CA2345944A1 - Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine - Google Patents

Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine Download PDF

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Publication number
CA2345944A1
CA2345944A1 CA002345944A CA2345944A CA2345944A1 CA 2345944 A1 CA2345944 A1 CA 2345944A1 CA 002345944 A CA002345944 A CA 002345944A CA 2345944 A CA2345944 A CA 2345944A CA 2345944 A1 CA2345944 A1 CA 2345944A1
Authority
CA
Canada
Prior art keywords
piperazine
aminoethyl
alkyl
fluorobenzothiazol
methoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002345944A
Other languages
English (en)
Inventor
Xiao-Shu He
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2345944A1 publication Critical patent/CA2345944A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Cette invention a trait à des composés correspondant à la formule (I) ou à leurs sels acceptables du point de vue pharmaceutique. Dans cette formule, A représente un alkylène substitué ou non, R¿1? et R¿2? sont identiques ou différents et représentent un hydrogène, un halogène, un alkyle, un alcoxy, un alkylthio, un hydroxy, un amino, substitué ou non, un cyano, un nitro, un sulfonamide, un trifluorométhyle ou un trifluorométhoxy, R¿3?, R¿4?, R¿5?, R¿6? et R¿8? représentent, de manière indépendante, un hydrogène ou un alkyle, X représente un soufre, un oxygène ou NR¿7?, la définition de R¿8? étant donnée dans le descriptif, m est un nombre entier dont la valeur est choisie entre 0, 1 ou 2, Ar représente un groupe aryle ou hétéroaryle comme défini dans le descriptif. Ces composés se révèlent des plus utiles pour le traitement et/ou la prévention de troubles neuropsychologiques, notamment mais sans se limiter à cette énumération, la schizophrénie, la manie, la démence, la dépression, l'anxiété, le comportement compulsif, l'abus de substances intoxicantes, les désordres moteurs du type maladie de Parkinson et les troubles du mouvement liés à l'utilisation d'agents neuroleptiques.
CA002345944A 1998-09-30 1999-09-30 Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine Abandoned CA2345944A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16357398A 1998-09-30 1998-09-30
US09/163,573 1998-09-30
PCT/US1999/022791 WO2000018767A2 (fr) 1998-09-30 1999-09-30 Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine

Publications (1)

Publication Number Publication Date
CA2345944A1 true CA2345944A1 (fr) 2000-04-06

Family

ID=22590612

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002345944A Abandoned CA2345944A1 (fr) 1998-09-30 1999-09-30 Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine

Country Status (7)

Country Link
EP (1) EP1117663A2 (fr)
JP (1) JP2002525373A (fr)
CN (1) CN1325397A (fr)
AU (1) AU6280199A (fr)
CA (1) CA2345944A1 (fr)
HK (1) HK1038749A1 (fr)
WO (1) WO2000018767A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU96502A (sh) 2000-06-21 2006-01-16 F. Hoffmann-La Roche Ag. Derivati benzotiazola
US6713499B2 (en) 2001-12-12 2004-03-30 Hoffman-La Roche Inc. 7-Amino-benzothiazole derivatives
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
TW200400035A (en) 2002-03-28 2004-01-01 Glaxo Group Ltd Novel compounds
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
WO2005021547A2 (fr) * 2003-08-28 2005-03-10 Pharmaxis Pty Ltd. Nouveaux agonistes des recepteurs cannabinoides cb2 et utilisations desdits agonistes
JP2007509095A (ja) * 2003-10-24 2007-04-12 エフ．ホフマン−ラ　ロシュ　アーゲー Ｃｃｒ３受容体アンタゴニスト
JP4668265B2 (ja) 2004-05-24 2011-04-13 エフ．ホフマン−ラ ロシュ アーゲー ４−ヒドロキシ−４−メチル−ピペリジン−１−カルボン酸（４−メトキシ−７−モルホリン−４−イル−ベンゾチアゾール−２−イル）−アミド
FR2877005A1 (fr) 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
DE602005008095D1 (de) 2004-11-05 2008-08-21 Hoffmann La Roche Verfahren zur herstellung von isonikotinsäurederivaten
SI1863818T1 (sl) 2005-03-23 2010-05-31 Hoffmann La Roche Derivati acetilenil pirazolo pirimidina kot antagonisti mglur
ATE463495T1 (de) 2005-09-27 2010-04-15 Hoffmann La Roche Oxadiazolylpyrazolopyrimidine als mglur2- antagonisten
PT2938597T (pt) 2012-12-27 2016-12-09 Université De Lille 2 Droit Et Santé Sais sulfato de n-(3-(4-(3-(isobutilamino)propil)-piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amina, sua preparação e sua utilização
CN105753811A (zh) * 2016-03-31 2016-07-13 湖南工程学院 一种多巴胺d4受体配基及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
WO1996039403A1 (fr) * 1995-06-05 1996-12-12 Neurogen Corporation 1(-n'-(arylalkylaminoalkyle)) aminoisoindoles utilises en tant que ligands de recepteurs de dopamine
TW593290B (en) * 1996-05-10 2004-06-21 Janssen Pharmaceutica Nv Alkylaminobenzothiazole and -benzoxazole derivatives
AU8296998A (en) * 1997-06-13 1998-12-30 Neurogen Corporation 2-aminoalkylaminoquinolines as dopamine d4 ligands
EP1027347A2 (fr) * 1997-10-31 2000-08-16 Neurogen Corporation 3-aminoalkylamino- 2h-1,4-benzoxazines et 3-aminoalkylamino- 2h-1,4-benzothiazines constituant des ligands specifiques d'un sous-type de recepteur de la dopamine

Also Published As

Publication number Publication date
HK1038749A1 (zh) 2002-03-28
EP1117663A2 (fr) 2001-07-25
AU6280199A (en) 2000-04-17
WO2000018767A2 (fr) 2000-04-06
WO2000018767A3 (fr) 2000-07-27
CN1325397A (zh) 2001-12-05
WO2000018767A9 (fr) 2001-04-19
JP2002525373A (ja) 2002-08-13

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Legal Events

Date Code Title Description
FZDE Discontinued