CA2326697A1 - Primer extension methods for detecting nucleic acids - Google Patents
Primer extension methods for detecting nucleic acids Download PDFInfo
- Publication number
- CA2326697A1 CA2326697A1 CA002326697A CA2326697A CA2326697A1 CA 2326697 A1 CA2326697 A1 CA 2326697A1 CA 002326697 A CA002326697 A CA 002326697A CA 2326697 A CA2326697 A CA 2326697A CA 2326697 A1 CA2326697 A1 CA 2326697A1
- Authority
- CA
- Canada
- Prior art keywords
- primer
- probes
- nucleic acid
- sample
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/067,212 US6566101B1 (en) | 1997-06-16 | 1998-04-27 | Primer extension methods for detecting nucleic acids |
| US09/067,212 | 1998-04-27 | ||
| PCT/US1999/008849 WO1999055912A1 (en) | 1998-04-27 | 1999-04-23 | Primer extension methods for detecting nucleic acids |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2326697A1 true CA2326697A1 (en) | 1999-11-04 |
Family
ID=22074469
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002326697A Abandoned CA2326697A1 (en) | 1998-04-27 | 1999-04-23 | Primer extension methods for detecting nucleic acids |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US6566101B1 (https=) |
| EP (1) | EP1073769A1 (https=) |
| JP (2) | JP4422897B2 (https=) |
| AU (1) | AU771294B2 (https=) |
| CA (1) | CA2326697A1 (https=) |
| WO (1) | WO1999055912A1 (https=) |
Families Citing this family (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6566101B1 (en) * | 1997-06-16 | 2003-05-20 | Anthony P. Shuber | Primer extension methods for detecting nucleic acids |
| US20020048752A1 (en) * | 1998-11-23 | 2002-04-25 | Stanley N. Lapidus | Methods for detecting lower-frequency molecules |
| CA2366778C (en) | 1999-04-09 | 2008-07-22 | Exact Sciences Corporation | Methods for detecting nucleic acids indicative of cancer |
| US6849403B1 (en) | 1999-09-08 | 2005-02-01 | Exact Sciences Corporation | Apparatus and method for drug screening |
| US6586177B1 (en) | 1999-09-08 | 2003-07-01 | Exact Sciences Corporation | Methods for disease detection |
| US6692918B2 (en) | 1999-09-13 | 2004-02-17 | Nugen Technologies, Inc. | Methods and compositions for linear isothermal amplification of polynucleotide sequences |
| WO2001042781A2 (en) | 1999-12-07 | 2001-06-14 | Exact Sciences Corporation | Supracolonic aerodigestive neoplasm detection |
| US6919174B1 (en) | 1999-12-07 | 2005-07-19 | Exact Sciences Corporation | Methods for disease detection |
| US7229756B1 (en) * | 2000-10-19 | 2007-06-12 | University Of Cincinnati | Alpha-2B-adrenergic receptor polymorphisms |
| EP1356094B1 (en) | 2000-06-26 | 2010-01-13 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| US7846733B2 (en) | 2000-06-26 | 2010-12-07 | Nugen Technologies, Inc. | Methods and compositions for transcription-based nucleic acid amplification |
| WO2002048402A2 (en) | 2000-12-13 | 2002-06-20 | Nugen Technologies, Inc. | Methods and compositions for generation of multiple copies of nucleic acid sequences and methods of detection thereof |
| US7078168B2 (en) * | 2001-02-27 | 2006-07-18 | Biotage Ab | Method for determining allele frequencies |
| GB0105330D0 (en) | 2001-03-02 | 2001-04-18 | Renovo Ltd | Genetic testing |
| JP4542312B2 (ja) | 2001-03-09 | 2010-09-15 | ニューゲン テクノロジーズ， インコーポレイテッド | Ｒｎａ配列の増幅のための方法および組成物 |
| WO2002072773A2 (en) | 2001-03-09 | 2002-09-19 | Nugen Technologies, Inc. | Methods and compositions for amplification of rna sequences |
| ATE420351T1 (de) * | 2001-08-31 | 2009-01-15 | Gen Probe Inc | Sonden mit affinitätsverschiebung zur quantifizierung von analytenpolynukleotiden |
| WO2003071252A2 (en) * | 2002-02-15 | 2003-08-28 | Exact Sciences Corporation | Methods for analysis of molecular events |
| JP2006523465A (ja) | 2003-04-14 | 2006-10-19 | ニューゲン テクノロジーズ， インコーポレイテッド | ランダムにプライミングされる複合プライマーを用いる大規模増幅 |
| US20100216153A1 (en) * | 2004-02-27 | 2010-08-26 | Helicos Biosciences Corporation | Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities |
| WO2005111244A2 (en) * | 2004-05-10 | 2005-11-24 | Exact Sciences Corporation | Methods for detecting a mutant nucleic acid |
| US7476734B2 (en) | 2005-12-06 | 2009-01-13 | Helicos Biosciences Corporation | Nucleotide analogs |
| US7981607B2 (en) | 2004-08-27 | 2011-07-19 | Esoterix Genetic Laboratories LLC | Method for detecting recombinant event |
| EP1802775B1 (en) | 2004-09-14 | 2010-05-26 | The Regents of the University of Colorado | Method for treatment with bucindolol based on genetic targeting |
| WO2006047787A2 (en) | 2004-10-27 | 2006-05-04 | Exact Sciences Corporation | Method for monitoring disease progression or recurrence |
| US7482120B2 (en) | 2005-01-28 | 2009-01-27 | Helicos Biosciences Corporation | Methods and compositions for improving fidelity in a nucleic acid synthesis reaction |
| US8669052B2 (en) | 2008-06-10 | 2014-03-11 | Rapid Pathogen Screening, Inc. | Lateral flow nucleic acid detector |
| US9777314B2 (en) * | 2005-04-21 | 2017-10-03 | Esoterix Genetic Laboratories, Llc | Analysis of heterogeneous nucleic acid samples |
| JP2008539742A (ja) * | 2005-05-11 | 2008-11-20 | サノフィ−アベンティス | Ｇｉｐプロモーター多型の使用 |
| WO2007030759A2 (en) | 2005-09-07 | 2007-03-15 | Nugen Technologies, Inc. | Improved nucleic acid amplification procedure |
| TR201910868T4 (tr) * | 2006-02-02 | 2019-08-21 | Univ Leland Stanford Junior | Dijital analizle invazif olmayan fetal genetik tarama. |
| AU2012201607B2 (en) * | 2006-05-01 | 2013-09-05 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention | Methods and agents for detecting Parechovirus |
| US20080050739A1 (en) | 2006-06-14 | 2008-02-28 | Roland Stoughton | Diagnosis of fetal abnormalities using polymorphisms including short tandem repeats |
| EP2589668A1 (en) * | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| US8137912B2 (en) | 2006-06-14 | 2012-03-20 | The General Hospital Corporation | Methods for the diagnosis of fetal abnormalities |
| WO2007147074A2 (en) | 2006-06-14 | 2007-12-21 | Living Microsystems, Inc. | Use of highly parallel snp genotyping for fetal diagnosis |
| US20090047694A1 (en) * | 2007-08-17 | 2009-02-19 | Shuber Anthony P | Clinical Intervention Directed Diagnostic Methods |
| US20090029372A1 (en) * | 2007-05-14 | 2009-01-29 | Kobenhavns Universitet | Adam12 as a biomarker for bladder cancer |
| GB2450356A (en) * | 2007-06-20 | 2008-12-24 | Secretary Trade Ind Brit | Method of Determining the Genotype of a Polymorphism using labelled nucleotides |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| LT2557517T (lt) | 2007-07-23 | 2023-01-10 | The Chinese University Of Hong Kong | Nukleino rūgščių sekos disbalanso nustatymas |
| US20090075266A1 (en) * | 2007-09-14 | 2009-03-19 | Predictive Biosciences Corporation | Multiple analyte diagnostic readout |
| US8431367B2 (en) | 2007-09-14 | 2013-04-30 | Predictive Biosciences Corporation | Detection of nucleic acids and proteins |
| US8852893B2 (en) | 2007-09-14 | 2014-10-07 | Physicians Choice Laboratory Services, Llc | Detection of nucleic acids and proteins |
| US7955822B2 (en) * | 2007-09-14 | 2011-06-07 | Predictive Biosciences Corp. | Detection of nucleic acids and proteins |
| US20100267041A1 (en) * | 2007-09-14 | 2010-10-21 | Predictive Biosciences, Inc. | Serial analysis of biomarkers for disease diagnosis |
| US20090203531A1 (en) | 2008-02-12 | 2009-08-13 | Nurith Kurn | Method for Archiving and Clonal Expansion |
| GB2470672B (en) | 2008-03-21 | 2012-09-12 | Nugen Technologies Inc | Methods of RNA amplification in the presence of DNA |
| US20130196310A1 (en) | 2008-05-20 | 2013-08-01 | Rapid Pathogen Screening, Inc. | Method and Device for Combined Detection of Viral and Bacterial Infections |
| US8815609B2 (en) | 2008-05-20 | 2014-08-26 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with diverting zone |
| US8609433B2 (en) * | 2009-12-04 | 2013-12-17 | Rapid Pathogen Screening, Inc. | Multiplanar lateral flow assay with sample compressor |
| US9068981B2 (en) | 2009-12-04 | 2015-06-30 | Rapid Pathogen Screening, Inc. | Lateral flow assays with time delayed components |
| US8962260B2 (en) | 2008-05-20 | 2015-02-24 | Rapid Pathogen Screening, Inc. | Method and device for combined detection of viral and bacterial infections |
| US20110086359A1 (en) * | 2008-06-10 | 2011-04-14 | Rapid Pathogen Screening, Inc. | Lateral flow assays |
| HUE031848T2 (en) | 2008-09-20 | 2017-08-28 | Univ Leland Stanford Junior | Non-invasive diagnosis of fetal aneuploidy by sequencing |
| CA2768391C (en) | 2009-07-21 | 2016-09-06 | Gen-Probe Incorporated | Methods and compositions for quantitative detection of nucleic acid sequences over an extended dynamic range |
| EP2480883B1 (en) | 2009-09-23 | 2020-04-01 | Celmatix, Inc. | Methods for assessing infertility and/or egg quality |
| WO2011143583A1 (en) * | 2010-05-13 | 2011-11-17 | Illumina, Inc. | Binding assays for markers |
| US8586301B2 (en) | 2010-06-30 | 2013-11-19 | Stratos Genomics, Inc. | Multiplexed identification of nucleic acid sequences |
| US20140235474A1 (en) | 2011-06-24 | 2014-08-21 | Sequenom, Inc. | Methods and processes for non invasive assessment of a genetic variation |
| KR20140072160A (ko) | 2011-10-03 | 2014-06-12 | 셀매틱스, 인크. | 추정 자손에 대한 상태 발병 위험을 평가하는 방법 및 장치 |
| US10196681B2 (en) | 2011-10-06 | 2019-02-05 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10424394B2 (en) | 2011-10-06 | 2019-09-24 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9367663B2 (en) | 2011-10-06 | 2016-06-14 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CA2850785C (en) | 2011-10-06 | 2022-12-13 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9984198B2 (en) | 2011-10-06 | 2018-05-29 | Sequenom, Inc. | Reducing sequence read count error in assessment of complex genetic variations |
| WO2013109981A1 (en) | 2012-01-20 | 2013-07-25 | Sequenom, Inc. | Diagnostic processes that factor experimental conditions |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10497461B2 (en) | 2012-06-22 | 2019-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10482994B2 (en) | 2012-10-04 | 2019-11-19 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9177098B2 (en) | 2012-10-17 | 2015-11-03 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
| US10162800B2 (en) | 2012-10-17 | 2018-12-25 | Celmatix Inc. | Systems and methods for determining the probability of a pregnancy at a selected point in time |
| US9836577B2 (en) | 2012-12-14 | 2017-12-05 | Celmatix, Inc. | Methods and devices for assessing risk of female infertility |
| US20130309666A1 (en) | 2013-01-25 | 2013-11-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| PL2981921T3 (pl) | 2013-04-03 | 2023-05-08 | Sequenom, Inc. | Metody i procesy nieinwazyjnej oceny zmienności genetycznych |
| EP4604127A3 (en) | 2013-05-24 | 2025-12-03 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| HUE042654T2 (hu) | 2013-06-21 | 2019-07-29 | Sequenom Inc | Eljárás genetikai variációk nem-invazív megállapítására |
| IL304949B2 (en) | 2013-10-04 | 2025-09-01 | Sequenom Inc | Methods and processes for non-invasive assessment of genetic variations |
| EP3495496B1 (en) | 2013-10-07 | 2020-11-25 | Sequenom, Inc. | Methods and processes for non-invasive assessment of chromosome alterations |
| SG11201700303UA (en) | 2014-07-17 | 2017-02-27 | Celmatix Inc | Methods and systems for assessing infertility and related pathologies |
| WO2016019042A1 (en) | 2014-07-30 | 2016-02-04 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| US10808287B2 (en) | 2015-10-23 | 2020-10-20 | Rapid Pathogen Screening, Inc. | Methods and devices for accurate diagnosis of infections |
| US20190390259A1 (en) * | 2016-04-05 | 2019-12-26 | Lariat Biosciences, Inc. | Compositions for and methods of enriching genetic mutants for detecting, diagnosing, and prognosing cancer |
| ITUA20163413A1 (it) * | 2016-05-13 | 2017-11-13 | Fondazione St Italiano Tecnologia | Reazione di amplificazione di acidi nucleici con primer cooperativi. |
| US11200963B2 (en) | 2016-07-27 | 2021-12-14 | Sequenom, Inc. | Genetic copy number alteration classifications |
| US11694768B2 (en) | 2017-01-24 | 2023-07-04 | Sequenom, Inc. | Methods and processes for assessment of genetic variations |
| JP7370862B2 (ja) | 2017-03-17 | 2023-10-30 | セクエノム， インコーポレイテッド | 遺伝子モザイク症のための方法およびプロセス |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5591582A (en) | 1985-07-23 | 1997-01-07 | The Board Of Rijks Universiteit Leiden | Methods for detecting activated RAS oncogenes |
| US5202231A (en) | 1987-04-01 | 1993-04-13 | Drmanac Radoje T | Method of sequencing of genomes by hybridization of oligonucleotide probes |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| EP0333465B1 (en) | 1988-03-18 | 1994-07-13 | Baylor College Of Medicine | Mutation detection by competitive oligonucleotide priming |
| CA2044591C (en) | 1989-02-13 | 2002-08-13 | James Langham Dale | Detection of a nucleic acid sequence or a change therein |
| JP2802125B2 (ja) | 1989-06-23 | 1998-09-24 | キヤノン株式会社 | 核酸の検出方法 |
| US6013431A (en) * | 1990-02-16 | 2000-01-11 | Molecular Tool, Inc. | Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators |
| IL97222A (en) | 1990-02-16 | 1995-08-31 | Orion Yhtymae Oy | Method and reagent for determining specific nucleotide variations |
| US5846710A (en) | 1990-11-02 | 1998-12-08 | St. Louis University | Method for the detection of genetic diseases and gene sequence variations by single nucleotide primer extension |
| US5627032A (en) | 1990-12-24 | 1997-05-06 | Ulanovsky; Levy | Composite primers for nucleic acids |
| IE66125B1 (en) | 1991-01-31 | 1995-12-13 | Zeneca Ltd | Detection method for variant nucleotides |
| US6004744A (en) | 1991-03-05 | 1999-12-21 | Molecular Tool, Inc. | Method for determining nucleotide identity through extension of immobilized primer |
| WO1992016657A1 (en) | 1991-03-13 | 1992-10-01 | E.I. Du Pont De Nemours And Company | Method of identifying a nucleotide present at a defined position in a nucleic acid |
| US5432065A (en) | 1993-03-30 | 1995-07-11 | United States Biochemical Corporation | Cycle sequencing with non-thermostable DNA polymerases |
| SE501439C2 (sv) | 1993-06-22 | 1995-02-13 | Pharmacia Lkb Biotech | Sätt och anordning för analys av polynukleotidsekvenser |
| WO1995012607A1 (en) | 1993-11-03 | 1995-05-11 | Molecular Tool, Inc. | Single nucleotide polymorphisms and their use in genetic analysis |
| US5610287A (en) * | 1993-12-06 | 1997-03-11 | Molecular Tool, Inc. | Method for immobilizing nucleic acid molecules |
| US5545527A (en) | 1994-07-08 | 1996-08-13 | Visible Genetics Inc. | Method for testing for mutations in DNA from a patient sample |
| US5589330A (en) | 1994-07-28 | 1996-12-31 | Genzyme Corporation | High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides |
| WO1996030545A1 (en) | 1995-03-24 | 1996-10-03 | Mitokor | Mutation detection by differential primer extension of mutant and wildtype target sequences |
| US5571676A (en) | 1995-06-07 | 1996-11-05 | Ig Laboratories, Inc. | Method for mismatch-directed in vitro DNA sequencing |
| GB9517914D0 (en) | 1995-09-02 | 1995-11-01 | Tepnel Medical Ltd | Identification of bases in nucleic acid sequences |
| AU711754B2 (en) | 1995-12-22 | 1999-10-21 | Esoterix Genetic Laboratories, Llc | Methods for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample |
| US5885775A (en) | 1996-10-04 | 1999-03-23 | Perseptive Biosystems, Inc. | Methods for determining sequences information in polynucleotides using mass spectrometry |
| US6566101B1 (en) * | 1997-06-16 | 2003-05-20 | Anthony P. Shuber | Primer extension methods for detecting nucleic acids |
| US5888778A (en) | 1997-06-16 | 1999-03-30 | Exact Laboratories, Inc. | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers |
-
1998
- 1998-04-27 US US09/067,212 patent/US6566101B1/en not_active Expired - Lifetime
-
1999
- 1999-04-23 WO PCT/US1999/008849 patent/WO1999055912A1/en not_active Ceased
- 1999-04-23 JP JP2000546055A patent/JP4422897B2/ja not_active Expired - Fee Related
- 1999-04-23 CA CA002326697A patent/CA2326697A1/en not_active Abandoned
- 1999-04-23 EP EP99921441A patent/EP1073769A1/en not_active Withdrawn
- 1999-04-23 AU AU38654/99A patent/AU771294B2/en not_active Ceased
-
2003
- 2003-02-05 US US10/358,989 patent/US20040110162A1/en not_active Abandoned
-
2009
- 2009-05-15 JP JP2009119325A patent/JP2009232850A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| US6566101B1 (en) | 2003-05-20 |
| JP2002512814A (ja) | 2002-05-08 |
| AU3865499A (en) | 1999-11-16 |
| JP2009232850A (ja) | 2009-10-15 |
| AU771294B2 (en) | 2004-03-18 |
| US20040110162A1 (en) | 2004-06-10 |
| JP4422897B2 (ja) | 2010-02-24 |
| EP1073769A1 (en) | 2001-02-07 |
| WO1999055912A1 (en) | 1999-11-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6566101B1 (en) | Primer extension methods for detecting nucleic acids | |
| US5888778A (en) | High-throughput screening method for identification of genetic mutations or disease-causing microorganisms using segmented primers | |
| US5834181A (en) | High throughput screening method for sequences or genetic alterations in nucleic acids | |
| AU697642B2 (en) | High throughput screening method for sequences or genetic alterations in nucleic acids | |
| US5589330A (en) | High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides | |
| US5679524A (en) | Ligase/polymerase mediated genetic bit analysis of single nucleotide polymorphisms and its use in genetic analysis | |
| US20050074787A1 (en) | Universal arrays | |
| US20020001800A1 (en) | Diagnostic methods using serial testing of polymorphic loci | |
| AU8162498A (en) | Methods for the detection of multiple single nucleotide polymorphisms in a single reaction | |
| WO1996003529A9 (en) | High throughput screening method for sequences or genetic alterations in nucleic acids | |
| US20030044780A1 (en) | Primer extension methods utilizing donor and acceptor molecules for detecting nucleic acids | |
| CA2282705A1 (en) | Nucleic acid analysis methods | |
| WO1997010366A2 (en) | High throughput screening method for sequences or genetic alterations in nucleic acids | |
| CA2205234A1 (en) | High throughput screening method for sequences or genetic alterations in nucleic acids | |
| AU7073696A (en) | High throughput screening method for sequences or genetic alterations in nucleic acids |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |