CA2325566C - Vaccine formulations comprising antiidiotypic antibodies which immunologically mimic group b streptococcal carbohydrates - Google Patents
Vaccine formulations comprising antiidiotypic antibodies which immunologically mimic group b streptococcal carbohydrates Download PDFInfo
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- CA2325566C CA2325566C CA2325566A CA2325566A CA2325566C CA 2325566 C CA2325566 C CA 2325566C CA 2325566 A CA2325566 A CA 2325566A CA 2325566 A CA2325566 A CA 2325566A CA 2325566 C CA2325566 C CA 2325566C
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C40—COMBINATORIAL TECHNOLOGY
- C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
- C40B40/00—Libraries per se, e.g. arrays, mixtures
- C40B40/02—Libraries contained in or displayed by microorganisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only microorganisms or vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4233—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-bacterial Ig
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Plant Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9808327.2 | 1998-04-20 | ||
| GBGB9808327.2A GB9808327D0 (en) | 1998-04-20 | 1998-04-20 | Antidiotypic compounds |
| PCT/IB1999/000799 WO1999054457A1 (en) | 1998-04-20 | 1999-04-20 | Vaccine formulations comprising antiidiotypic antibodies which immunologically mimic group b streptococcal carbohydrates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2325566A1 CA2325566A1 (en) | 1999-10-28 |
| CA2325566C true CA2325566C (en) | 2011-02-08 |
Family
ID=10830608
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2325566A Expired - Fee Related CA2325566C (en) | 1998-04-20 | 1999-04-20 | Vaccine formulations comprising antiidiotypic antibodies which immunologically mimic group b streptococcal carbohydrates |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6676938B1 (enExample) |
| EP (1) | EP1071763B1 (enExample) |
| JP (2) | JP4446601B2 (enExample) |
| AT (1) | ATE425251T1 (enExample) |
| CA (1) | CA2325566C (enExample) |
| CY (1) | CY1109140T1 (enExample) |
| DE (1) | DE69940545D1 (enExample) |
| GB (1) | GB9808327D0 (enExample) |
| WO (1) | WO1999054457A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10027695A1 (de) * | 1999-05-27 | 2001-04-19 | Max Delbrueck Centrum | Vakzine gegen konformationsabhängige Antigene sowie gegen Antigene, die keine oder nicht ausschließlich Proteine oder Peptide sind |
| ES2330083T3 (es) * | 2000-10-27 | 2009-12-04 | Novartis Vaccines And Diagnostics S.R.L. | Acidos nucleicos y proteinas de estreptococos de los grupos a y b. |
| AU2003260102A1 (en) * | 2002-08-26 | 2004-03-11 | Chiron Corporation | Conserved and specific streptococcal genomes |
| ES2505695T3 (es) | 2003-07-31 | 2014-10-10 | Novartis Vaccines And Diagnostics, Inc. | Composiciones inmunógenas para Streptococcus pyogenes |
| US8945589B2 (en) | 2003-09-15 | 2015-02-03 | Novartis Vaccines And Diagnostics, Srl | Immunogenic compositions for Streptococcus agalactiae |
| CA2575548A1 (en) | 2004-07-29 | 2006-07-27 | John L. Telford | Immunogenic compositions for gram positive bacteria such as streptococcus agalactiae |
| EP1807446A2 (en) * | 2004-10-08 | 2007-07-18 | Novartis Vaccines and Diagnostics, Inc. | Immunogenic and therapeutic compositions for streptococcus pyogenes |
| US20090104218A1 (en) * | 2004-12-22 | 2009-04-23 | J. Craig Venter Institute | Group B Streptococcus |
| EP2298795A1 (en) | 2005-02-18 | 2011-03-23 | Novartis Vaccines and Diagnostics, Inc. | Immunogens from uropathogenic escherichia coli |
| PT2054431E (pt) * | 2006-06-09 | 2011-11-03 | Novartis Ag | Confórmeros de adesinas bacterianas |
| JP2010500399A (ja) | 2006-08-16 | 2010-01-07 | ノバルティス アーゲー | 尿路病原性大腸菌由来の免疫原 |
| WO2008108830A2 (en) * | 2006-10-30 | 2008-09-12 | Novartis Ag | Immunogenic and therapeutic compositions for streptococcus pyogenes |
| JP5653215B2 (ja) | 2007-09-12 | 2015-01-14 | ノバルティス アーゲー | Ｇａｓ５７変異体抗原およびｇａｓ５７抗体 |
| EP2537857B1 (en) * | 2007-12-21 | 2017-01-18 | GlaxoSmithKline Biologicals SA | Mutant forms of streptolysin O |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| CN103429606A (zh) | 2010-10-01 | 2013-12-04 | 现代治疗公司 | 设计核酸及其使用方法 |
| CA2831613A1 (en) | 2011-03-31 | 2012-10-04 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| KR20190099538A (ko) | 2011-10-03 | 2019-08-27 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드, 및 핵산, 및 이들의 용도 |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| AU2013243954A1 (en) | 2012-04-02 | 2014-10-30 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cosmetic proteins and peptides |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| DK2922554T3 (en) | 2012-11-26 | 2022-05-23 | Modernatx Inc | Terminalt modificeret rna |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| BR112016007255A2 (pt) | 2013-10-03 | 2017-09-12 | Moderna Therapeutics Inc | polinucleotídeos que codificam receptor de lipoproteína de baixa densidade |
| EP3773348B1 (en) | 2018-04-10 | 2025-04-02 | Alps Holding Llc | Spinal interbody cage comprising top and bottom faces with mesh structures, pillars and slots |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5476784A (en) * | 1993-04-06 | 1995-12-19 | Rice; Peter A. | Gonococcal anti-idiotypic antibodies and methods and compositions using them |
| WO1997045449A1 (en) * | 1996-05-29 | 1997-12-04 | Derek Nigel John Hart | Dendritic cell receptor |
| US6140091A (en) * | 1997-06-20 | 2000-10-31 | Boston Biomedical Research Institute | Anti-idiotype vaccines to elicit catalytic antibodies |
| US6444787B1 (en) * | 1997-12-31 | 2002-09-03 | Research Development Institute, Inc. | Method of isolating a peptide which immunologically mimics microbial carbohydrates including group B streptococcal carbohydrates and the use thereof in a vaccine |
-
1998
- 1998-04-20 GB GBGB9808327.2A patent/GB9808327D0/en not_active Ceased
-
1999
- 1999-04-20 AT AT99914725T patent/ATE425251T1/de active
- 1999-04-20 CA CA2325566A patent/CA2325566C/en not_active Expired - Fee Related
- 1999-04-20 WO PCT/IB1999/000799 patent/WO1999054457A1/en not_active Ceased
- 1999-04-20 EP EP99914725A patent/EP1071763B1/en not_active Expired - Lifetime
- 1999-04-20 DE DE69940545T patent/DE69940545D1/de not_active Expired - Lifetime
- 1999-04-20 US US09/673,867 patent/US6676938B1/en not_active Expired - Fee Related
- 1999-04-20 JP JP2000544789A patent/JP4446601B2/ja not_active Expired - Fee Related
-
2003
- 2003-11-07 US US10/703,886 patent/US6900302B2/en not_active Expired - Fee Related
-
2009
- 2009-05-21 JP JP2009123637A patent/JP2009179645A/ja not_active Withdrawn
- 2009-06-09 CY CY20091100604T patent/CY1109140T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1071763B1 (en) | 2009-03-11 |
| CY1109140T1 (el) | 2014-07-02 |
| GB9808327D0 (en) | 1998-06-17 |
| JP2002512026A (ja) | 2002-04-23 |
| ATE425251T1 (de) | 2009-03-15 |
| EP1071763A1 (en) | 2001-01-31 |
| DE69940545D1 (de) | 2009-04-23 |
| JP2009179645A (ja) | 2009-08-13 |
| WO1999054457A1 (en) | 1999-10-28 |
| US20040101536A1 (en) | 2004-05-27 |
| US6900302B2 (en) | 2005-05-31 |
| US6676938B1 (en) | 2004-01-13 |
| JP4446601B2 (ja) | 2010-04-07 |
| CA2325566A1 (en) | 1999-10-28 |
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