CA2339404A1 - Immunogenes peptidiques de synthese et anticorps contre ces immunogenes - Google Patents

Immunogenes peptidiques de synthese et anticorps contre ces immunogenes Download PDF

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Publication number
CA2339404A1
CA2339404A1 CA002339404A CA2339404A CA2339404A1 CA 2339404 A1 CA2339404 A1 CA 2339404A1 CA 002339404 A CA002339404 A CA 002339404A CA 2339404 A CA2339404 A CA 2339404A CA 2339404 A1 CA2339404 A1 CA 2339404A1
Authority
CA
Canada
Prior art keywords
species
peptide
antibody
antibodies
target protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002339404A
Other languages
English (en)
Inventor
Marc Goldford
Mark X. Triscott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Aldrich Co LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2339404A1 publication Critical patent/CA2339404A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne des procédés permettant de sélectionner des immunogènes peptidiques pour une protéine cible issue d'une première espèce dont une séquence d'acide aminé est différente de la protéine analogue issue d'une seconde espèce. Le procédé consiste à sélectionner des fragments de peptide de la protéine cible qui soient hydrophiles et dont la séquence s'écarte de la séquence de la protéine analogue par au moins un acide aminé. L'invention concerne également des anticorps faits en utilisant les immunogènes sélectionnés conjugués à une molécule porteuse. L'invention concerne en outre des anticorps faits selon ce procédé sur un facteur tissulaire du lapin qui n'inter-réagit pas avec un facteur tissulaire humain.
CA002339404A 1999-06-30 2000-06-27 Immunogenes peptidiques de synthese et anticorps contre ces immunogenes Abandoned CA2339404A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14169999P 1999-06-30 1999-06-30
US60/141,699 1999-06-30
PCT/US2000/017609 WO2001000237A1 (fr) 1999-06-30 2000-06-27 Immunogenes peptidiques de synthese et anticorps contre ces immunogenes

Publications (1)

Publication Number Publication Date
CA2339404A1 true CA2339404A1 (fr) 2001-01-04

Family

ID=22496830

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002339404A Abandoned CA2339404A1 (fr) 1999-06-30 2000-06-27 Immunogenes peptidiques de synthese et anticorps contre ces immunogenes

Country Status (5)

Country Link
EP (1) EP1105158A1 (fr)
JP (1) JP2003503040A (fr)
AU (1) AU755574B2 (fr)
CA (1) CA2339404A1 (fr)
WO (1) WO2001000237A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2353637T3 (es) 1998-08-07 2011-03-03 Immunex Corporation Moléculas denominadas ldcam.
WO2001075086A2 (fr) * 2000-03-31 2001-10-11 Zymogenetics, Inc. Inhibiteur de proteinase a plusieurs domaines
MXPA06000974A (es) 2003-07-25 2006-08-31 Amgen Inc Antagonistas y agonistas de ldcam y metodos para su uso.
US20080234311A1 (en) * 2006-11-08 2008-09-25 Jinhe Li IMMUNOASSAY FOR DETECTION AND QUANTIFICATION OF AMYLOID-beta PEPTIDES
JP4597172B2 (ja) * 2007-08-29 2010-12-15 丸大食品株式会社 ウシミオグロビン部分ペプチドに対する抗体、及び当該抗体を用いた検査方法並びに検査用キット
US9580544B2 (en) 2010-03-18 2017-02-28 New Jersey Institute Of Technology Polyesters from asymetrical monomers based upon bisanhydrohexitols

Also Published As

Publication number Publication date
WO2001000237A9 (fr) 2002-05-02
WO2001000237A1 (fr) 2001-01-04
AU755574B2 (en) 2002-12-19
EP1105158A1 (fr) 2001-06-13
JP2003503040A (ja) 2003-01-28
AU6338400A (en) 2001-01-31

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