CA2341177A1 - Procede d'immunotherapie contre les infections staphylococciques comprenant la selection des donneurs et la stimulation des donneurs - Google Patents
Procede d'immunotherapie contre les infections staphylococciques comprenant la selection des donneurs et la stimulation des donneurs Download PDFInfo
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- CA2341177A1 CA2341177A1 CA002341177A CA2341177A CA2341177A1 CA 2341177 A1 CA2341177 A1 CA 2341177A1 CA 002341177 A CA002341177 A CA 002341177A CA 2341177 A CA2341177 A CA 2341177A CA 2341177 A1 CA2341177 A1 CA 2341177A1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
On décrit un procédé et une composition d'immunisation passive de patients contaminés ou susceptibles d'être infectés par des bactéries de Staphylococcus tels que le S. aureus et S. epidermidis . Le procédé consiste à sélectionner ou à préparer un pool de plasma donneur ayant un taux élevé d'anticorps destiné à des adhésines de Staphylococcus ou à des constituants de surface de microbe reconnaissant les molécules matricielles adhésives (MSCRAMM) soigneusement sélectionnés, ou bien à des fragments ou des à constituants de ces derniers, ou encore à des séquences présentant une homologie substantielle avec ces derniers. Le pool de plasma donneur peut être préparé par combinaison de sang individuel ou d'échantillons de composants sanguins possédant un taux d'anticorps supérieurs à la normale par rapport à une ou plusieurs des adhésines sélectionnées ou à d'autres protéines qui se lient à des protéines de matrices extracellulaires, ou au moyen de l'administration de protéines ou de peptides soigneusement sélectionnés à un hôte en vue d'induire l'expression d'anticorps désirés, suivie de la récupération du pool de plasma ou de sérum à taux élevé accru chez l'hôte. Dans tous les cas, le pool de plasma donneur est de préférence purifié et concentré avant son introduction par voie veineuse dans le patient, et la présente invention présente un intérêt du fait qu'un patient peut être immunisé contre une grande variété d'infections par staphylocoque potentiellement dangereuses. Des kits permettant d'identifier des donneurs potentiels ayant des taux élevés des adhésines sélectionnées sont également décrits. La présente invention concerne par conséquent des procédés et des compositions qui sont très efficaces contre les infections associées aux bactéries de Staphylococcus.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9844998P | 1998-08-31 | 1998-08-31 | |
| US60/098,449 | 1998-08-31 | ||
| PCT/US1999/019729 WO2000012132A1 (fr) | 1998-08-31 | 1999-08-31 | Procede d'immunotherapie contre les infections staphylococciques comprenant la selection des donneurs et la stimulation des donneurs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2341177A1 true CA2341177A1 (fr) | 2000-03-09 |
Family
ID=22269332
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002341177A Abandoned CA2341177A1 (fr) | 1998-08-31 | 1999-08-31 | Procede d'immunotherapie contre les infections staphylococciques comprenant la selection des donneurs et la stimulation des donneurs |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1121149A4 (fr) |
| JP (1) | JP2002523474A (fr) |
| AU (1) | AU762978B2 (fr) |
| CA (1) | CA2341177A1 (fr) |
| NO (1) | NO20010981L (fr) |
| WO (1) | WO2000012132A1 (fr) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7128919B2 (en) * | 2000-08-08 | 2006-10-31 | St. Jude Children's Research Hospital | Group B streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof |
| US7892552B2 (en) | 2001-08-08 | 2011-02-22 | University Of Utah Research Foundation | Group B Streptococcus polypeptides nucleic acids and therapeutic compositions and vaccines thereof |
| IL157041A0 (en) | 2001-01-26 | 2004-02-08 | Inhibitex Inc | Monoclonal antibodies to the clfa protein and method of use in treating and preventing infections |
| EP2339344A1 (fr) * | 2001-06-15 | 2011-06-29 | Inhibitex, Inc. | Anticorps monoclonaux et polyclonaux à réaction croisée qui reconnaissent des protéines de surface de staphylocoques à coagulase négative et de staphylocoques dores |
| EP1804833A2 (fr) | 2004-09-22 | 2007-07-11 | GlaxoSmithKline Biologicals SA | Compositions immunogenes de staphylocoques |
| GB0526038D0 (en) | 2005-12-21 | 2006-02-01 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| EP2476433A1 (fr) | 2006-03-30 | 2012-07-18 | GlaxoSmithKline Biologicals S.A. | Composition immunogène |
| US9181329B2 (en) | 2007-08-31 | 2015-11-10 | The University Of Chicago | Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions |
| EP2666784B1 (fr) | 2007-08-31 | 2017-04-05 | University Of Chicago | Méthodes et compositions associées à l'immunisation contre des maladies et d'affections pulmonaires staphylococciques |
| US8758765B2 (en) | 2008-07-29 | 2014-06-24 | The University Of Chicago | Compositions and methods related to Staphylococcal bacterium proteins |
| WO2010085590A1 (fr) | 2009-01-23 | 2010-07-29 | Biosynexus Incorporated | Anticorps opsoniques et protecteurs spécifiques de bactéries à gram positifs à acide lipotéichoïque |
| AU2010271116B2 (en) | 2009-04-03 | 2015-08-13 | University Of Chicago | Compositions and methods related to Protein A (SpA) variants |
| NZ616921A (en) | 2009-07-15 | 2015-06-26 | Genentech Inc | Gram-positive bacteria specific binding compounds |
| GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
| US8808699B2 (en) | 2010-04-05 | 2014-08-19 | The University Of Chicago | Compositions and methods related to protein A (SpA) antibodies as an enhancer of immune response |
| ES2655701T3 (es) | 2010-07-02 | 2018-02-21 | The University Of Chicago | Composiciones y métodos relacionados con variantes de la proteína A (SpA) |
| JP5793194B2 (ja) * | 2010-09-09 | 2015-10-14 | ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ | 感染防御ブドウ球菌抗原が関与する方法および組成物 |
| US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
| CA2845259A1 (fr) | 2011-08-15 | 2013-02-21 | The University Of Chicago | Compositions et procedes lies aux anticorps anti-proteine a du staphylocoque |
| ES2806945T3 (es) | 2012-04-26 | 2021-02-19 | Univ Chicago | Antígenos de coagulasa estafilocócica y métodos para su uso |
| CA2910320A1 (fr) | 2012-04-26 | 2013-10-31 | University Of Chicago | Compositions et procedes associes a des anticorps qui neutralisent l'activite coagulase dans une maladie a staphylococcus aureus |
| GB201310008D0 (en) | 2013-06-05 | 2013-07-17 | Glaxosmithkline Biolog Sa | Immunogenic composition for use in therapy |
| MX2016007533A (es) | 2013-12-09 | 2016-12-14 | Univ New York | Composiciones y metodos para el suministro fagocitico de agentes anti-estafilococicos. |
| RU2558114C1 (ru) * | 2014-01-23 | 2015-07-27 | Федеральное государственное бюджетное военное образовательное учреждение высшего профессионального образования Военно-медицинская академия им. С.М. Кирова Министерства обороны Российской Федерации (ВМедА) | Способ отбора доноров для получения плазмы крови, эффективной при лечении пациентов с инфекционными заболеваниями и осложнениями после оперативных вмешательств, травм и ожогов |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| RU2601372C2 (ru) * | 2014-11-17 | 2016-11-10 | Федеральное государственное бюджетное военное образовательное учреждение высшего профессионального образования Военно-медицинская академия им. С.М. Кирова Министерства обороны Российской Федерации (ВМедА) | Способ отбора доноров крови для получения плазмы с целью лечения пациентов с инфекционными заболеваниями и осложнениями после оперативных вмешательств, травм и ожогов |
| MX2017007652A (es) | 2014-12-10 | 2017-10-11 | Glaxosmithkline Biologicals Sa | Metodo de tratamiento. |
| RU2606377C1 (ru) * | 2015-10-12 | 2017-01-10 | Федеральное государственное бюджетное военное образовательное учреждение высшего профессионального образования Военно-медицинская академия им. С.М. Кирова Министерства обороны Российской Федерации (ВМедА) | Способ отбора образцов крови доноров с повышенным содержанием дефензинов для получения моноиммунной плазмы крови |
| US11214600B2 (en) | 2016-02-12 | 2022-01-04 | The University Of Chicago | Compositions and methods related to antibodies that neutralize coagulase activity during Staphylococcus aureus disease |
| RU2665170C2 (ru) * | 2016-12-08 | 2018-08-28 | Федеральное государственное бюджетное военное образовательное учреждение высшего образования Военно-медицинская академия им. С.М. Кирова Министерства обороны Российской Федерации (ВМедА) | Способ лечения пациентов с осложнениями внутригоспитальными инфекциями |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| WO2021067785A1 (fr) | 2019-10-02 | 2021-04-08 | Janssen Vaccines & Prevention B.V | Peptides de staphylococcus et procédés d'utilisation |
| CN111909279B (zh) * | 2020-08-14 | 2022-06-24 | 石河子大学 | 一种金黄色葡萄球菌与无乳链球菌免疫原融合表达及其应用 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK219084D0 (da) * | 1984-05-02 | 1984-05-02 | Frederik Carl Peter Lindberg | Antigen |
| ES2198405T3 (es) * | 1991-11-22 | 2004-02-01 | Nabi Biopharmaceuticals | Antigenos de superficie de tipo i asociados a staphylococcus epidermis. |
| EP0680337A4 (fr) * | 1993-01-12 | 1997-07-30 | Anthony George Gristina | Procedes et compositions pour application directe a forte concentration d'anticorps, produisant une immunite passive. |
| US5648240A (en) * | 1994-05-24 | 1997-07-15 | Texas A&M University | MHC II analog from Staphylococcus aureus |
| JP2001505061A (ja) * | 1996-02-29 | 2001-04-17 | ワシントン ユニヴァーシティ | バクテリア性エラスチン結合タンパク、これをコードする核酸配列およびこれを使用した診断並びに治療方法 |
| CA2255669A1 (fr) * | 1996-05-16 | 1997-11-20 | The Texas A & M University System | Compositions de proteine de liaison du collagene et procedes d'utilisation |
| SE9602496D0 (sv) * | 1996-06-20 | 1996-06-20 | Bengt Guss | Method and means for producing a fibrinogen binding protein and its use in biotechnology |
| CA2277793A1 (fr) * | 1997-01-21 | 1998-07-23 | The Texas A & M University System | Compositions de proteines se liant a la fibronectine et leurs procedes d'utilisation |
| CA2310217A1 (fr) * | 1997-11-26 | 1999-06-03 | Inhibitex, Inc. | Proteines liant la matrice extracellulaire issues du staphilococcus aureus |
| ATE422368T1 (de) * | 1998-08-31 | 2009-02-15 | Inhibitex Inc | Multikomponenten impfstoffe gegen staphylococcus aureus |
-
1999
- 1999-08-31 CA CA002341177A patent/CA2341177A1/fr not_active Abandoned
- 1999-08-31 AU AU56966/99A patent/AU762978B2/en not_active Ceased
- 1999-08-31 EP EP99943981A patent/EP1121149A4/fr not_active Withdrawn
- 1999-08-31 WO PCT/US1999/019729 patent/WO2000012132A1/fr active IP Right Grant
- 1999-08-31 JP JP2000567243A patent/JP2002523474A/ja active Pending
-
2001
- 2001-02-27 NO NO20010981A patent/NO20010981L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO20010981D0 (no) | 2001-02-27 |
| AU762978B2 (en) | 2003-07-10 |
| AU5696699A (en) | 2000-03-21 |
| JP2002523474A (ja) | 2002-07-30 |
| EP1121149A1 (fr) | 2001-08-08 |
| NO20010981L (no) | 2001-04-26 |
| EP1121149A4 (fr) | 2002-03-20 |
| WO2000012132A1 (fr) | 2000-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |