CA2339368A1 - Inhibition de la 3$g(a)-hydroxysteroid-deshydrogenase de type 3 - Google Patents
Inhibition de la 3$g(a)-hydroxysteroid-deshydrogenase de type 3 Download PDFInfo
- Publication number
- CA2339368A1 CA2339368A1 CA002339368A CA2339368A CA2339368A1 CA 2339368 A1 CA2339368 A1 CA 2339368A1 CA 002339368 A CA002339368 A CA 002339368A CA 2339368 A CA2339368 A CA 2339368A CA 2339368 A1 CA2339368 A1 CA 2339368A1
- Authority
- CA
- Canada
- Prior art keywords
- alpha
- inhibitor
- beta
- effective amount
- therapeutically effective
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
- A61K31/5685—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone having an oxo group in position 17, e.g. androsterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention porte sur de nouveaux procédés de traitement et/ou inhibition du développement du cancer de la prostate, de l'hyperplasie prostatique bénigne, des prostatites, de l'acné, de la séborrhée, de l'hirsutisme ou de l'alopécie masculine à l'aide de 3.alpha.-hydroxystéroid-déshydrogénase de type 3 seule ou combinée à d'autres produits pharmaceutiques actifs tels que les inhibiteurs 17.beta.-hydroxystéroid-déshydrogénase de type 5. L'invention porte également sur de nouveaux inhibiteurs et produits pharmaceutiques.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9562398P | 1998-08-07 | 1998-08-07 | |
US60/095,623 | 1998-08-07 | ||
PCT/CA1999/000724 WO2000007576A2 (fr) | 1998-08-07 | 1999-08-06 | INHIBITION DE LA 3$G(a)-HYDROXYSTEROID-DESHYDROGENASE DE TYPE 3 |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2339368A1 true CA2339368A1 (fr) | 2000-02-17 |
Family
ID=22252842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002339368A Abandoned CA2339368A1 (fr) | 1998-08-07 | 1999-08-06 | Inhibition de la 3$g(a)-hydroxysteroid-deshydrogenase de type 3 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1102582A2 (fr) |
JP (1) | JP2002522380A (fr) |
CN (1) | CN1322130A (fr) |
AR (1) | AR021757A1 (fr) |
AU (1) | AU5144999A (fr) |
CA (1) | CA2339368A1 (fr) |
ID (1) | ID28791A (fr) |
NO (1) | NO20010651L (fr) |
WO (1) | WO2000007576A2 (fr) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6995278B2 (en) * | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
WO2008124922A1 (fr) * | 2007-04-12 | 2008-10-23 | Endorecherche, Inc. | Stéroïdes 17-alpha-substitués utilisés comme anti-androgènes systémiques et modulateurs sélectifs du récepteur de l'androgène |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
EP1321146A3 (fr) * | 1998-03-11 | 2004-06-02 | Endorecherche Inc. | Inhibiteurs de la 17beta-hydroxysteroide deshydrogénase du type 5 et du type 3 ainsi que leurs méthodes d'utilisation |
US7087592B1 (en) | 1999-08-23 | 2006-08-08 | Entre Med, Inc. | Compositions comprising purified 2-methoxyestradiol and methods of producing same |
US6891953B1 (en) | 2000-06-27 | 2005-05-10 | Microsoft Corporation | Method and system for binding enhanced software features to a persona |
US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
AU2001288386B2 (en) * | 2000-11-27 | 2006-11-02 | Entremed, Inc. | 2-substituted estrogens as antiangiogenic agents |
US6710037B2 (en) * | 2001-05-01 | 2004-03-23 | Schering Corporation | Method of treating androgen-dependent disorders |
DE60239207D1 (de) * | 2001-08-10 | 2011-03-31 | Takeda Pharmaceutical | Gnrh-agonistische kombinationsmittel |
US7524866B2 (en) | 2001-11-29 | 2009-04-28 | Gtx, Inc. | Prevention and treatment of androgen—deprivation induced osteoporosis |
EP1574212A1 (fr) * | 2001-11-29 | 2005-09-14 | GTX Inc. | Prévention et traitement des maladies induite par la privation d'androgène |
WO2005089256A2 (fr) | 2004-03-12 | 2005-09-29 | Entremed, Inc. | Agents anti-angiogeniques |
US7419972B2 (en) | 2004-07-02 | 2008-09-02 | Schering Ag | 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 |
DE102004032674A1 (de) * | 2004-07-02 | 2006-01-26 | Schering Ag | Neue 2-substituierte Estra-1,3,5(10)-trien-17-one als Inhibitoren der 17β-Hydroxysteroiddehydrogenase Typ 1 |
AU2007227256B2 (en) | 2006-03-20 | 2012-10-04 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
AU2008292420A1 (en) * | 2007-08-31 | 2009-03-05 | Astellas Pharma Inc. | Piperidine derivative |
CN101698834B (zh) * | 2009-09-08 | 2012-05-23 | 北京利德曼生化股份有限公司 | 3α-羟基类固醇脱氢酶及其核苷酸序列、重组载体、重组宿主细胞和试剂盒 |
PE20150353A1 (es) * | 2012-07-10 | 2015-03-28 | Bayer Pharma AG | Derivados de estra-1,3,5(10),16-tetraeno 3-sustituidos, metodos para su preparacion, preparaciones farmaceuticas que los contienen, asi como su uso para la preparacion de medicamentos |
KR20150118153A (ko) * | 2013-02-21 | 2015-10-21 | 바이엘 파마 악티엔게젤샤프트 | 17.베타.-히드록시스테로이드 데히드로게나제 (akr1 c3)의 억제를 위한 에스트라-1,3,5(10),16-테트라엔-3-카르복스아미드 |
CN104873520A (zh) * | 2014-02-27 | 2015-09-02 | 天津药物研究院 | 一种11β-羟基类固醇脱氢酶抑制剂、药用组合物及其用途 |
CN104873525A (zh) * | 2014-02-27 | 2015-09-02 | 天津药物研究院 | 一种11β-羟基类固醇脱氢酶抑制剂及其药用组合物和用途 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3562260A (en) * | 1965-08-23 | 1971-02-09 | Ormonoterapia Richter Spa | 2-carbonyl-estratrienes and method of their preparation |
US4340602A (en) * | 1978-10-18 | 1982-07-20 | Wayne State University | Compositions inhibiting estrogen sulfotransferase activity |
AU556749B2 (en) * | 1983-02-22 | 1986-11-20 | Liehr, J.G. | Pharmaceutical compositions of 2-fluoroestradiol |
US4568673A (en) * | 1984-03-20 | 1986-02-04 | Wayne State University | Compositions inhibiting murine MXT ductal carcinoma |
US5504074A (en) * | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
BR9908592A (pt) * | 1998-03-11 | 2001-04-24 | Endorech Inc | Processo para inibir a atividade de 17ß-hidroxiesteróide desidrogenase tipo 5, composição farmacêutica, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 5, processo para inibir 17ß-hidroxiesteróide desidrogenase tipo 3, inibidor de 17ß-hidroxiesteróide desidrogenase tipo 3, processos para tratar, ou reduzir o risco de desenvolver, câncer da próstata, hiperplasia prostática benigna, acne, seborréia, hirsutismo ou alopécia androgênica, sìndrome de ovário policìstico, câncer de mama, endometriose ou leiomioma, para inibir as secreções hormonais testiculares, para tratar puberdade precoce, e, kit |
-
1999
- 1999-08-06 CN CN99811739A patent/CN1322130A/zh active Pending
- 1999-08-06 ID IDW20010531A patent/ID28791A/id unknown
- 1999-08-06 EP EP99936218A patent/EP1102582A2/fr not_active Withdrawn
- 1999-08-06 WO PCT/CA1999/000724 patent/WO2000007576A2/fr not_active Application Discontinuation
- 1999-08-06 AU AU51449/99A patent/AU5144999A/en not_active Abandoned
- 1999-08-06 AR ARP990103961A patent/AR021757A1/es unknown
- 1999-08-06 JP JP2000563261A patent/JP2002522380A/ja active Pending
- 1999-08-06 CA CA002339368A patent/CA2339368A1/fr not_active Abandoned
-
2001
- 2001-02-07 NO NO20010651A patent/NO20010651L/no not_active Application Discontinuation
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6995278B2 (en) * | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
WO2008124922A1 (fr) * | 2007-04-12 | 2008-10-23 | Endorecherche, Inc. | Stéroïdes 17-alpha-substitués utilisés comme anti-androgènes systémiques et modulateurs sélectifs du récepteur de l'androgène |
AU2008238559B2 (en) * | 2007-04-12 | 2012-05-31 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
US9284345B2 (en) | 2007-04-12 | 2016-03-15 | Endorecherche, Inc. | 17alpha-substituted steroids as systemic antiandrogens and selective androgen receptor modulators |
Also Published As
Publication number | Publication date |
---|---|
AR021757A1 (es) | 2002-08-07 |
NO20010651D0 (no) | 2001-02-07 |
AU5144999A (en) | 2000-02-28 |
NO20010651L (no) | 2001-04-05 |
ID28791A (id) | 2001-07-05 |
JP2002522380A (ja) | 2002-07-23 |
WO2000007576A3 (fr) | 2000-03-30 |
WO2000007576A2 (fr) | 2000-02-17 |
CN1322130A (zh) | 2001-11-14 |
EP1102582A2 (fr) | 2001-05-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2339368A1 (fr) | Inhibition de la 3$g(a)-hydroxysteroid-deshydrogenase de type 3 | |
US6541463B1 (en) | Inhibitors of type 5 and type 3 17β-hydroxysteroid dehydrogenase and methods for their use | |
Aggarwal et al. | An overview on 5α-reductase inhibitors | |
JP3581802B2 (ja) | ステロイドスルファターゼインヒビター | |
US5763432A (en) | Steriod inhibitors of estrone sulfatase and associated pharmaceutical compositions and methods of use | |
Banday et al. | Steroidal pyrazolines and pyrazoles as potential 5α-reductase inhibitors: Synthesis and biological evaluation | |
JP2001510471A (ja) | アンドロゲン合成インヒビター | |
EP0646007B1 (fr) | NOUVELLES 4-AZA-5$g(a)-ANDROSTAN-ONES SUBSTITUEES EN POSITION 17$g(b), SATUREES ET DELTA-17 ET DELTA-20 OLEFINIQUES ET SATUREES UTILISEES COMME INHIBITEURS DE 5$g(a)-REDUCTASE | |
EP3013846B1 (fr) | Dérivés thérapeutiquement actifs d'estratriène-thiazole à substitution azote en position 17 en tant qu'inhibiteurs de la 17bêta.-hydroxystéroïde déshydrogénase | |
US5264427A (en) | 20-substituted pregnene derivatives and their use as androgen synthesis inhibitors | |
JP2014094952A (ja) | 局所活性「ソフト」抗アンドロゲン剤 | |
CA2564963A1 (fr) | Promedicaments steroides a effet androgene | |
US10265329B2 (en) | Altering steroid metabolism for treatment of steroid-dependent disease | |
Arellano et al. | New ester derivatives of dehydroepiandrosterone as 5α-reductase inhibitors | |
JP5290189B2 (ja) | 6−アルコキシアルキルエストラジオール誘導体およびその使用 | |
MXPA01001405A (en) | INHIBITION OF TYPE 3 3&agr;-HYDROXYSTEROID DEHYDROGENASE | |
JPH06510982A (ja) | 抗テストステロン化合物およびその使用方法 | |
EP1321146A2 (fr) | Inhibiteurs de la 17beta-hydroxysteroide deshydrogénase du type 5 et du type 3 ainsi que leurs méthodes d'utilisation | |
AU2004200173A1 (en) | Inhibitors of Type 5 and Type 3 17B-Hydroxysteroid Dehydrogenase and Methods for Their Use | |
AU2017276477A1 (en) | 15β-substituted estrone derivatives as selective inhibitors of 17β-hydroxysteoid-dehydrogenases, method of preparation and use thereof | |
Haidar et al. | 5.7 enzyme inhibitor examples for the treatment of prostate tumor | |
Weintraub et al. | 4-Amino-17β-(Cyclopropyloxy) androst-4-en-3-one, 4-Amino-17β-(Cyclopropylamino) androst-4-en-3-one and Related Compounds as C17, 20-Lyase and 5α-Reductase Inhibitors | |
PH26838A (en) | Aromatic steroid 5-alpha reductase inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Dead |