CA2325045C - Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe - Google Patents

Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe Download PDF

Info

Publication number
CA2325045C
CA2325045C CA002325045A CA2325045A CA2325045C CA 2325045 C CA2325045 C CA 2325045C CA 002325045 A CA002325045 A CA 002325045A CA 2325045 A CA2325045 A CA 2325045A CA 2325045 C CA2325045 C CA 2325045C
Authority
CA
Canada
Prior art keywords
group
amino
humectant
butanoic acid
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002325045A
Other languages
English (en)
Other versions
CA2325045A1 (fr
Inventor
Akira Aomatsu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=15097314&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2325045(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Priority claimed from PCT/US1999/010186 external-priority patent/WO1999059572A1/fr
Publication of CA2325045A1 publication Critical patent/CA2325045A1/fr
Application granted granted Critical
Publication of CA2325045C publication Critical patent/CA2325045C/fr
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Arrangement Of Transmissions (AREA)
  • Body Structure For Vehicles (AREA)

Abstract

L'invention concerne une composition solide stabilisée contenant un dérivé de l'acide 4-amino-3-substitué-butanoïque, que l'on peut obtenir en incorporant un humectant en tant que stabilisant.
CA002325045A 1998-05-15 1999-05-10 Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe Expired - Lifetime CA2325045C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13312298A JP3761324B2 (ja) 1998-05-15 1998-05-15 乗用田植機
JP10/133112 1998-05-15
PCT/US1999/010186 WO1999059572A1 (fr) 1998-05-15 1999-05-10 Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe

Publications (2)

Publication Number Publication Date
CA2325045A1 CA2325045A1 (fr) 1999-11-25
CA2325045C true CA2325045C (fr) 2005-05-03

Family

ID=15097314

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002325045A Expired - Lifetime CA2325045C (fr) 1998-05-15 1999-05-10 Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe

Country Status (16)

Country Link
JP (1) JP3761324B2 (fr)
CN (1) CN1171587C (fr)
AT (1) ATE407668T1 (fr)
CA (1) CA2325045C (fr)
CY (1) CY1108488T1 (fr)
DE (1) DE69939532D1 (fr)
DK (1) DK1077691T3 (fr)
EA (1) EA006553B1 (fr)
EE (1) EE05530B1 (fr)
EG (1) EG26287A (fr)
ES (1) ES2312208T3 (fr)
GE (1) GEP20032987B (fr)
IL (2) IL139202A0 (fr)
NZ (1) NZ507162A (fr)
PT (1) PT1077691E (fr)
UA (1) UA76398C2 (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4904636B2 (ja) * 2001-05-29 2012-03-28 井関農機株式会社 トラクタフレーム
JP5047022B2 (ja) * 2008-03-24 2012-10-10 ヤンマー株式会社 上下分割式のエンジン収納用パッケージの結合構造
WO2013008182A1 (fr) * 2011-07-10 2013-01-17 Mahesh Kandula Précurseurs d'analogues de l'acide γ-aminobutyrique (gaba)
WO2014037832A2 (fr) 2012-09-06 2014-03-13 Mahesh Kandula Compositions et méthodes de traitement de l'épilepsie et de maladies neurologiques
JP2015519333A (ja) 2012-05-07 2015-07-09 セリックスビオ プライヴェート リミテッド 神経疾患の治療のための組成物および方法
WO2013168019A1 (fr) * 2012-05-07 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur neuropathique
CN104603096A (zh) 2012-05-07 2015-05-06 塞利克斯比奥私人有限公司 用于治疗神经肌肉障碍和神经退行性疾病的组合物和方法
WO2013167990A1 (fr) 2012-05-07 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la dépression
US9309233B2 (en) 2012-05-08 2016-04-12 Cellix Bio Private Limited Compositions and methods for the treatment of blood clotting disorders
US9403826B2 (en) 2012-05-08 2016-08-02 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory disorders
US9434704B2 (en) 2012-05-08 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of neurological degenerative disorders
US9266823B2 (en) 2012-05-08 2016-02-23 Cellix Bio Private Limited Compositions and methods for the treatment of parkinson's disease
US9522884B2 (en) 2012-05-08 2016-12-20 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic disorders
WO2013167999A2 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement d'affections neurologiques
WO2013168000A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur sévère
US9242939B2 (en) 2012-05-10 2016-01-26 Cellix Bio Private Limited Compositions and methods for the treatment of respiratory disorders
WO2013168016A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement du syndrome métabolique
WO2013168015A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes pour le traitement de l'asthme et de l'allergie
WO2013168002A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement d'affections neurologiques
US9499527B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of familial amyloid polyneuropathy
US9321775B2 (en) 2012-05-10 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of moderate to severe pain
US9499526B2 (en) 2012-05-10 2016-11-22 Cellix Bio Private Limited Compositions and methods for the treatment of neurologic diseases
WO2013167997A2 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement du syndrome métabolique
US20150087674A1 (en) * 2012-05-10 2015-03-26 Mahesh Kandula Compositions and methods for the treatment of severe pain
US9346742B2 (en) 2012-05-10 2016-05-24 Cellix Bio Private Limited Compositions and methods for the treatment of fibromyalgia pain
WO2013168011A1 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement de la douleur chronique
WO2013168005A2 (fr) 2012-05-10 2013-11-14 Mahesh Kandula Compositions et méthodes de traitement du syndrome des jambes sans repos et de la fibromyalgie
AU2013264896A1 (en) 2012-05-23 2014-11-27 Cellixbio Private Limited Compositions and methods for the treatment of multiple sclerosis
WO2013175377A2 (fr) 2012-05-23 2013-11-28 Mahesh Kandula Compositions et méthodes pour le traitement de la mucosite
US9492409B2 (en) 2012-05-23 2016-11-15 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
WO2013175357A2 (fr) 2012-05-23 2013-11-28 Mahesh Kandula Compositions et méthodes pour le traitement d'une maladie inflammatoire de l'intestin
US9434729B2 (en) 2012-05-23 2016-09-06 Cellix Bio Private Limited Compositions and methods for the treatment of periodontitis and rheumatoid arthritis
WO2013175347A2 (fr) 2012-05-23 2013-11-28 Mahesh Kandula Compositions et méthodes pour le traitement de troubles respiratoires
US9108942B1 (en) 2014-11-05 2015-08-18 Mahesh Kandula Compositions and methods for the treatment of moderate to severe pain
WO2014020480A2 (fr) 2012-08-03 2014-02-06 Mahesh Kandula Compositions et méthodes pour le traitement de la migraine et de maladies neurologiques
WO2014037833A2 (fr) 2012-09-06 2014-03-13 Mahesh Kandula Compositions et méthodes de traitement d'une inflammation et de troubles lipidiques
EP2892878A4 (fr) 2012-09-08 2016-02-24 Cellix Bio Private Ltd Compositions et méthodes de traitement d'une inflammation et de troubles lipidiques
US9333187B1 (en) 2013-05-15 2016-05-10 Cellix Bio Private Limited Compositions and methods for the treatment of inflammatory bowel disease
WO2014195961A1 (fr) 2013-06-04 2014-12-11 Mahesh Kandula Compositions et procédés de traitement du diabète et du pré-diabète
US9096537B1 (en) 2014-12-31 2015-08-04 Mahesh Kandula Compositions and methods for the treatment of mucositis
WO2016046835A1 (fr) 2014-09-26 2016-03-31 Cellix Bio Private Limited Compositions et méthodes de traitement de l'épilepsie et de troubles neurologiques
AU2014407862B2 (en) 2014-09-29 2020-03-26 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
CN104352476A (zh) * 2014-10-21 2015-02-18 齐宏 一种加巴喷丁胶囊及其制备方法
CN107108535B (zh) 2014-10-27 2020-04-28 塞尔利克斯生物私人有限公司 用于治疗多发性硬化的富马酸单甲酯与哌嗪或乙二胺的三组分盐
US9150557B1 (en) 2014-11-05 2015-10-06 Cellix Bio Private Limited Compositions and methods for the treatment of hyperglycemia
US9173877B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Compositions and methods for the treatment of local pain
US10208014B2 (en) 2014-11-05 2019-02-19 Cellix Bio Private Limited Compositions and methods for the treatment of neurological disorders
US9175008B1 (en) 2014-11-05 2015-11-03 Cellix Bio Private Limited Prodrugs of anti-platelet agents
US9284287B1 (en) 2014-11-05 2016-03-15 Cellix Bio Private Limited Compositions and methods for the suppression of carbonic anhydrase activity
US9321716B1 (en) 2014-11-05 2016-04-26 Cellix Bio Private Limited Compositions and methods for the treatment of metabolic syndrome
US9290486B1 (en) 2014-11-05 2016-03-22 Cellix Bio Private Limited Compositions and methods for the treatment of epilepsy
US9932294B2 (en) 2014-12-01 2018-04-03 Cellix Bio Private Limited Compositions and methods for the treatment of multiple sclerosis
US9206111B1 (en) 2014-12-17 2015-12-08 Cellix Bio Private Limited Compositions and methods for the treatment of neurological diseases
EP3242869B1 (fr) 2015-01-06 2021-10-27 Cellixbio Private Limited Compositions et méthodes pour le traitement d'une inflammation et de la douleur

Also Published As

Publication number Publication date
EA006553B1 (ru) 2006-02-24
PT1077691E (pt) 2008-11-04
DK1077691T3 (da) 2008-10-27
ES2312208T3 (es) 2009-02-16
CY1108488T1 (el) 2014-04-09
ATE407668T1 (de) 2008-09-15
EE05530B1 (et) 2012-04-16
UA76398C2 (en) 2006-08-15
IL139202A0 (en) 2001-11-25
CN1171587C (zh) 2004-10-20
DE69939532D1 (de) 2008-10-23
JP3761324B2 (ja) 2006-03-29
EE200000671A (et) 2002-04-15
CN1300213A (zh) 2001-06-20
CA2325045A1 (fr) 1999-11-25
GEP20032987B (en) 2003-06-25
JPH11318133A (ja) 1999-11-24
IL139202A (en) 2014-12-31
EG26287A (en) 2013-06-12
EA200001154A1 (ru) 2001-06-25
NZ507162A (en) 2003-11-28

Similar Documents

Publication Publication Date Title
CA2325045C (fr) Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe
EP1077691B1 (fr) Compositions solides contenant des derives de l'acide gamma-aminobutyrique, et procede de preparation associe
IL148126A (en) Use of Rampril or Ramiprilat or their pharmaceutical salt preparation to prepare a heart failure medication in patients without previous heart failure
KR100602047B1 (ko) 감마-아미노부티르산 유도체의 안정화된 제약 제제 및그의 제조 방법
US5151433A (en) Stabilized medicinal substances, a process for the preparation thereof, and stable medicinal formulations
US5990152A (en) Dosage forms containing thioctic acid or solid salts of thioctic acid with improved release and bioavailability
CA2065603C (fr) Preparation de vitamine d stabilisee
SI20059A (sl) Izboljšana, hitro razpadajoča, multipartikularna tableta
WO1999020276A1 (fr) Composition medicamenteuse stable
EA002428B1 (ru) Стабильные композиции, содержащие левозимендан и альгиновую кислоту
MXPA00009535A (en) Gamma-aminobutyric acid derivatives containing, solid compositions and processfor preparing the same
MXPA00010737A (en) Stabilized pharmaceutical preparations of gamma-aminobutyric acid derivatives and process for preparing the same
EP0742008A1 (fr) Compositions pharmaceutiques à libération contrÔlée

Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20190510