CA2333893A1 - Produits de clivage de delta et procedes associes - Google Patents
Produits de clivage de delta et procedes associes Download PDFInfo
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- CA2333893A1 CA2333893A1 CA002333893A CA2333893A CA2333893A1 CA 2333893 A1 CA2333893 A1 CA 2333893A1 CA 002333893 A CA002333893 A CA 002333893A CA 2333893 A CA2333893 A CA 2333893A CA 2333893 A1 CA2333893 A1 CA 2333893A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne un peptide de clivage de Delta, des fragments, des dérivés et des analogues de ce dernier, et les acides nucléiques le codant. L'invention se rapporte également à un peptide soluble de Delta, à des fragments, des dérivés et des analogues de ce dernier, et aux acides nucléiques le codant. L'invention concerne aussi des complexes protéiniques de Delta et de Kuz. L'invention concerne des procédés permettant de détecter et de mesurer l'activation de Delta en observant et en mesurant les produits de clivage de Delta, qui indiquent une activation de Delta. L'invention concerne des procédés permettant de détecter et de mesurer l'activation de Kuz en observant et en mesurant les produits de clivage de Delta, qui indiquent une activation de Kuz. L'invention concerne également des procédés permettant de détecter une molécule qui module l'activation de Delta ou la fonction de Kuz en observant ou en mesurant une modification dans la quantité ou le motif des produits de clivage de Delta. La présente invention repose en partie sur la découverte que, sous sa forme active, c'est-à-dire la forme qui assure la médiation de la transduction du signal et qui se lie à Notch, Delta est un fragment soluble composé du domaine extracellulaire.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9251398P | 1998-07-13 | 1998-07-13 | |
| US60/092,513 | 1998-07-13 | ||
| US10483498P | 1998-10-19 | 1998-10-19 | |
| US60/104,834 | 1998-10-19 | ||
| PCT/US1999/015817 WO2000002897A2 (fr) | 1998-07-13 | 1999-07-13 | Produits de clivage de delta et procedes associes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2333893A1 true CA2333893A1 (fr) | 2000-01-20 |
Family
ID=26785768
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002333893A Abandoned CA2333893A1 (fr) | 1998-07-13 | 1999-07-13 | Produits de clivage de delta et procedes associes |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1096946A2 (fr) |
| JP (1) | JP2002520007A (fr) |
| AU (1) | AU5099499A (fr) |
| CA (1) | CA2333893A1 (fr) |
| WO (1) | WO2000002897A2 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0861261T3 (da) | 1995-06-28 | 2009-12-14 | Imp Cancer Res Tech | Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå |
| US6692919B1 (en) | 1997-07-23 | 2004-02-17 | Yale University | Activated forms of notch and methods based thereon |
| US6649346B2 (en) | 2001-03-30 | 2003-11-18 | Board Of Regents, The University Of Texas | Methods of identifying agents that affect cleavage of amyloid-β precursor protein |
| WO2003012441A1 (fr) * | 2001-07-25 | 2003-02-13 | Lorantis Limited | Procede de detection de modulateurs de signalisation de notch |
| GB0300428D0 (en) * | 2003-01-09 | 2003-02-05 | Lorantis Ltd | Medical treatment |
| GB0307472D0 (en) * | 2003-04-01 | 2003-05-07 | Lorantis Ltd | Medical treatment |
| AU2005209909B8 (en) * | 2004-02-03 | 2009-01-15 | The Regents Of The University Of Michigan | Compositions and methods for characterizing, regulating, diagnosing, and treating cancer |
| DK2758073T3 (en) | 2011-09-23 | 2019-01-14 | Oncomed Pharm Inc | VEGF / DLL4 BINDING AGENTS AND APPLICATIONS THEREOF |
| JP6967003B2 (ja) | 2015-09-23 | 2021-11-17 | メレオ バイオファーマ ５ インコーポレイテッド | がんの処置のための方法および組成物 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0861261T3 (da) * | 1995-06-28 | 2009-12-14 | Imp Cancer Res Tech | Nukleotid- og proteinsekvenser af hvirveldyrs-Delta-gener og fremgangsmåder baseret derpå |
| CA2263883C (fr) * | 1996-08-29 | 2003-07-08 | The Regents Of The University Of California | Kuz, nouvelle famille de metalloproteases |
| EP1004669B1 (fr) * | 1997-05-14 | 2007-04-18 | Asahi Kasei Kabushiki Kaisha | Nouvel inhibiteur de differentiation |
-
1999
- 1999-07-13 JP JP2000559126A patent/JP2002520007A/ja active Pending
- 1999-07-13 CA CA002333893A patent/CA2333893A1/fr not_active Abandoned
- 1999-07-13 EP EP99935534A patent/EP1096946A2/fr not_active Withdrawn
- 1999-07-13 AU AU50994/99A patent/AU5099499A/en not_active Abandoned
- 1999-07-13 WO PCT/US1999/015817 patent/WO2000002897A2/fr not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000002897A9 (fr) | 2000-07-20 |
| WO2000002897B1 (fr) | 2000-05-04 |
| WO2000002897A3 (fr) | 2000-03-16 |
| EP1096946A2 (fr) | 2001-05-09 |
| JP2002520007A (ja) | 2002-07-09 |
| AU5099499A (en) | 2000-02-01 |
| WO2000002897A2 (fr) | 2000-01-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20050713 |