CA2339300C - Methods and compositions for use in spliceosome mediated rna trans-splicing - Google Patents
Methods and compositions for use in spliceosome mediated rna trans-splicing Download PDFInfo
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- CA2339300C CA2339300C CA2339300A CA2339300A CA2339300C CA 2339300 C CA2339300 C CA 2339300C CA 2339300 A CA2339300 A CA 2339300A CA 2339300 A CA2339300 A CA 2339300A CA 2339300 C CA2339300 C CA 2339300C
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
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| US09/133,717 US6083702A (en) | 1995-12-15 | 1998-08-13 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US09/133,717 | 1998-08-13 | ||
| US09/158,863 | 1998-09-23 | ||
| US09/158,863 US6280978B1 (en) | 1995-12-15 | 1998-09-23 | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| PCT/US1999/018371 WO2000009734A2 (en) | 1998-08-13 | 1999-08-12 | Methods and compositions for use in spliceosome mediated rna trans-splicing |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2339300A1 CA2339300A1 (en) | 2000-02-24 |
| CA2339300C true CA2339300C (en) | 2015-11-24 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2339300A Expired - Fee Related CA2339300C (en) | 1998-08-13 | 1999-08-12 | Methods and compositions for use in spliceosome mediated rna trans-splicing |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6280978B1 (enExample) |
| EP (2) | EP1105513A2 (enExample) |
| JP (2) | JP4353390B2 (enExample) |
| AU (1) | AU773186B2 (enExample) |
| CA (1) | CA2339300C (enExample) |
| IL (1) | IL141409A0 (enExample) |
| WO (1) | WO2000009734A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20020115207A1 (en) * | 1995-12-15 | 2002-08-22 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US20020193580A1 (en) * | 1995-12-15 | 2002-12-19 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US20030027250A1 (en) * | 1995-12-15 | 2003-02-06 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US20060088938A1 (en) * | 1995-12-15 | 2006-04-27 | Mitchell Lloyd G | Methods and compositions for use in spliceosome mediated RNA trans-splicing in plants |
| US20030077754A1 (en) * | 1995-12-15 | 2003-04-24 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| FR2790955B1 (fr) * | 1999-03-19 | 2003-01-17 | Assist Publ Hopitaux De Paris | Utilisation d'oligonucleotides stabilises comme principe actif antitumoral |
| GB2362383B (en) * | 2000-05-19 | 2003-12-31 | Devgen Nv | Gene expression system |
| WO2002008408A2 (en) * | 2000-07-21 | 2002-01-31 | Trustees Of Boston University | Modular vector systems |
| DE10057014B8 (de) * | 2000-11-17 | 2008-04-30 | Steven Dooley | Verfahren zur Herstellung von zielzellspezifischen Arzneimitteln |
| EP1358203A4 (en) * | 2001-01-08 | 2006-11-22 | Intronn Inc | METHOD AND COMPOSITION FOR CONNECTING IN SPLICEOSOME-MEDIATED RNA TRANS SPLICING |
| US20040126774A1 (en) * | 2001-01-08 | 2004-07-01 | Mitchell Lioyd G. | Correction of factor VIII genetic defects using spliceosome mediated RNA trans splicing |
| DE10139492B4 (de) * | 2001-08-13 | 2004-06-09 | Eul, Joachim, Dr. | Verfahren zur Reparatur einer mutierten RNA aus einer gendefekten DNA und zum gezielten Abtöten von Tumorzellen durch RNA-Transspleißen sowie Verfahren zum Nachweis von natürlich-transgespleißter zellulärer RNA |
| US20030153054A1 (en) * | 2002-02-12 | 2003-08-14 | Mitchell Lloyd G. | Methods and compositions for use in spliceosome mediated RNA trans-splicing |
| US20050137153A1 (en) * | 2002-02-20 | 2005-06-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of alpha-1 antitrypsin (AAT) gene expression using short interfering nucleic acid (siNA) |
| CA2477295A1 (en) * | 2002-02-25 | 2003-09-04 | Intronn, Inc. | Trans-splicing mediated imaging of gene expression |
| US7399753B2 (en) * | 2002-02-25 | 2008-07-15 | Virxsys Corporation | Trans-splicing mediated photodynamic therapy |
| US20040214263A1 (en) * | 2002-03-20 | 2004-10-28 | Mitchell Lloyd G. | Spliceosome mediated RNA trans-splicing |
| US20040018520A1 (en) * | 2002-04-22 | 2004-01-29 | James Thompson | Trans-splicing enzymatic nucleic acid mediated biopharmaceutical and protein |
| US20030204861A1 (en) * | 2002-04-30 | 2003-10-30 | Madaiah Puttaraju | Transgenic animal model for spliceosome-mediated RNA trans-splicing |
| JP2005536231A (ja) * | 2002-05-08 | 2005-12-02 | イントロン，インコーポレーテッド | アデノウイルスに細胞選択的複製をもたらすための、スプライセオソーム媒介型ｒｎａトランススプライシングの使用 |
| WO2003104412A2 (en) | 2002-06-05 | 2003-12-18 | Intronn, Inc. | Spliceosome mediated rna trans-splicing and correction of factor viii genetic defects using spliceosome mediated rna trans spling |
| EP1549755A4 (en) * | 2002-06-05 | 2006-09-20 | Intronn Inc | SPREAD OSOM-MEDIATED TRANS-RNA SPLEISSEN IN STEM CELLS |
| US20040018622A1 (en) * | 2002-07-17 | 2004-01-29 | Mitchell Lloyd G. | Spliceosome mediated RNA trans-splicing for correction of skin disorders |
| AU2003285009B2 (en) * | 2002-10-23 | 2010-10-07 | Virxsys Corporation | Screening methods for identification of efficient pre-trans-splicing molecules |
| WO2004087958A1 (en) * | 2003-03-31 | 2004-10-14 | Council Of Scientific And Industrial Research | Stn gene oligonucleotide primers for detecting salmonella species and detection prosses using the same |
| US8053232B2 (en) * | 2004-01-23 | 2011-11-08 | Virxsys Corporation | Correction of alpha-1-antitrypsin genetic defects using spliceosome mediated RNA trans splicing |
| US7968334B2 (en) * | 2004-01-23 | 2011-06-28 | Virxsys Corporation | Expression of apoAI and variants thereof using spliceosome mediated RNA trans-splicing |
| CA2553828A1 (en) * | 2004-01-23 | 2005-08-04 | Intronn, Inc. | Expression of apoa-1 and variants thereof using spliceosome mediated rna trans-splicing |
| US20060094110A1 (en) * | 2004-07-30 | 2006-05-04 | Mcgarrity Gerard J | Use of spliceosome mediated RNA trans-splicing for immunotherapy |
| US20060134658A1 (en) * | 2004-08-09 | 2006-06-22 | Garcia-Blanco Mariano A | Use of RNA trans-splicing for generation of interfering RNA molecules |
| DE102004047492B4 (de) * | 2004-09-23 | 2006-07-20 | Jost-Werke Gmbh & Co. Kg | Verfahren zum Übertragen von elektrischer, pneumatischer oder hydraulischer Energie sowie ein Energieübertragungssystem |
| US7871795B2 (en) * | 2004-10-08 | 2011-01-18 | Virxsys Corporation | Targeted trans-splicing of highly abundant transcripts for in vivo production of recombinant proteins |
| JP5017118B2 (ja) * | 2004-10-08 | 2012-09-05 | バークシス コーポレーション | 組換えタンパク質をインビボ生産するための、非常に豊富な転写産物の標的化トランススプライシング |
| US7879321B2 (en) * | 2004-10-08 | 2011-02-01 | Virxsys Corporation | Use of RNA trans-splicing for antibody gene transfer and antibody polypeptide production |
| DE102006009000B3 (de) * | 2006-02-23 | 2007-09-06 | Tutech Innovation Gmbh | Rechengen |
| JP5081462B2 (ja) * | 2007-02-02 | 2012-11-28 | 富士フイルム株式会社 | トランススプライシング法による融合タンパク質作製方法 |
| EP2151248A1 (en) * | 2008-07-30 | 2010-02-10 | Johann Bauer | Improved pre-mRNA trans-splicing molecule (RTM) molecules and their uses |
| EP2326711A2 (en) * | 2008-08-20 | 2011-06-01 | VIRxSYS Corporation | Compositions and methods for generation of pluripotent stem cells |
| US8923125B2 (en) * | 2008-10-24 | 2014-12-30 | Qualcomm Incorporated | Wireless network resource adaptation |
| ES2578993T3 (es) | 2009-10-08 | 2016-08-03 | Association Institut De Myologie | Moléculas de ácido nucleico y métodos para intercambiar uno o más exones mediante corte y empalme en trans |
| WO2013016595A1 (en) | 2011-07-28 | 2013-01-31 | The Regents Of The University Of California | Exonic splicing enhancers and exonic splicing silencers |
| WO2014045283A1 (en) * | 2012-09-24 | 2014-03-27 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Restoration of the cftr function by splicing modulation |
| US9447411B2 (en) | 2013-01-14 | 2016-09-20 | Cellecta, Inc. | Methods and compositions for single cell expression profiling |
| WO2017087900A1 (en) | 2015-11-19 | 2017-05-26 | The Trustees Of The University Of Pennsylvania | Compositions and methods for correction of heritable ocular disease |
| CN109642241B (zh) * | 2016-04-01 | 2023-06-27 | 新加坡国立大学 | 反式剪接RNA（tsRNA） |
| KR20250150157A (ko) | 2018-04-17 | 2025-10-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 트랜스-스플라이싱 분자 |
| EP4013873A1 (en) | 2019-08-16 | 2022-06-22 | Massachusetts Institute Of Technology | Targeted trans-splicing using crispr/cas13 |
| EP4522758A2 (en) | 2022-05-13 | 2025-03-19 | Ascidian Therapeutics, Inc. | Abca4 trans-splicing molecules |
| EP4590825A1 (en) * | 2022-09-22 | 2025-07-30 | Rna Morph Ltd | Folding oligonucleotides |
| EP4594505A1 (en) | 2022-09-30 | 2025-08-06 | Centre National de la Recherche Scientifique | Therapy by trans-splicing of opa1 pre-messenger rnas for the treatment of diseases associated with opa1 gene mutations |
| CN120641122A (zh) | 2022-11-23 | 2025-09-12 | 安铂生物公司 | 基因修饰核酸内切酶 |
| WO2025128343A1 (en) | 2023-12-11 | 2025-06-19 | Just-Evotec Biologics, Inc. | Protein expression using trans-splicing and split selectable markers |
Family Cites Families (5)
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| NZ241310A (en) * | 1991-01-17 | 1995-03-28 | Gen Hospital Corp | Trans-splicing ribozymes |
| NZ241311A (en) * | 1991-01-17 | 1995-03-28 | Gen Hospital Corp | Rna sequence having trans-splicing activity, plant strains |
| US5498531A (en) * | 1993-09-10 | 1996-03-12 | President And Fellows Of Harvard College | Intron-mediated recombinant techniques and reagents |
| US5667969A (en) * | 1993-11-12 | 1997-09-16 | University Research Corporation | Alteration of sequence of a deleterious target molecule by ribozyme catalyzed trans-splicing |
| EP0883344B2 (en) * | 1995-12-15 | 2010-06-09 | VIRxSYS Corporation | Therapeutic molecules generated by trans-splicing |
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1998
- 1998-09-23 US US09/158,863 patent/US6280978B1/en not_active Expired - Lifetime
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1999
- 1999-08-12 JP JP2000565168A patent/JP4353390B2/ja not_active Expired - Fee Related
- 1999-08-12 IL IL14140999A patent/IL141409A0/xx unknown
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- 1999-08-12 WO PCT/US1999/018371 patent/WO2000009734A2/en not_active Ceased
- 1999-08-12 EP EP99943690A patent/EP1105513A2/en not_active Withdrawn
- 1999-08-12 CA CA2339300A patent/CA2339300C/en not_active Expired - Fee Related
- 1999-08-12 EP EP04077408A patent/EP1489185A1/en not_active Withdrawn
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2007
- 2007-07-05 JP JP2007177115A patent/JP2007312780A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP1105513A2 (en) | 2001-06-13 |
| EP1489185A1 (en) | 2004-12-22 |
| WO2000009734A2 (en) | 2000-02-24 |
| JP4353390B2 (ja) | 2009-10-28 |
| WO2000009734A3 (en) | 2000-05-18 |
| CA2339300A1 (en) | 2000-02-24 |
| IL141409A0 (en) | 2002-03-10 |
| AU773186B2 (en) | 2004-05-20 |
| JP2007312780A (ja) | 2007-12-06 |
| AU5673599A (en) | 2000-03-06 |
| JP2004504001A (ja) | 2004-02-12 |
| US6280978B1 (en) | 2001-08-28 |
| WO2000009734A9 (en) | 2000-07-13 |
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