CA2345944A1 - Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine - Google Patents

Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine Download PDF

Info

Publication number
CA2345944A1
CA2345944A1 CA002345944A CA2345944A CA2345944A1 CA 2345944 A1 CA2345944 A1 CA 2345944A1 CA 002345944 A CA002345944 A CA 002345944A CA 2345944 A CA2345944 A CA 2345944A CA 2345944 A1 CA2345944 A1 CA 2345944A1
Authority
CA
Canada
Prior art keywords
piperazine
aminoethyl
alkyl
fluorobenzothiazol
methoxyphenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002345944A
Other languages
English (en)
Inventor
Xiao-Shu He
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Neurogen Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2345944A1 publication Critical patent/CA2345944A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Cette invention a trait à des composés correspondant à la formule (I) ou à leurs sels acceptables du point de vue pharmaceutique. Dans cette formule, A représente un alkylène substitué ou non, R¿1? et R¿2? sont identiques ou différents et représentent un hydrogène, un halogène, un alkyle, un alcoxy, un alkylthio, un hydroxy, un amino, substitué ou non, un cyano, un nitro, un sulfonamide, un trifluorométhyle ou un trifluorométhoxy, R¿3?, R¿4?, R¿5?, R¿6? et R¿8? représentent, de manière indépendante, un hydrogène ou un alkyle, X représente un soufre, un oxygène ou NR¿7?, la définition de R¿8? étant donnée dans le descriptif, m est un nombre entier dont la valeur est choisie entre 0, 1 ou 2, Ar représente un groupe aryle ou hétéroaryle comme défini dans le descriptif. Ces composés se révèlent des plus utiles pour le traitement et/ou la prévention de troubles neuropsychologiques, notamment mais sans se limiter à cette énumération, la schizophrénie, la manie, la démence, la dépression, l'anxiété, le comportement compulsif, l'abus de substances intoxicantes, les désordres moteurs du type maladie de Parkinson et les troubles du mouvement liés à l'utilisation d'agents neuroleptiques.
CA002345944A 1998-09-30 1999-09-30 Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine Abandoned CA2345944A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US16357398A 1998-09-30 1998-09-30
US09/163,573 1998-09-30
PCT/US1999/022791 WO2000018767A2 (fr) 1998-09-30 1999-09-30 Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine

Publications (1)

Publication Number Publication Date
CA2345944A1 true CA2345944A1 (fr) 2000-04-06

Family

ID=22590612

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002345944A Abandoned CA2345944A1 (fr) 1998-09-30 1999-09-30 Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine

Country Status (7)

Country Link
EP (1) EP1117663A2 (fr)
JP (1) JP2002525373A (fr)
CN (1) CN1325397A (fr)
AU (1) AU6280199A (fr)
CA (1) CA2345944A1 (fr)
HK (1) HK1038749A1 (fr)
WO (1) WO2000018767A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA02012596A (es) 2000-06-21 2003-04-10 Hoffmann La Roche Derivados de benzotiazol.
US6713499B2 (en) * 2001-12-12 2004-03-30 Hoffman-La Roche Inc. 7-Amino-benzothiazole derivatives
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
TW200400035A (en) 2002-03-28 2004-01-01 Glaxo Group Ltd Novel compounds
US7087761B2 (en) 2003-01-07 2006-08-08 Hoffmann-La Roche Inc. Cyclization process for substituted benzothiazole derivatives
WO2005021547A2 (fr) * 2003-08-28 2005-03-10 Pharmaxis Pty Ltd. Nouveaux agonistes des recepteurs cannabinoides cb2 et utilisations desdits agonistes
MXPA06004304A (es) * 2003-10-24 2006-06-05 Hoffmann La Roche Antagonistas del receptor ccr-3.
JP4668265B2 (ja) 2004-05-24 2011-04-13 エフ．ホフマン−ラ ロシュ アーゲー ４−ヒドロキシ−４−メチル−ピペリジン−１−カルボン酸（４−メトキシ−７−モルホリン−４−イル−ベンゾチアゾール−２−イル）−アミド
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
ATE400557T1 (de) 2004-11-05 2008-07-15 Hoffmann La Roche Verfahren zur herstellung von isonikotinsäurederivaten
MX2007011483A (es) 2005-03-23 2007-10-12 Hoffmann La Roche Derivados de acetilenil-pirazolo-pirimidina como antagonistas de glutamato metabotropico 2.
CA2623721C (fr) 2005-09-27 2014-05-13 F. Hoffmann-La Roche Ag Oxadiazolylpyrazolopyrimidines en tant qu'antagonistes de mglur2
LT2938597T (lt) * 2012-12-27 2017-01-25 Alzprotect N-(3-(4-(3-(diizobutilamino)propil)piperazin-1-il)propil)-1h-benzo[d]imidazol-2-amino sulfatinės druskos, jų paruošimas ir panaudojimas
CN105753811A (zh) * 2016-03-31 2016-07-13 湖南工程学院 一种多巴胺d4受体配基及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9306578D0 (en) * 1993-03-30 1993-05-26 Merck Sharp & Dohme Therapeutic agents
AU5982696A (en) * 1995-06-05 1996-12-24 Neurogen Corporation 1-(n'-(arylalkylaminoalkyl)) aminoisoindoles as dopamine rec eptor ligands
TW593290B (en) * 1996-05-10 2004-06-21 Janssen Pharmaceutica Nv Alkylaminobenzothiazole and -benzoxazole derivatives
WO1998056786A1 (fr) * 1997-06-13 1998-12-17 Neurogen Corporation 2-aminoalkylaminoquinoleines utilisees comme ligands de la dopamine d¿4?
CA2307905A1 (fr) * 1997-10-31 1999-05-14 Neurogen Corporation 3-aminoalkylamino- 2h-1,4-benzoxazines et 3-aminoalkylamino- 2h-1,4-benzothiazines constituant des ligands specifiques d'un sous-type de recepteur de la dopamine

Also Published As

Publication number Publication date
WO2000018767A9 (fr) 2001-04-19
WO2000018767A3 (fr) 2000-07-27
HK1038749A1 (zh) 2002-03-28
JP2002525373A (ja) 2002-08-13
EP1117663A2 (fr) 2001-07-25
WO2000018767A2 (fr) 2000-04-06
AU6280199A (en) 2000-04-17
CN1325397A (zh) 2001-12-05

Similar Documents

Publication Publication Date Title
US6432958B1 (en) 2-piperazinoalkylaminobenzoazole derivatives: dopamine receptor subtype specific ligands
US5159083A (en) Certain aminomethyl phenylimidazole derivatives; a class of dopamine receptor subtype specific ligands
US6281218B1 (en) Benzimidazolone derivatives having mixed serotonin and dopamine receptors affinity
CA2345944A1 (fr) Derives de 2-piperazino -alkyl- aminobenzoazole: ligands specifiques du sous-type du recepteur de la dopamine
CZ415999A3 (cs) Derivát cyklického diaminu a farmaceutický prostředek, který ho obsahuje
AU2006292429A1 (en) Carbazole derivatives
US6245768B1 (en) 1-(N′-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands
EP0623620B1 (fr) Dérivés de pyrrolopyrazines à activité 5-HT3
CA2307905A1 (fr) 3-aminoalkylamino- 2h-1,4-benzoxazines et 3-aminoalkylamino- 2h-1,4-benzothiazines constituant des ligands specifiques d'un sous-type de recepteur de la dopamine
EP1020451B1 (fr) Composes anilide et medicaments les contenant
US5602168A (en) 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; dopamine receptor subtype specific ligands
US6288230B1 (en) 2-(2, 3-dihydrobenzofuran-5-yl)-4-aminomethylimidazoles: dopamine receptor subtype specific ligands
US5744472A (en) 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands
US6100255A (en) 3-aminoalkylamino-2H-1,4-benzoxazines and 3-aminoalkylamino-2H-1,4-benzothiazines: dopamine receptor subtype specific ligands
US6211366B1 (en) Bridged 4-phenyl-2-aminomethylimidazoles
US5932729A (en) 1-(N'-(arylalkylaminoalkyl)) aminoisoindoles; a new class of dopamine receptor subtype specific ligands
US6291463B1 (en) 1-(Benzothiazol-2-yl)-4-(1-phenylmethyl) piperazines: dopamine receptor subtype specific ligands
CZ2006779A3 (cs) Piperazinové deriváty alkyloxindolu
CA2293480A1 (fr) 2-aminoalkylaminoquinoleines utilisees comme ligands de la dopamine d4
US6166205A (en) 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands
WO1999064396A1 (fr) 1-aryl-3-benzylaminopyrrolidine substitue: ligands specifiques aux sous-types des recepteurs de dopamine
August 2-piperazinoalkylaminobenzoazole derivatives: dopamine receptor subtype specific ligands
EP0573360B1 (fr) Composés pyrrolothiénopyraziniques comme antagonistes des récepteurs 5-HT3
AU4832699A (en) 1-(benzothiazol-2-yl)-4-(1-phenylmethyl)piperazines: dopamine receptor subtype specific ligands
WO2000012500A2 (fr) 2-aryl-4-[4-heteroaryl]piperazin-1-yl methylimidazoles: ligands pour le sous-type de recepteur d4 de la dopamine

Legal Events

Date Code Title Description
FZDE Discontinued