CA2332533A1 - Novel metalloproteases having thrombospondin domains and nucleic acid compositions encoding the same - Google Patents

Novel metalloproteases having thrombospondin domains and nucleic acid compositions encoding the same Download PDF

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Publication number
CA2332533A1
CA2332533A1 CA002332533A CA2332533A CA2332533A1 CA 2332533 A1 CA2332533 A1 CA 2332533A1 CA 002332533 A CA002332533 A CA 002332533A CA 2332533 A CA2332533 A CA 2332533A CA 2332533 A1 CA2332533 A1 CA 2332533A1
Authority
CA
Canada
Prior art keywords
mpts
gly
pro
leu
ser
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002332533A
Other languages
English (en)
French (fr)
Inventor
Renu Anand Heller
Paul Klonowski
Fengrong Zuo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2332533A1 publication Critical patent/CA2332533A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CA002332533A 2000-02-18 2001-02-16 Novel metalloproteases having thrombospondin domains and nucleic acid compositions encoding the same Abandoned CA2332533A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18415200P 2000-02-18 2000-02-18
US60/184,152 2000-02-18

Publications (1)

Publication Number Publication Date
CA2332533A1 true CA2332533A1 (en) 2001-08-18

Family

ID=22675774

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002332533A Abandoned CA2332533A1 (en) 2000-02-18 2001-02-16 Novel metalloproteases having thrombospondin domains and nucleic acid compositions encoding the same

Country Status (4)

Country Link
BE (1) BE1014089A4 (nl)
CA (1) CA2332533A1 (nl)
IE (1) IE20010121A1 (nl)
NL (2) NL1017393C2 (nl)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU8513198A (en) * 1997-07-25 1999-02-16 Du Pont Pharmaceuticals Company Aggrecan degrading metallo proteases
US6391610B1 (en) * 1999-08-06 2002-05-21 The Cleveland Clinic Foundation Nucleic acids encoding zinc metalloproteases
WO2001042468A1 (en) * 1999-12-09 2001-06-14 Lexicon Genetics Incorporated Human adam-ts proteases and polynucleotides encoding the same
EP1356028A2 (en) * 2001-01-31 2003-10-29 Incyte Genomics, Inc. Protein modification and maintenance molecules

Also Published As

Publication number Publication date
IE20010121A1 (en) 2002-12-11
NL1017393C2 (nl) 2003-01-09
NL1017393A1 (nl) 2001-08-22
NL1022252A1 (nl) 2003-01-23
NL1022252C2 (nl) 2003-11-18
BE1014089A4 (fr) 2003-04-01

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Legal Events

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EEER Examination request
FZDE Dead