CA2325445A1 - Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer - Google Patents

Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer Download PDF

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Publication number
CA2325445A1
CA2325445A1 CA002325445A CA2325445A CA2325445A1 CA 2325445 A1 CA2325445 A1 CA 2325445A1 CA 002325445 A CA002325445 A CA 002325445A CA 2325445 A CA2325445 A CA 2325445A CA 2325445 A1 CA2325445 A1 CA 2325445A1
Authority
CA
Canada
Prior art keywords
pbr
cell
cells
tumor
cell proliferation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002325445A
Other languages
English (en)
French (fr)
Inventor
Vassilios Papadopoulos
Martine Culty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Georgetown University
Georgetown University Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Georgetown University, Georgetown University Medical Center filed Critical Georgetown University
Publication of CA2325445A1 publication Critical patent/CA2325445A1/en
Abandoned legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA002325445A 1998-03-25 1999-03-25 Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer Abandoned CA2325445A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/047,652 1998-03-25
US09/047,652 US7267977B2 (en) 1998-03-25 1998-03-25 Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer
PCT/US1999/006515 WO1999049316A2 (en) 1998-03-25 1999-03-25 Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer

Publications (1)

Publication Number Publication Date
CA2325445A1 true CA2325445A1 (en) 1999-09-30

Family

ID=21950183

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002325445A Abandoned CA2325445A1 (en) 1998-03-25 1999-03-25 Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer

Country Status (6)

Country Link
US (1) US7267977B2 (https=)
EP (2) EP1757295A1 (https=)
JP (1) JP2003508343A (https=)
AU (1) AU3364899A (https=)
CA (1) CA2325445A1 (https=)
WO (1) WO1999049316A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7267977B2 (en) 1998-03-25 2007-09-11 Georgetown University Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer
US7056694B1 (en) 1998-08-11 2006-06-06 Georgetown University DNA encoding peripheral-type benzodiazipine receptor associated protein 7 and applications or methods of use
JP2004500009A (ja) * 1998-08-11 2004-01-08 ジョージタウン・ユニバーシティ・メディカル・センター 周辺型ベンゾジアゼピン受容体関連タンパク質、クローン化発現及びその使用方法
US7078434B1 (en) * 1999-08-12 2006-07-18 Societe De Conseils De Recherches Et D'applications Scientifiques Sas Use of Ginkgo extract
JP2003507336A (ja) * 1999-08-12 2003-02-25 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス イチョウ抽出物の使用
US20020039746A1 (en) * 2000-01-14 2002-04-04 Sjoberg Eric Richard Methods for identifying peripheral benzodiazepine receptor binding agents
DE10234201A1 (de) * 2002-07-26 2004-02-12 Freie Universität Berlin Verwendung einer Zusammenstellung zur Behandlung neuroendokriner und gastrointestinaler Tumoren
JP4362457B2 (ja) * 2005-04-26 2009-11-11 独立行政法人科学技術振興機構 神経因性疼痛治療剤
AU2007211251A1 (en) * 2006-01-31 2007-08-09 Georgetown University Method to detect breast cancer cells
EP2059813A2 (en) * 2006-06-26 2009-05-20 Technion Research & Development Foundation LTD. Methods and kits for diagnosing cancer
US9075060B2 (en) 2009-06-16 2015-07-07 Technion Research & Development Foundation Limited Methods for diagnosing oral or oral-pharyngeal cancer
CN105283552A (zh) * 2013-03-13 2016-01-27 澳大利亚核科学和技术组织 具有非功能性tspo基因的转基因非人类生物体
US12234701B2 (en) 2022-09-12 2025-02-25 Saudi Arabian Oil Company Tubing hangers and related methods of isolating a tubing
US12188328B2 (en) 2023-05-15 2025-01-07 Saudi Arabian Oil Company Wellbore back pressure valve with pressure gauge
US12442257B2 (en) 2023-05-23 2025-10-14 Saudi Arabian Oil Company Completing and working over a wellbore

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5407799A (en) * 1989-09-14 1995-04-18 Associated Universities, Inc. Method for high-volume sequencing of nucleic acids: random and directed priming with libraries of oligonucleotides
US5350836A (en) 1989-10-12 1994-09-27 Ohio University Growth hormone antagonists
US5663062A (en) * 1992-04-03 1997-09-02 Stratagene Oligonucleotide libraries useful for producing primers
US5585479A (en) * 1992-07-24 1996-12-17 The United States Of America As Represented By The Secretary Of The Navy Antisense oligonucleotides directed against human ELAM-I RNA
US5840708A (en) * 1992-12-14 1998-11-24 Allegheny University Of The Health Sciences Administration of oligonucleotides antisense to dopamine receptor MRNA for diagnosis and treatment of Neurological pathologies
US5948676A (en) 1996-10-10 1999-09-07 The Trustees Of Columbia University In The City Of New York Immediate early protein from Kaposi's sarcoma-associated herpesvirus, DNA encoding same and uses thereof
US7267977B2 (en) 1998-03-25 2007-09-11 Georgetown University Peripheral-type benzodiazepine receptor: a tool for detection, diagnosis, prognosis, and treatment of cancer
EP1092026A2 (en) 1998-07-02 2001-04-18 Incyte Pharmaceuticals, Inc. Neurotransmission associated proteins
JP2004500009A (ja) 1998-08-11 2004-01-08 ジョージタウン・ユニバーシティ・メディカル・センター 周辺型ベンゾジアゼピン受容体関連タンパク質、クローン化発現及びその使用方法

Also Published As

Publication number Publication date
WO1999049316A2 (en) 1999-09-30
US20030157095A1 (en) 2003-08-21
AU3364899A (en) 1999-10-18
US7267977B2 (en) 2007-09-11
EP1063997A2 (en) 2001-01-03
JP2003508343A (ja) 2003-03-04
WO1999049316A3 (en) 1999-11-11
EP1757295A1 (en) 2007-02-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued