CA2340589A1 - Marqueurs de reaction toxicologique - Google Patents

Marqueurs de reaction toxicologique Download PDF

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Publication number
CA2340589A1
CA2340589A1 CA002340589A CA2340589A CA2340589A1 CA 2340589 A1 CA2340589 A1 CA 2340589A1 CA 002340589 A CA002340589 A CA 002340589A CA 2340589 A CA2340589 A CA 2340589A CA 2340589 A1 CA2340589 A1 CA 2340589A1
Authority
CA
Canada
Prior art keywords
nucleic acid
dna
molecule
molecules
misc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002340589A
Other languages
English (en)
Inventor
Mary Jane Cunningham
Gary B. Zweiger
Scott R. Panzer
Jeffrey J. Seilhamer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Incyte Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/141,825 external-priority patent/US6403778B1/en
Priority claimed from US09/172,711 external-priority patent/US6160105A/en
Priority claimed from US09/172,108 external-priority patent/US6160104A/en
Application filed by Individual filed Critical Individual
Publication of CA2340589A1 publication Critical patent/CA2340589A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

L'invention concerne une composition comprenant plusieurs molécules d'acides nucléiques. La composition peut être utilisée sous la forme d'éléments hybridables d'un jeu ordonné de microéchantillons. La présente invention concerne aussi des procédés pour cribler des composés et des agents thérapeutiques à la recherche de réactions métaboliques indiquant la présence d'un composé toxique.
CA002340589A 1998-08-28 1999-08-27 Marqueurs de reaction toxicologique Abandoned CA2340589A1 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US09/141,825 US6403778B1 (en) 1998-05-04 1998-08-28 Toxicological response markers
US09/141,825 1998-08-28
US09/172,711 1998-10-13
US09/172,711 US6160105A (en) 1998-10-13 1998-10-13 Monitoring toxicological responses
US09/172,108 US6160104A (en) 1998-10-13 1998-10-13 Markers for peroxisomal proliferators
US09/172,108 1998-10-13
PCT/US1999/019768 WO2000012760A2 (fr) 1998-08-28 1999-08-27 Marqueurs de reaction toxicologique

Publications (1)

Publication Number Publication Date
CA2340589A1 true CA2340589A1 (fr) 2000-03-09

Family

ID=27385714

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002340589A Abandoned CA2340589A1 (fr) 1998-08-28 1999-08-27 Marqueurs de reaction toxicologique

Country Status (5)

Country Link
EP (1) EP1108067A2 (fr)
JP (1) JP2002523112A (fr)
AU (1) AU6022299A (fr)
CA (1) CA2340589A1 (fr)
WO (1) WO2000012760A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6881571B1 (en) 1998-03-11 2005-04-19 Exonhit Therapeutics S.A. Qualitative differential screening
FR2798392B1 (fr) * 1999-09-13 2005-07-15 Exonhit Therapeutics Sa Marqueurs genetiques de la toxicite, preparation et utilisations
WO2002008453A2 (fr) * 2000-07-21 2002-01-31 Phase-1 Molecular Toxicology Genes canins de toxicite
US7590493B2 (en) 2000-07-31 2009-09-15 Ocimum Biosolutions, Inc. Methods for determining hepatotoxins
WO2002010453A2 (fr) * 2000-07-31 2002-02-07 Gene Logic, Inc. Modelisation en toxicologie moleculaire
EP1368499A2 (fr) * 2001-01-29 2003-12-10 Phase-1 Molecular Toxicology Inc. Genes de rats en rapport avec la toxicologie, et leurs utilisations
EP1392871A4 (fr) 2001-05-22 2006-04-19 Gene Logic Inc Modelisation en toxicologie moleculaire
US7447594B2 (en) 2001-07-10 2008-11-04 Ocimum Biosolutions, Inc. Molecular cardiotoxicology modeling
US20040241690A1 (en) * 2001-08-03 2004-12-02 Takayuki Souka Method of evaluating biocompatibility
WO2003018792A1 (fr) * 2001-08-24 2003-03-06 National Institute Of Advanced Industrial Science And Technology Procede de detection d'une substance toxique
US7469185B2 (en) 2002-02-04 2008-12-23 Ocimum Biosolutions, Inc. Primary rat hepatocyte toxicity modeling
EP1344834A3 (fr) * 2002-03-14 2004-06-02 F. Hoffmann-La Roche Ag Méthodes pour la prédiction de la toxicité d'un composé
GB0215509D0 (en) * 2002-07-04 2002-08-14 Novartis Ag Marker genes
JP2006512075A (ja) * 2002-12-31 2006-04-13 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー イヌｃｙｐ１ａ２配列

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6114114A (en) * 1992-07-17 2000-09-05 Incyte Pharmaceuticals, Inc. Comparative gene transcript analysis
WO1997013877A1 (fr) * 1995-10-12 1997-04-17 Lynx Therapeutics, Inc. Mesure de profils d'expression genique pour evaluer la toxicite

Also Published As

Publication number Publication date
WO2000012760A3 (fr) 2000-08-03
EP1108067A2 (fr) 2001-06-20
WO2000012760A2 (fr) 2000-03-09
JP2002523112A (ja) 2002-07-30
AU6022299A (en) 2000-03-21

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Legal Events

Date Code Title Description
FZDE Discontinued