CA2340593C - Use of vegf-c or vegf-d gene or protein to prevent restenosis - Google Patents
Use of vegf-c or vegf-d gene or protein to prevent restenosis Download PDFInfo
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- CA2340593C CA2340593C CA2340593A CA2340593A CA2340593C CA 2340593 C CA2340593 C CA 2340593C CA 2340593 A CA2340593 A CA 2340593A CA 2340593 A CA2340593 A CA 2340593A CA 2340593 C CA2340593 C CA 2340593C
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- polypeptide
- polynucleotide
- vegf
- seq
- amino acid
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- 108010071207 serylmethionine Proteins 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000002741 site-directed mutagenesis Methods 0.000 description 1
- 210000002460 smooth muscle Anatomy 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- 239000012192 staining solution Substances 0.000 description 1
- 238000007619 statistical method Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000012353 t test Methods 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000001732 thrombotic effect Effects 0.000 description 1
- 239000003106 tissue adhesive Substances 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000029812 viral genome replication Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/82—Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Surgery (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Materials For Medical Uses (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10558798P | 1998-10-26 | 1998-10-26 | |
| US60/105,587 | 1998-10-26 | ||
| PCT/US1999/024054 WO2000024412A2 (en) | 1998-10-26 | 1999-10-26 | Use of vegf-c or vegf-d gene or protein to prevent restenosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2340593A1 CA2340593A1 (en) | 2000-05-04 |
| CA2340593C true CA2340593C (en) | 2012-05-08 |
Family
ID=22306672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2340593A Expired - Fee Related CA2340593C (en) | 1998-10-26 | 1999-10-26 | Use of vegf-c or vegf-d gene or protein to prevent restenosis |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP1126870B1 (enExample) |
| JP (2) | JP4769929B2 (enExample) |
| CN (1) | CN1338943A (enExample) |
| AT (1) | ATE275417T1 (enExample) |
| AU (1) | AU768330B2 (enExample) |
| CA (1) | CA2340593C (enExample) |
| DE (1) | DE69920031T2 (enExample) |
| ES (1) | ES2229788T3 (enExample) |
| NO (1) | NO20012017L (enExample) |
| NZ (1) | NZ510121A (enExample) |
| PT (1) | PT1126870E (enExample) |
| WO (1) | WO2000024412A2 (enExample) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818220B1 (en) | 1994-11-14 | 2004-11-16 | Licentia Ltd. | Vascular endothelial growth factor C (VEGF-C) protein and gene mutants thereof, and uses thereof |
| US7727761B2 (en) | 1995-08-01 | 2010-06-01 | Vegenics Limited | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
| US6361946B1 (en) | 1997-02-05 | 2002-03-26 | Licentia Ltd | Vascular endothelial growth factor C (VEGF-C) protein and gene, mutants thereof, and uses thereof |
| US7125714B2 (en) | 1997-02-05 | 2006-10-24 | Licentia Ltd. | Progenitor cell materials and methods |
| US7223724B1 (en) | 1999-02-08 | 2007-05-29 | Human Genome Sciences, Inc. | Use of vascular endothelial growth factor to treat photoreceptor cells |
| JP4981229B2 (ja) | 2000-02-25 | 2012-07-18 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | ハイブリッド血管内皮成長因子ＤＮＡｓおよびタンパク質に関与する物質および方法 |
| AU2001268149B2 (en) * | 2000-06-01 | 2005-08-18 | University Of North Carolina At Chapel Hill | Methods and compounds for controlled release of recombinant parvovirus vectors |
| TWI257307B (en) | 2000-07-12 | 2006-07-01 | Orthologic Corp | Pharmaceutical composition for cardiac tissue repair |
| MXPA02003434A (es) | 2000-08-04 | 2002-09-02 | Human Genome Sciences Inc | Factor de crecimiento endotelial vascular 2. |
| DK2314293T3 (en) | 2001-01-16 | 2017-04-18 | Vascular Therapies Llc | IMPLANTABLE DEVICE CONTAINING RESORBABLE MATERIAL MATERIAL AND RAPAMYCINE FOR PREVENTION OR TREATMENT OF VASCULOPROLIFERATIVE DISEASES |
| MXPA03009408A (es) | 2001-04-13 | 2004-01-29 | Human Genome Sciences Inc | Factor de crecimiento endotelial vascular 2. |
| FI20010898A0 (fi) * | 2001-04-30 | 2001-04-30 | Ylae Herttuala Seppo | Ekstrasellulaarinen superoksididismutaasi (EC-SOD) geeniterapia restenoosoin ehkäisemiseksi |
| GB0120690D0 (en) | 2001-08-24 | 2001-10-17 | Novartis Ag | Organic compounds |
| BR0309676A (pt) * | 2002-04-30 | 2005-02-22 | Fit Biotech Oyl Plc | Dispositivo médico |
| PL195457B1 (pl) * | 2002-08-05 | 2007-09-28 | Zaklady Farm Polpharma Sa | Kaseta ekspresyjna, dwucistronowy wektor plazmidowy, środek farmaceutyczny oraz ich zastosowanie |
| US20070254956A1 (en) * | 2003-10-29 | 2007-11-01 | Koichi Shudo | Medicament for Therapeutic and/or Preventive Treatment of Restenosis or Reocclusion After Vascular Recanalization Operation |
| JP4832290B2 (ja) * | 2004-03-18 | 2011-12-07 | 健輔 江頭 | 薬剤・遺伝子溶出型ステント |
| EP1919944B1 (en) | 2005-08-15 | 2011-03-23 | Vegenics Pty Ltd | Modified vegf and pdgf with improved angiogenic properties |
| CA2663547C (en) | 2006-09-22 | 2020-08-25 | Orthologic Corp. | Method of treating endothelial dysfunction |
| JP2011512408A (ja) | 2008-02-19 | 2011-04-21 | セラドン・コーポレーション | 心筋層へのウイルスベクターの取り込みを増大させるための組成物 |
| CN101361988B (zh) * | 2008-09-12 | 2011-12-21 | 西南交通大学 | 一种具有生物相容性的血管支架或心脏瓣膜表面涂层的制备方法 |
| WO2012088563A1 (en) * | 2010-11-24 | 2012-07-05 | Vegenics Pty Limited | Vegfr-2-specific forms of vegf-d and vegf-c and uses thereof |
| CN108640994A (zh) * | 2018-06-28 | 2018-10-12 | 浙江众意生物科技有限公司 | 一种vegf-c单克隆抗体及试剂盒 |
| CA3131428A1 (en) * | 2019-03-29 | 2020-10-08 | Jerald Wayne CURRAN | Systems and methods for left ventricular unloading in biologic therapy or vectored gene therapy |
| CN119454907A (zh) * | 2025-01-09 | 2025-02-18 | 浙江大学 | Vegf-c156s在制备减轻静脉移植物狭窄的药物中的应用 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998033917A1 (en) * | 1994-11-14 | 1998-08-06 | The Ludwig Institute For Cancer Research | Vascular endothelial growth factor c (vegf-c) protein and gene, mutants thereof, and uses thereof |
| US5830879A (en) * | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
| DE69734359T2 (de) * | 1996-08-23 | 2006-07-06 | Ludwig Institute For Cancer Research | Rekombinanter vaskulärer endothelzellen wachstumsfaktor d (vegf-d) |
| US6013780A (en) * | 1996-09-06 | 2000-01-11 | Technion Research & Development Co. Ltd. | VEGF145 expression vectors |
| US5980887A (en) * | 1996-11-08 | 1999-11-09 | St. Elizabeth's Medical Center Of Boston | Methods for enhancing angiogenesis with endothelial progenitor cells |
| WO1998049300A2 (en) * | 1997-04-25 | 1998-11-05 | Collateral Therapeutics | Truncated vegf-related proteins |
-
1999
- 1999-10-26 AT AT99956559T patent/ATE275417T1/de not_active IP Right Cessation
- 1999-10-26 WO PCT/US1999/024054 patent/WO2000024412A2/en not_active Ceased
- 1999-10-26 JP JP2000578021A patent/JP4769929B2/ja not_active Expired - Fee Related
- 1999-10-26 AU AU13147/00A patent/AU768330B2/en not_active Ceased
- 1999-10-26 DE DE69920031T patent/DE69920031T2/de not_active Expired - Lifetime
- 1999-10-26 NZ NZ510121A patent/NZ510121A/xx unknown
- 1999-10-26 PT PT99956559T patent/PT1126870E/pt unknown
- 1999-10-26 CA CA2340593A patent/CA2340593C/en not_active Expired - Fee Related
- 1999-10-26 CN CN99812544A patent/CN1338943A/zh active Pending
- 1999-10-26 EP EP99956559A patent/EP1126870B1/en not_active Expired - Lifetime
- 1999-10-26 ES ES99956559T patent/ES2229788T3/es not_active Expired - Lifetime
-
2001
- 2001-04-24 NO NO20012017A patent/NO20012017L/no unknown
-
2011
- 2011-01-27 JP JP2011015549A patent/JP5231587B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5231587B2 (ja) | 2013-07-10 |
| WO2000024412A3 (en) | 2000-08-03 |
| EP1126870A2 (en) | 2001-08-29 |
| CN1338943A (zh) | 2002-03-06 |
| NO20012017D0 (no) | 2001-04-24 |
| NO20012017L (no) | 2001-06-26 |
| DE69920031D1 (de) | 2004-10-14 |
| AU768330B2 (en) | 2003-12-11 |
| DE69920031T2 (de) | 2005-09-22 |
| PT1126870E (pt) | 2005-01-31 |
| NZ510121A (en) | 2003-02-28 |
| WO2000024412A2 (en) | 2000-05-04 |
| EP1126870B1 (en) | 2004-09-08 |
| ATE275417T1 (de) | 2004-09-15 |
| JP2002528420A (ja) | 2002-09-03 |
| AU1314700A (en) | 2000-05-15 |
| JP4769929B2 (ja) | 2011-09-07 |
| CA2340593A1 (en) | 2000-05-04 |
| ES2229788T3 (es) | 2005-04-16 |
| JP2011173874A (ja) | 2011-09-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20141027 |