CA2344762C - Epreuves permettant une evaluation rapide d'etats ischemiques et necessaires a cet effet - Google Patents

Epreuves permettant une evaluation rapide d'etats ischemiques et necessaires a cet effet Download PDF

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Publication number
CA2344762C
CA2344762C CA002344762A CA2344762A CA2344762C CA 2344762 C CA2344762 C CA 2344762C CA 002344762 A CA002344762 A CA 002344762A CA 2344762 A CA2344762 A CA 2344762A CA 2344762 C CA2344762 C CA 2344762C
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CA
Canada
Prior art keywords
albumin
solid support
metal
ala
naturally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002344762A
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English (en)
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CA2344762A1 (fr
Inventor
David Bar-Or
Edward Lau
James V. Winkler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ischemia Technologies Inc
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Ischemia Technologies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/165,926 external-priority patent/US6461875B1/en
Priority claimed from US09/165,581 external-priority patent/US6492179B1/en
Application filed by Ischemia Technologies Inc filed Critical Ischemia Technologies Inc
Priority claimed from PCT/US1999/022905 external-priority patent/WO2000020840A1/fr
Publication of CA2344762A1 publication Critical patent/CA2344762A1/fr
Application granted granted Critical
Publication of CA2344762C publication Critical patent/CA2344762C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842—Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Cette invention a trait à des méthodes permettant de détecter rapidement des états ischémiques ainsi qu'aux nécessaires utilisés à cet effet. Elle concerne également une méthode rapide de recherche et de quantification de l'ischémie, reposant sur des techniques de détection et de quantification de l'existence d'une modification de la sérumalbumine protéique survenant après une manifestation ischémique. Ces techniques de détection et de quantification consistent à évaluer et à quantifier la capacité de fixation du cobalt de l'albumine circulante, à analyser et à évaluer la capacité de la sérumalbumine à fixer du cobalt exogène, à détecter et à évaluer la présence de cuivre endogène dans un prélèvement d'albumine purifiée et à utiliser un dosage immunologique spécifique de la forme altérée de la sérumalbumine, forme découlant d'une manifestation ischémique. Cette invention porte, en outre, sur la détection et la mesure d'une manifestation ischémique par mesure de dérivés d'albumine à N-terminus se manifestant à la suite d'une manifestation ischémique, y compris des espèces tronquées d'albumine dépourvues de un à quatre acides aminés N-terminus ou de l'albumine porteuse d'un reste d'acide aspartique (Asp) N-terminus acétylé.
CA002344762A 1998-10-02 1999-10-01 Epreuves permettant une evaluation rapide d'etats ischemiques et necessaires a cet effet Expired - Fee Related CA2344762C (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US10273898P 1998-10-02 1998-10-02
US09/165,581 1998-10-02
US09/165,926 US6461875B1 (en) 1998-10-02 1998-10-02 Test for rapid evaluation of ischemic states and kit
US09/165,581 US6492179B1 (en) 1998-10-02 1998-10-02 Test for rapid evaluation of ischemic states and kit
US09/165,926 1998-10-02
US60/102,738 1998-10-02
US11539299P 1999-01-11 1999-01-11
US60/115,392 1999-01-11
PCT/US1999/022905 WO2000020840A1 (fr) 1998-10-02 1999-10-01 Epreuves permettant une evaluation rapide d'etats ischemiques et necessaires a cet effet

Publications (2)

Publication Number Publication Date
CA2344762A1 CA2344762A1 (fr) 2000-04-13
CA2344762C true CA2344762C (fr) 2008-12-23

Family

ID=27493289

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002344762A Expired - Fee Related CA2344762C (fr) 1998-10-02 1999-10-01 Epreuves permettant une evaluation rapide d'etats ischemiques et necessaires a cet effet

Country Status (4)

Country Link
EP (1) EP1125107A4 (fr)
JP (1) JP2002526764A (fr)
AU (1) AU769727B2 (fr)
CA (1) CA2344762C (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1571970T3 (da) * 2002-10-02 2011-11-28 Dmi Biosciences Inc Diagnose og monitorering af sygdomme
CN101261270B (zh) * 2007-03-09 2012-11-07 中国人民解放军军事医学科学院微生物流行病研究所 一种免疫层析多重检测试纸盘及免疫层析多重检测方法
EP1983345A1 (fr) * 2007-04-17 2008-10-22 Roche Diagnostics GmbH Moyen et procédé pour l'évaluation du risque d'une intervention cardiaque chez des patients souffrant d'une maladie cardiaque coronarienne stable basés sur le GDF-15
US11169159B2 (en) * 2017-07-03 2021-11-09 Abbott Laboratories Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood
CN110132872A (zh) * 2019-06-14 2019-08-16 湖北科艾乐检测科技有限公司 一种灌溉水水体重金属检测方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4492753A (en) * 1982-10-06 1985-01-08 Immudx, Inc. Method and means for assessment and prediction of risk of subsequent ischemic cardiac events
US5227307A (en) * 1991-07-26 1993-07-13 Diagnostic Markers, Inc. Test for the rapid evaluation of ischemic state
WO2000020454A1 (fr) * 1998-10-02 2000-04-13 Diagnostic Markers, Inc. Procedes et substances pour detecter et mesurer les lesions provoquees par des radicaux libres

Also Published As

Publication number Publication date
JP2002526764A (ja) 2002-08-20
AU769727B2 (en) 2004-02-05
EP1125107A1 (fr) 2001-08-22
CA2344762A1 (fr) 2000-04-13
EP1125107A4 (fr) 2002-04-17
AU6409599A (en) 2000-04-26

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