CA2346499A1 - Dna sequences for enzymatic synthesis of polyketide or heteropolyketide compounds - Google Patents

Dna sequences for enzymatic synthesis of polyketide or heteropolyketide compounds Download PDF

Info

Publication number
CA2346499A1
CA2346499A1 CA002346499A CA2346499A CA2346499A1 CA 2346499 A1 CA2346499 A1 CA 2346499A1 CA 002346499 A CA002346499 A CA 002346499A CA 2346499 A CA2346499 A CA 2346499A CA 2346499 A1 CA2346499 A1 CA 2346499A1
Authority
CA
Canada
Prior art keywords
seq
dna
pepocos6
sequences
pep
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002346499A
Other languages
English (en)
French (fr)
Inventor
Stefan Beyer
Helmut Bloecker
Petra Brandt
Paul M. Cino
Brian A. Dougherty
Steven L. Goldberg
Gerhard Hoefle
Rolf Mueller
Hans Reichenbach
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2346499A1 publication Critical patent/CA2346499A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002346499A 1998-10-09 1999-10-11 Dna sequences for enzymatic synthesis of polyketide or heteropolyketide compounds Abandoned CA2346499A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE1998146493 DE19846493A1 (de) 1998-10-09 1998-10-09 DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
DE19846493.2 1998-10-09
PCT/US1999/023535 WO2000022139A2 (en) 1998-10-09 1999-10-11 Dna sequences for enzymatic synthesis of polyketide or heteropolyketide compounds

Publications (1)

Publication Number Publication Date
CA2346499A1 true CA2346499A1 (en) 2000-04-20

Family

ID=7883888

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002346499A Abandoned CA2346499A1 (en) 1998-10-09 1999-10-11 Dna sequences for enzymatic synthesis of polyketide or heteropolyketide compounds

Country Status (6)

Country Link
EP (1) EP1119628A2 (de)
JP (1) JP2002527067A (de)
AU (1) AU6512699A (de)
CA (1) CA2346499A1 (de)
DE (1) DE19846493A1 (de)
WO (1) WO2000022139A2 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1386922B1 (de) 1996-12-03 2012-04-11 Sloan-Kettering Institute For Cancer Research Synthese von Epitholonen, Zwischenprodukte, Analoga und ihre Verwendung
US6121029A (en) * 1998-06-18 2000-09-19 Novartis Ag Genes for the biosynthesis of epothilones
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
KR100716272B1 (ko) 1998-11-20 2007-05-09 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
EP1320611B1 (de) * 2000-04-28 2005-11-09 Kosan Biosciences, Inc. Heterologe herstellung von polyketiden
US7649006B2 (en) 2002-08-23 2010-01-19 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto and analogues thereof
WO2004018478A2 (en) 2002-08-23 2004-03-04 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones, intermediates thereto, analogues and uses thereof
CN112941002B (zh) * 2021-02-08 2023-04-25 中国科学院天津工业生物技术研究所 生产多巴胺的大肠杆菌重组菌株及其构建方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993013663A1 (en) * 1992-01-17 1993-07-22 Abbott Laboratories Method of directing biosynthesis of specific polyketides
US5716849A (en) * 1994-06-08 1998-02-10 Novartis Finance Corporation Genes for the biosynthesis of soraphen
HU229833B1 (en) * 1996-11-18 2014-09-29 Biotechnolog Forschung Gmbh Epothilone d production process, and its use as cytostatic as well as phytosanitary agents
NZ508326A (en) * 1998-06-18 2003-10-31 Novartis Ag A polyketide synthase and non ribosomal peptide synthase genes, isolated from a myxobacterium, necessary for synthesis of epothiones A and B
KR100716272B1 (ko) * 1998-11-20 2007-05-09 코산 바이오사이언시즈, 인코포레이티드 에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질

Also Published As

Publication number Publication date
WO2000022139A9 (en) 2000-09-08
DE19846493A1 (de) 2000-04-13
EP1119628A2 (de) 2001-08-01
JP2002527067A (ja) 2002-08-27
WO2000022139A3 (en) 2001-01-18
AU6512699A (en) 2000-05-01
WO2000022139A2 (en) 2000-04-20

Similar Documents

Publication Publication Date Title
Mattheus et al. Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster
Perlova et al. Identification and analysis of the chivosazol biosynthetic gene cluster from the myxobacterial model strain Sorangium cellulosum So ce56
Sun et al. A complete gene cluster from Streptomyces nanchangensis NS3226 encoding biosynthesis of the polyether ionophore nanchangmycin
US5945320A (en) Platenolide synthase gene
KR100834488B1 (ko) 플라디에놀라이드의 생합성에 관여하는 폴리펩티드를코딩하는 ｄｎａ
König et al. The Pipecolate‐Incorporating Enzyme for the Biosynthesis of the Immunosuppressant Rapamycin—Nucleotide Sequence Analysis, Disruption and Heterologous Expression of Rap P from Streptomyces Hygroscopicus
Pang et al. Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome
JPH09224687A (ja) ポリケチドシンターゼ遺伝子
JP2002505881A (ja) スピノシン殺虫剤生産のための生合成遺伝子
US7452693B2 (en) Discrete acyltransferases associated with type I polyketide synthases and methods of use
CA2346499A1 (en) Dna sequences for enzymatic synthesis of polyketide or heteropolyketide compounds
Izumikawa et al. Cloning of modular type I polyketide synthase genes from salinomycin producing strain of Streptomyces albus
JP2008278895A (ja) ブテニル−スピノシン殺虫剤生産のための生合成遺伝子
Kotowska et al. Type II thioesterase from Streptomyces coelicolor A3 (2)
US20040219645A1 (en) Polyketides and their synthesis
Kang et al. Toward steadfast growth of antibiotic research in China: From natural products to engineered biosynthesis
US7332576B2 (en) Biosynthetic gene cluster for ambruticins and the encoded proteins
KR20130097538A (ko) 해양 미생물 하헬라 제주엔시스의 제주엔올라이드 생합성 유전자 클러스터
AU2008201937B2 (en) Biosynthetic genes for butenyl-spinosyn insecticide production
KR100549690B1 (ko) 에프알-008 폴리케타이드 합성에 관여하는 유전자
EP2247740B1 (de) Für den biosyntheseweg für die etnangien-produktion codierende gene
SOCKALINGAM Genetic studies on a soil streptomyces sp. that produces an antifungal compoud
AU2006274822A1 (en) Genes involved in the biosynthesis of thiocoraline and heterologous production of same
Sucipto Synthetic biotechnology to engineer myxopyronin production
AU2002305118A1 (en) Biosynthetic genes for butenyl-spinosyn insecticide production

Legal Events

Date Code Title Description
FZDE Discontinued