BE1014089A4 - Nouvelles metalloproteases possedant des domaines thrombospondine et compositions d'acides nucleiques les codant. - Google Patents
Nouvelles metalloproteases possedant des domaines thrombospondine et compositions d'acides nucleiques les codant. Download PDFInfo
- Publication number
- BE1014089A4 BE1014089A4 BE2001/0104A BE200100104A BE1014089A4 BE 1014089 A4 BE1014089 A4 BE 1014089A4 BE 2001/0104 A BE2001/0104 A BE 2001/0104A BE 200100104 A BE200100104 A BE 200100104A BE 1014089 A4 BE1014089 A4 BE 1014089A4
- Authority
- BE
- Belgium
- Prior art keywords
- nucleic acid
- mpts
- activity
- metalloprotease
- antagonist
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne de nouvelles métalloprotéases possédant un ou des domaines thromboqpodine (protéines MPTS) et des polypeptides qui leur sont liés, ainsi que des compositions d'acides nucléiques codant pour ces protéines. les compositions de polypeptides et d'acides nucléiques de l'invention trouvent une utilisation dans toutes sortes d'applications, notamment des applications disgnostiques, des applications de sélection d'agents thérapeutiques, ainsi que des applications thérapeutiques pour toutes sortes de maladies différentes. L'invention a également trait à des procédés pour traiter des maladies associées à l'activité agrécanase, par exemple des pathologies caractérisées par la présence de produits de clivage de l'agrécane, telles que la polyarthrite rhumatoïde et l'arthose.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US18415200P | 2000-02-18 | 2000-02-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
BE1014089A4 true BE1014089A4 (fr) | 2003-04-01 |
Family
ID=22675774
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BE2001/0104A BE1014089A4 (fr) | 2000-02-18 | 2001-02-15 | Nouvelles metalloproteases possedant des domaines thrombospondine et compositions d'acides nucleiques les codant. |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE1014089A4 (fr) |
CA (1) | CA2332533A1 (fr) |
IE (1) | IE20010121A1 (fr) |
NL (2) | NL1017393C2 (fr) |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999005291A2 (fr) * | 1997-07-25 | 1999-02-04 | Du Pont Pharmaceuticals Company | Metalloproteases decomposant l'aggrecan |
WO2001042468A1 (fr) * | 1999-12-09 | 2001-06-14 | Lexicon Genetics Incorporated | Nouvelles protéases humaines et polynucléotides codant pour ces protéases |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6391610B1 (en) * | 1999-08-06 | 2002-05-21 | The Cleveland Clinic Foundation | Nucleic acids encoding zinc metalloproteases |
EP1356028A2 (fr) * | 2001-01-31 | 2003-10-29 | Incyte Genomics, Inc. | Molecules de modification et de maintenance de proteines |
-
2001
- 2001-02-14 IE IE20010121A patent/IE20010121A1/en not_active IP Right Cessation
- 2001-02-15 BE BE2001/0104A patent/BE1014089A4/fr not_active IP Right Cessation
- 2001-02-16 CA CA002332533A patent/CA2332533A1/fr not_active Abandoned
- 2001-02-19 NL NL1017393A patent/NL1017393C2/nl not_active IP Right Cessation
-
2002
- 2002-12-23 NL NL1022252A patent/NL1022252C2/nl not_active IP Right Cessation
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999005291A2 (fr) * | 1997-07-25 | 1999-02-04 | Du Pont Pharmaceuticals Company | Metalloproteases decomposant l'aggrecan |
WO2001042468A1 (fr) * | 1999-12-09 | 2001-06-14 | Lexicon Genetics Incorporated | Nouvelles protéases humaines et polynucléotides codant pour ces protéases |
Non-Patent Citations (1)
Title |
---|
HURSKAINEN TIINA L ET AL: "ADAM-TS5, ADAM-TS6, and ADAM-TS7, novel members of a new family of zinc metalloproteases: General features and genomic distribution of the Adam-TS family", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 274, no. 36, 3 September 1999 (1999-09-03), pages 25555 - 25563, XP002158991, ISSN: 0021-9258 * |
Also Published As
Publication number | Publication date |
---|---|
IE20010121A1 (en) | 2002-12-11 |
NL1017393C2 (nl) | 2003-01-09 |
NL1017393A1 (nl) | 2001-08-22 |
NL1022252A1 (nl) | 2003-01-23 |
CA2332533A1 (fr) | 2001-08-18 |
NL1022252C2 (nl) | 2003-11-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RE | Patent lapsed |
Effective date: 20040228 |