CA2339858A1 - Traitement de tumeurs au moyen d'oligonucleotides agissant sur le recepteur du facteur de croissance insulunoide i - Google Patents
Traitement de tumeurs au moyen d'oligonucleotides agissant sur le recepteur du facteur de croissance insulunoide i Download PDFInfo
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- CA2339858A1 CA2339858A1 CA002339858A CA2339858A CA2339858A1 CA 2339858 A1 CA2339858 A1 CA 2339858A1 CA 002339858 A CA002339858 A CA 002339858A CA 2339858 A CA2339858 A CA 2339858A CA 2339858 A1 CA2339858 A1 CA 2339858A1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/13—Tumour cells, irrespective of tissue of origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/126—Immunoprotecting barriers, e.g. jackets, diffusion chambers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
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- C12N2310/00—Structure or type of the nucleic acid
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La présente invention concerne un procédé permettant d'induire une résistance à la croissance tumorale ou une régression de la croissance tumorale. Ce procédé consiste à prendre des cellules tumorales et à les mettre en culture in vitro ou ex vivo avec en supplément un agent proapoptotique pendant un certain temps. Le procédé consiste ensuite à transférer ces cellules tumorales dans une chambre de diffusion, produisant ainsi une chambre contenant les cellules. Le procédé consiste enfin à introduire chez l'homme cette chambre pendant une période de traitement suffisante, ce qui induit une résistance à la croissance tumorale ou une régression de la croissance tumorale.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9635498P | 1998-08-13 | 1998-08-13 | |
| US11359998P | 1998-12-24 | 1998-12-24 | |
| US60/096,354 | 1998-12-24 | ||
| US60/113,599 | 1998-12-24 | ||
| PCT/US1999/018306 WO2000009145A1 (fr) | 1998-08-13 | 1999-08-13 | Traitement de tumeurs au moyen d'oligonucleotides agissant sur le recepteur du facteur de croissance insulunoide i |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2339858A1 true CA2339858A1 (fr) | 2000-02-24 |
Family
ID=26791616
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002339858A Abandoned CA2339858A1 (fr) | 1998-08-13 | 1999-08-13 | Traitement de tumeurs au moyen d'oligonucleotides agissant sur le recepteur du facteur de croissance insulunoide i |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1105150A1 (fr) |
| JP (1) | JP2002522506A (fr) |
| AU (1) | AU5479899A (fr) |
| CA (1) | CA2339858A1 (fr) |
| WO (1) | WO2000009145A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR035885A1 (es) | 2001-05-14 | 2004-07-21 | Novartis Ag | Derivados de 4-amino-5-fenil-7-ciclobutilpirrolo (2,3-d)pirimidina, un proceso para su preparacion, una composicion farmaceutica y el uso de dichos derivados para la preparacion de una composicion farmaceutica |
| MX2017012982A (es) * | 2015-04-10 | 2018-07-06 | Univ Jefferson | Metodos y composiciones para tratar el cancer e incrementar la inmunidad terapeutica reduciendo selectivamente los monocitos m2 inmunomoduladores. |
| US20180256625A1 (en) * | 2017-03-09 | 2018-09-13 | Thomas Jefferson University | Methods and compositions for treating cancers using antisense |
| CA3057974A1 (fr) * | 2017-04-19 | 2018-10-25 | Bio-Path Holdings, Inc. | Acides nucleiques p-ethoxy destines a inhiber l'igf-1r |
| US20210403918A1 (en) * | 2018-11-02 | 2021-12-30 | Thomas Jefferson University | Methods and compositions for treating hepatocellular carcinoma using antisense |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5714170A (en) * | 1994-11-16 | 1998-02-03 | Thomas Jefferson University | Method of inducing resistance to tumor growth |
| JP2000500654A (ja) * | 1995-11-14 | 2000-01-25 | トーマス・ジェファーソン・ユニバーシティ | 可溶性ｉｇｆ−１受容体による腫瘍成長に対する誘導耐性 |
| US5958872A (en) * | 1996-04-01 | 1999-09-28 | Apoptosis Technology, Inc. | Active survival domains of IGF-IR and methods of use |
| WO1999023259A1 (fr) * | 1997-11-04 | 1999-05-14 | Inex Pharmaceutical Corporation | Composes antisens du recepteur du facteur de croissance de substances apparentees a l'insuline 1 |
-
1999
- 1999-08-13 JP JP2000564647A patent/JP2002522506A/ja active Pending
- 1999-08-13 AU AU54798/99A patent/AU5479899A/en not_active Abandoned
- 1999-08-13 EP EP99941078A patent/EP1105150A1/fr not_active Withdrawn
- 1999-08-13 WO PCT/US1999/018306 patent/WO2000009145A1/fr not_active Application Discontinuation
- 1999-08-13 CA CA002339858A patent/CA2339858A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1105150A1 (fr) | 2001-06-13 |
| WO2000009145A1 (fr) | 2000-02-24 |
| AU5479899A (en) | 2000-03-06 |
| JP2002522506A (ja) | 2002-07-23 |
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