 209820 209880 209940 210000 210060 210120 210180

82 1358456 Thai Revision Date: August 3, 100, No. 97] Amendment to the 350-N9 patent specification

tttgatitgc tgcataaatg gttgtttgtt cagatttgtc ctctgatagt caat 11 iggc ctargtcctg catt taagtc gtttcagctt cctttcccca gcattatttc accatgctgt ctccagct 11 atatgaactt ggatggcatt t tcctaccca gcagtggttt ggtatmat tttgtctgtt cctgccgggt gatcacctga ctaaaaatac ggctaaggca gccatcgcac ctgaagtata catttttcac gccaccttgc atttctatta 11 tccaatct gtacaatgat agatgccctt attatcacaa atgtggtttt ttaaatcaac gtattttgtt tcttataata cttttttgaa cgctgcaacc aggattacag tttcaccatg tcccaaagtg gaagggcccc tastgtgcat atuctctga tcttcuttg t ttncttgt agatgagtag agtttctttt ttttgttgcc aatggtattg t ttaatccat tctacttatg ttgcttgttt tgagggctct t ttggttact gttctttigg taaagtagt t gaatctataa tgagcatgga gtagttctcc tctctttgaa attggtgtat gcggtggctc ggicgggagt aaaattaacc ggagaatcgc tccagcctgg ttattttttg tgctagtata tatacttgct atat t tacaa caatacctt t gaataaaaat tatccgggtg atggatat ta tgtcatgtat attgtgtttc gaggattttg tgtttctctg acagtcttgg tctgcttccc. gtgcccacta ttcaggctgg cfgtttctct tctccctcca Gaattttctt cggccagtga agaagtgtct aaatttgtat gitgcaaaaa gctgtgcaga attgcttttg cctaggtttt ct tgaattaa gctagccagt ttctcaggt t gt tctgttcc gtagccttgt cttaggattg ttttccaat t atiaccttgg atgttcttcc ttgaagaggt gcaattgtga aagaatggtt acacctgtaa ttgagaccag aggcgtagtg ttgatcctgg gcaacaagag atagtgctat tagaaataca tattagtcct gagcacgtca tatttgattt ggcaagagca agggagtttt aattttgtca tctat tagta tatgat tgca tgtctatatt ggagggagag tctgt tgccc aggttcaagc ccacatcagg tctcaaactc agttttggta tcttttttag ttcaccacac tgaigagcat gttcatatcc gagttcattg ttttctctca agcgctttag gtgttttaga cttciagggt ttttigtata 11 tcccagca tgtcaaagat attggtctat agtatagttt acttggcgat ctgtgaagaa gcagtatggc atttgtttgt cct tcacatc atgggagttc gcattttgca tcccagcact cctgaccaac gcgcatgcct gagecggagg tgaaactcca aaaagcaat t actgatgttc aatagttgtt tctgcaaata tctcacctaa gccatccttg ct tctatgac aatgcttttt tggtatatta tttggttatg cataagaggt gtcgtttgtt aggctggagt aat tctcctg ctaatttttg ctgacctcaa tcagagtaat tct tcgtcca actctaaagt titticatgt tgcacccact tagatcctgg ttctgtaggt tttaattaga Catgaagtcc ttttatggtt aggtgtaa gg ccattiatta cagatagttg aictcigtit gaagtcaggt gcaggctcit agtcattggt cattttaacg atcctctttt ccttgtaagt actcatgct t ct tcttttgt ttgggaggcc atggagaaac gtaatcccag ttgcagtgag tctgaaaaaa gttttattaa gtatattgat tcttagtgaa aagatcattt gt tccctggc tt t tgctctg tagat tgttg cttcatatat tatttattga ttgctggatt cttggtcttt ttttagtttc gcagtgacgt cctcagcctt tatttttagt gttrrnggc ttttgaiggg atattagatc tgcctgttca gtgatcctcc actggtcica gttgactgac agacacittt tcccatrtgt ttgcccgtgc ttaggtctaa aagggatcca aatagggaat tagatatgca tggtaccagt agcctgatgc ttttggttcc agcttgatgg atat tgatic atttcattga tggattccta tggctctctg taaatttatt taggcaggtg cccatctctg ctacttggga ctgagatcgt aaattttatt ttttattttt tttgtatcct ttcct taaga tacitttttc tagaactcta ggtgtttcat actttttttt tgagatgatc ctcttgaatg cagtttgcta agttttcttt gt tttttttt gatcttggat ccaagtagct agagatgggg cgccttggtc taagagttgg uttgtgtgt aacaactgat 210240 210300 210360 210420 210480 210540 210600 210660 210720 210780 210840 210900 210960 211020 211080 211140 211200 211260 211320 211 380 211 440 211 500 211 560 211 620 211 680 211 740 211 800 211 860 211 920 211 980 212 040 212 100 212 160 212 220 212 280 212 340 212 400 212 460 212 520 212 580 212 640 212 700 212,760,831,358,456 No. 97135019 Patent Specification correcting the present date correction: 100 August 3, said gaattccctc atatagagtt tcutguci atcttgatct itittcatag aattatcttt tgrtggggca cagaratgca ttatcagagt tgincrctt caagcagaga agaacaaart atttaggagr tccgtttgtg cataicgatg ctatgtatac tgttagaaga atcacaigat catttaagig icaaactgag agtcaaaaga cttggctggg cagggiggct ctcaccigia atcccagcac ttgggaaagc caagttggca ggangcatg aggccaggaa ctcaagatca gtctgggctg catagagaga ccccatcrct anlaiaaaa aggttttgag gctgggcacg gtggctcaca cctgtaaicc caacactttg ggaggccgag gcgggcagat cacatgaggt caggagttea agaccagcci ggccaacatg gtgaaacccc atctcracta aaaatacaaa aartagccag gigtgttggc acgtgcctgt aatcccagct actcgggagg ctgaggcagg agaattgett gaactgggag gcagaggttg cagigatcca Agatcacgcc actgcactcc agtctgggcg acagagtgag actccgtctc aaaataagta aataaaiaaa aaataaaagg taaacactca gtgaaataaa aaaaaatt ct aigggatata ggaacaacaa igacaaiagt aaacatatgt cactagacta aacagttcac aaatactgaa gtcaggtttt ctggcaaaac aaccagctct gctgtgaaaa aataaaatct ccagttccag acagaaactg aagattgrag · gaagagaaat aagacaacta ttctcagtca ctacagaaga tcataataaa ctcctcaact ctctgttgga taaattcttt acaaatggaa attaaaatag taacacttaa aatgtatagt aattttaagc tttaaagtgc tttgcatgtt attcattcag agcactaaat ctaaaacaat ttaggccagg tacagtggct cacgcctgta atcccagcac tttgggaggc caaggtggec agatcaccrg aggtcagggg 11tgagatga gcctggtcaa catggtgaaa ccccgtctct gtgaaaaata caaaaattag tgtatactia ccgggcgtgg tggcacgtcc ctgtaagccc aactactcgg gaggetgagg caggagaatc gcttgaaccc eggaggeaga ggttgcagtg atccaagatc acaccactgc aciccagcct gggcgacaga gtgagactct gtctcaaaat aaataaaaaa taaaaggtaa acactcagtg aagtaaaaaa taatΐtetat gggatatagg aacaacaata atcatagtaa acatatgt tg tatacttaca ctaaacagt t tacaaatact gaagtcaggt 11tctggcag aacaaccagc tettctgtga aaaaataaaa tctccagttc cagacagaaa atgaagattg taggaagaga aataagacaa ctattctcag tcactacaga agat tataat tagtaacact cagagcacta ca cttttgga caacatggtg cgcctgtaat ggaggttgca tccgtctcaa ttgaaatcca ttggagtttt tctgggagaa t tacatatgt cagaaacgta accagtgatc ccat tagatc gttcgcactc ggtaatgnt aaacccctca tcaaatgtat aatctaaaac ggccaaggcg aaacictgtc cccagctact gtgageegag aaaaataaaa aataccattt acaaaat tac atatatatag gtgtaatata traaatarag tgtttcatgg tcataaggag ctatggcaat gctcgcctgc ac tctctc 11 agtaatttta aatttaggcc ggtggatcac tctgctaaaa tgggagactg atcacaccat taaataaata aaggtactct ctgtatttta atagatagat tatgtaaiΐ t aaagragtac aagacaat 11 ct tgcaacct cigatgcigc cacicacctc ggataaattc aget ΐ taaag aggcccggtg ctgaggtcaa atacaaaaat aggeaggaga tgcactccag aataaaiaaa aagccnaat gtaatttttt atgatatat t ggatacaat t tgtaragcag t tccacagat agaicccrcg cactcaictg ctgctgtgtg 11 tacaaaig tget t tgcat gctcacgccr gagt tagccaggcg atcacugaa cctgggcgac acagt ttaag agctgagtga tgtcaggcca tatatgtgta tcctaucaa cagiccccaa agggtgcggg cafgcgcagt acaggaggca gcctggucc tegaga Gaaat taaaa ntattcatt gtaatcccag ccagccigac cagtggcaga cctagaaggc agagigagac cat ctgctct aaatacagtg aacttaatla taatatatai ttgaittcag cnttrrtgg tggtcrgggg tcacaaiagg gagctcaggc taataggcca 212820 2i2880 212940 213000 213060 213120 213180 213240 213300 213360 213420 213480 213540 213600 213660 213720 213780 213840 213900 213960 214020 214080 214140 214200 214260 214320 214380 214440 214500 214560 214620 214680 214740 214800 214860 214920 214980 215040 215100 215160 215220 215280 215340

84 Revision date: August 3, 100

1,358,456 No. 97135019 Patent J specification Revised caaaciggia ctggicagag gcctgggagt tggggactcc tgngtgtag ggaggaaaca cacatgcaag agacagtgtt ctatttgaig ttitciggag atgctarcgt gaagacactg tagacttacc tttttaggct tagaaaatgt ttaiattaaa tctcaactgi cagagiccag attgaaggci gttctaaagg catgacctta ttcatcataa cacttttgct gctaaaacaa gcttcagaca cattcagtac attttgttn gatccaatat ttatttgatc cagaggcctt tccttttgaa gggcgttttg gaaacagcct tatctgtaat catgtgtact aattgaataa cgtttacact ttccagtgca aatttgctta atittcaaag gaaaaaagga aaacaaaaac acttctgaca taatcagttt icactgagat tgtatagaat agagat11tc catctccttt atgaaaaatt caaatgacat ggctatteat gaaataccat attacataat taccaggttt ttcactgaaa act at tgccc aaatagtctg ggtaagcaaa ttcatcatca cctctggaga tacagtctgt tataactaat gaaatccagc taagatttgi aitcaaatat itcctgactc taaaatgaaa gagttgcttt tataaaattt tcaaaattgt gagaacagat gtgtttgcca tgtaaaaaca ttttggttgr gggaggtgga ccacagctaa ccaattgttc acaatagcta acattgtaga accttcagta ttaaattcac taactcactt catcatcaaa attccctatg aggcgttact gtgctccitg catagg ttac caaactgaag ctttctcaga gtcacatagc taagtaaatg ttggtcccga gatttgactc cagtgttctc tgatgccaca ggcccagitc tttacctgca gtactatcat ttgggaataa tttggtttct gcagccataa tataiaattt gtgggttgct ttcctttcat aggtatggac aaacactatg tcataaaatc agagctacaa cttaaaagcc tctaaaiaac accttgagat aacaaaactg tatettaggt tetaatatat gtgatcatac tatacaggca gtccttggtt tgcatagtag tctgggacag taaaaaatgg tcatgcaaac tgaaaccatg caaaacaaac ttaataatta atggggaaat ttacaattgt tttgtgatct ttaaatattt ttgtgaaaca tcttactgtt ttaaaaagtc atatatagaa atgaaaatat agtaaaacta ggttataaat ettagtaett cataatttaa aacattagga atattgagag ttaacctttt atttctttgt aaacagctta tcaagagtat tttgatcttg ccttcccata aagcttaggg ccgggcgcgg tggctcacgc ctgtaatccc agcactttgg gaggeegagg tgggcagatc acgaggtcag gagttegaga ccagccgcca ggctgaaacc ccatttctac taaaaacccc atggtgaaac cccatttcta ctaaaaatac aaaaattagc caggtgtggt ggcgtgtgcc tgtagtccca geigettagg aggetgagge agaagaateg cttgaacccg ggaggeggag gttgcagtga gegtaaatea caccactgca cttcagcctg gtgacagagc tagactccat ctcaaaaaaa aaaca aaaaa aaaaacttag gacactgagc. aagaatcttt tetatgettt ggcaaattgt catcctcatt tctaagtttg gatcaccttc caacatttta tcctctgcac tttaaacatc tggaaatatc tttgtgagta cctttaatgt gccagcatca cttcctcttc gacattttca tcctttttgc aactactgta ctgtactiit ctttttcttt ttettttgag atgaagatgg agtctcactc tgtcgcccag gctggagtgc agtggcacaa tctcggctcg ttgcaacctc catcccccgg gttcaggcaa ttctcctgcc tcagcctccc cagtagctgg gattacaggt gcgtgccacc ttgcccggct aattttttaa aatattttta gtagagaegg ggtttcacca tcttggccag gctggtcttg aactcctgac ctcgtgatcc acccacctcg gcctcccaaa gtgctgggat tacaggcatg agccaccaca cccggccata ctgtactttt tcatttaata gattgaaaaa tttgc.ctcca ctaaatttet ttgggtgaac atctaaagtc cctcaaacag cattagtgtc aacatttcca tattcagtta ntettetai aactccattt aggtagtttt ggggaitttt itagaggeag ggtttcacta tgttgcctca gctcctgggc ccaagcaatg ctictgcctc agcccctgga gtagctagga ctacaggcac accccactgc acctggctcc atttatgttt nttmttc agatttcait 215400 215460 215520 215580 215640 215700 215760 215820 215880 215940 216000 216060 216120 216180 216240 216300 2163 60 216420 216480 216540 216600 216660 216720 216780 216840 216900 216960 217020 217080 217140 217200 217260 217320 217380 217440 217500 217560 217620 217680 217740 217800 217860 217920 85 1358456 Patent specification 971350丨9 Amendment date: August 1980 3曰tccaacatig tcactctttg itgctgtcct ttctitcttg taancatu ugtaaaaca 217980 icac.atggat ttaicacrag gagacaagac aaggcaacra catccitagc tgtciaigag 2.18040 tgaactgaat aacagatacg tagtaaccaa tcactggccg actttgaatg aagiggtgtc 218100 attggccgtt ggtcatgatg ttatgtagtg aitttataga ctgaagtgct ggcagcaaag 218160 artgtgcgtt aigcactgct cacaatcaat ataiitggtc attgaaatn ggaccaiggi 218220 ttgaggagta gctggtgut taactaaagc atagtaact〇aaacttaccc ataicagaac 218280 ctcgccaaga gaggactacc atgaaagrta aatgaggggc attaggitcc ataaaggatc 218340 ataaaaatac Lactctactc tattatacat tracatatac acatgtgtat cctaaagtaa 218400 taagctagtt itaaaatatt aaccatactt aatgattaat antattata tctaartata 218460 ataattttac ttgccaccta gggatitaga agagttcaga gggaiitaat gtatgatcca 218520 ggaag tttga aagi ttgaat igggccaggc gcggiggctc acgcctataa tentgggag 218580 tgtaatet11 gggaggeega ggtgggcgga tcacgaggtc aggagatega gacϊatcctg 218640 gctaacacgg tgaaacccca gctctactaa aaaracaaaa aaaiiagctg ggcgtggtcg 2] 8700 tgggcgcctg tagtcccagc tactggggag gctgaggigg gagaatggcg tgaacctggg 218760 aggeagaget tgcagtgagc egagategeg ccactgcact ccagcctggg agagagigag 218820 actccatctc aaaaaaaaaa aaaaaaaaaa agaaagtttg aatagatact t rcct t taga 218880 tatgaagaca ttcagcatca attcattgct cttaaagcag atctcatgar ggtttantt 218940 ttaaaaagaa gaagaaagaa aagaaaacac aagtgcagaa ggatatgaac accatgatac 219000 ticttataga acaataatgt aaacaatatt atttggttat tgagaaacai ttacartata 219060 aatgtaaaaa ctcataattc ataatattca cccatatgga aggagagaaa atggtttaaa 219120 at111tccac attgcaat11 cttatatacc tatgtttaat gagacagtat tttatatgga 219180 cacctgagtg tttttcatca cacggtaata cttacatatc acattattca aattaattac 219240 taatatttaa aattcctatt ttggactgaa ggaattgaat tgacttataa gttgttcttt 219300 tagccctaaa aitctgtatg tattctttga Cttttatatt agaaaccat c aaagctgggc 219360 gtggtggctc ctgcctataa tcctagtact ttgggaggca gaggcagggg gctgacatgc 219420 gcctaggcat tcaacaccag cctggacaac atagcaagac tctgtctcta cacacacaca 219480 aaattagcca ggtgtggtgg tgcatacctg tagtcccagc tactcaggac actgaggtgg 21.9540 aaggatcact tgagcctgag aggeagagee tgeagtaage cctgattgtg ccactgcacr 219600 ccagtgtggg tgacagagcg agaccctgtc ttaaaaaaag ataaaaacia tcaaatgtag 219660 tgcgtgttta 111tggggac raaatgctta ttmaaggg gatggttaaa gracicagca 219720 ttatttaggg agttaaagcc ttaggtttta aacctgattr ggggttgage tctgggaagg 219780 aaaagatgat tgattcatag gcaccctgat acagtcactt atgatctgaa aagcagatg! 219840 actctaaggc actcaaaata aaaataacac cagtcctatg ettatetett aaagtcargt 219900 tgttttctgc aaggtgttaa aaatcaaaar aagattgttc taataacatΐ gaagtitegt 219960 cagtatatgt gtargataca agcgaaattg atgggtaact aertgeagta taattctitt 220020 agaattatgt acttttagat tgacttacca gaactgctga aataaaaaac actccaattt 220080 aatttgaaat agtgggaaca ttggctctgc tgcagtgatt ttaagtgtat acatgcccga 220140 ctgtgaatgg attaagttca teattggtg c tgeettgagg tgattcagaa acttten11 220200 gccattgcag gtagagcggg aaaaggccar terntggee aacctacagg agtcacagac 220260 acagctggaa cacaccaagg gggcactgac ggageageat gagegggige accggcrcac 220320 agageaegte aalgccatga ggggcctgca aagcagcaag gagctcaagg ctgagctgga 220380 cggggagaag ggccgggact caggggagga ggcccatgac tatgaggtgg acaicaatgg 220440 tttagagatc ettgaatgea aatacagggi ggcagtaact gaggigattg atcigaaagc 220500 86 date of amendment: 100 Years August 3

1,358,456 97] 350] No. 9 patent specification Revised tgaaattaag gccrtaaagg agaaatataa taaatctgta gaaaactaca ctgatgagaa ggccaagiat gagagtaaaa tccagatsta tgatgagcag gtgacaagcc ttgagaagac caccaaggag agtggtgaga agatggccca catggagaag gagttgcaaa agatgaccag catagccaac gaaaatcaca gtacccitaa tacggcccag gatgagttag igacattcag tgaggagtta gcrcagcm accaccatgt gtgtctatgt aaiaatgaaa crcccaacag ggtcaigctg gatiaetata ggcagagcag agtcacccgc agtggcagcc tgaaagggcc cgatgatccc agaggaettt tgtccccacg attagccagg cggggtgtgt catccccggt agaaacaagg acctcatctg aaccagttgc aaaagaaagc acagaggcca gcaaagaacc aagtccaact aagaccccca caatctctcc tgttattact gccccaccgt catctccagt attggataca agtgacatcc gcaaagagcc aatgaatatc tacaacctta atgccataat ccgggaccaa atcaagcatc tgcagaaagc tgtggaccgg tccttgcaac tgtetegtea aagagcagcg getegggage tagcccccat gattgataaa gacaaggaag ccttaatgga agagatcctc aagctaaagt ccctgctgag caccaaacgg gageagateg ccacattgag ggcggtgtlg aaagccaaca agcaggtaat ctcattctac tggtgaaagc atgccagtca aagctttctt aactaattta ttccct aatt ttaitgagia tegagtateg tcaagatgag agttcagatt cttggtaagt ggataaataa aactgtccca gtgccagatc agaatgteat aataaitatt gtttttaaat gatgaaatac ctgtgcccag ttaggtggag gcagaggtga ggaacttaaa gcaggaacac aggagaagat ctagatgcct ttctgcagat gtagaaaggc agctcaggcg gtgctgggct gaagcctggc agtgagtggc igtggaaaca ggagatggag ggtggcagaa taggctggca aggcaggtta caccaaccag ggcgatacag caagaaagac aaacacccag caggcagcta gagcaaacag agggaaatct gggtacatat ggtgaagaag gtctgatggc caataactgg accccagctt tggagcigga ggttcagatt caagactcaa tttetaggag tatagcaaaa ttattattat taitattttt tatttttgtt ttgagacaga gtctcgctct gttgtccagg ctggagtgca ctggcgccat ctctgctcac tgcaacctcc gcctcctggg ttcaagcgat tctcatgcct cagcctccga ageagetgag attacaggca tgigccacca .tgcctggcta actitttgtg gagacagaat ttcaccatat ggtctcgaac tcctgacctc aagtgatccg cccacctcgg cctcccaaag tgctgggatt acaggcatga ac.caccgcgc ccagccaagt atagcaagat taaaaggagt gttttgtcct tcatcccaaa ettagagaaa caagagcgct aaataaatga ataagteagg gatgaaagge aagacaactg tgaggacctg agtgagtaac aga tgtetagget aacaaag ccagacagat tgttaccaac aaattaaata gtttggggcc actttagcaa ggaaataata gagagtgtgt gtgagagagt ataagaatga gctctacctg tgctactgac cacgtatctg aaatttaggt tcatttggga tgttaaccca cctgggtcag aggttaagta atagggaget tttcctagct attgatettg tccttctgga caagtagtaa tgttacaaca tgaacctgtc taattcccag ccctccttaa tgactgaaat tgttttcacc ctgagittta ccttggtggg agtgctgcga aatataggea ggaaaattat tttcaccttt atttagttta tctgaaaaga tattettgaa agacacatat ttgagaaagg tgctgaataa atgttggtgt tgataaagag aagcaacaaa gcaccaaata ccctcctgca aacgcaagca gtgccagtga atagtaggtc aagggagctc ttggtctttg gagaatgagg attaatttca gattcagagt gtcttctcca tttgccatca tctggggaaa accacgccct tattatetea tctacagtgc agctttcaag tccicatctc tagttcccat aaatctattt atataattga catctatacc ataagccata atattgtttg cactattaac atgttttata taaacciaag ggcaaaatat gactttattt tatgitgtea ctttagagaa atagaaaaga ttagagtgaa tgaaaccatc attctcagca aactatcgca aggacaaaaa 220560 220620 220680 220740 220800 220860 220920 220980 221040 221100 221160 221220 221280 221340 221400 221460 221 520 221 580 221 640 221 700 221 760 221 820 221 880 221 940 222 000 222 060 222 120 222 180 222 240 222 300 222 360 222 420 222 480 222 540 222 600 222 660 222 720 222 780 222 840 222 900 222 960 223 020 223,080,871,358,456 correction Date: May 3, Shu 2000 S Patent Specification No. 97135019 Revised tgagaacaat agcaattaia accgaacacc aggaagggga caitaggaga catgtataca anaaaatat gaatttgtga tctgctataa gataaggct t cttctctgac acgcctgtaa ttgagaccag aggcgtggtg ttgaaccccg ggcaacaaga aggtatagar gattacatat aggaat tccg gatgtaaaca ittcactgtg gaaatgtnc gatgggatcc cctgaaggta gccactcatg t tcagat111 racat tagag tgcatttggt tagct tcaag 1111 taaggt aaaataggca gggacatggt agataccgca gaggggaaca caggaaaaat caaaccccca ctgaact taa 11 tact taag aagcaccgtc tccctgcct t icaacgt tac ttcctagagg acaagnctc Acatcacaca t ΐ tacctaai tatgtaacaa atatatataa gagatctgac 11 taaagacc acacaaggac ticncctaa igccagcact cctgaccaac gcgggigcct gggggcggag gcgaaaatct aaggacact t titctgggag caattgcctg gtaccacagg cit tgtggta agattttgga aggtccaaac at tt tataca acargaggtc gaagcan π t tacagtcta cigcacgttc tattaacaga taaggtgaga ttctactata tggagcrgga tgt rctcact acacacactg aacaaatgga tgacacacat aagt taaaaa gattttnca catctagcac ccagaagact acatgctgta agcggaaaag gctcataggt ccggggcctg giaaatgacg acctgracgt aataaataaa tctaatt t la caatgat tea atgctarcct aggitgaata itgggaggcc atggagaaac gtaatcccag gugcggtga gtcttaaaaa ggccaaccaa gcagtaagta ragctgttta aaatcagaac caggttgagt ttrtggacat atgaaattta attttntaa aggtgtagaa ggattttgga tatgggctca aigatgttgg tgacat tcac attcrggggt cagccataag gaccat tatc tataagrggg gttcctgttg tactasget t tracctatgt taaataaata laggcacagt tgtgctagat cagcciccrg atccaagt ta act rcacasa gggaatcgaa ttgiggggtg aguaatggg tgtgcacaig ataaaaaaag ggteggaata gagtggtcat ggggcar ret ttaacaatti aaggccagtg accgtcccta ctactcggga gcctagattg aaaaaaaatc cagagaciaa gggatgcaaa caagacagga agaacaaagc atccctrttc ttgeatatat cttatgtttc tgattccgtg tmgtggct ttaaggatgc gtaaattaaa ggctgttgct tatatttatt acaggggaaa aaagaaaaga crtagcaaac Agetaaaiga gaggetgaag acatacctgg aac aaacctg ggcattctgt gccttcigai getgaagatt caatgagaac gggggagggg tgcagcacac tacccragaa aaaagar rag aaggaauta aaataaccaa rgarcaagcc aggtcrgggc gatcact tga ctaaaaatac ggctgaggca catgattgca aagatgetta ti tgtgaaca aataaatgac ct tatcaagc at tcctagct cgaaatgttt acaraatgag atgtattcct gctgaaacaa catgtcagca tcaacctgia tgaaaacaca gtgatgetta tagacat tgt aaaggaaatc atgagatcat taacacagga igagagcaaa gatgagagga tgaagaaata cacatccigc agtctctatg gaagtcagta caaasaagac gcagaggaag cct tagt ttg acaiggacac agagggatag caacatggca cr taaagtaa agtgaatgaa t tat tgraac iaccarat ta atccagataa gcaatggctc ggicaggagt aaaat taacc ggagaatcac ctccagccig actgaaacag ageat tcart ataatetagt actttagagt gaagttttat tgggggacaa ttatcttggg atatacatag agttttgact cicaaaaggt ccarttgcat tttctagcaa ttgccgtaaa gaaatgt t tg tccctgtm gtcat t taca acagaaaacc tagacacara aggagatgat at tggtacaa agctgtaccc aatettetea aatget tatg taacacatgg Caactaaggt ltat taaagg gcntggagi gacaaaatag aataataiat icagggaatg ctcacaaagg cctaigtggc tggaaataag acnntt ta tttagaaagt caactttgga atgtgtggag aaagiggtga 223140 223200 223260 223320 223380 223440 223500 223560 223620 223680 223740 223800 223860 223920 223980 224040 224100 224160 224220 224280 224340 224400 224460 224520 224580 224640 224700 224760 224820 224880 224940 225000 225060 225120 225180 225240 225300 225360 225420 225480 225540 225600 225660 88 1358456 Revised period: 100 years, August 3, No. 97135019, revised patent specification

aagcagaaat act t tgcaca tcacaaacaa tmattccc cattrcacaa cactaaacaa ctgtaatat t taaagtcica atcaaaacag ctatagatgt gaaatgttaa tagraatggg ccagtttgta atcaaacagg 111 tact tgt tcggacatgc ccctact tt t attgtatgca aacatggatt attctatgt tt ttgat tat t tgtataaagt cat taaatat agcgggcttc aaaaact tcc ttcactttcc ttttcctgat ctagctaatc aagcttagaa gcaatgtttg aaaggct tta taggatggct cct tctgtgc ataaaaatat aaagagagtc atagctaaat aaaagtgcct atcacatcag cccaggctag agcgat tctc cggciaatt t cgat ttcctg igagccaccg cagcaaatcc gtcaatggac taaatgattt cttagataci crtaaacaia ctgccgtttt tctgaagatt ttttaatctg taacaaagta tggcactttg aaaccaaggt gttgttcatt aaaatcargt caatccctaa gtgtgtgcca ccaaatccca atggagattt aattagaaag tatagtttat t tgggcccac cctattgaag t tcattttgg t tat taaact tagggcaatt ctgtgtccaa tttiataaaa atgaaaattg tcaagaacaa atgaactgaa caacaaggta aaattcacag aagtgtgaag tgttttccag tttttaagta tccctccaaa at Tatcacct tacctttagt ctaattactt agggcagtgg ctgcctcacc ittgtacttt acctcatgat cgcccggctg agigagi tat aaacaaatct tgtatttcig gaccatggga cttttctgtt tccccaggtc cctccaagta aat ttaaatc ccctatccca catatgaagg agtcttcctg agtatggggt gttcccagtt gtatacactg gggtagctct gat tcaaaca tgaaggaatt taattagttc catatactca agagcacagg ctgtgct tct ctccctcctt actgtcat tc taaccacatt agcgcatacc gaacataata taagcagtgt atatgaaaat ggctitgaaa acagtatttt ccctgccttt aaaatctgtg agccccctac agctaatat t taaaaagct t ctgaaataga actgtgcgag ataatttttt tgcgatctca ctcccgagta tagcagagac ctgcccgcct tattttgtgt ggatact taa acaaacaaaa rttcagatct rtciatgtgc tiaaatgaat aatttctgcc rttacagaac caatcaaaac acattgattt tttgaagctg ggaaatcccg arttgtatac tggcttcaac attttatgca tgatttgaaa aatgttttaa atatttcact tttatcactt tattataaat tgacaaaatt ttactaaata gicctaaaat tct tagctcc atgaat tcac tatgtttata ggcacagcat gattttctgc gaaaaagcaa gaagatgctg cttcctatga gtgcatgttg gaagtccact tgaacactct aataggttgt tcaataagga gttctgtgaa aagatactgt ttttttttga cggcctccca gctcactgca gctgggaata ggggtttcac ttacaaattt atgtgtctaa ttgtggataa ttaaacatga aanacitaa ctgaggcttt agctcttctg aiacagaagt t cacaagaaa aattaagaaa cccatttcaa ttagtaatgg actttgaaaa atgcaaacig ttgattcagt cactattaat ctcattcaac atatttcatt cttttcctta tacaatggig tgagttctaa attggtaaaa cgcatacttt tgatactgac aacacatttt taaaatgtaa gaagcaatct tttagacagc tggtgactga caaccttctc ctgggtgtgg agtgtattcg ctgacgtatc ggatccagaa t tctagaat t aaaaaacccc ggaagtacar cataatgaag gacggagtct acctccgcct caggcacctg cctgttagcc aagtgctggg agtgattgtt ttctggaaaa ggggtatttg rtatccccca gt iacatcta gctttrtaaa ttttctgaat attttatgag ctaci tcgga gaattiattt gcaacaaaaa atttctctgc gt tatagt 11 tgtgctatgc cagtgtgt 11 tccaagaact at 11 tataac gtttggacaa aatgtatgat tatgtctttt catattccaa aaattttttt cagcaatctg tctggctcgc gacattaaag ccaaatcaat gtatgatgga tgaggtggcg aaccatgacg atccctgaga taggtggggt gtgagtagtc taaaagcaag at tctattac tatgcacccc acttcctaga gaaagtatat at taataatc tactctgttg cccgggttct ccaccacgcc aggatggtct at tacaggcg aagaatgtat 225720 225780 225840 225900 225960 226020 226080 226140 226200 226260 226320 226380 226440 226500 226560 226620 226680 2 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 。 t igcactacc cccaggctgg ctgagatacg gatgcaaact aataat t tac tgagct t tat cagagcgaga caaattgtct agcgggtaaa gccaccrcta cactaagctt agccrgclgt ttgttttttg tttctaat tc taaaacgtat taraggcata aaaaagagct t tcgtctgt t ttaagactgt ggagactgag gtgagaccct cccagcact t ctggccaaca gtggcacact tgggaggcag agcgagactc mt taaaaa attgtgggit t tcggtcaaa tctgaccact tgcagagaca tggctatcca agcagtcccg gtggggaggc cacagacacc atct tcatag gttgtggagg ttgctaatgt Tctaaccccc gt11 tcagaa cagigtcaaa cccaggctga agcaatcctc acacccgcta tctcaaacic ggtatgagcc tggcgcaaaa at t tggctga aggagtcccc ctccgtctca at t ttcacag taaactcaga cct tccaaat atctttcnc atctgtatga acaactcatt aggcaaatca aaatatagat gcctataata actgtaagac acacagcagc ctccat atgg gcaagaagat gtctct t taa tgagaggcca tggtgaaacc cctgtaat tc aggttacagt agtctcaaaa tgtcccatat atctacat tc tttattactt tctctgtttt atcagrcacc caacattcgg tacggtgcag atggaggagg gggtctttcc tgcccaatcc tcugagat gnagcagct gcaaaaactc acgcagcaaa t aaagacctac agtgcagigg ccacgtcacc atttttgtgg ctgggctcaa accatgcccg t icacgaata tacatgtaaa cagaaactga aaaataataa actttttttt aaaaaaacaa gtatatgtgc t tcggcacaa aacct tgtga gctctgtcat gtcaaartga aaggaaatgt aacttgttac acttcaggta cccacgaraa gctgggtgca cact tgaggc aaaataataa aggtgggagg ccgtctctac cagcaactcg gagccaagat aacaaataaa atctcattgt taitgctaga t tcagcttaa ggttccagat gcagaggatg gccctgaccc ggcaaact tg gtgcccacca gtcagcagtg tggccagat t ggaagcaaaa agatcaaaac ctcctct tga t tcaatatac t ctggttgaga caagaccaac tttctttaia iltttttttt cgctaictcg tcagcctccc tttttgrgga gagatccgcc accaaaicct at tacratgg agtgttaaaa gatcacacca taatttttta ggcatgaaca aacaaaat tc caggttttgc gtatgaaacc aatctiggt At tcctccaa tagtggacat ctctgtccct gtggctgata caggagttcg tgactgggcg atcact tgag taaaaaaaat gcaggctgag cacgccactg caaaacaaca atggatgaac cctttaaacc ctcccaaat t gtgatgaata agaagaagac agaggctgga gaaagagcaa tagacact ta gcactcagag t tagt taact gaaaaaatgg ct 111 tgata t taatcgtaa tgt tgaaata ttttitttga gt tcactgca gagtacctag ggcagggtct caccicggcc accaat tgtg cmacr tgc acaaacaaaa ctgtactcca taaaaaggaa gtat t tgt ta agaatgagci ct t tggtaag tgaataaaga tttgcagggt aatcat tgaa agctgcaatc aacattatta agaatacaat tgtgtgagac ggggtttaag cctgtaatcg agaccagtct tggtggctca gtctggagtt acaaaaat ta gcatgagaat cactccagcc acaacaaaat atatattcca agtcttctaa cagtttcacc tgtcacccag tctgaacact ggacttagag gatcggcagc cctcctgcat gaaaaggtat gcaaaaaiaa gagctggcat atigigtua tataat π tc cattrtngc gatagggtci gcctggacat gactgcaggc cgccatgt tg tccaaaagrc taicttgtai agatt tagta aaagatctct gcctgggtga ttgttatccc rtcatatttt ttttctccac gaaaaaagat tgt ttcggac tttctgtttt aatactcagt Tatactaaac tt t tggatac gtcatacagt ttgactgt ta acattgccta cagcact t tg gggcaacaca tgccagtaat caagaccagc gcttggcatg cgcttgaacc tgggcga tac aataataaat gt 11 tctgct at t tctaaat aagattttcc ttggatgaga ttgttacgaa tttgaccatg cctaaagtaa agtcagggcc gcatgcagcg atgrgctct t ataaatggtc tgtagtcct ΐ aagigtctgt 228300 228360 228420 228480 228540 228600 228660 228720 228780 228840 228900 228960 229020 229080 229140 229200 229260 229320 229380 229440 229500 229560 229620 229680 229740 229800 229860 229920 229980 230040 230100 230160 230220 230280 230340 230400 230460 230520 230580 230640 230700 230760 230820

90 Revision date: August 3, 100

1358456 Λ Patent Specification No. 97135019 Revised taataitttt gctactcttt gtatgtgtaa ataigcctci cccnacctc caacctgaga attggtagat aaaggtggat attaagaatg aagctgtgit ciacctgggt taiaattrta aaagicattg tacctΐtgga aatggtgctg tttatcagct tctctttaac ggggcaagga tatgaaiatg ttctcttagg gaaacttttg tccatatgac caaaactgat gaca〇actga aaggggatgt ctatatctag ataaaatggg atggaatacg cacagtcctt ttcttgaaag caggttttig tgctmtca tttggcatgg gaatattgcc cagagaaacc acttgtaagg tttttagggg cttgattttg t 〇agtcctgg ctgttgagtt acttaccctg iattttcggt raatggtaac atttttattt taggagcttt cattaaagac tcaaataara tattttctat ttgcggttca agctgactaa ctgtaataaa tcttttttcc agtatccaga acagtttcca aatagggttg tatcctgatg tggaaactaa aaaaaaaaaa agcaaaaaga ttgatttaca taitiaaaaa attaaatgcc agtataaata atgttgtcac tggtgaggcg ttaaaaggta attaaagtaa aacttttttg tttcctatat gtaittttct tggatctcct gcaagacaat cctttgtgat cagagccgtc ccaggacttc aggggcttcc tacctacaga atttattaag agttccccct gatcccacct ccacagaatc atttcttctg aagggccccc cttccatgag tgaattcatc ca tttcaccttc agggcacc ggctcagcaa ggaaaaaagg ttaaccgtgg ctccaccagg taaacatttt itccttgggt gcatgtgatg caaatgatta gttgaataga ctctcccctt ccttccggtc actcaggctc acccagctgc agagtatacc tttgatgatg tgtaaattcc tataagtcaa gtaaaaactt ccttacactt agcttcccat ttcctccttc actcatattc cttagaatga cagacttcca tttaacagcc aaagatggca aatgagagtt ggaaggaatg ggataggtaa agggaaatta gcaacaagca caacgcacac acacttggat cctatttgca gtttggtagc tcatggcgat tccatcttgg tcagatttgg ccagttctct cttatcgttt ttaatgtaat ttccgtaaag ggagagccat atgtataaca aggcttttgg gctgatttcc ttttgtggtg actcagaacg tctcctcaat cattatattg agaataaaag taaaaccttc taagattttg ctcctcaaga acatttaggt cttagtataa tgttcttgta gat tgcaggc cccccactgg ttaatgct ta ccaacatgtt cacact tagc ttcactattt tgcatttttc tttcttcctt ccttcctttc attcttttia cttgttctat gaagaggcct aacttgaaaa tgtgacatat ggcaaataga gaaaattatt cttgcaaata aaaatcatcc tntaaggaa tccctgcatg tgagtatagg gcagaagtgg caaacaagga gcccataaac caaagtaagc ttaaaggcag ctgitatttg actattgcca gaaaataaaa aataaaacta 11taagttag ttattgacag ttaaaaattc aagagatttt atatgaacat cagtatrtct ggcctctttt ggaagattct gaatatctgg cagccctagg tctgcgttca cgcatgtcaa cacctgttgg agctctgtag tggctgctgc tgttagggca agcttcgcac tttgccacag tcaccactcc tccttattac ttatacccag cctgctatcc tctctcctgg cccctcctgt agtctttgag tttgccaccg ttgaaataga attttttttt tcattttacc ttaattcctt tcagcctttg gatctctaat actttcctta tctgattcat gaagtcagcc tactgattgg gattaaaaga tgtggtgtag aaactgatag tgcatttcac gttctaaagg tgtttgagga aattggragt gataatgagt tggaatggtg taatagccaa aatatacacc taagaagaaa aaaagtaaaa actgcttggt gt111taatt tcatttctat tttgcaaacc tcataactga tttcctattg ttttagacct ccttggaagg taccttgaag tattctgtga atcaccaaag tggtaatgat ttatcaggat acctaactcg gataaaaccc acaagtctic tttttagtgt tccaaatgga tttagtagca ctatctactg gaacttagaa aagaaattgg tatgattaat aaataacicc tatigctgtt taattaaaaa gataacatct caataaggtt aaaaattaat aatcaatgtt aacaacaata actgttttca tttttgtatg actggttttt gtttacatga 230880 230940 231000 231060 231120 231180 231240 231300 231360 231420 231480 231540 231600 231660 231720 231 780 231840 231900 231960 232020 232080 232140 232200 232260 232320 232380 232440 232500 232560 232620 232680 232740 232800 232860 232920 232980 233040 233100 233160 233220 233280 233340 233400 91 1358456 Revision date:] August 3rd, pp. 97130019 Patent Specification Amendment of atatatcncn t rtccatgtt titcagatgc cattatttgt tanacattt tgctccattc actttccctt tacaactcta ttagttttga cgaggccggc gaatcacttg acaaaaatta gtgggatccc tccagcctgg aggaatgtgg tattgataac gaagtaaagc attaacgctt ttaaatgaat aaatatctgc acatatcaaa agagaaaata tgggaaatag getagetagt gaatgttttt tgtgtgtata tatatatata ttgagacgga tgcaagctct actacaggcg tcacagtatt aaagtgctgg tctttttaga ggaccat tga tcagttgaag tgnat t tat cagaaagcct gaggcactga gatcggtttg ggctcagctt ttaactnct catgctcatc cr tgatgacc tatattgtta gctatctagt igt tatcaca tatatiatag Ttctcaagag tgatgttgct 11 tcccacat aagtcagtta ataaccagaa tgcagtggtt ggctcaggag gccaggtgtg ttgagacagg gigacagagt aattcagaat ctttataatt tgttattata agtaaat tat tactacagaa at tat tacca cattttitat tgacatataa tagatt ttat aacaatatct gataageat t tatatgtata tatatatata gttttcctct gcctcccagg cccgtcacca agccaggatg gattacaggc igatttttaa aacaattacc aattgagaga tctgtacaag catctcct ta ttttcaacat ctgcat tagt ctgcaacctc igttcttgac t tagt 11 tea rtgactcaaa tcattacatt cttgttttta ttaatcacta agcactgctg tgagatcact gtcaagaagg tgggaaict t gcatacatga aataccat tg cacacctgta ttttagacca gtagtgggca gaggcggaag gagacactgt aatcaccaga ctcaccat 11 gccttaggaa tatcaaatca agtgacggac atatatgt ta gatgctttta taccagtctt gagtat 1111 attaatcart gt 11 tacata tatatatgtg tatgtatagt gtcacccagg t teatgteat cacctggcta gtctcaatct gtgagccact ttatictaat tcaactaaaa ggtatgtgtc agttactttc aatgcacaat tagtagaata acaacctttt agccct taca tttatcctta cagntcagt agggaccctg §tt raagcca ittgttaaag cttctcttct ggaataccct cagt taaaag giatatcaat tctgctact t atgagagtac acct tagaaa atcccagcac gcct tggcaa cctgtagicc titcagcgaa ctcaaaaaaa ccagaaggtc Atgtaaagit tttttaatta atcttagcaa catccacacc ttttccctca ctatataaaa atgt tctata aaat tcagga t taaaaggaa tatatgtata tgt atatata tttgggggtt ctggagtgga tctcctgcct atttrttgta cctgatcatg gtgcccagcc aageagatat atgaaatcag gtrtaaaaat aaatagattt ttctccattc t tgtatagta aagggaaaat attgcagtgc tcctggcaca taccagcrga t tgtcatcaa tgaacattat ttattgtatc tgiccactga catgcat tea ttgaacatcc gtactaaaag tatccacact catatattgt tgattactat tttgggaggc catggtgaaa cagctacrca ccgagatcgc aaaaaaaaat atgetaatga aaaataataa tgtatcgtgg cattttctaa aaataaattg gcigaactat tet ntcaat taagaaatat gt t taaccat aattetetat tatatatgtg tatgtgtgtg tgtttttttt gcggcgcaac cagcctcccg tttttagtag atccgccatc taaaatatat ggectttatt tttaatttgt ttaagacaca tat t tetatg tggagaatca airgattaat tctggcgttt ttctggccat caaat tccag tctgagaagt ggagt r tgta atcacaagct atagattttg ggtagttttr gcttcicatc ttatgtmt cccataaaac gtgcacatct cttaaactct ttatgagatt caaggcaggt acccgtctct ggaggctaaa accactacac tagagatata cagcttaaca aagaggaaag aatcaaccag aaggtcctag tagcttctac atagggtaag aagccaagaa caraagccca tataaaattt taaigtatca tgtatatata tgtgtatata tctttttttr ct Tggctcac agtagctggg agat gg〇gtt tcggcctccc 111 tagtaca tttctattga ttttaatcct gaacataaaa agatggtaaa actatagggi gcat tatact ccctctggct ggcrtgcttg tgtccttcca gcctatcagc at rggacagc 233460 233520 233580 233640 233700 233760 233820 233880 233940 234000 234060 234120 234180 234240 234300 234360 234420 234480 234540 234600 234660 234720 234780 234840 234900 234960 235020 235080 235140 235200 235260 235320 235380 235440 235500 235560 235620 235680 235740 235800 235860 235920 235980

92 Revision period: August 3, 100 years

1358456 > No. 97135019 Patent Specification Revised agattgiatg tcttcacaaa attgttgcct anntiagc cagcattna tcttgaacc naactacct aggcciatat ccttctcctc ctcctccgtc ccctcttcct cttccicctc cgtcccctct tcctcctcct cctcatcatc ttaccattta atcaataait gcaatcagcc tgicagaata cgtaaaggga atccatgiaa ttcacaggcg ggagttgtta ttictgtagt aaagacctga ctgcagcatt tacacatgat aaataggaaa tggcaaacct ggggaagcaa gtttgaactc aatctggaag taatagccta agcagcugc tcttcacact gtgtttccca tgtcaccctt ttcctcttag gtaicttgct tctccctctc atttcaatct cctccttcct tctgttcctc catccitcca tccctccctc ctgtcittci ctgacacaat gactcagcta gtttaagaga atggtattat ittgaagtct gaaaatgttt ctgtgatati itgcuttta ctgatcttta aagcaactca cagaagtgta ttagccttag atacgtaatc accccitgag atatatagtc aacagtacac actgacatgt tcatagtaaa aactgcctit atgittcact gcattcaagc aagtagatat cacgtattgc aaagcctatg ttcttaagca tgtaccaaaa tcacatttat ttcattaatc catttactca ttcaccagaa tgtaacaaaa tttagtgaat atctgctatg igtcaggcac trttcttggc tcttgatata caatgatatt caaataaaac tcaiagtctg gtaggggag ttgtttgttt g taggagacaa atatgtactg atgttaatag atattcctga aataaataaa ggaattagga tggttaggaa cgtccttcca gaagaaatgc aaggctggcc atgaaaggtg actatatcgt aataggcaga aggtggcagc gcaggtatgg gtcgtaagaa gaaccttata ggaaaggagg tcaacttgcc ccagtgccat gagctcagca ctacaacctg gtgcaggact tcgaagtaat agaaagcgag gctgcaaagg tggacaggga cctgaagaca gagggccagg ttagtgagag cagacttacc acgggcatag cttagcagti ttaagaatag gatcagattt tcatttgata aaatcaccct gatgacaagg tggagagtgg attagatgtg ggtaacatcg aagataaaga agcaggtaca gagactcata aaatatgcag aigagaggta gtggagacca gaatcaaaac tgtgaggaat aggaatgttt aaatatgtcc caagttacaa ttcagttaca tatttcatca gccagcatgt cctgtgcaca cacgacctgc tcttactgct ttccatgttc tgtatgtgga aggagatcag tcaatcttga actcatggcc tcagtatttt gtactttata atttatattt tttcctatag aggcttttct attratgtgt attccacttc cccatatcac taaactgtct ttttccacag gattcaattc ttgaactagt aggagtgaag ggcagtctgt tgaaacctgt aatctcttag gcttgtattt tctttgaaca tagtttccac agaattcttc cctgtagggg aaggcctggg cacttcttga tgtcagaaca tgttgtcttt agtttggaat ctgccaaaac aaaagtta aa tcaaaaatgt taaticcigi caccccagca ctrcgggagg ccaaagcagg aggattgctt gagcccagga gtccgagact ggcctgggta acatagcgag acctcgtctc tacattaaaa tttaaaaatt agctggatgt gctggcatgc actcatagic ccagctgctc aggaggctaa ggcgggagga ttgcttgagt ctgggaggtc gaggctgcag tgagccactg cactccagcg agtgatggag igagaccctg tctcagaaaa aaaaaaaaaa agaagaaaaa atatattaat tcacaaaatt gtcaaccaca tgttgagaaa tacatttita tacttgctgt atatttttca ataggtaatg gttcaaaaat tttaaagtac aaagggtata cagtagatgg tagatttctg ccacaactgt gcccacccaa ccttttgtat ttttccagaa acaitctata catatataag gaaatgcata taaatatala catatataaa aacatatgca ttttacatat gtgttaatac cattggcaca accacagaca ttatgcatgc cggttitttt cacttgatgt atctgggttc ttctttccta tacatttatc mttgmc ttttgagtca gaagaagtta tgaaggggaa ggaagacatg cttgagctct ttaagaaagc ttggaatgtt tctatgtgtg caatagaaat atttcttgcc aaatgataaa atgacagcta caagaatgtt tctattcaga actattcaat agaaatatga tataaaccat 236040 236100 236160 236220 236280 236340 236400 236460 236520 236580 236640 236700 236760 236820 236880 236940 237000 23 7060 237120 237180 237240 237300 237360 237420 237480 237540 237600 237660 237720 237780 237840 237900 237960 238020 238080 238140 238200 238260 238320 238380 238440 238500 238560 93 1358456 Revision date: August 3, 100, pp. 97130019 Patent Specification Amendment tacccttttc atacatctct tatttgttac tagatctcct tgtcaatata aaaacttaat atatgtaaat caggcaccat i tgagcccag aiaaaaagat agatgggagg tgcacrccag agtgaacita tcaacatgga tggatccct t tacaaaaact ggaggccaag tgtgctagtt tacgtgtata tatatataca tattcagtct cat t tcaaat tagaacttct aatgactgat ttcitttttt gcacaatat t cctcccaact agragagaca tcctcctgcc ctcatttnc. ctgattggtg ggctcatgcc agatcgagac agctgggcat tcgcttgaac ctgggcaaca tact taggta tagtttttta gtgccttaaa catatataia ct tet tccca aartggaccc ttcgtgtttt t tcctgtcca gcaaaataag aactctgtag 11 ttagtacc ttaaartctc ggctcacgcc gagttcaaga taucgggca at tgcngag gctgggtgac at 11 tagtag at rcataggt gaggccaaga acaaaaat ta gtgtggggat cutccagcc tatatataia cacacacacg t tgaaat tea gctcaacagc. tagt tttaac tttaaaataa tttttttta a gcctcaccgc ageraggatt gggtttctcc tcagcct tee 111 taaactg gcagtgcttt tgtaatccca catcctggcc ggtggtgcgt ccaggaggtg agaacgaaac tatcctaaca at aaggtitaaa gactgaaaac cagtaagaga at tcgacaaa tattttgttt gaaat ctatgatgaa caagaatgtg attatgtaat ragtagtcta tataatccca ccagcctggg tagtggcatg cccaggagat agagcaagac tagat t ttaa ggctaacacc gttcgagacc gccaggcatg cgcttgagcc tgggtgacag tatatatata taccgtaa tacat

cacacacaca grattatgea etaatttege tagatagaat aatttaagat gacagaatct aacctccgcc acaggtatgt atgttggtca aaagtgctgg acatagacca ttaaaataga gcactttggg aacatggtga gcctgtaatc gaggitgeag gccatctcaa aaacatat tc tgaagt tgta atgcatcctg acatcaaagt gaagataaag aatgcaatac tatttttgtt itcct taaaa aggatgaaac tatrt tatat 11 taaagtct gtagtcatgt gcactttggg caacarggcg cgcctgtact igaggctgca cctgt r rcaa ttgacacact tataaticca agcctgggca gtggtgcatg caggaagcag agtgagaccc tatatatata catacacata cuacagcat taagggctac t tccacacag ggcatgtat t tgetet tgt t tcccaggt tc gccaccatgc ggctggtctt gat tacaggc aagtgctatt tacatat taa aggetgagge aaccccgtct ccagctact t tgagctgaga t taaaaaaaa cttaaacatt aaagcccatg ccagttttaa ett tcaaggt ataatactga t tagragaac tttgtt tact gan tcatat titr taaria tagarcarac 111 agat ΐ 11 tagaaaaagt aggccaaaat aaaccatgtc cicagctact gtgagccatg aaaataaata atatccataa Ctttgggagg tcatggtgaa ccigtagitc aggttgcagt tgtcaaaaaa tatatatata

catacacan atet tgat tt tgrgttggac aaatctaaat teggnttat gcccaggctg aagcgartci ctggctaatt gaaitcctga atgagccact ttgctgat tc atgtitgage gggeagatea ctactaaaaa gggaggctga tcacgccati agaaaaagtt cttaaaacag tttcuatti atageagaat tgaitat t tc gtaaaccatt atetgatgae gt tctctcct tcaaaacctg cigaagagat mtcaarcc gi taaaat π aaaaagaagt gaaggatcac tctacaaaaa caggaggctg atcgtgcaac aaaagaaaca rgtgatcati ccgaggiggg accctgtctc cacciactca gagccaggat aataiatata tacgtgtata crgiuttci gaacragcca ggtgcagrtc t tgaataact ttetit tert gagtgcaatg ccrgcctcag rtgtaititt cctcagttga gcgccctgcc tget t tgtet caggcgtggt caaggicaag tacaaaaai t ggcaggagaa gcactccagc tgiacctata tataaigact taageagaga nattgatac rtgrgccrtc ccatgctaca catggrccta ctgtccagta ageaugtat caacargaaa atat tgacia tanaaaicc 238620 238680 238740 238800 238860 238920 238980 239040 239100 239160 239220 239280 239340 239400 239460 239520 239580 239640 239700 239760 239820 239880 239940 240000 240060 240120 240180 240240 240300 240360 240420 240480 240540 24060 0 240660 240720 240780 240840 240900 240960 241020 241080 24!140 94 1358456 .0 97] 350] Amendment to Patent Specification No. 9 Amendment Date: August 3, 100

aiggaaattg aaagttcctt atttiaatcc ttaggagaaa aaciataan ittctctaat atatccataa agtgaaagaa gaagtactta tugatauc ttaattgtta catatttaag agcaagagta attagttcat acttatgttc acciaagtcc acccatacat tgctgaggat agcggccttc agaaggtggc tgtttccgga ggagiaacag ggaggaacag gtgggctgag atatacatga ggcccaggac attccageca ataactgtct gcctcicctg actctgccca aacccgaaat gatgctttct agctcacaca aaaatatata tatatatata tatatatata tatatatata tatatatata tatatatatc agcaggcaga tacicaagci gaaagagaca ttactggggt tcgtttctag aicacagatc ctgcctcagg ctcactgaag tgaccagcct ccacccagta acaacaaact agtctaaatc cagaataaaa caaitataca ttitaatctt accaccttct acctgtgtgt gctgtccacc ctcaagacag agaaiagccc gtattccacc aaccagcaat cactagccta caacaccaaa tccacagtlt ctttggtatc ctttgtgcca gggagttggg tgctgaacaa tctacctgta acattccctt gccttcatat cccaaagctc tgcaagcaaa gaagagttct ggtgggcagc tagggccatt tgngtagtc cagaggaaga gagccatccg iatcttctgt gctgtactca tacciattta atccaatctg ctggcaccag tctattatat tcaactgttt gcccccactg taactacata acaaccacct ciattacaac

agtgattaia tatctgcaaa gccaatctct gagcctacaa tgaat tcaag ctaaataaat acagcatact aaaaaggaaa ctgigtgttg ctgaattctg tctaaaaaag ctgatttaat taaacggt ta gctctaaggg gtgtagttag tgargtagtg ggtgggtgga tgtctctaca ggaggctgag tgcaccactg gaaatgatgt tagtaat taa atagagcagg gtcctccaca tccccagtgt gt tgactat t ccactaaat ΐ ataccacaaa aggcattatc gaatactaag aggt taacca tgaagaaatc ttattctgtc gt tatgatat ataccatata attcccatta tgaactgagt acaacgtgcc tataccatta tctggaatgt ggaaaattga agttgggcag aatgttcatg agccaggcgt tcact tgagc aaaaaaacaa gtgggagaat cactctagcc agtgaaaata acttatatag gaagcatcgc cacccatctc at 11 tacctg ccattctttg cattgtcct t tttaaagtt t tgagagggta tatccaaact aaaacatatt atgagaaagt actacttccc tgtccatttc ctggaagggc atctcccagc catgactggg tctggaggtc ctcagcatac tataccatac gtatagttcc caagaaaagg tctaatatat aaaacaaact agacaaggca ggaaggagta aacactttga tttctctgtc catatctaaa agtatattgt ccgtcaacat gacagccacc cctttctaca cactaaatct gggcagcctg agctccggct gaaggcccag gettgctact ggtggctcat Gcctgtaatc ccaggagttc aagacca gcc aaattagcca ggcatgatgg igettgagee caggaggtgg tgggtgacag. tgcctacata tagttacata gcactiatac ctcatcaacc agcaaagatt tgccaccctc agggattcct it tagtcate tattgatttt aaaggtatga gaggaaaaag itttcttcaa aaagtgtaaa tgtcacctct cagccaataa 11tgtgaact gtacatgcaa gtacct tgea cacaataggt teettataaa tctgagactc actgtgtaaa ttataacatg gaatgtttct tttttgatga gtgatgttcc aaaatgggtg tacatggaat taaactcctc ggcticagtg gtgageatag tcccattcct cccgcact 11 tgggcaacat tgtgtgcctg gggctgcagt aataaataaa ctagactact cctagtgcac ettgeatate at tcaat 111 gaaaagcaca gtcataaaga tagteat tga tagccaagt t aagggacttc acccagagaa tgtgaaagga tetgatgeta atetaegett tatget tata tcccccctaa tttaaagtga tgagttcrtg ggatttgata atggaagcca tgaggcattg gctctcctga ctcaactgat ttattttaaa gggaggeega ggtgaaaccc tagtttcagg gagctgtgat aagaaagaaa taaagtgacc cacactcgt t tctgtgttct cctggcagt t actcaaaatg tgccatagaa tatactctcc tattttaact 241200 241260 241320 241380 241440 241500 241560 241620 241680 241740 241800 241860 241920 241980 242040 242100 242160 242220 242280 242340 242400 242460 242520 242580 242640 242700 242760 242820 242880 242940 243000 243060 243120 243180 243240 243300 243360 243420 243480 243540 243600 243660 243720 95 1358456 Amendment date: August 3, 2000 No. 97135019 Patent Specification Amendment

Gggaggccga ggcgggtgga tcacgaggtc aagagatgga gaccattctg tgacacgcac ctgtaatccc aggtactcgg gaggctgagg caggagaatc

rtagtcat ta tcacttcagr cctct tgtgt taaaataatt tgrggtggct aggtcaggag caaaaattag caggagaatr gcactrcagc agaaaggaga atttigcaga gtggtggctt icaggagttc aaat tagctg gataattgct tgcactccag gcacagtggc ggtcaggagt aaaaat tagc aggacaatca ctctagcctg taagatgccg gtuaaggag tagtccattc tgtgtcnac tgtacattta ggctgagatg gccactgcat aaaagaaaga cct ctggatccca atgcccagtc gangaat aaccatagga gaataagcca igcactactt ttatttttct aaatactttt aiaagcatct t taatca cuggttiag ataagtcitt gaaagtcrgt ta acttaaaaaa cacgcctgta t tcaagagca ccgggcatgg cgct ctgggcaaca aaaagaaaag atgatctaga atgtctgtaa aagaccagcc ggcatggtgg tgaaccagga cctggactac icacacctgt rtgagaccag ct tgaacctg ggtgacagag tctcaaaaaa acacatt tcc t tttgctcta tacaaagaga gaatagaagc ggaggatcac tccggcctgg aatttaaagt tcttttaaaa t tatgtattg gacatcaaaa tagtagattt acat taggaa tctgtaaact agttatactt ttt tgagata cctatrtrct aat it tcaga gaganttct cacagatgag grcagigatg aaaaaaaaaa atcccagcac tgaacc tgggcacagt Gcctggccaa tggcgcacgc tgggaggtgg gagcaagact aaaaatttgc gcaggactgt tcccagca ct tggtcaatat tgcat tcctg cgcgggaggc agagcgagac aatcccagca cctggccaag ggcgggcgcc ggaggtggag caagactctg aaaaaaaaat tcatcttaag aactgagcct aaatragtct cagggatgtg trgagcctgg gtgacagaac aggaagggct gactagttct acattagaat gcaaaaagag gt tcctgagi gang tea tt ragat tttca acggtttaat actgaattgi taaaaatgaa iccat tgat t 11 ctc 111 u atct tctgag gt tcrcagga cnccaraac tugggaagc catggtgaaa ctgiaatttc aggctgcagr ctgtctcaaa atttaagact catrttaact ttgggaggcc ggtaaaaccc taatcccagc agaggttgca tctgtctcga ctttgggagg atggtgaaac tgtaatccca gttgcagtea tctcaaaaaa tggtgtittc gacttttttg tgccrcccag gtgatcagt t atgcacaccc gagrtagagg aagaccct〇t accgt t tget gaggtccttt cagt taaaca gtaagttggc aget i tget t ggaaattctt agataretag tigetigiga t tctcccacc aaaaaaagcc tacagaagaa tggcaiaiag ggactgci tc ctagat taga ngaaaar rt cgaggtgggc ccctgtctct agciactcag gagccaagai Aaaaaaaaaa tatatgaaaa aaagt tartt gaggcaggtg caicictact tactcaggag gtgagccaag aaaaaaaaaa ccaaggcggg cccatctcta gctactcagg gccgagatcg aaaaaagt ta ttggtttgtt ctgct ctgat ttcttcattg iggatcagaa gigatcccag ctgcagtgag ctctaaaaaa ictggccaag actctgagta taaatttttt iataaacctg caattaaatt attetn tet tat t raaaca agacaaggca agaaatgtgg aagaaacaac gatgccciga at tatttaig tggagccggc ΐ rgt tactct tgtggccagg ggatcgct tg actaaaaata gaggctgagg ggiacccact aaaaaaaaaa tacataan t ttggccaggr gatcacgagg aaaaatacaa gctgaggcag atggcgccac agttggccag tggatcacaa ctaaaaatac aggctgaggc tgcctctgca ttcttagtgg gccaacatgg act tgaatct ttgtgrttta gctggtcatc cacttcagat gaactgaaaa ciactcagga ccgagatcgt taaaaagaag ct tcacctct ggtatttatg ictcttttta taggtgaacc tctgtgaatc itgaaaatga ttttgetttt 11 ucaaaca atiacatgt t tgacat tggr acctctcaga 243780 243840 243900 243960 244020 244080 244140 244200 244260 244320 244380 244440 244500 244560 244620 244680 244740 244800 244860 244920 244980 245040 245100 245160 245220 245280 245340 245400 245460 245520 245580 245640 245700 245760 245820 245880 245940 246000 246060 246120 246180 246240 246300 96 1,358456 Revision date:]August 3rd, 97th] Amendment to Patent Specification No. 50丨9

ataitttcta agatcaaaca iataattgat m tgatgat ctgttattga igccagctgg t ttttaactg 11 taat tacc cacatgctca cgttittata ctttgtttta aaggttttgt aggcatgctc gaactatatg ccaggtctta ctttttgttc taatggactt attagcagat taactgatgt ctatgtgttt agigtaccat atatttatgt rttttcctta aggaattcat gcttctttcc gtgaggaata ttattttcaa tgataacact 11 tgt tagaa gtgaattaat agggaggtgg ataaggcagg tactgcaagg gtggctcaca caggagtatg aattagctgg agaatcact t gcactccagc ggagatgaga agaaataatg taiaatgata cttgttgt ta cctccct t tc gtgtgattn catttcattg ct ut tagtg gcatcaattc ctttgcttaa ccttgctct t gtgtaagaat ctctccccat tggt ΐ taat t tttctcittt tcagctagtc caaatciata tcattctaca cagttgtcat ΐίtttgcatt tctggaaatt tgctgtgtta ΐ tcacccgat tttaacaggg gat tataaaa taaattcatc aaatgtttct ttat ttctaa aggactgttt atiaaccttt atttactggt gacttatata aaat taacct agatgttgtt taaacagtga ΐ ΐ tgcaccac gtcctgcctg gaagcagggg cctgtaatct agactagcct Gcgtggtagc gaacctggga ctgggtgacg gaagtgctaa actgaaattt gcttgttgaa atagcatita ct t tgtccat ίrt taaigai agtggtgict gat tcugai tgacatttca caagaacaga gagaaggtca ctggcagcag ttatcctcca gtaagitgtt gcaagat t atctgatatt accactgaaa tcgctgaaga ttatgtgaag gtctatattg tttaacgaag aagactgatg aagtcagaaa gatgtaatac tgctgacagt attagatttt atctcatgct at tctctact aaatgt tcaa ctgttaattc tatgttattt ttaaagtcct taaaatct tt acaatgacag cat tgatgat ataaat tccc ctctcaagga tctagaat tc cagcactt tg gggcaacacg atgcacgtgt ggtgaagatt gagcaagact aggagtttgc gactt tgcat atgaat ttct tg ctttgtttct catgtctaat taaaaaaaat catargttt t tgtagtitaa aaggtacagc ccatcatcgt t ttctaaaca aatgtact 11 tgtctt tcct cagaaataga aaataaaaat catcaggaca aatctaaaaa cgaci t teat gaggaaccag aaatutttg aatgat tgt taaatatgtc t tacactatc gtttggtgaa gcttcacagc tgaaaatagt cttcttttat ctatatgtgt gttgttacta actaacatta ggcacatctl acagttacca atcagataat ggatgtctaa actaataaat tagcaaagtg gctgcatagt tgtaagaaat ggaggctgag gtgaaactct aatcccagct gcagtgagcc ctgtctcaaa aggaageaga t Agtctgatag cctatgatcc cgaagctgaa tgatggactc gaasaaaata tciigiitgg cttarttctc tggtcttcat accacct tga gaagg ttatt tacctcttgg accataagct aagctgacig agat ttt tgc gcaaatggga tgctccctct get tgtcact atgctttt ta atgtgt t tea tctatcaaga tgaagtgttt atctgtgggi aagggatgag tctccatttt tamtccta atataatatt gtttttcagt caaggagaat ttaatcattt aaatgatggc aagaagaata atttatccat at tgtaaact aaatccaagg ttgtggggaa gtggctagag gccaaaggaa gcaggcggat gtctctacta actcgggagg gagatggaga aaaaaaaaag cacctcct 11 acaagagcat at 11 tgacct aacct taagg agagetgeat ttaaacaaga Gatetan ί ί

UttgLttCt tagaiatgtg gttaactctg ttttgaaaga tgccactgta attgataaca tactgcaggg atgaatatta agatgggtga ctacttagea gaagtgtgat agatttgtca acaattcctt gtataegeta ggtgatataa acttttagaa atagccaact tattcatatc gctactgt ta tctttctcag ttatttgttt gtattttgat tgtagattta aatttaaaaa attgatcatc tcttattcct ctcctttcaa atttttttta ttgaagaat t agaatagata gctgggcgca tgcttgaggt aaaatacaaa ctgaggcata tcacgccact aaatgccgaa tgggatggcc t teegaigaa ttct tatttc gccttcgact get t tcacaa 246360 246420 246480 246540 246600 246660 246720 246780 246840 246900 246960 247020 247080 247140 247200 247260 247320 247380 247440 247500 247560 247620 247680 247740 247800 247860 247920 247980 248040 248100 248160 248220 248280 248340 248400 248460 248520 248580 248640 248700 248760 248S20 248880 97 1358456 August 3rd No. 97135019 Patent Specification Amendment acat tctctc aaacggaiag ctggtigttg icatgctgaa gccaggcgcg cgutgagtg aagttttaaa tgaacccggg tgacagagrg aatggctgca agactccagt tcagaat tcc tgcacagtat magtttcc gcta agaagg gatggagttt aacctccacc acaggcgcac ccatgttggc ctaaagtgct 11 tgtgct tc tt ttaattca tggmatt t act t tggagc cagactggat caaaatcaag ggccaccttc tattaarcct gtgicactt t aaggttctga catcaigggc ctcactcigc tgttctaatc tttgittttg agctcactgc gctgggacta agttttcacc tcagt t tccc irtciaggca gcicacgcct gatggagacc actgggcgtg cact igaacc accigatct t aaaaactgag gaactggtat atggagaaga gtggctcatg caggagi tea aaat tagctg aagcagaggt agaciccarc gaagcatcat gcatctaagt tgggtgtggg atggacanr cccagtacca aatctgctaa cgctcttgtt ccccgggt tc gccaccacgc caggctggtc gggattacag ttgcctncg actct tggai agactgaaga aagtatcaaa gcct taaaca gtgtccgcag tcactgtcct ctcttct t ta aatitagtca gagttagggc cattccactg cactctctcc tgtaaaatgg agacagagtc aacctccacc caggcacgcc atgttggcca aaagtgctgg ctaaaaagcr graatcccag aiccrggcca grggtgcatg cgggaggcgg cacgtgaacc gctaagaaca ciaaaagaga gctgaagagc ccigtaatcc. agagcagcct ggcgtagigg tgcaatgagc tcaaaaaaaa Tggcaaatgc gtgttagtaa aaactictat aiattttcta ctgttttgac at tcgaatgc gcccaagctg aagcaattct ccggataat t tcgaactcct gcatgagcaa tatataict t tgcttaattt agtactcteg ggctgtgtta acagaagtta

Stcigttttc cgcaictctg caaggacacc cctctigtaa ticaatatat aaagggcgtg atgggcccta gcatratgac tcgctctgtt tcccgggttc ctaccatgcc ggctggtctt gat tacaggc 11 rgt teat t cact t tggga acatggcgaa cctgtagtcc aggttgcagt ctgcaagatr gnaagteae gacagagatc acagaggaga cagcgctt tg iggcaacatg cactggggag cgagagcaca aagaaagaag aaggaaatta cigatiargg aactgtgcaa ctaacacaac cact t tcaca aganctcct gagtgtgatg tctgcctcag tittgrattt gacctcaggt ccacacccag 11 teat rt tg tgaataan t gcagagtaag gtctgctggg attttctcac tcctgaggtc tgcactgcat aatcagaitg aggtcctgtc gaarttaggg ggtggacagt agaaaatcac taccaatctc gctcaggctg aagagt tctc cagctaattr gaactcctga atgagccact ataaaagcca ggctgaggca accccgtctc eager act ta gageegagat ggtatuaai ucttcagtg ί rictgatgg gagaatagag ggaggctgag gcaaaaccci gctgaggtgg ctacigcact aaagctgaga ttgtgatgta agagcacctt cttttctaic tgacattcca ct tetgreta gcttitt ttt gcgcgatctc cctcctgagt t tagtagaaa ggtccaccca Ccccagatta agtttccttg gagagaattt aaggagcact gcttccatca agttctggag tccgtccttg ccctggtgtc gattagggee ttca aataca gaacacaatt cagaaacctg ttaaccct tc agttgagttt gagtgcagtg atggctcagc ttgttatttt actgaagcta gcgcctggac tacagaggcc ggcggatcac tactaaaaar ggaggctgag tgcaccacig gttctcacn tccctagcta actciaaatr aataaagagg gegageggat gicictacaa gaggategee ccagcctggg tgccatagga cccicact ra tgtgctatta tccacgtcag ctcccgtcag tagtgetttt tttttttttt ggctcattgc agctgggatt tggggtttca cct tggcctc tcct tet taa aattaaaact gggctgttct aactgct tet tgaatgacca gcccgaagt t gattgeagaa tctctgcatg aactctaaca gitgcattcr cagtctataa ggcacaagt t tgatcctcag ggtt tgtttg gtgigatctc t tcccaagia agtagagatg tctgccagcc tcact tgagt aggcacagig gaggtcaaga acaaaagt ta gcaggagaat cactccagcc 248940 249000 249060 249120 249180 249240 249300 249360 249420 249480 249540 249600 249660 249720 249780 249840 249900 249960 250020 250080 250140 250200 250260 250320 250380 250440 250500 250560 250620 250680 250740 250800 250860 250920 250980 251040 251100 251160 251220 251280 251340 251400 251460

98 1358456 j Revision date: August 3, 100, 971,350] Amendment to Patent Specification No. 9

tggcgacaga gtgagactcc acctcagaaa aaaaagtaat acagaaagtg accttgcata aacttagttt ctcatttcta aacaaaaata aaatgtatct catagagttt ttacaaggat tcaagagctt trgcatgcaa attgtctgca aatatatata tatagcactt tttataagca ttacatatta ccattatttc tcatccttct ttcttctaca tucttctgc ccgctcttcc ttttcigtca ttgcctaaaa tccctattaa tgaatagttt gaaagaacat ggccaggttt gcagaaagaa gaaagagaga tatccttttc cctcccataa ggactaaaag aggatgtctc tgtgctttga tcattaacca tggcgtgttg attttaggac aatcrataac tctctgtcaa tticctactt aacagctttc aaaatiaaat gttcttgctt ttctactaac tgttaatcat ctgttcttat tgaaaggtct tiaatgaata ttgactgttt actccaagtt tataagattt ttggtctaaa gtggttgtct tagtccattt tctgttcctt ataacagaat acttgaaact gggtgattta taaagaaaag gaatttgtca tttgcagtta tggaggctga gaagtccaag gtcacggtga gagccttctt gctggtgggg actctgcaga gtcccaaagt ggtgcagggc atcacatggc aagggggctg tacatgctaa gtcaggtctg tcucctctt atagagccac caatttcact cccatcataa cccatgaatc cattaaccca tgaatccatt aatccatgaa

tggatt tatc cct t tcaata aaccatagca tctatgatag gaatacagca t tatatcatc cgcaatggct gtcaggggat aaaaat tagc aggagaatgg ctgtgcgaca tcaaaacagg aagagactga gaatatttaa gttntacac tcctcggcaa taaaagccag cataagacca atttittttt tgtagactca tatgaaatat tatcgaggtc aataggatcc cataaagttt aaaaatgact gctgcccaaa gacaagacag cattcatgag ctgccacan gtggtatcta caattgttca agttagcaaa aacttccat t cacacctgta cgagaccatc caggcgtggt tgtgaaccca gagtgagact aaaggaaaag aaaatcatga gtaagaggat ggtggaaaag atttctggaa tgtgagttca gggaaatggt aatattcttg taactaattg ggtcticact atgattctca aaaatattca aaatggatat t tatagcact aatgccatga tgccactgta agcagacct t ggagattaag tttaaatcta aagaaattta gataataact tctcctgcct atcccagcac ctggctaaca ggtgggtgcc egagggggag ccatctcaaa aagaaagcac acttatgaaa taatacctat aaaagtttct atggatgaat tcaagaatga aaaataatgt agacaaatag aaigataigt tagcctgacc tattttctga tcagatagga gaaatattgt acctgtaaac ggtttctgct ctcttcactg tatgatccaa tatcaacatg tttactttca ttaaaccttt aagagtctca atttttaagg tttgggaggc cggtgaaacc tgtagtccca cttg ccgaga aaaaaaaaag acgtccctt t gatagaggaa atatgtcaga ctaaactgta tacaaatgct cttgaactgg agaaatcaat gcaaagggtc ttattattaa tttaagagag agaggcgaaa gctggaattc aaagctcaat gttttaatag ggcatatctt tcacctctta aattttggag aatagataat tttatagaca tcaagaggcg atatgagtat cgaggcaggc ccgtctctac gctactcggg tcacaccact aatatatgag ttttctcact gaggtgccta agaagaaatg gaccaacaaa ctctatagaa actacccaca gggcaagcaa tctagaggat caaattcatt t tgctaatct aaataaatgc tatttcacat caagcactgt ggaaatagca gactgggatg accacacatg aaaagttcca gggatattca agcagcatgt gtcttgggaa tgtgtgttcc gtgggctggg agatcacgag taaaaataca aggctgaggc gcactccagc ttgcccattt tgttgaagga aggagaaaga tagaaatata ctttgcctca tggggattgt ttctctatct ttaaccaggc aatataattg gacttatatt tacataaagc taaatgacgg gtatt ttaaa aagatggagg gigtgatgtg tctcagataa atttcctttc ttatcacctc atttttagaa ggatgtgcac aaaccggaac aaggtcagag agcaaggaga cgagtgaggg aaattgacat cacgtcttaa aaggaagaaa tgggettggg cctgatggct 251520 251580 251640 251700 251760 251820 251880 251940 252000 252060 252120 252180 2522 40 252300 252360 252420 252480 252540 252600 252660 252720 252780 252840 252900 252960 253020 253080 253140 253200 253260 253320 253380 253440 253500 253560 253620 253680 253740 253800 253860 253920 253980 254040 99 Revision date: 100 years August 3曰

Patent Specification No. 1358456 97135019 Revised cacacctata attccagcac tttcagaggc cggggcgggt agatcat t tg aggccaggag ttcgagacca gcctggccat ggtgaaaccc catctccacc aaacatacaa aaattagcca ggcatggcag cacatgcctg taatcccagc ractctggag gctgtaacac aagagtcaci taaacctggg aagtggagti tgcaatgagc caagatcacg tcactreact ccagcctggg caacagagcg agactccatc tcaaaaaaaa aaaaaaaaga aagaaagata agaaaaaaag gaagaacrtg gataettgge ctgaggagaa ctcagaggac agagatagtr rtcatgggaa

aegatettgt gaaaaagtag ggatgeatta gttcrcaagt caggaaaatg aggaggtgga gtcaagcgat gctacaggag actgtttgee acaaagagtt gctgctgtgc ctgccccaga gcacttgggc ccaaagaagc cacctctgca gcctcacrac tcatcgtggc tgggtttggt ctccacagat gggetttcac tcacatggtg ctcaccagtg cccactgctg ccatctgggc caggtgtgga gccaaaacat agaagtgttc cttgtctcci acatgagctg ttccttccca tcccaaacag ccaccagtgg gctcctggac tccctaaggc attgaerttt agaaaattgg gtagtnggc tgggcgcagt ggctcacgcc tataatccca gcactttggg aggeegagge aggeagatea cctgaggtca ggagtttgag accagcctgg ccaacatggc gataccccat ctctactaaa attataaaaa ttggccgggc atggtggtgc atgcctgtaa tcccagctac rtgggaggct gaggeaggag aattgcttga acccgcgagg cggaggttgc agtgagctga gatcatgcca ttgcactcca gcctgggcaa caagagcgaa actctgtctc aaagaaaaaa aaagaaaatt ggttagtttt ctaaattgea ttgaaaattt tataaataat agaagcccga gagaaagcca cacagcaaaa ctttetetet ctgccaatga aatgtattat tttcagccac ctctttttaa aaacaalatt atcttcattc ctgtaccctt cattttgctt tgtatttttg agagcgctgg ttgccttaaa atcagtatct caaatctctg gcaaagttcc ttctgtttct ttgactctat gaccctgata ttttetagag gtagctggtg tcaatttgag aagcatccag aggagtgaat agaaaagagg ccttageatt aaaaagacta aatttaaatc cttgtteege cacttcctaa ctgtgtgacc ttgggcaagt taatacacat gctgagcttg gattaatcag tggaggcttg taggacacct actgtgatgg caaatrctgt gtttgtttct ageaggagag at11taaaaa gaagttaaag aaaaaaatat gtgagacrat gatattctcc catattatca aaaacactta ttttcctcaa tgtaggaata gtgcaagcct gtcgacccag ctat11ta £ a ggctgaagtg ggagcatcac atgagcccag gagttcaaga ccaggcttta agagaccctg tctcrtaaaa cagataacaa atgtaaagrt tataggaaag attacatcat gttgattcag caaalairtt cctctcttat ttctcccttt cttttctatc ttcccttcta cgtgaggccc ttgtttatgg aggaatgtea tacaagggta ctcttcttgt gcataicgag acagacctat agatgctttg agetataata ttccatattc atccctgccc tggaggeatt agtaatetet tgagccaggc acagtgtaca cacttgtagt cccatctact caggagattg aggeaggagg at tact tgaa ctcactgcat tacagcctga gcgacatagc aagacctggc ctctaaaaaa aatacataaa taatctcttg agtatgetat gacatttccc aagcctgigg ccttatcata taaacgtaca gcattttcta attccattct gatcatttca aaiaaacact ttaattttar gataaaatgt cttatta ctg Ttactaaaga ccataaaaag tttgtagtta caaagaagtt atttgactaa ctcattatgt tagatgtcag cctagatatc acaacctcca ggaagcacrc cctaaccact tagatttagt tgtgtttggt tagttagatt tagttat £ tt tgattagtta gattcagtct aatttaattt aauaacttc egetgigagg tcctgtaaca ccctacacti tccciatcat aggaggcaat acagtgatac ttctgcaagt tcagctcagc ccrrggacca racaatcctg garrcaaatr gcaccrctac ctcctagtgg agtttgtcaa guacttaac 254100 254160 254220 254280 254340 254400 254460 254520 254580 254640 254700 254760 254820 254880 254940 255000 255060 255120 255180 255240 255300 255360 255420 255480 255540 255600 255660 255720 255780 255840 255900 255960 256020 256080 256140 256200 256260 256320 256380 256440 256500 256560 256620 100 Revision date: August 3, 100

1,358456 Patent Specification No. 97135019 Revised ctaagttccc ctttccitat agatgaagtg agattaataa aacagggtta tagaagagca igtatattaa gtgcctatac agtgcctgag acatcgtaaa caataaataa gtactagatg ctgicaicat caccatcacc atcaccatca ccaccatcat caccarcacc atcacacttc aatgtagttg cttattaaat atgcitatct tccttgataa aacagagacc acattttctc rgrtcacctt tttccccctg ctgcctaaca cagtttctga cacaaaaiag gagtttagta acttgactgt tgaatggitt agacaaaccc tggtggccaa acaacagcaa tggctttgtg ggttctacaa tgccigctcc ttcatgcaca tagttgtcat cttttancc ccccaaagca acgagatgtg gtctagttcc ttcaagggtg agcctagcag aatagatcct agacggagca ggggagatca ctcagagcct gcagcatctc agagctacaa gggacttcct cagcctccca acctacctcc ttcatittac aaagtacatc ctaagacaca tccgtggctc agccaggcta caattgacac aactggaggg ctgtagaccc gagaagaggg atttagaaga caactgagtc agagcaatgt agctacattt iagtttaatt ttttaagtcc atcaccattt tatctatgaa atttgttttt tattctttaa ggataacacg tagctaagtg cttataaata ataaatgaaa aataatcatc attagcttgg ctaggagcag tggctcacac ctacaatccc cacatcugg gaggccgagg caggaagact gcttgagg cc cggagttcaa gaccagccta ggcaaaatag ctagaaccig tctctacaaa aattiaaaaa attagcaggg tgtggtggtg tgtgcctgtg gtcccagcta ctcaagaggc tgaggcagga ggatcacttg agcccaggcg ttggatgctg aagtgagcta tgatagccac ctaggcaaca gcatgacatc ctgtctcaaa aactaaataa ataggccgag tgcagtggct cacacctgta atcccagcac tctgagaggc caaggtgggt ggatcacccg aagtcaggag ttagagacca gcctggttaa cacggtgaaa ccccgtctct actaaaaata caaacaatta gctgggcgtg gtggcgcacg ctigtaatcc caactactcg ggaggctgag gcaggagaat tgcatgaacc caggaggcgg agattgcagt gagccgagat tgtgccattg cactccagcc tgggcaacaa gagcaaaact cttgtctcaa aaataaaata aaataaaaaa taaatattag ccagagatga tgttacttct aatgaaggaa aaagtgatat tcactacaaa taagaagaat gtctaccacc tctctagcat ttcattaagg gagtacactg tggttctgat cacctgctgt ctgaatttta ccataaatta tattttgaat gaataataat ctgtgactgt attggcaaaa caaagtcaaa tatatgagat atttttaaaa gatgtaagcc. attttaatac tctagttact ctaattctaa ggatcgctat tccacagagg ccactactct gctttagaag agtttcatta tacctccctg gcaatgtaag acataaggaa tccagagtgg tttttacatc cattgcattt acccaaatac accatc ggag ggcagcacac acctggttga cttaactgcc tgtctggtgg ccttatcaaa atagttgtca aattagtcta agacattcct aaattaccac tcagataggc aggaaagctg ttggagaaga caaaaggagc aaagattttt aaaagacaaa agaatgcatt ccttaagact ctgagtttct acaaaaggga atctggagct aatcaatgct gcaaaatggg aaaacggagt taaaaaagga atttcctcaa tctgagaaaa cagatttgit atatttgaaa gatttttact gagtatgatc atccgaacac cagctactaa acaaaaatca gatctccttg ttcctattaa gatgcgctaa ttaataagat ggcaacaaag accaccatat aaaagggttc cttcagtaat gtrttctiga gtgaacaaaa atcaagccig ccttatattg tattctactt tgcatcacaa acagtirtag tgtatttctg gaaaagcatc agcagt1111 tcgaattita aattctggag ttatgtaact atataggcag gcttttttat aacagaatat aacagtgata cttaaataga agacttcaaa tgtaaatatc agtagagcct cgttaaggct ataaatccag actttgtgat aatgtggatt aaatattatt lacataacat ataaggaggc cgggtgcagt ggctcacgcc tgtaatccca gcactttggg aggccgaggc aggtggatca cctgaggtca ggagttcaag accagcctga ccaatatggt gaaaccctgt 256680 256740 256800 256860 256920 256980 257040 257100 257160 257220 257280 257340 257400 257460 257520 257580 257 640 257700 257760 257820 257880 257940 258000 258060 258120 258180 258240 258300 258360 258420 258480 258540 258600 258660 258720 258780 258840 258900 258960 259020 259080 259140 259200 101 1358456 Revision date:] August 3rd, No. 97135019 Patent specification Amendment this tgggaggctg aggaggcgga agcaaaactc agcaaataca taagtttaat tgcarttcta ctgctct t tg cagctaaagc u taaaatgg agtcactaac caatatataa ctactaatca atatgtccat gagatctaag tcattatatt catatatcct actgtattta aaaaaaagct cagctgcttt atuatcagt caactagccg cacccagctg acgcatcatt acacctgcag ctgccagctg ttagtccact ctacttttta accaatatac tatactccat ctcaggaggc gctatgatac aaacaaaaaa acacccgtaa t tgagaccag tgggtgtggt ct tgaaccca ggtgacagag ccaacaaaca ggtaatctca gttacagtga ctctagataa tttctgttct aatacaaaat aggcaggaga ggttgcagtg igtctcaaat gtctaagcag tccaatttta Accagcttct attttttm ngatmta taaaaacaat aatttactat aatcaatttt tagaaaagat gtgicctgat tgctaagcaa aatagaccct aatgtacttg agaaaaaaaa gaatcaggat agtcactgtt ttcttgtaga ggaggcaaga catgtcagat gtat 11 tgct tcc ctgcgtt gtagactcta gtttcattcc ttitcttttg taat tgacct gaatatgtac tgaggtagga cactgcacac cacagtaaaa tcccagcact cctgggcaac ggcacatgcc ggaggtggag agagattcca ggaagaatat gcactttggg gtaaaatcac aiagatagat ctgtccactc tagccgggtg atcacctcgg agetgaga11 aaacaaacaa ttggcaagag act tgt ttgc tgcatgat tc agaacaccag etagetagea tacaaagtgg gtaatagaca cagaaaactg tatattgeae agtaaagtca gtaaccacca ttaittttag agaaateteg aaaagcctgt atttctgtgt actaacacct ttgtcagcag ctgcccaact ccatagaccc gtattttatt cccagtagga caggctgcct tttccaaaaa tctttaaaai gatttgat tc aattattatt ggatcaatcg ctgcctggtg taaaacttaa gtggaaggcc atggtgaaac tctaatccca gttgcagtga tctaaaaaaa aaagaattag aggetgagge atcactgcac agacagacag agtagccttg tggtggcaca gaggetgagg gcaccat tgc acaaacacat gaaatgct tc aaaaatct 11 taatatagtc gcactacttt etttat taac agttctcat tt tetaagat t taaagat tat acttttctca gttatctgaa ccacattcag atataacaaa ctactaatgc cttttctatt gaatgcacat tgctctgtca cctgctgcct gtcaggtaaa cagctcccct tcaagtgtgg atacaagaga tcagcccct t ataaaagctg atatttattt ctgtact tra tgtcaat tta cttgagcctg agtaagaacc agtgtttaaa gaggeagagg cccgtctcta cctactcagg gctgagctgg aataaaaaat atataaagge aggaggattg tccagcctgg atagaacagc gtaaaactga tgccigiaai caggagaatc actccagcct ataaggaaag aattatuaa ttggagaaat acctagtacc ettggagtag ctagtgtgtt cagguagct tctgccaaca ttccttgnt agttacciat tgc £ ttccat gtttagaatt ataccaaaga tgtgtcacta ggcatcat tc tcctcactaa tctctttgta ccgtaccgcc ttcagatgtc t tccgacacc gctacataga gctggggttt igtctgtgta gaat tgt tat tcctggggaa tatgtat taa aaaaaataaa ggagttcaag tgttgctaaa taggccaggc gat tacctga ctaaaaatac aggetgagge tgccactgca taaaaaatat rgggtgcagt ct tgagtcca graacagagc igtataaaag ait tgaaagg ccctgctcci gcctgaaccc gggcaacaag ggatt tgeta gaataatttt atgaegtata agtaaacaga atgauaacc atattgrgac t tctagtcca aitetattgi aat taagat r gggactgaca tttggaataa ggaagaterr caaatggcca attttttaat aagaagaaaa atctctcagg cacatgtcta acagtgctca ct t tccct tc tgaacrgcct Cacacattgg attttgctgg aatact tgga gatgtttgtc tctgagggat aacatcacta atccccgcta getgeagega aaaca aaaca atgatggctc ggtcaggagt aaaaat tage aggagaatca ctccagccta atatctcagg ggcrcaigct tgaamgtg aagaccctgi tgtttcigig tggagaaaaa 259260 259320 259380 259440 259500 259560 259620 259680 259740 259800 259860 259920 259980 260040 260100 260160 260220 260280 260340 260400 260460 260520 260580 260640 260700 260760 260820 260880 260940 261000 261060 261120 261180 261240 261300 261360 261420 261480 261540 261600 261660 261720 261780

102 1) 58456 Amendment period:] August 3, 00, pp. 97135019

cat tgtagtt cttgaaaaat acaat tccga gaacctccac atctccagcc catctgctca tttgagcagg aagctacatg cagtgecagc tcagtggaac cctgtaatcc agaccagcct tttaaattag ttggagggtc actccagcct aaaaatacat ttgttcccac caacagcact gtaatcccag accttggcca gtgatgtgcg tgggaggcgg gcaaaaaaga aacaatataa gggctcttca ggtcagtgct tgagctctgg agattttttt caattatgia ccacagggat ctcaaatgt t actgttcccc tcttttccaa tgggtcaatg atagccaaca aaacattaca tttgtttgtt agcattcaaa tgt taaaaca t aactttggaa gacaatagat atctgttatc ttaacctctc gattgggtct gcctcagaag tccaaagga acagcgtctc acctggcctc gtgt tctctc ggcaggccca tggtcagggg tgaagcccaa attgagttag cagcagtttg ggggaacaca ccaggtataa acttgagctc gggtaacaga tataaaatag cacct tcagc aatttcggtt cactitggga acatggtgaa cctgtaatct aggttgcagt aaaaaaaaaa ataitcaaac cctacagtcc gggcacatga aatcagattg aatttctttt actgagggaa aatacttttt taatttgctg ggctatgttg actactgctt aacttttttt gtctagttcc gatttacttt tccagtttct atcgtggtct aattgctggg t taatacctt t tcgaattct gcct tccata tggtttagtt agataatat t ggt ttgcaca Aa£ctttcca agcgt tc cat tgatggtgcc cttatcacag aacact t tcc tcagagccag gtgtcacatg cacagaaagg ggaggctgag gggagacctc tggcacatgg gggaggtcaa gtgagaccct gttgctagcc aacagggct t agaaataata ggccaaggcc accccgtctc caggttctcg. gagctgagat agaaataatg tcgtctcagi attctccacc cagctgtgca cttgggttga gctggctaag ttcagcgagg tagtatctta aagaaagcgt cccaaactgg gaagtgtttc tttccacctt atctgttctg aaagaaaagc acccacatga acgtaaagaa atgatgactg cattgccctt tagtataaac agggataagc ttttggcgtt igctgtgaca gtcctgaaca aatcagtcat caggacctca agacctcagt ctgt tgccct atgigtgtct gggacctggg gtctcagagg tacattattg gcgggaggat cacccccgac ctgtagtccc gactgcagca gtctcaaaaa agcagtticc taagaaaggt atgataggtc ggtggatcac tactaaaaat ggaggctgag cacgccactg taattataga gggattctga aagcaccccc ctaaatattg attcccact t attccatttc cacgctcctg ccattcctca ggagcgggct act tgaaccc cattaagtag gcttgttitt agattaataa aatttaatga atacagcctg atganaaat actcttttcc titactcct t cagacaaggg acagttatta tttttgtttg gtgaccttta ctgaactgga gaattgccct cciccatcct agrccggttg tciaccaggg gaggagtaga gtgccacaag cggttgtgca gccaggtgtg ggcitgaacc ctctaccaaa agctatttgg agctgtgatt acaaataaat aattggtgig ΐ t ttcgctaa aggcgtggtg aaggtcaaga acaaaaatta gcaggagaat caitacagcc tt tatctcaa atttgtagcg agccct iacc at tatacctg ctaataccca ttcacttgta gcttggagtg agacaaagat gctgttttgt tgggctcgag gaaatggaaa tgagaaccag atttaggttg attacaaaca gtctagagcc gcatatagat cacccataca ct tggcagaa ttcatuctt cacccat 111 tttttgtttt tgtgagat ta gagt ΐ tgcig ccaicctggt ggaatgctic iggttttcat gaaggcttct tgtcagtagc tgtggaaaca gccagctgta gtggctiacg cagaact tea tutttttn gaagctgagg gcatcactgc aaataaaaag tgt tagt tga tgccatttta gcgcaggcct gatcgagacc gctgggcatg cacttgaacc tggcgacaga ttatataagt gttaagaaca ccaaggcctg agagagtgaa ctggttgttt aagttcagat tctgctcagt ctgcaatctc ttgcttcaga caacct tcct ggctggcagg tt tgactaaa cttactacta tticcagctt caat tctact ctgaaaagac cactgccaaa aagt taacac tacacaiati tgt tgt tgtt tgt ttgagac 261840 261900 261960 262020 262080 262140 262200 262260 262320 262380 262440 262500 262560 262620 262680 262740 262800 262 860 262920 262980 263040 263100 263160 263220 263280 263340 263400 263460 263520 263580 263640 263700 263760 263820 263880 263940 264000 264060 264120 264180 264240 264300 264360 103 1358456 Patent specification 971350丨9 Amend this revision period: August 3, agagtctccc tcrgrtgccc aggctggagt gcagtggcgr gatcnggci cactggcacc 264420 tccacctcct gggttc.aagc aattctictg cctcagccac ccgagtagci gggattacag 264480 stgtgtgcca ccacacccag ctaattttig tatitriagt agagacaggg ntcaccatg 264540 ttggccaggc rgcccngaa ctcctgacct ccagtgatci gccrgccrca gcctcctaaa 264600 gtactggggi tacaagcatg agccaccaca cctggicna cacccatttr tatgtgacga 264660 aattgaggtx igggaaggta aaatgactig rtcaaggtca caiaiccrga acacaaciga 264720 gcctagrgac rcctacctac caccacaggi ggctgcacrg cagaggagaa arctarrtca 264780 Guacactgt gaggagcaaa gtcagagtat gtaaaicacc caccatgair cct t uccct 264840 caaactgaag aggaatgttt gtttaatgag aaacagaaga tgtgctaaga atgttgagtt 264900 atϊtcacatc aggtgtictg 11tctcat11 tgaaaaaiga ΐtttgagtgc tgggcccagt 264960 ggc tcatgcc tgtaatccca gcacttrggg aggccaaggr gggcagarca cctgaggtca 265020 ggagttcgag accagcctgg ccaatatggt gaaacggcat ctctactaaa aatacagaaa 265080 ttagccaggc atggtggcag gcacctgiaa tcccagctcc tcaggaggct gaggcaggag 265140 aatcacttgg aacagggagg cggaggttgc agtgaaccaa gatcacgctr ggacaacrcc 265200 agcitgggca acagagtgag actccatctt aaaaaaaaaa ttattttgta cnccctcgg 265260 tttatacata tattcaaaca get11taagg tgaaigattt tttaataaaa gageamte 265320 tcacctttaa caatgtagaa cttttcagcc ggacarggtg actcacctct gtagtcccag 265380 cactttggaa ggctgaggtg ggaagattgc ttgagcccag gatttetaga tcagcctagg 265440 caacttggtg aaaccctgtc ctttaaaaca aaatacaaga attaggeatg gtggcctgca 265500 tctgtagtcc cagctactca ggaggctgcg gtgggaggat cgtttcagcc taggagttca 265560 aggeageagt gageegagat tgtgccactg cgctccggcc tgggtggcag aagaggaccc 265620 tgtctccaaa aacagaaaaa aagtagaact ittccatgta tacttrttac aggctaanc 265680 cattgtagag ctaaattatc aaaattgt11 atagataata ggtattataa taigaaagga 265740 atgcccaagg tatatagcct tggatataat attgaaatar atagagitgi ttg giattia 265800 gcacttccct tciatcaagt agttttctac ttgggaaaaa aaaagaaact tcctgaagat 265860 gtaiccaatt ttatatetta gtaacagctt cctaaacttg ccatttacaa catgaic-tac 265920 ctatgtaaag taaaatcaat ggtaaatgtt gaataacaag tggactcttg aaaatattta 265980 gcaatcacaa ctgaaactga attcattcta tgccttaaat gattataatt tatcaaatat 266040 ttatatccaa gaaatagtat cttaacctgt aagccaagaa tgtgtgtctt acaggttaat 266100 ttacacataa tatacaccat gtgattgcag cattrtatgc aaattaaaaa tat taatact 266160 atagataata actuatgta agaaatetat ctaaaggaat gaaaaaaati taaatcatca 266220 egaatgatgt aatgtcaagg tgttaggcaa agtgagttgt aacccatatt taagetatag 266280 cracacactt cagctggtca ggaagaaata tttgtcttcc tttatcaaaa agagtattgg 266340 ggccaggtgc agcggctcac gcctgtaatc ccaacacttt gggaggctga ggcgggigga 266400 tcacaaggtc aggagttega gacrgtcatg gctaacacag igaaaccccg rctctactaa 266460 aaaaaaaaaa atacaaaaaa ttagccaggt gttgtggcat gtgcctgtag tcccagctac 266520 tegggagget gagacaggag aatcacttga acccggaagg tggaggtggc agtgagccaa 266580 gatcgcgcca gtgcactcca ggctgggcga ca grttgaga ctgtctcaaa aaaaaaaaaa 266640 agtattggat tacacaaggt cttcaaaaac atatetttet tgggtggaca ca〇tggctca 266700 tgcctgtaat ccttgcgctt tgggaagcag aggeaggetg atcacrtgag gtcaggagtt 266760 cgagaccagc cigggcaaca tggtgaaact ctgtctctac iaaaaaiaca aaaattagee 266820 aggtgtggtg gcgcaggcct gtaatcccag ctactcagga ggctgaggca ctagaatrgc 266880 ttgaacctgg gaggeagagg ttgcagtgag ctgggatcgt gccactgcac tccagcctgg 266940 104 Fixed Date: August 3, 100 day

1) 58456 of 971350] No. 9 patent specification Revised gcgacaaagt gagattcrgc tcaaaaaaaa aaagaaaaga aaagaaaaga aaaaaaagcc atatctttct tgtgtaatgt gacgaitcig cat tact tgc cataaatcac at atgmagtt ccciaaaaag aaanagitc tggtgctgac ttccacagca cgtataglaa aat tggagt t ttit tract a tatgtgctgt ggaagicagc agtctaagtc atgcatat rr gcagaaaaac tgttaggicg atgggaaagt ctggcciata acctgctgtt taccaggccg tgcataat tcaaactctg tttggagggt caagtgtgaa tct tgccata cat tat 11 tc tgttttaaat attttcrrtt ctrtctrctt tttttttttr rtitgagacg gagttrtgct ctrgttaccc aggctggagt gcaatggcgt gatctcagct caccgcaacg tctgcctccc gggttcaagc gattctcctg cctcagcctc ctgagtagct gggaitacag gcatglgcca ccacgcccgg ctaatttttr tttttttttt ttrtttttgt atttttagta gagacagggt ttctccargt tggtcaggat ggtcttgaac tcccaaccac aggtgatccg cctgcctcgg cctcccaaag tgctgggatt gcaggcgtga gccactatgc tiggcctaag attttctica tttattttcc ΐ1111ΐ1111 tttttttttt ttttttgaga cggagtctcg Ctctgtcgrc caggctggag tgcaatggcg cgatctcggc tcactgcaag ctccgcctcc cgggitcacg ccattctcct acctcagcct ccgga giagc tgggactaca ggcgcccgcc accacgccca gctaattttt ΐ111ΐtaatΐ atttttagta gagacggggt ttcaccatgt ggtctctatc tcctgagctc atgatccgcc cgccttggcc tcctgaagtg ctgggattac aggcgtgcgc caccgcgccc aggcttattt tccaatttat aaatgaggcc gggcacggtg gctcgtgtgt gtaatctcag cactttgaga ggccgaggtg ggcagatcac ttgaagtcag gagttcgaga ccagcctggc caaaatggtg aaagtccgtc tctactaaaa atacaaaaaa ttagccggac gcggtggtgg gcccttgtaa tcccagctac tcgggaggct gaagcaggag aattgcttga acccaggagg cagaggttgc agtgagccga gatcgtgcca ctgcactcct gcctgggcga cagtgagatt ccatatcaaa aaaatttaca tggccaggat aatgaaacta tgcgctattt tcttaggctt tttgttgaag gtccagttct cccatgttta cataccacat tttaaaaata ggtaggaaaa acaattttta tcactgcttg tcitaaccag tacagaacag caaagcttct tttaaactat atttacagca cttcaaagag tttgggaaga aagaataacc tcaagccagt cagatatttt ccataattat gattttgtat gagatatagg tagaggataa tttcagtacc aaagataaaa attatttaat actaatttta atgactccat tacattttaa actccattaa atttaaagct aattttaatt agctttaaaa agctatgctt aaattaatag taataatgag cct tgaattg ttctctcaaa taaaatgcaa catcacttci ggtagaaatg aattatatag tactgaci11 catagtttaa gggaatataa cagagtttta gaaaaatact cttttctaat taaaaaaaca aatctccatg ttgtgattcc cccattgcta gtcacatttt tttttttttt ttgagacgga gtctcgccct gttgccaaac tggagtacag tggcgccatc ttggctcgct gcaacctctg cctcccatgt tcaagtgatt ctcctgcctc agcctcccga atagctggga ctacaggcac acgccaccat acccagctaa tttttttttt gtat 11 ΐ tag tagagacagg gtttcaccat gttggccagg atggtctcaa ictcttgacc tcataatcct cctgccttgg cctcccaaag tgctgggatt acaggtgtga gccaccgcgc ccggccgcta gtcaaatttt aaaaggccca aacccaaatg tgitttgtca ttttacccta ggaaactcaa tgattttgct tctttattct tcaagaitat tcatccagac cctgataggc ctgagcacag gttcatttaa actagaggct aicacaggcg rcgtttggaa agttacatta tacacttaac aaatgggaaa tgttaggctg ggcicggtgg ctcacgccig taatcccaac. acttggggag gccgaggcag gtggatcacc agaggtcagg agitcgagac cagcctggcc aacatagcaa aaccccatca ctactgaaaa tacaaaaatt ggcagggcat ggiagtgcat gcatgtaatc ccagctgctc gggaggctga 267000 267060 267120 267180 267240 267300 267360 267420 267480 267540 267600 267660 267720 26 7780 267840 267900 267960 268020 268080 268140 268200 268260 268320 268380 268440 268500 268560 268620 268680 268740 268800 268860 268920 268980 269040 269100 269160 269220 269280 269340 269400 269460 269520 105 1358456 971350〗 9 Patent Specification Amendment Amendment Date: 丨 August 3 day ggcaggagaa tcgcngaac icgggaggcg gaggctgcag tgagcrgaga tggasccaci 269580 gcacaccagc ctgggcaaaa caacgagact ccatctaaaa aaaaaagggg ggggggggtg 269640 aaataiaaaa ctcttcctia taccrccaag cccaagcagg iagggggaat tcttagagca 269700 aattagacit ccacaggcaa aiicitiaic ciagtgaatc rggatciacc agataactar '269760 agaatcctci aaactccaaa gcctiggrca acctgtcagi accarcagca tcactgggag 269820 ctcattaaaa atgtagaatc tcagatctca ccccacacct aatgaatccg aatctgccci 269880 ttatactgag crccccaggt aarttgcatg catauaaag 11tgaaaaga actgatctca 269940 tgaaatctta cagctaacac agagacctag gagaacaaga ccgtgcaaaa attgagaaga 270000 acttctgtaa aatgctgggg gcaagaaaat agggaaaaca agaaaagaga agagtgacti 270060 igagggaaga gtgcatatat catttcctta atacatttca mrtcttt t rtatgccttg 270120 ttttgaaaag ctaccattat cttggcatgc tttagatgga aaccattiac tgtgcagatt 270180 tctgttcttg ctatgcaaaa atatctcgtc taacccctac caugtgcct 270240 ggccctttga aatgtgtttc ttgctgacgt gcttgtiter cctttccagt cctgacacag 270300 ctcrccctga ggagcagcca cattccagct cccagtgcgc ccctctccac tgtctcrcca 270360 agcctccica cccciagtct tcatctcctg tggacgaaca tctggggtgg aag! 11tgia 270420 gccacacaca ggatactgee caagatccag cgggtgntt cttctcggtt gttagatgta 270480 caattggati ttctcaaaat aatgtccatc gttttggaag aegagagaaa gtigagaaga acacgaagca 270540 cagaccctga tgtgataaaa catittgtgg tttctctgag tcacagataa acttctgcca 270600 tcaaatggct acagtteatt taaatttaaa aaaaagaaaa aagaaacaga aaacgtgtct 270660 cagatggctg getttacctc gatageataa gagagaccta agacatgraa aataegtata 270720 ttgeagrate atetttcctc acactccaaa treagetagg gaagttgatt ccaatatgtt 270780 tgteattgat atttattttg tactttattr gctacatgat ttatgtctat acaaataatt 270840 tctctgaggt gaatttaatt cattiatttt caaataagca taatttgctc aattaagtat 270900 gagtttgaat ttagtttgaa alctggaatt Ggccagactg iggtcatitt tettgea 270957 106

Claims (1)

1358456 Amendment to Patent Specification No. 9*7135019 VII. Scope of Application: Includes Japanese Revision 1. A JP period that determines a body suffering from high myopia - Π00年〇月3^ Obtaining a biological sample from the individual, and determining the BICD1 gene in the biological sample (sequence recognition % nucleotide polymorphic SNP rs7966276 (A/T), SNP rsll5lQU2^ single or SNP rsl0771923 (A/G) At least one, (A/T), wherein when SNPs rs7966276(A/T) were detected as ττ tornado type, SNPs rsll51029 (A/T) were detected as ΤΤ genotype, < ^ rsl0771923 (A/ G) When detected as GG genotype, 'represents the risk increase of the high-nose myopia of the SNPs in the ILJ body', where the height is regarded as the diopter^ _6D ° 2. The decision as described in item 1 of the patent application scope A method for risking an individual's sacral myopia' wherein the individual is a mammal. S degree 3. A method for determining the risk of a myoelectric-myopia as described in claim 1 of the scope of the patent application, wherein the biological sample It is selected from the group consisting of blood, water, cerebrospinal fluid, or tissue from the skin, muscles, conjunctiva, and placenta.